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| 1 | Outbreak of Dengue Fever in Central China,2013显示文摘In 2013,the first dengue fever(DF) outbreak in central China was reported in the central of Henan province,northern temperate regions,although they have been sequentially recorded in Southern China.106 suspected DF cases were reported and 73 patients were confirmed dengue virus type 3(DEN-3) infections.62/392(15.8%) local health persons showed DEN antibodies positive.To this day Henan is the northernmost province in China which has been reported about outbreak of DF and what is important is that it warns us the endemic range of DF has been expanded geographically in China. | HUANG Xue Yong MA Hong Xia WANG Hai Feng DU Yan Hua SU Jia LI Xing Le TANG Xiao Yan MA Hong Peng ZU Bing Can ZHANG Qiao Hong CHEN Hao Min XU Bian Li | 2014 | Biomedical and Environmental Sciences2014，27，11： | 30 |
| 2 | Exosome-functionalized polyetheretherketone-based implant with immunomodulatory property for enhancing osseointegration显示文摘The host immune response effecting on biomaterials is critical to determine implant fates and bone regeneration property.Bone marrow stem cells(BMSCs)derived exosomes(Exos)contain multiple biosignal molecules and have been demonstrated to exhibit immunomodulatory functions.Herein,we develop a BMSC-derived Exos-functionalized implant to accelerate bone integration by immunoregulation.BMSC-derived Exos were reversibly incorporated on tannic acid(TA)modified sulfonated polyetheretherketone(SPEEK)via the strong interaction of TA with biomacromolecules.The slowly released Exos from SPEEK can be phagocytosed by co-cultured cells,which could efficiently improve the biocompatibilities of SPEEK.In vitro results showed the Exos loaded SPEEK promoted macrophage M2 polarization via the NF-κB pathway to enhance BMSCs osteogenic differentiation.Further in vivo rat air-pouch model and rat femoral drilling model assessment of Exos loaded SPEEK revealed efficient macrophage M2 polarization,desirable new bone formation,and satisfactory osseointegration.Thus,BMSC-derived Exos-functionalized implant exerted osteoimmunomodulation effect to promote osteogenesis. | Lei Fan Pengfei Guan Cairong Xiao Huiquan Wen Qiyou Wang Can Liu Yian Luo Limin Ma Guoxin Tan Peng Yu Lei Zhou Chengyun Ning | 2021 | Bioactive Materials2021，6，9： | 11 |
| 3 | Accurate mirror-based camera pose estimation with explicit geometric meanings显示文摘An accurate closed form solution is proposed to estimate camera pose by several mirrored reference object images acquired via a planar mirror under different unknown poses. Compared with state-of-the-art methods, our method is more accurate when there are more than three images and has explicit geometric meanings. This method also properly handles cases in which some of the mirror poses are parallel. The central idea is to minimize an error metric based on all reflections of rotation, which enables the camera rotation to be estimated directly by SVD of sum of mirrored camera rotations. After that, the camera translation is computed by solving a large system of linear equations to minimize object space collinearity error. Both synthesized data and real data experiments show the advantages of our approach. | LI Xin LONG Gu Can GUO Peng Yu LIU Jin Bo ZHANG Xiao Hu YU Qi Feng | 2014 | Science China(Technological Sciences)2014，57，12： | 6 |
| 4 | Autophagy Attenuates MnCl2-induced Apoptosis in Human Bronchial Epithelial Cells显示文摘Objective To investigate the role of autophagy in MnC l2-induced apoptosis in human bronchial epithelial 16 HBE cells.Methods Cell proliferation was measured by MTT assay.Mitochondrial membrane potential(MMP) and apoptosis were measured by flow cytometry.Autophagic vacuoles were detected by fluorescence microscopy.Cellular levels of apoptosis and autophagy-related proteins were measured by western blotting.Results 16 HBE cell proliferation was inhibited by Mn Cl2 in a dose-and time-dependent manner.Mn Cl2-induced 16 HBE cell growth inhibition was related to MMP depolarization prior to the induction of apoptosis.Our data revealed that Mn Cl2-induced apoptosis in 16 HBE cells was mediated by decreased expression of Bcl-2 and increased levels of cleaved caspase-3.It was observed that when we exposed 16 HBE cells to MnCl_2 in a dose-dependent manner,the formation of autophagic vacuoles and the levels of LC-3B-II were elevated.RNA interference of LC3 B in these Mn Cl2-exposed cells demonstrated that MMP loss and apoptosis were enhanced.Additionally,the pan-caspase inhibitor Z-VAD-FMK increased the cellular levels of Bcl-2 and decreased apoptosis,but did not affect the cellular levels of LC3 B in Mn Cl2-treated 16 HBE cells.Conclusion Mn Cl2 dose-and time-dependently inhibits 16 HBE cell proliferation and induces MMP loss and apoptosis.Autophagy acts in a protective role against Mn Cl2-induced apoptosis in 16 HBE cells. | YUAN Zhun YING Xian Ping ZHONG Wei Jian TIAN Shi Min WANG Yu JIA Yong Rui CHEN Wen FU Juan Ling ZHAO Peng ZHOU Zong Can | 2016 | Biomedical and Environmental Sciences2016，29，7： | 5 |
| 5 | Mechanically exfoliated MoS_(2) nanosheets decorated with SnS_(2) nanoparticles for high-stability gas sensors at room temperature显示文摘Due to its unique physical,chemical and surface electronic properties,molybdenum disulfide(MoS_(2))nanosheets open up a new avenue for nitrogen dioxide(NO2)detection at room temperature.Nevertheless,the gas sensing properties of pure MoS_(2) nanosheets are inevitably degenerated by the adsorption of atmospheric oxygen,which results in weak stability for MoS_(2)-based gas sensors.Reducing surface defects and constructing heterojunctions may be effective strategies to improve the gas sensing properties of MoS_(2) nanosheets.In this work,we design a novel nanocomposite based on MoS_(2) nanosheets decorated with tin disulfide(SnS_(2))nanoparticles(MoS_(2)/SnS_(2))via combining the mechanical exfoliation method with the facile hydrothermal method.The experimental results indicate that,after surfaces decoration with SnS_(2) nanoparticles,the as-prepared gas sensor based on MoS_(2)/SnS_(2) nanocomposites exhibits reliable long-term stability with the maximum response value drift of less than 3%at room temperature.Moreover,the MoS_(2)/SnS_(2) sensor also possesses desirable gas sensing properties upon NO_(2) at room temperature,such as high sensitivity,rapid response/recovery speed(28 s/3 s,5×10^(-6) NO_(2)),satisfactory selectivity,favorable repeatability and reversibility.The improved gas sensing properties of MoS_(2)/SnS_(2) nanocomposites can be attributed to the unique electronic properties of MoS 2 nanosheets with the fewer layers structure and the competitive adsorption effect of SnS_(2) nanoparticles.This work elucidates that SnS_(2) nanoparticles serving as an effective antioxidative decoration can promote the stability of MoS_(2) nanosheets,providing a promising approach to achieve high-stability NO2 gas sensors at room temperature. | Jia-Bei Liu Jin-Yong Hu Can Liu Yu-Ming Tan Xiang Peng Yong Zhang | 2021 | Rare Metals2021，40，6： | 5 |
| 6 | Identification of a new stripe rust resistance gene in Chinese winter wheat Zhongmai 175显示文摘Stripe rust is a serious foliar disease posing a grave threat to wheat production worldwide. The most economical and environmentally friendly way to control this disease is to breed and deploy resistant cultivars. Zhongmai 175 is an elite winter wheat cultivar conferring resistance to a broad spectrum of Puccinia striiformis f. sp. tritici(Pst) races. To identify the resistance gene in the cultivar, genetic analysis was conducted using the parents, F1, F2 and F2:3 populations derived from the cross of Lunxuan 987/Zhongmai 175. Segregations in the F2 and F2:3 populations indicated a single dominant gene conferring resistance to stripe rust in Zhongmai 175, temporarily designated Yr ZM175. Bulked segregant analysis(BSA) with wheat i Select 90 K SNP array determined a preliminary location of Yr ZM175. Subsequently, Yr ZM175 was mapped on chromosome 2AS using simple sequence repeats(SSR), expressed sequence tags(EST) and newly-developed kompetitive allele specific PCR(KASP) markers, being flanked by Xgwm636 and Xwmc382 at genetic distances of 4.9 and 8.1 c M, respectively. Comparison of reaction patterns of Yr ZM175 on 23 Pst races or isolates and pedigree analysis with other genes on chromosome 2AS suggested that it is likely to be a new gene for resistance to stripe rust. The resistance gene and linked molecular markers will be useful in wheat breeding targeting for the improvement of stripe rust resistance. | LU Jia-ling CHEN Can LIU Peng HE Zhong-hu XIA Xian-chun | 2016 | Journal of Integrative Agriculture2016，15，11： | 3 |
| 7 | Corrosion Behavior of 316L Stainless Steels Exposed to Salt Lake Atmosphere of Western China for 8 years显示文摘The evolution of corrosion behavior of 316 L stainless steels exposed to salt lake atmosphere for 8 years was investigated.The results showed that the stainless steel in salt lake atmosphere had a greater corrosion rate during the initial exposure time and relatively lower corrosion rate during the subsequent exposure time.Dust depositions accumulated on the downward surface caused severe local corrosion of stainless steel.As exposure time prolonged,the relative amount of Croxide and Feoxidein the corrosion products gradually increased,which may directly affect the corrosion rate of stainless steels.Moreover,the maximum pit depth followed a power function with respect to exposure time. | Mingxiao Guo Junrong Tang Tianzhen Gu Can Peng Qiaoxia Li Chen Pan Zhenyao Wang | 2021 | Acta Metallurgica Sinica(English Letters)2021，34，4： | 3 |
| 8 | Whole-Genome Sequences Analysis Displays Relationship of SARS-CoV-2 Delta Variant Between Four Local Cases and Passengers of a Flight from South Africa—Shenzhen City,Guangdong Province,China,June 2021显示文摘On June 14,2021,a customs officer(Case A)went to the infirmary at Baoan International Airport in Shenzhen due to a runny nose and fever.He was admitted to the Central Hospital of Baoan immediately.This patient preliminarily tested positive for coronavirus disease 2019(COVID-19)infection,caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),using a quantitative realtime reverse transcription polymerase chain reaction(qRT-PCR)method in this hospital.Then,a mixed specimen of nasopharyngeal swab. | Yaqing He Renli Zhang Qiuying Lyu Bo Peng Shujiang Mei Ying Sun Dongfeng Kong Chaoqiong Peng Ziquan Lyu Xinyi Wei Can Zhu Xiaoliang Xiao Shimin Li Qingju Lu Jiancheng Chen Hang Zhang Xuan Zou Tiejian Feng Long Chen | 2021 | China CDC weekly2021，3，50： | 3 |
| 9 | Experimental study on spray cooling under reduced pressures显示文摘Spay cooling is a complicated flow and heat transfer process affected by multi-factors among which the environmental pressure is extremely important. However the influence of pressure is not investigated sufficiently, especially the reduced pressure. In the present study, spray cooling under low initial environmental partial pressures and vapor partial pressures with R21 are investigated with a closed spray and condensation system. To study the influence of initial environmental partial pressure, different amounts of nitrogen are inflated into the vacuum flash chamber, while the vapor partial pressure is kept constant. To study the influence of vapor partial pressure, a cascade refrigerator is used to condense the vapor with different condensation temperatures so that the vapor partial pressure can be maintained or adjusted, while the initial environmental partial pressure is kept constant.The experimental results show that the spray cooling power increases monotonically with the increasing spray flow rate in the experimental range, while the cooling efficiency decreases with the increasing spray flow rate. The spray cooling power and cooling efficiency vary with the initial environmental partial pressure or the vapor partial pressure non-monotonously, which indicates there is an optimal pressure for the heat transfer performance. Besides, the mechanism of the non-monotonous variation trend is discussed based on the key aspects including flash evaporation, convection and boiling. Especially, the boiling heat transfer curve is applied to explain the trend. | PENG Can XU XiangHua LI Ye Ming LI YuLong LIANG XinGang | 2019 | Science China(Technological Sciences)2019，62，2： | 2 |
| 10 | S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest显示文摘In this study,a new parameter,S phase cell percentage(S fraction)normalized BrdU(SFN-BrdU)incorporation rate,was introduced to detect S arrest.The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells.Theoretical analysis indicated that only S | ZHAO Peng FU Juan Ling YAO Bi Yun JIA Yong Rui ZHOU Zong Can | 2014 | Biomedical and Environmental Sciences2014，27，3： | 2 |
| 11 | Generating Giant Membrane Vesicles from Live Cells with Preserved Cellular Properties显示文摘Biomimetic giant membrane vesicles,with size and lipid compositions comparable to cells,have been recognized as an attractive experimental alternative to living systems.Due to the similarity of their membrane structure to that of body cells,cell-derived giant plasma membrane vesicles have been used as a membrane model for studying lipid/protein behavior of plasma membranes.However,further application of biomimetic giant membrane vesicles has been hampered by the side-efects of chemical vesiculants and the utilization of osmotic bufer.We herein develop a facile strategy to derive giant membrane vesicles(GMVs)from mammalian cells in biofriendly medium with high yields.Tese GMVs preserve membrane properties and adaptability for surface modifcation and encapsulation of exogenous molecules,which would facilitate their potential biological applications.Moreover,by loading GMVs with therapeutic drugs,GMVs could be employed for drug transport to tumor cells,which represents another step forward in the biomedical application of giant membrane vesicles.Tis study highlights biocompatible GMVs with biomimicking membrane surface properties and adaptability as an ideal platform for drug delivery strategies with potential clinical applications. | Qiaoling Liu Cheng Bi Jiangling Li Xuejiao Liu Ruizi Peng Cheng Jin Yang Sun Yifan Lyu Hui Liu Huijing Wang Can Luo Weihong Tan | 2019 | Research2019，，1： | 2 |
| 12 | Fast response speed of mechanically exfoliated MoS2 modified by PbS in detecting NO2显示文摘MoS2,acting as a promising gas sensing material,has shown huge potential in monitoring of toxic and harmful gases at room temperature.However,MoS2-based gas sensors still suffer from poor gas sensing performance such as poor sensitivity,long response time.Constructing the hete ro structure is an effective approach to improve gas-sensing performance of MoS2.Herein,PbS@MoS2 composites synthesized by mechanical exfoliation combining with wet-chemical precipitation are used to investigate its performance in detecting NO2 at room temperature.The response value of PbS@MoS2 gas sensor against NO2 is significantly improved compared with the pure MoS2 gas sensor.At the same time,the modification with PbS also accelerates the response speed of MoS2,and the response time is almost reduced by two orders of magnitude,from hundreds of seconds to less than ten seconds.The enhanced response value and fast response time are mainly benefited from the modulation effect of NO2 to PbS@MoS2 heterostructure and the mechanically exfoliated MoS2 surface with few defects.This work can be expected to provide useful guidance for designing composite materials with excellent gas sensing properties. | Junjiang Tan Jinyong Hu Jianxu Ren Jinfeng Peng Can Liu Yiqiao Song Yong Zhang | 2020 | Chinese Chemical Letters2020，31，8： | 2 |
| 13 | Chemical synthesis and characterization of two α4/7-conotoxins显示文摘-Conotoxins 是对烟碱的醋胆素受体(nAChRs ) 的特定的子类型作为有势力和选择对手起作用的小抑制二硫化物的肽。我们以前从食虫的 Conus leopardus 从 molluscivorous Conus marmoreus 和 Lp1.4 克隆二 -conotoxins, Mr1.1。他们俩有 -conotoxins 的亚科的典型 4/7-type 框架 neuronal nAChRs 上的那行为。在这个工作,我们化学上综合了这二毒素并且描绘了他们的功能的性质。合成 Mr1.1 能首先禁止唤起的醋胆素(ACh ) 水流 reversibly 在表示卵母细胞的老鼠 7 nAChR,而 Lp1.4 是老鼠的意外特定的 blocker 胎儿的肌肉 11 受体。尽管他们的抑制亲密关系是相对低的,他们的唯一的受体识别侧面为毒素受体相互作用研究使他们成为珍贵工具。Mr1.1 能也压制煽动性的反应在 vivo 伤害,建议它应该进一步关于它在为疼痛的治疗的痛觉缺失和它的机制或治疗学的目标的分子的角色被调查。 | Can Peng Weihua Chen Tanya Sanders Geoffrey Chew Jing Liu Edward Hawrot Chengwu Chi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，10： | 2 |
| 14 | Overexpression of OsSPL9 enhances accumulation of Cu in rice grain and improves its digestibility and metabolism显示文摘Copper(Cu)is an essential trace mineral element for all forms of life,and is an important structural component and co-factor for a variety of metalloenzymes(Pen^a et al.,1999;Bertinato and L'Abbe,2004).In humans,Cu deficiency is not common because of the ubiquitous occurrence of Cu and ease of gastrointestinal absorption(Zidar et al.,1977;Uauy et al.,1998).However,because of the low Cu content in most sources of feed,the use of Cu as a growth promoter to maximize animal production has been well documented in animal feeding(Braude,1945;Lu et al.,2010).Pre- | Mingfeng Tang Chuanshe Zhou Lu Meng Donghai Mao Can Peng Yuxing Zhu Daoyou Huang Zhiliang Tan Caiyan Chen Chengbing Liu Dechun Zhang | 2016 | Journal of Genetics and Genomics2016，43，11： | 2 |
| 15 | Effects of UV on the Corrosion Behavior of Pure Aluminum 1060 in Simulated Nansha Marine Atmosphere显示文摘The corrosion behavior of pure aluminum 1060 subjected to a wet-dry cyclic accelerated test in simulated Nansha marine atmosphere in the dark and under UV illumination has been investigated by means of scanning electron microscopy(SEM),electrochemical impedance spectroscopy(EIS),and Mott–Schottky measurements in this work.The results show that under the two conditions,the native oxide films are constantly destroyed and the thicknesses of the oxide films continuously decrease in the first 24 days of the corrosion test.In particular,UV illumination can diminish the pitting corrosion susceptibility of the native oxide films to an extent in terms of a photo-induced modifi cation of the native oxide film on the pure aluminum surfaces.Besides,UV illumination can also reduce the carrier concentration in the oxide films,thus reducing the conductivity and the corrosion rate. | Can Peng Mingxiao Guo Tianzhen Gu Xiaohan Li Chuan Wang Zhenyao Wang Cheng Sun | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，7： | 1 |
| 16 | Primary Testicular NK/T-Cell Lymphoma:A Study of Two Cases and Review of Literature显示文摘Primary testicular NK/T-cell lymphoma is an extremely rare entity progressed rapidly.The aim of this study was to examine clinical and pathological features of primary testicular NK/T-cell lymphoma and to investigate the effective diagnosis and prognosis.In this paper,the two cases of primary testicular NK/T-cell lymphoma were observed by light microscopy,immunohistochemistry and examined by in situ hybridization for Epstein-Barr Virus(EBV) DNA and the literatures were reviewed.The two patients respectively present with bilateral and right-side painless testicular enlargement.The morphology of neoplastic cells of case 1 were small to medium,tumor cells of case 2 were small,medium and large mixed.The tumor cells grew diffusely with irregular and distort nuclear,destructed the organizational structure of the normal testis,and damaged blood vessels,meanwhile,coagulation necrosis was exist.Immunohistochemical staining of neoplastic cells showed positive for CD45,CD2,CD56,CD3ε(cytoplasm staining pattern),CD45RO and Granzyme B,and negative for CD57,CD20,CD79α,CD30,CK,MPO,TdT,Bcl-2 and PLAP were negative.In addition,the EBV DNA was detected in the lymphoma by In situ hybridization.In conclusion,the expression of CD56,CD3ε,and Granzyme B associated proteins and EBV examination by in situ hybridization play a vital role in diagnosis and differential diagnosis of primary testicular NK/T-cell lymphoma. | Xiao Lin Dan Li Peng Xie Can Mi Qing Lin | 2010 | Chinese Journal of Cancer Research2010，22，3： | 1 |
| 17 | The oxidation of benzothiophene using the Keggin-type lacunary polytungstophosphate as catalysts in emulsion显示文摘 | Yongna Zhang Hongying Lü Lu Wang Yuliang Zhang Peng Liu Hongxian Han Zongxuan Jiang Can Li | 2010 | Journal of Molecular Catalysis A Chemical2010，，1： | 1 |
| 18 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 19 | First Report in China on the Identification and Drug Sensitivity of Mycobacterium elephantis Isolated from the Milk of a Cow with Mastitis显示文摘Objective In this study, milk from a cow with mastitis was analyzed to determine the presence of mycobacterial infection. Milk quality and security problems pertaining to the safe consumption of dairy products were also discussed in this study. Methods Milk was preprocessed with 4% Na OH. Then, mycobacteria were isolated from the milk sample on L-J medium. The isolate was identified using multiple loci Polymerase Chain Reaction(PCR) and multi-locus sequence analysis with 16 S r RNA, sod A, hsp65, and ITS genes. The drug sensitivity of the isolate to 27 antibiotics was tested through alamar blue assay. Results Smooth, moist, pale yellow colonies appeared on the L-J medium within a week after inoculation. Based on the results of multiple loci PCR analysis, the isolate was preliminarily identified as non-tuberculous mycobacteria. The 16 S r RNA, Sod A, hsp65, and ITS gene sequences of the isolate exhibited 99%, 99%, 99%, and 100% similarities, respectively, with those of the published reference strains of Mycobacterium elephantis(M. elephantis). The drug sensitivity results showed that the strain is resistant to isoniazid, p-aminosalicylic acid, and trimesulf but is sensitive to ofloxacin, rifampicin, amikacin, capreomycin, moxifloxacin, kanamycin, levofloxacin, cycloserine, ethambutol, streptomycin, tobramycin, rifabutin, ciprofloxacin, linezolid, cefoxitin, clarithromycin, and minocycline. Conclusion To the best of our knowledge, this study is initially to report the isolation of M. elephantis from the milk of a cow with mastitis in China. | JI Ling Yun XU Dong Lei YIN Shu Peng LIU Hai Can LI Gui Lian JIANG Yi WEI Jian Hao ZENG Hao LOU Yong Liang LYU Jian Xin WAN Kang Lin | 2017 | Biomedical and Environmental Sciences2017，30，7： | 1 |
| 20 | Primary testicular diffuse large B-cell lymphoma shows an activated B-cell-like phenotype显示文摘 | Dan Li Peng Xie Can Mi | 2010 | Pathology - Research and Practice2010，，9： | 1 |
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