维普期刊资源整合服务平台（V6.5）

413篇 您的检索式：作者名="Dillon P"

选中清除导出查看参考文献查看引证文献引用追踪共21页首页上一页第1页下一页末页 /21 跳转

	题名	作者	年代	出处	被引量
1	Cyclooxygenase-2 plays a central role in the genesis of pancreatitis and associated lung injury显示文摘BACKGROUND: The exact mechanism by which cyclooxy- genase-2 (COX-2) promotes inflammation in pancreatitis in obscure. This study was undertaken to investigate the role of COX-2 inhibition in an animal model of pancreati- tis , a disease process characterized by a systemic inflamma- tory response and ensuing neutrophil-mediated lung injury. METHODS: Pancreatitis was induced in 24 Sprague-Daw- ley rats by intraperitoneal injection of 20% L-arginine (500 mg/100 g body weight). The animals were randomized into 3 groups (8 rats in each group); controls and rats with pancreatitis intravenously resuscitated with either normal saline (0.9% NaCl 3 ml/kg) at 24 and 48 hours or COX-2 inhibitor (parecoxib 1 mg/kg). Pancreatic and lung inju- ries were assessed histologically. Lung injury was assessed utilizing wet;dry ratio and myeloperoxidase activity to in- dicate pulmonary neutrophil infiltration. A Western blot was used to determine COX-2 protein expression in pancrea- tic tissue. RESULTS: The animals treated with COX-2 inhibitors dis- played significantly less pancreatic and lung injuries than their normal saline counterparts. Histological pancreatic and lung injury scores were significantly reduced (P <0.05) in the COX-2 treated group. Lung wet: dry ratios were sig- nificantly improved and pulmonary neutrophil infiltration was attenuated in the COX-2 group (P<0.05). Western blot analysis confirmed attenuated COX-2 protein expression. CONCLUSION: This study shows, for the first time in a rat model, that adjuvant COX-2 inhibition significandy attenu- ates the severity of both pancreatitis and its associated sys- temic inflammatory response and end-organ injury.	Gavin O'Brien Conor J Shields Desmond C Winter John P Dillon	2005	Hepatobiliary & Pancreatic Diseases International2005，4，1：	12
2	A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference显示文摘	Rubinson D A Dillon C P Kwiatkowski A V	2003	Nat Genet2003，33，3：	1
3	Flotation technique for separating fecal pellets and small marine organisms from sand显示文摘	Dillon W P	1964	Limnology and oceanography1964，9，：	1
4	显示文摘	Mo Y G Dillon R O Snyder P G	1999	Thin Solid Films1999，355，：	1
5	Alentivirus-based system to functionally silence genes in primarymammalian cells, stem cells and transgenic mice by RNAinterference 显示文摘	Rubinson D A Dillon C P Kwiatkowski A J	2003	Nat Genet2003，33，3：	1
6	Separation and charac- terization of Nom by high - performance liquid chromatography and on - line three - dimensional excitation emission matrix fluo- rescence detection 显示文摘	Wu F C Evans R D Dillon P J	2003	Environmental Science & Technology2003，37，16：	1
7	The health and psycho - social consequence of ketamine use显示文摘	Copeland J Dillon P	2005	Int J Drug Policy2005，16，：	1
8	Role of aquifer storage in water reuse显示文摘	Dillon P Pavelic P Toze S	2006	Desalination2006，188，13：	1
9	Developmental aspects and mechanisms of rat caudal hypothalamic neuronal responses to hypoxia显示文摘	Horn E M Dillon G H Fan Y P	1999	J Neurophysiol1999，81，4：	1
10	The health and psycho-social consequences of ketamine use显示文摘	Copeland J Dillon P	2005	Int J Drug Policy2005，16，2：	1
11	Metal oxide nano-particles for improved electrochromic and lithium battery technologies显示文摘	DILLON A C MAHAN A H DESHPANDE R PARILLA P A JONES K M LEE K H	2008	Thin Solid Films2008，516，：	1
12	Prospective evaluation of multidetector-row CT angiography for the diagnosis of vasospasm following subarachnoid hemorrhage:a comparison with digital subtraction angiography显示文摘	Chaudhary S R Ko N Dillon W P Yu M B Liu S Criqui G I	2008	Cerebrovasc Dis2008，25，12：	1
13	Effects of backpacking holidays in Australia on alcohol,tobacco and drug use of UK residents显示文摘	Bellis MA Hughes KE Dillon P	2007	BMC Public Health2007，7，：	1
14	Radiation injury of the brain (review)显示文摘	Valk P E Dillon W P	1991	AJNR1991，12，1：	1
15	A Lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference显示文摘	Rubinson D A Dillon C P Kwiatkowski A V	2003	Nat Genet2003，33，3：	1
16	A comparison of formulations for the vector finite element analysis of waveguides显示文摘	DILLON B M WEBB J P	1991	Trans Microwave Theory and Tech1991，42，2：	1
17	Sorghum resolvedas a distinct genus based on combined ITS1, ndhF and Adh1analyses 显示文摘	Dillon S L Lawrence P K Henry R J	2007	Plant Syst Evol2007，268，1234：	1
18	Biological pretreatment of sugar cane bagasse for the production of cellulases and xylanases by Penicillium echinulatum显示文摘	Camassola M Dillon A J P	2009	Industrial Crops and Products2009，29，23：	1
19	Sorption and degradation of selected five endocrine disrupting chemicals in aquifer material 显示文摘	Ying G-G Kookana S R Dillon P	2003	Water Research2003，37，15：	1
20	The potential of riverbank filtration for drinking water supplies in relation to microsystin removal in brackish aquifers显示文摘	Dillon P J Miller M Fallowfield H	2002	Journal of Hydrology2002，，266：	1

返回顶部每页显示：

共21页首页上一页第1页下一页末页 /21 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示