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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Archery Algorithm:A Novel Stochastic Optimization Algorithm for Solving Optimization Problems显示文摘Finding a suitable solution to an optimization problem designed in science is a major challenge.Therefore,these must be addressed utilizing proper approaches.Based on a random search space,optimization algorithms can find acceptable solutions to problems.Archery Algorithm(AA)is a new stochastic approach for addressing optimization problems that is discussed in this study.The fundamental idea of developing the suggested AA is to imitate the archer’s shooting behavior toward the target panel.The proposed algorithm updates the location of each member of the population in each dimension of the search space by a member randomly marked by the archer.The AA is mathematically described,and its capacity to solve optimization problems is evaluated on twenty-three distinct types of objective functions.Furthermore,the proposed algorithm’s performance is compared vs.eight approaches,including teaching-learning based optimization,marine predators algorithm,genetic algorithm,grey wolf optimization,particle swarm optimization,whale optimization algorithm,gravitational search algorithm,and tunicate swarm algorithm.According to the simulation findings,the AA has a good capacity to tackle optimization issues in both unimodal and multimodal scenarios,and it can give adequate quasi-optimal solutions to these problems.The analysis and comparison of competing algorithms’performance with the proposed algorithm demonstrates the superiority and competitiveness of the AA. | Fatemeh Ahmadi Zeidabadi Mohammad Dehghani Pavel Trojovsky Štěpán Hubálovsky Victor Leiva Gaurav Dhiman | 2022 | Computers, Materials & Continua2022，，7： | 2 |
| 3 | Heterogeneity of c-myc expression in histologically similar infiltrating ductal carcinomas of the breast 显示文摘 | PAVELIC ZP PAVELIC K CARTER C P | 1992 | J Cancer Res Clin Oncol1992，118，1： | 1 |
| 4 | Treatment of acute agitation in psychotic disorders显示文摘 | PAVEL M JAN P JAROMIR S | 2005 | Neuroendocrinol Lett2005，26，4： | 1 |
| 5 | Inhibition effect of free ammonia and free nitrous acid on nitrite-oxidising bacteria during sludge liquor treatment:influence of feeding strategy 显示文摘 | PAVEL S JAN B LUKAS P | 2014 | Chemical Papers2014，68，7： | 1 |
| 6 | Role of aquifer storage in water reuse显示文摘 | Dillon P Pavelic P Toze S | 2006 | Desalination2006，188，13： | 1 |
| 7 | Beam quality factor of higher order modes in a step-index fiber显示文摘 | HIDEHIKO Y PAVEL P MASUD M | 2006 | IEEE J Lightwave Technology2006，24，3： | 1 |
| 8 | Detection of Pglycoprotein with four monoclonal antibodies in normal and tumor tissues显示文摘 | Pavelic Z P Reising J Pavelic L | 1993 | Arch Otolaryngol Head Neck Surg1993，119，7： | 1 |
| 9 | Comparative assess- ment of five methods of determining sap flow in peach trees显示文摘 | Gonzalez - Altozano P Pavel E Oncins J | 2008 | Agri- cultural Water Management2008，95，5： | 1 |
| 10 | Shevchenko Impact of insurance for operational risk: Is it worthwhile to insure or be in- sured for severe losses? 显示文摘 | W P Gareth D 13 Aaron V Pavel | 2011 | Insurancez Mathematics and Eco- nomics2011，48，2： | 1 |
| 11 | Water quality effects on clogging rates during reclaimed water ASR in a carbonate aquifer显示文摘 | Pavelic P Dillon P J Barry K E | 2007 | Journal of Hydrology2007，334，12： | 1 |
| 12 | Distributed multi-agent architecture for automation systms显示文摘 | Francisco P M Pavel Tichy Petr Slechta | 2004 | Expert System with Applications2004，26，： | 1 |
| 13 | True blue:Blue-emitting aluminum(III) quinolinolate complexes显示文摘 | Cesar P B Montes V A Pavel A | | 0，，24： | 1 |
| 14 | 显示文摘 | Pavel C Zverev P G Jelinkova H | 2000 | Optics Communications2000，177，： | 1 |
| 15 | Efficient Raman Shifting of Picosecond Pulses Using BaWO4 Crystal 显示文摘 | Cerny Pavel Zverev P G Jelinkova H Basiev T T | 2000 | Optics Communications2000，177，16： | 1 |
| 16 | Prototype selection for dissimilarity-based classifiers 显示文摘 | El'zbieta PeRkalska Robert P W Duin Pavel Paclik | 2006 | Pattern Recognition2006，39，2： | 1 |
| 17 | Potential danger of light emitting diode illumination to the eye, in children and teenagers显示文摘 | Pavel P Zak Mikhail A Ostrovsky | 2012 | Light Eng2012，20，3： | 1 |
| 18 | An inquiry into good hospital gnver- nance: a New Zealand-Czech comparison显示文摘 | Elizabeth D Pavel T Petr P | 2006 | Health Research Poliey and Systems2006，4，2： | 1 |
| 19 | Design and fabrication of poly ( dimethylsiloxane ) arrayed wavegui-de grating显示文摘 | Jack S K Daniel P P Pavel N | 2010 | Optics Express2010，21，21： | 1 |
| 20 | Mariella Constantinescu, Study of one dimensional solidification with free convection in an infinite plate geometry显示文摘 | Stefania Zuca Pavel P M | 1999 | Energy Conversion & Management1999，40，： | 1 |
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