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| 1 | Involvement and therapeutic implications of airway epithelial barrier dysfunction in type 2 inflammation of asthma显示文摘Type 2 inflammation is a complex immune response and primary mechanism for several common allergic diseases including allergic rhinitis,allergic asthma,atopic dermatitis,and chronic rhinosinusitis with nasal polyps.It is the predominant type of immune response against helminths to prevent their tissue infiltration and induce their expulsion.Recent studies suggest that epithelial barrier dysfunction contributes to the development of type 2 inflammation in asthma,which may partly explain the increasing prevalence of asthma in China and around the globe.The epithelial barrier hypothesis has recently been proposed and has received great interest from the scientific community.The development of leaky epithelial barriers leads to microbial dysbiosis and the translocation of bacteria to inter-and sub-epithelial areas and the development of epithelial tissue inflammation.Accordingly,preventing the impairment and promoting the restoration of a deteriorated airway epithelial barrier represents a promising strategy for the treatment of asthma.This review introduces the interaction between type 2 inflammation and the airway epithelial barrier in asthma,the structure and molecular composition of the airway epithelial barrier,and the assessment of epithelial barrier integrity.The role of airway epithelial barrier disruption in the pathogenesis of asthma will be discussed.In addition,the possible mechanisms underlying the airway epithelial barrier dysfunction induced by allergens and environmental pollutants,and current treatments to restore the airway epithelial barrier are reviewed. | Xiang Dong Mei Ding Jinjin Zhang Ismail Ogülür Yagiz Pat Mübeccel Akdis Yadong Gao Cezmi A.Akdis | 2022 | Chinese Medical Journal2022，，5： | 4 |
| 2 | Isolation and characterization of endophytic colonizing bacteria from agronomic crops and prairie plants显示文摘 | ZINNIEL D K PAT L HARRIS N B | 2002 | Appl Envir Microbiol2002，68，： | 1 |
| 3 | Stage III endome- trial cancer; preoperative predictability, prognostic fac- tors, and treatment outcome显示文摘 | Denschlag D Tan L Pat el S | 2007 | Am J Obstet Gynecol2007，196，6： | 1 |
| 4 | Energetics of ammonium perchlorate decomposi- tion steps显示文摘 | Peter P Pat L | 1998 | JMolStruct(Theochem)1998，454，： | 1 |
| 5 | Stage IH endometrial cancer: preoperative predictability,prognlstic factors,and treatment out- come显示文摘 | DenschIag D Tan L Pat el S et a| | 2007 | Am J Obstet Gynecol2007，196，6： | 1 |
| 6 | Including technical and security risks in the management of information systems:A programmatic risk management model显示文摘 | Robin L Dillon M Elisabeth Paté-Cornell | 2005 | Systems Engineering2005，8，4： | 1 |
| 7 | Processing, mosaicking and management of the Monterey Bay digital sidescan-sonar images显示文摘 | Pat S Chavez JoAnn Isbrecht Peter Galanis Gregory L Gabel Stuart C Sides Deborah L Soltesz Stephanie L Ross Miguel G Velasco | 2002 | Marine Geology2002，，1： | 1 |
| 8 | The computational support of scientific discovery显示文摘 | Pat L | 2000 | International Journal of Human-Computer Studies2000，53，3： | 1 |
| 9 | Isolation and characterization of endophytic colonizing bacteria from agronomic crops and prairie plants 显示文摘 | DENISE K Z PAT L NBETH H | 2002 | Applied and Environmental Microbiology2002，，5： | 1 |
| 10 | Altered metabolism of carotenoids during pale-bid syndrome in chickens infected with Eimeria acervrdina 显示文摘 | Juiusz K T Pat B L | 1991 | Poul Sci1991，70，： | 1 |
| 11 | Comparison of density functional calculations of C-NO2, N-NO2 and C-NF2 dissociation energies 显示文摘 | Peter P Pat L | 1996 | Journal of Molecular Structure (Theochem)1996，388，： | 1 |
| 12 | Advances in ents with early- the field显示文摘 | REINTGEN C REINTGEN D SOLIN local-regional treatment for pat stage breast cancer: a review of Breast Cancer 2010 10(3):180-1 L J | 2010 | Clin2010，87，： | 1 |
| 13 | Isolation and characterization of endophytic colonizing bacteria from agronomic crops and prairie plants显示文摘 | Deni K Pat L Beth N | 2002 | Applied and Environmental Microbiology2002，68，5： | 1 |
| 14 | Epiploic appendagitis: the emergency department presentation 1 1 This study has not been previously published. It has been presented in abstract form at the New England Regional SAEM Conference in April, 2001.显示文摘 | Eric L Legome Austin L Belton Robert E Murray Pat M Rao Robert A Novelline | 2002 | Journal of Emergency Medicine2002，，1： | 1 |
| 15 | The Argatroban and tissue - type plasminogen activator stroke study: Final Re- sults of a Pilot Safety Study显示文摘 | Andrew DB Andrewva Pat L Jessica L | 2012 | Stroke2012，43，： | 1 |
| 16 | The Argatroban and TissueType Plasminogen Activator Stroke Study Final Results of a Pilot Safety Study显示文摘 | Andrew DB Andrew va Pat L | 2012 | Stroke2012，43，： | 1 |
| 17 | Associations among caregiving difficulties,burden,and rewards in caregivers to older post-rehabilitation patients 显示文摘 | Sara E Lisa F Pat L | 1998 | The Journals of Gerontology1998，53，3： | 1 |
| 18 | The tol like receptor TLR4 is necessary for lipopolysaccharide induced oligodendrocyte injury in the CNS显示文摘 | L ehnardt S L achance C Pat rizi S | | 0，，07： | 1 |
| 19 | Manipulating nitrogen in pig diets to reduce manure nitrogen excretion and odors 显示文摘 | SUTTON A L KEPHART K B PAT T ERSON J A | 1998 | Swine Day1998，，： | 1 |
| 20 | Chemotherapeutic potential of the volatile oils from Zanthoxylum rhoif olium Lam leaves显示文摘 | Saulo L da Silva Pat ricia M S Figueiredo | 2007 | European Journal of Pharmacology2007，576，： | 1 |
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