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| 1 | When worlds collide: Th17 and Treg cells in cancer and autoimmunity显示文摘The balance between Th17 cells and regulatory T cells(Tregs)has emerged as a prominent factor in regulating autoimmunity and cancer.Th17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer,though their role in carcinogenesis is less well understood.Tregs are required for self-tolerance and defense against autoimmunity and often correlate with cancer progression.This review addresses the importance of a functional homeostasis between these two subsets in health and the consequences of its disruption when these forces collide in disease.Importantly,we discuss the ability of Th17 cells to mediate cancer regression in immunotherapy,including adoptive transfer and checkpoint blockade therapy,and the therapeutic possibilities of purposefully offsetting the Th17/Treg balance to treat patients with cancer as well as those with autoimmune diseases. | Hannah M.Knochelmann Connor J.Dwyer Stefanie R.Bailey Sierra M.Amaya Dirk M.Elston Joni M.Mazza-Mc.Crann Chrystal M.Paulos | 2018 | Cellular & Molecular Immunology2018，15，5： | 50 |
| 2 | Intercontinental disjunctions between eastern Asia and western North America in vascular plants highlight the biogeographic importance of the Bering land bridge from late Cretaceous to Neogene显示文摘这评论在脉管的植物(flowering 植物,裸子植物,蕨纲植物和 lycophytes ) 的主要的系从迟了的白垩纪显示出在东方亚洲和西方的北美洲之间的一个靠近的 biogeographic 连接到迟了的晚第三纪。东方亚洲北方的美国 disjuncts,针叶树展出在东方亚洲和西方的北美洲之间的 disjuncts 的一个高比例。蕨纲植物的几个系也在二个区域显示出一个最近的分离模式。在 flowering 植物,模式通常在适度的元素在之间被显示出东北亚洲和西北的北美洲,以及寡妇 boreotropical 和晚第三纪 mesophytic 和具球果的植物群的元素。在在最近的种系发生的分析支持的植物的东方亚洲和西方的北美洲之间的洲际 biogeographic 分离的许多盒子从迟了的白垩纪越过 Beringian 区域强调 Bering 陆地桥或植物迁居的重要性到迟了的晚第三纪,在特别期间中新世。Beringian 区域允许自从上新世,在白令海峡的开始以后过滤和某些植物 taxa 的移植,作为许多同种的 taxa 或密切相关的种类发生在 Beringia 的双方上。 | Jun Wen Ze-Long Nie Stefanie M. Ickert-Bond | 2016 | Journal of Systematics and Evolution2016，54，5： | 20 |
| 3 | Developing integrative systematics in the informatics and genomic era, and calling for a global Biodiversity Cyberbank显示文摘Systematics 是发现的科学,组织并且解释所有生活有机体的差异。在 genomics 和生物多样性信息科学的最近的开发正在转变 systematics 并且开创了许多新机会。在生物多样性信息科学的主要 digitization 努力和开发帮助了 systematics 社区探索方法在组织提高效率,出版,并且利用系统的信息。同时, genomics 很快正在便于生活的树的建设,改进分类分类,并且解开复杂进化历史。在信息科学和 genomics 时代, systematics 有一个不可思议的能力为发现以及与其它一起与计算、探索的平台集成,当在生物集合和形态学维持它的核心力量时,联系了学科。我们要求将作为生物多样性数据的许多类型的主要仓库工作保证系统的数据的广阔、成长的数量的长期的可持续性的新全球 cyberinfrastructure 或生物多样性 Cyberbank 的建立。这生物多样性 Cyberbank 将为 systematics 研究包含新、有效的分析管道,特别为高效地产生分类处理(修订,电子书和植物群) 。综合 systematics 要求训练下一代的组织主义者与分类, phylogenomic 和信息科学技巧到关于生物多样性和它的集会探讨宏大问题并且继续开发生物多样性 Cyberbank。综合 systematics 必须积极地也为探讨 Anthropocene 的生物多样性危机在 systematics 和集合的重要性上教育公众和政策制造者,并且生物多样性 Cyberbank 可以代表一个强大的工具为超出。 | Jun Wen AJ Harris Stefanie M. Ickert-Bond Rebecca Dikow Kenneth Wurdack Elizabeth A. Zimmer | 2017 | Journal of Systematics and Evolution2017，55，4： | 18 |
| 4 | Acupuncture treatment in gastrointestinal diseases: A systematic review显示文摘The purpose of this work was to assess the evidence for effectiveness of acupuncture (AC) treatment in gastrointestinal diseases. A systematic review of the Medline-cited literature for clinical trials was performed up to May 2006. Controlled trials assessing acupuncture point stimulation for patients with gastrointestinal diseases were considered for inclusion. The search identified 18 relevant trials meeting the inclusion criteria. Two irritable bowel syndrome (IBS) trials, 1 Crohn's disease and 1 colitis ulcerosa trial had a robust random controlled trial (RCT) design. In regard to other gastrointestinal disorders, study quality was poor. In all trials, quality of life (QoL) improved significantly independently from the kind of acupuncture, real or sham. Real AC was significantly superior to sham acupuncture with regard to disease activity scores in the Crohn and Colitis trials. Effi cacy of acupuncture related to QoL in IBS may be explained by unspecific effects. This is the same for QoL in in? ammatory bowel diseases (IBD), whereas specific acupuncture effects may be found in clinical scores. Further trials for IBDs and in particular for all other gastrointestinal disorders would be necessary to evaluate the efficacy of acupuncture treatment. However, it must be discussed on what terms patients benefi t when this harmless and obviously powerful therapy with regard to QoL is demystifi ed by further placebo controlled trials. | Antonius Schneider Konrad Streitberger Stefanie Joos | 2007 | World Journal of Gastroenterology2007，13，25： | 18 |
| 5 | 5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stages显示文摘5-Hydroxymethylcytosine (5hmC ) 是被连接了到基因规定和癌症致病的重要哺乳动物的 DNA epigenetic 修正。这里,我们用定序途径的一枝敏感化学基于标签的低输入的猎枪在传播没有房间的 DNA (cfDNA ) 探索了 5hmC 的诊断潜力。我们从七种不同癌症类型的 49 个病人定序没有房间的 5hmC 并且发现了能被用来与高精确性预言癌症类型和阶段的不同特征。明确地,我们发现肺癌症在 cfDNA 导致 5hmC 的进步全球损失,而 hepatocellular 癌和胰腺的癌症在没有房间的 hydroxymethylome 导致疾病特定的变化。我们的 proof-of-principle 结果建议没有房间的 5hmC 签名可以潜在地被使用不仅识别癌症类型而且在一些癌症追踪肿瘤舞台。 | Chun-Xiao Song Senlin Yin Li Ma Amanda Wheeler Yu Chen Yan Zhang Bin Liu Junjie Xiong Weihan Zhang Jiankun Hu Zongguang Zhou Biao Dong Zhiqi Tian Stefanie S Jeffrey Mei-Sze Chua Samuel So Weimin Li Yuquan Wei Jiajie Diao Dan Xie Stephen R Quake | 2017 | Cell Research2017，27，10： | 17 |
| 6 | Collections-based systematics: Opportunities and outlook for 2050显示文摘系统的生物学是在集合生根的一个学科。这些集合在研究和保存起重要作用并且对我们关于生物多样性和保存教育社会的努力不可分。集合在全世界并且整个最近、地质的时间提供有机体的分发的一个无价的记录,并且他们是行星的生物、物理、文化的差异的唯一的直接文档:过去,现在,和未来。在生物信息学和 cyberinfrastructure 的最近的开发由开创新机会正在转变 systematics,作为一个结果学生, digitization 努力逐渐地使大量生物多样性数据可得到。训练的基于收集的 systematics 社区需要有综合技巧的组织主义者下一代,在不同规模关于生物多样性探讨宏大问题,开发社区宽的 cyberinfrastructure ,有效地传播系统的数据到生物学家和公众,并且积极地在 Anthropocene 的生物多样性危机在 systematics 和集合的重要性上教育公众和政策制造者。明确地,我们要求新全球生物多样性 CyberBank,比得上为基因数据的 GenBank,主修是所有生物多样性数据,以及系统的生物学的一个世界组织的仓库带这域的行动。我们也为分类的书构画出新工作流,它两个都利用综合的传统的力量多样的基于收集的分类数据和联机资源和生物信息学工具的能力。 | Jun Wen Stefanie M. Ickert-Bond Marc S. Appelhans Laurence J. Dorr Vicki A. Funk | 2015 | Journal of Systematics and Evolution2015，53，6： | 15 |
| 7 | Chloroplast phylogenomics of the New World grape species (Vitis, Vitaceae)显示文摘Vitis L。(葡萄类) 是经济地很重要的水果庄稼,葡萄和酒的来源。在类以内的种系发生的关系是高度争论的。此处,我们从整个 plastomes 采用顺序数据试图提高 Vitis 种系发生的分辨率。结果作为 monophyletic 支持新世界 Vitis 亚属 Vitis。在 clade 以内, V。californica 是到仍然保持新的姐妹世界 Vitis 亚属 Vitis。在亚属 Vitis 以内,而且,欧亚的 clade 要用体力地被支持并且是到新世界 clade 的姐妹。Vitis vinifera ssp 的 clade。vinifera 和 V。vinifera ssp。sylvestris 是到 Vitis 的核心亚洲人 clade 的姐妹。在北美洲的几普遍的种被发现例如,是在 plastome 树上的 nonmonophyletic 广泛地定义的 Vitis cinerea 和 V。aestivalis 各个需要被分成几种。可能也 nonmonophyly 某种类由于在北美的 Vitis 的杂交的普通出现。由进九个系列的 Munson 的北美的 Vitis 的分类基于种系发生的结果被讨论。分叉时间和系多样化的分析在在晚第三纪开始的北美洲支持 Vitis 的快速的放射。 | Jun Went AJ Harris Yash Kalburgi Ning Zhang Yuan Xu Wei Zheng Stefanie M. Ickert-Bondt Gabriel Johnson Elizabeth A. Zimmer | 2018 | Journal of Systematics and Evolution2018，56，4： | 14 |
| 8 | Virtual screening of inorganic materials synthesis parameters with deep learning显示文摘Virtual materials screening approaches have proliferated in the past decade,driven by rapid advances in first-principles computational techniques,and machine-learning algorithms.By comparison,computationally driven materials synthesis screening is still in its infancy,and is mired by the challenges of data sparsity and data scarcity:Synthesis routes exist in a sparse,highdimensional parameter space that is difficult to optimize over directly,and,for some materials of interest,only scarce volumes of literature-reported syntheses are available.In this article,we present a framework for suggesting quantitative synthesis parameters and potential driving factors for synthesis outcomes.We use a variational autoencoder to compress sparse synthesis representations into a lower dimensional space,which is found to improve the performance of machine-learning tasks.To realize this screening framework even in cases where there are few literature data,we devise a novel data augmentation methodology that incorporates literature synthesis data from related materials systems.We apply this variational autoencoder framework to generate potential SrTiO_(3) synthesis parameter sets,propose driving factors for brookite TiO_(2) formation,and identify correlations between alkali-ion intercalation and MnO_(2) polymorph selection. | Edward Kim Kevin Huang Stefanie Jegelka Elsa Olivetti | 2017 | npj Computational Materials2017，，1： | 14 |
| 9 | Innate immune signaling and regulation in cancer immunotherapy显示文摘先存在的 T 煽动房间的肿瘤微型环境有预示的用途并且能也为对当代的癌症免疫疗法的反应预兆。对联系肿瘤的抗原的自发的 T 房间回答的产生取决于天生的有免疫力的激活,运动打它我干扰素(IFN ) 生产。最近的工作为在这个过程察觉到的 cytosolic DNA 的 STING 小径揭示了一个主要角色。事件的这串联贡献 Batf3 系树枝状的房间(DC ) 的激活,它看起来对反肿瘤免疫中央。Non-T 煽动房间的肿瘤为 Batf3 DC 招募缺乏 chemokines,有很少 Batf3 DC,并且缺乏一种类型我 IFN 基因签名,建议那没有通过天生的有免疫力的激活可以是因缺乏自发的 T 房间激活和累积的最终的原因。与手里的这个信息,为触发天生的有免疫力的激活和 Batf3 DC 招募的新策略正在被开发,包括为 de novo 免疫者 priming 的新奇圈套收缩筋。最终,有效天生的有免疫力的使活跃之物的成功的发展应该扩展能对免疫疗法作出回应的病人的部分,例如与检查点封锁抗体。 | Leticia Corrales Vyara Matson Blake Flood Stefani Spranger Thomas F Gajewski | 2017 | Cell Research2017，27，1： | 13 |
| 10 | Porous and Ultra-Flexible Crosslinked MXene/Polyimide Composites for Multifunctional Electromagnetic Interference Shielding显示文摘Lightweight,ultra-flexible,and robust crosslinked transition metal carbide(Ti3C2 MXene)coated polyimide(PI)(C-MXene@PI)porous composites are manufactured via a scalable dip-coating followed by chemical crosslinking approach.In addition to the hydrophobicity,anti-oxidation and extreme-temperature stability,efficient utilization of the intrinsic conductivity of MXene,the interfacial polarization between MXene and PI,and the micrometer-sized pores of the composite foams are achieved.Consequently,the composites show a satisfactory X-band electromagnetic interference(EMI)shielding effectiveness of 22.5 to 62.5 dB at a density of 28.7 to 48.7 mg cm−3,leading to an excellent surface-specific SE of 21,317 dB cm^(2)g^(−1).Moreover,the composite foams exhibit excellent electrothermal performance as flexible heaters in terms of a prominent,rapid reproducible,and stable electrothermal effect at low voltages and superior heat performance and more uniform heat distribution compared with the commercial heaters composed of alloy plates.Furthermore,the composite foams are well attached on a human body to check their electromechanical sensing performance,demonstrating the sensitive and reliable detection of human motions as wearable sensors.The excellent EMI shielding performance and multifunctionalities,along with the facile and easy-to-scalable manufacturing techniques,imply promising perspectives of the porous C-MXene@PI composites in next-generation flexible electronics,aerospace,and smart devices. | Zhi-Hui Zeng Na Wu Jing-Jiang Wei Yun-Fei Yang Ting-Ting Wu Bin Li Stefanie Beatrice Hauser Wei-Dong Yang Jiu-Rong Liu Shan-Yu Zhao | 2022 | Nano-Micro Letters2022，14，4： | 12 |
| 11 | 推特(Twitter)对中国论文的国际关注度影响研究显示文摘文章调查在国外社交媒体上的传播能否提高中国国际科技论文的关注度,并增加论文的被引用次数。通过分析163635篇在2012年发表并被Web of Science收录的中国国际科技论文及其收到的推文数和引用数,发现在同一个期刊内,在推特上被推送过的论文的被引用次数比没有被推送过的多近20%。已有研究发现在论文收到的推文数和被引用次数之间存在微弱的统计学相关性,这种相关性也存在于中国国际科技论文之中。 | 舒非 Stefanie Haustein 全薇 | 2017 | 图书馆论坛2017，37，6： | 11 |
| 12 | Evolution of the Madrean-Tethyan disjunctions and the North and South American amphitropical disjunctions in plants显示文摘The present paper reviews advances in the study of two major intercontinental disjunct biogeographic patterns:(i) between Eurasian and western North American deserts with the Mediterranean climate(the Madrean-Tethyan disjunctions);and(ii) between the temperate regions of North and South America(the amphitropical disjunctions).Both disjunct patterns have multiple times of origin.The amphitropical disjunctions have largely resulted from long-distance dispersal,primarily from the Miocene to the Holocene,with available data indicating that most lineages dispersed from North to South America.Results of recent studies on the Mediterranean disjuncts between the deserts of Eurasia and western North America support the multiple modes of origin and are mostly consistent with hypotheses of long-distance dispersal and the North Atlantic migration.Axelrod's Madrean-Tethyan hypothesis,which implies vicariance between the two regions in the early Tertiary,has been favored by a few studies.The Beringian migration corridor for semiarid taxa is also supported in some cases. | Jun WEN Stefanie M. ICKERT-BOND | 2009 | Journal of Systematics and Evolution2009，47，5： | 11 |
| 13 | Technical and conceptual considerations forusing animated stimuli in studies of animalbehavior显示文摘Rapid technical advances in the field of computeropened new avenues in animal behavior research.animation (CA) and virtual reality (VR) haveAnimated stimuli are powerful tools as theyoffer standardization, repeatability, and complete control over the stimulus presented, thereby"reducing" and "replacing" the animals used, and "refining" the experimental design in line withthe 3Rs. However, appropriate use of these technologies raises conceptual and technical questions.In this review, we offer guidelines for common technical and conceptual considerations related tothe use of animated stimuli in animal behavior research. Following the steps required to create ananimated stimulus, we discuss (I) the creation, (11) the presentation, and (111) the validation of CAsand VRs. Although our review is geared toward computer-graphically designed stimuli, consider-ations on presentation and validation also apply to video playbacks. CA and VR allow both new be-havioral questions to be addressed and existing questions to be addressed in new ways, thus weexpect a rich future for these methods in both ultimate and proximate studies of animal behavior. | Laura CHOUINARD-THULY Stefanie GIERSZEWSKI Gil G. ROSENTHAL Simon M. READER Guillaume RIEUCAU Kevin L. Woo Robert GERLAI Cynthia TEDORE Spencer J. INGLEY John R. STOWERS Joachim G.FROMMENI Francine L. DOLINS Klaudia WITTE | 2017 | Current Zoology2017，63，1： | 10 |
| 14 | Increased liver stiffness in alcoholic liver disease:Differentiating fibrosis from steatohepatitis显示文摘AIM:To test if inflammation also interferes with liver stiffness (LS) assessment in alcoholic liver disease (ALD) and to provide a clinical algorithm for reliable fibrosis assessment in ALD by FibroScan (FS).METHODS:We first performed sequential LS analysis before and after normalization of serum transaminases in a learning cohort of 50 patients with ALD admitted for alcohol detoxification. LS decreased in almost all patients within a mean observation interval of 5.3 d. Six patients (12%) would have been misdiagnosed with F3and F4 fibrosis but LS decreased below critical cut-off values of 8 and 12.5 kPa after normalization of trans-aminases. RESULTS:Of the serum transaminases,the decrease in LS correlated best with the decrease in glutamic oxaloacetic transaminase (GOT). No significant chang-es in LS were observed below GOT levels of 100 U/L. After establishing the association between LS and GOT levels,we applied the rule of GOT < 100 U/L for reliable LS assessment in a second validation cohort of 101 patients with histologically confi rmed ALD. By ex-cluding those patients with GOT > 100 U/L at the time of LS assessment from this cohort,the area under the receiver operating characteristic (AUROC) for cirrhosis detection by FS improved from 0.921 to 0.945 while specificity increased from 80% to 90% at a sensitivity of 96%. A similar AUROC could be obtained for lower F3 fibrosis stage if LS measurements were restricted to patients with GOT < 50 U/L. Histological grading of inflammation did not further improve the diagnostic accuracy of LS.CONCLUSION:Coexisting steatohepatitis markedly increases LS in patients with ALD independent of fibrosis stage. Postponing cirrhosis assessment by FS during alcohol withdrawal until GOT decreases to < 100 U/mL signif icantly improves the diagnostic accuracy. | Sebastian Mueller Gunda Millonig Lucie Sarovska Stefanie Friedrich Frank M Reimann Maria Pritsch Silke Eisele Felix Stickel Thomas Longerich Peter Schirmacher Helmut Karl Seitz | 2010 | World Journal of Gastroenterology2010，16，8： | 10 |
| 15 | Metabolism of tissue macrophages in homeostasis and pathology显示文摘Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and anabolism to generate cellular energy and structural components.The emerging field of immunometabolism highlights the importance of cellular metabolism for the maintenance and activities of immune cells.Macrophages are embryo-or adult bone marrow-derived leukocytes that are key for healthy tissue homeostasis but can also contribute to pathologies such as metabolic syndrome,atherosclerosis,fibrosis or cancer.Macrophage metabolism has largely been studied in vitro.However,different organs contain diverse macrophage populations that specialize in distinct and often tissue-specific functions.This context specificity creates diverging metabolic challenges for tissue macrophage populations to fulfill their homeostatic roles in their particular microenvironment and conditions their response in pathological conditions.Here,we outline current knowledge on the metabolic requirements and adaptations of macrophages located in tissues during homeostasis and selected diseases. | Stefanie K.Wculek Gillian Dunphy Ignacio Heras-Murillo Annalaura Mastrangelo David Sancho | 2022 | Cellular & Molecular Immunology2022，19，3： | 9 |
| 16 | Ephrin-B2 is differentially expressed in the intestinal epithelium in Crohn's disease and contributes to accelerated epithelial wound healing in vitro显示文摘AIM: Eph receptor tyrosine kinases and their membrane bound receptor-like ligands, the ephrins, represent a bi-directional cell-cell contact signaling system that directs epithelial movements in development. The meaning of this system in the adult human gut is unknown. We investigated the Eph/ephrin mRNA expression in the intestinal epithelium of healthy controls and patients with inflammatory bowel disease (IBD).METHODS: mRNA expression profiles of all Eph/ephrin family members in normal small intestine and colon were established by real-time RT-PCR. In addition, differential expression in IBD was investigated by cDNA array technology, and validated by both real-time RT-PCR and immunohistochemistry. Potential effects of enhanced EphB/ephrin-B signaling were analyzed in an in vitro IEC-6 cell scratch wound model.RESULTS: Human adult intestinal mucosa exhibits a complex pattern of Eph receptors and ephrins. Beside the known prominent co-expression of EphA2 and ephrinA1,we found abundantly co-expressed EphB2 and ephrin-B1/2.Interestingly, cDNA array data, validated by real-time PCR and immunohistochemistry, showed upregulation of ephrin-B2 in both perilesional and lesional intestinal epithelial cells of IBD patients, suggesting a role in epithelial homeostasis. Stimulation of ephrin-B signaling in ephrinB1/2 expressing rat IEC-6-cells with recombinant EphB1Fc resulted in a significant dose-dependent acceleration of wound closure. Furthermore, fluorescence microscopy showed that EphB1-Fc induced coordinated migration of wound edge cells is associated with enhanced formation of lamellipodial protrusions into the wound, increased actin stress fiber assembly and production of laminin at the wound edge.CONCLUSION: EphB/ephrin-B signaling might represent a novel protective mechanism that promotes intestinal epithelial wound healing, with potential impact on epithelial restitution in IBD. | Christian Hafner Stefanie Meyer Thomas Langmann Gerd Schmitz Frauke Bataille Ilja Hagen Bernd Becker Alexander Roesch Gerhard Rogler Michael Landthaler Thomas Vogt | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 17 | Protective effects of ischemic preconditioning and application of lipoic acid prior to 90 min of hepatic ischemia in a rat model显示文摘AIM: To compare different preconditioning strategies to protect the liver from ischemia/reperfusion injury focusing on the expression of pro- and anti-apoptotic proteins. Interventions comprised different modes of ischemic preconditioning (IP) as well as pharmacologic pretreatment by α-lipoic acid (LA). METHODS: Several groups of rats were compared: sham operated animals, non-pretreated animals (nt), animals receiving IP (10 min of ischemia by clamping of the portal triad and 10 min of reperfusion) prior to sustained ischemia, animals receiving selective ischemic preconditioning (IPsel, 10 min of ischemia by selective clamping of the ischemic lobe and 10 min of reperfusion) prior to sustained ichemia, and animals receiving 500 μmol α-LA injected i.v. 15 min prior to the induction of 90 min of selective ischemia. RESULTS: Cellular damage was decreased only in the LA group. TUNEL-positive hepatocytes as well as necrotic hepatocyte injury were also decreased only by LA (19 ± 2 vs 10 ± 1, P < 0.05 and 29 ± 5 vs 12 ± 1, P < 0.05). Whereas caspase 3- activities in liver tissue were unchanged, caspase 9- activity in liver tissue was decreased only by LA pretreatment (3.1 ± 0.3 vs 1.8 ± 0.2, P < 0.05). Survival rate as the endpoint of liver function was increased after IP and LA pretreatment but not after IPsel. Levels of lipid peroxidation (LPO) in liver tissue were decreased in the IP as well as in the LA group compared to the nt group. Determination of pro- and anti-apoptotic proteins showed a shift towardsanti-apoptotic proteins by LA. In contrast, both our IP strategies failed to influence apototic cell death. CONCLUSION: IP, consisting of 10 min of ischemia and 10 min of reperfusion, protects only partly against ischemia/reperfusion injury of the liver prior to 90 min of selective ischemia. IPsel did not influence ischemic tolerance of the liver. LA improved tolerance to ischemia, possibly by downregulation of pro-apoptotic Bax. | Friedrich Duenschede Kirsten Erbes Nina Riegler Patrick Ewald Achim Kircher Stefanie Westermann Arno Schad Imke Miesmer Simon Albrecht-Schck Ines Gockel Alexandra K Kiemer Theodor Junginger | 2007 | World Journal of Gastroenterology2007，13，27： | 8 |
| 18 | Differences in neuroplasticity after spinal cord injury in varying animal models and humans显示文摘Rats have been the primary model to study the process and underlying mechanisms of recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can regain weight-bearing abilities without therapeutic interventions, as assessed by the Basso, Beattie and Bresnahan locomotor scale. However, many human patients suffer from permanent loss of motor function following spinal cord injury. While rats are the most understood animal model, major differences in sensorimotor pathways between quadrupeds and bipeds need to be considered. Understanding the major differences between the sensorimotor pathways of rats, non-human primates, and humans is a start to improving targets for treatments of human spinal cord injury. This review will discuss the neuroplasticity of the brain and spinal cord after spinal cord injury in rats, non-human primates, and humans. A brief overview of emerging interventions to induce plasticity in humans with spinal cord injury will also be discussed. | Mallory E.Filipp Benjamin J.Travis Stefanie S.Henry Emma C.Idzikowski Sarah A.Magnuson Megan YF Loh Daniel J.Hellenbrand Amgad S.Hanna | 2019 | Neural Regeneration Research2019，14，1： | 8 |
| 19 | Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury显示文摘We previously found that argon exerts its neuroprotective effect in part by inhibition of the toll-like receptors(TLR)2 and 4.The downstream transcription factors signal transducer and activator of transcription 3(STAT3)and nuclear factor kappa B(NF-κB)are also affected by argon and may play a role in neuroprotection.It also has been demonstrated that argon treatment could mitigate brain damage,reduce excessive microglial activation,and subsequently attenuate brain inflammation.Despite intensive research,the further exact mechanism remains unclear.In this study,human neuroblastoma cells were damaged in vitro with rotenone over a period of 4 hours(to mimic cerebral ischemia and reperfusion damage),followed by a 2-hour post-conditioning with argon(75%).In a separate in vivo experiment,retinal ischemia/reperfusion injury was induced in rats by increasing intraocular pressure for 1 hour.Upon reperfusion,argon was administered by inhalation for 2 hours.Argon reduced the binding of the transcription factors signal transducer and activator of transcription 3,nuclear factor kappa B,activator protein 1,and nuclear factor erythroid 2-related factor 2,which are involved in regulation of neuronal damage.Flow cytometry analysis showed that argon downregulated the Fas ligand.Some transcription factors were regulated by toll-like receptors;therefore,their effects could be eliminated,at least in part,by the TLR2 and TLR4 inhibitor oxidized phospholipid 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine(OxPAPC).Argon treatment reduced microglial activation after retinal ischemia/reperfusion injury.Subsequent quantitative polymerase chain reaction analysis revealed a reduction in the pro-inflammatory cytokines interleukin(IL-1α),IL-1β,IL-6,tumor necrosis factorα,and inducible nitric oxide synthase.Our results suggest that argon reduced the extent of inflammation in retinal neurons after ischemia/reperfusion injury by suppression of transcription factors crucial for microglial activation.Argon has no known side effects or narcotic properties;therefore,therapeutic use of this noble gas appears ideal for treatment of patients with neuronal damage in retinal ischemia/reperfusion injury.The animal experiments were approved by the Commission for Animal Care of the University of Freiburg(approval No.35-9185.81/G14-122)on October 19,2012. | Ulrich Goebel Stefanie Scheid Sashko Spassov Nils Schallner Jakob Wollborn Hartmut Buerkle Felix Ulbrich | 2021 | Neural Regeneration Research2021，16，1： | 8 |
| 20 | A novel long non-coding RNA Myolinc regulates myogenesis through TDP-43 and Filip1显示文摘 | Giuseppe Militello Mohammed Rabiul Hosen Yuliya Ponomareva Pascal Gellerts Tyler Weirick David John Sajedah Mahmoud Hindi Kamel Mamchaoui Vincent Mouly Claudia Doring Lidan Zhang Miki Nakamura Ashok Kumar So-ichiro Fukada Stefanie Dimmeler Shizuka Uchida | 2018 | Journal of Molecular Cell Biology2018，10，2： | 7 |
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