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| 1 | Mediastinal node staging by positron emission tomographycomputed tomography and selective endoscopic ultrasound with fine needle aspiration for patients with upper gastrointestinal cancer:Results from a regional centre显示文摘AIM To investigate the impact of endoscopic ultrasound-guided fine-needle aspiration(EUS-FNA) and positron emission tomography-computed tomography(PET-CT) in the nodal staging of upper gastrointestinal(GI) cancer in a tertiary referral centre.METHODS We performed a retrospective review of prospectively recorded data held on all patients with a diagnosis of upper GI cancer made between January 2009 and December 2015. Only those patients who had both a PET-CT and EUS with FNA sampling of a mediastinal node distant from the primary tumour were included. Using a positive EUS-FNA result as the gold standard for lymph node involvement, the sensitivity, specificity, positive and negative predictive values(PPV and NPV) and accuracy of PET-CT in the staging of mediastinal lymph nodes were calculated. The impact on therapeutic strategy of adding EUS-FNA to PET-CT was assessed.RESULTS One hundred and twenty one patients were included. Sixty nine patients had a diagnosis of oesophageal adenocarcinoma(Thirty one of whom were junctional), forty eight had oesophageal squamous cell carcinoma and four had gastric adenocarcinoma. The FNA results were inadequate in eleven cases and the PET-CT findings were indeterminate in two cases, therefore thirteen patients(10.7%) were excluded from further analysis. There was concordance between PET-CT and EUS-FNA findings in seventy one of the remaining one hundred and eight patients(65.7%). The sensitivity, specificity, PPV and NPV values of PET-CT were 92.5%, 50%, 52.1% and 91.9% respectively. There was discordance between PET-CT and EUS-FNA findings in thirty seven out of one hundred and eight patients(34.3%). MDT discussion led to a radical treatment pathway in twenty seven of these cases, after the final tumour stage was altered as a direct consequence of the EUS-FNA findings. Of these patients, fourteen(51.9%) experienced clinical remission of a median of nine months(range three to forty two months). CONCLUSION EUS-FNA leads to altered staging of upper GI cancer, resulting in more patients receiving radical treatment that would have been the case using PET-CT staging alone. | Chris Harrington Lyn Smith Jennifer Bisland Elisabet López González Neil Jamieson Stuart Paterson Adrian John Stanley | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，1： | 4 |
| 2 | 基于自动测量的诊室血压高血压诊断标准与心血管病风险显示文摘与血压相关的心血管事件风险很大程度是基于台式水银血压计的人群测量数据。考虑到电子血压计逐步替代台式水银血压计,该研究采用全自动血压计在研究对象独自安静休息时多次读取数据,以探讨导致心血管风险显著增加的血压水平。方法:纳入〉65岁的未经治疗的高血压社区居民3627例。从社区药店和家庭医生获得受试者未受干扰时的坐位自动诊室血压数据。针对致命性及非致命性心血管事件,受试者随访(4.9±1.0)年。 | Myers MG Kaczorowski J Paterson JM Dolovich L Tu K 赵狄 练桂丽 | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 3 | Comparative genetics mapping of allotetraploid cot ton and its diploid progenitors显示文摘 | BRUBAKER C L Paterson A H Wendel J F | 1999 | Genome1999，42，： | 1 |
| 4 | Aspergillus infections in transplant recipients 显示文摘 | Singh N Paterson D L | 2005 | Clin Microbiol Rev2005，18，1： | 1 |
| 5 | Setting and revising antibacterial susceptibility breakpoints显示文摘 | Tumidge J Paterson D L | 2007 | Clin Microbiol Rev2007，20，3： | 1 |
| 6 | Fluid capacity distributions of random porous media 显示文摘 | Chan D Y C Hughes B D Paterson L | 1988 | Transport in Porous Media1988，，3： | 1 |
| 7 | Extended spectrum β-lactamases:a clinical update显示文摘 | David L Paterson Robert A etal | 2005 | Clin Microbiol Rev2005，18，4： | 1 |
| 8 | A rapid method for extraction of cotton (Gossypium spp ) genomic DNA suitable for RFLP or PCR analysis显示文摘 | PATERSON A H BRUBAKER C L WENDEL J F | | 0，，02： | 1 |
| 9 | Health care professional sup- port for self-care management in chronic illness:insights from diabetes research显示文摘 | Thorne S E Paterson B L | 2001 | PatientI Educ Couns2001，42，1： | 1 |
| 10 | Targeted disruption of gene function in Drosophila by RNA interference (RNAi) :a role for nautilus in embryonic somatic muscle formation显示文摘 | Misquitta L Paterson BM | 1999 | Proc Natl Aead Sci USA1999，96，： | 1 |
| 11 | A rapid method for extraction of cotton genomic DNA suitable for RFLP or PCR analysis 显示文摘 | Paterson A H Brubaker C L Wendel J F | 1993 | Plant Mol Biol Rep1993，11，2： | 1 |
| 12 | Concurrent signatures 显示文摘 | CHEN L KUDLA C PATERSON K | 2004 | Lecture Notes in Computer Science2004，3027，： | 1 |
| 13 | Shock wave lithotripsy monotherapy for renal calculi显示文摘 | Paterson R F Lifshitz D A Kuo R L | 2002 | Int Braz J Urol2002，28，4： | 1 |
| 14 | Adherence to protease inhibitor therapy and outcomes in patients with HIV infection显示文摘 | Paterson D L Swindells S Mohr J | 2000 | Annals of Internal Medicine2000，133，1： | 1 |
| 15 | Recommendation for treatment of severe infections caused by Enterobacteriaceae producing extended-spectrum β-lactamases (ESBLs)显示文摘 | PATERSON D L | 2000 | Clin Microbiol Infect2000，6，2： | 1 |
| 16 | Acinetobacter baumannii: emergence of a suceessful pathogen 显示文摘 | Peleg A Y Seifert H Paterson D L | 2008 | Clin Microbiol Rev2008，21，： | 1 |
| 17 | Experiences of burnout and coping strategies utilized by occupational therapists显示文摘 | Gupta S Paterson M L Lysaght R M | 2012 | Canadian Journal of Occupational Therapy2012，79，： | 1 |
| 18 | Urban soils as pollutant sinks a case study from Aberdeen, Scotland显示文摘 | Paterson E Sanka M Clark L | 1996 | Applied Geochemistry1996，11，： | 1 |
| 19 | TAT-apoptin is efficiently delivered and induees apoptosis in cancer cells显示文摘 | Guelen L Paterson H Gaken J | 2004 | Oncogene2004，23，： | 1 |
| 20 | Tigecycline efflux as a mechanism for nonsusceptibility in Acinetobacter baumannii显示文摘 | Peleg A Y Adams J Paterson D L | 2007 | Antimicrob Agents Chemother2007，51，6： | 1 |
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