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| 1 | 抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家共识显示文摘核苷(酸)类似物(NAs)是当前慢性乙型肝炎抗病毒治疗的主要药物,核苷(酸)类似物具有迅速抑制HBV复制和安全性良好的特点,但随着NAs的应用推广,NAs相关的肾脏、骨骼、肌肉及神经系统等不良反应的报道逐渐增加,这些不良反应的总体发生率并不高,但若不及时发现与处理有可能引起较为严重的临床后果。为优化NAs相关不良反应的临床管理,抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家委员会结合最新的循证医学证据形成本共识。 | Experts Committee of management of side effects of nucleos(t)ide analogues for hepatitis B virus | 2016 | 中华实验和临床感染病杂志(电子版)2016，10，5： | 7 |
| 2 | 抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家共识显示文摘核苷(酸)类似物(NAs)是当前慢性乙型肝炎抗病毒治疗的主要药物,NAs具有迅速抑制HBV复制和安全性良好的特点,但随着NAs的应用推广,NAs相关的肾脏、骨骼、肌肉及神经系统等不良反应的报道逐渐增加,这些不良反应的总体发生率并不高,但如不及时发现与处理有可能引起较为严重的临床后果。为优化NAs相关不良反应的临床管理,抗乙型肝炎病毒核苷(酸)类似物不良反应管理专家委员会结合最新的循证医学证据形成本共识。 | Experts committee of management of side effects of nucleos(t)ide analogues for hepatitis B virus | 2016 | 中国肝脏病杂志(电子版)2016，8，3： | 7 |
| 3 | Chance-constrained Coordinated Optimization for Urban Electricity and Heat Networks显示文摘Urban electricity and heat networks(UEHN)consist of the coupling and interactions between electric power systems and district heating systems,in which the geographical and functional features of integrated energy systems are demonstrated.UEHN have been expected to provide an effective way to accommodate the intermittent and unpredictable renewable energy sources,in which the application of stochastic optimization approaches to UEHN analysis is highly desired.In this paper,we propose a chance-constrained coordinated optimization approach for UEHN considering the uncertainties in electricity loads,heat loads,and photovoltaic outputs,as well as the correlations between these uncertain sources.A solution strategy,which combines the Latin Hypercube Sampling Monte Carlo Simulation(LHSMCS)approach and a heuristic algorithm,is specifically designed to deal with the proposed chance-constrained coordinated optimization.Finally,test results on an UEHN comprised of a modified IEEE 33-bus system and a 32-node district heating system at Barry Island have verified the feasibility and effectiveness of the proposed framework. | Zhinong Wei Juan Sun Zhoujun Ma Guoqiang Sun Haixiang Zang Sheng Chen Side Zhang Kwok W.Cheung | 2018 | CSEE Journal of Power and Energy Systems2018，4，4： | 6 |
| 4 | Intelligent identification of two-dimensional nanostructures by machine-learning optical microscopy显示文摘Two-dimensional (2D)materials and their heterostructures,with wafer-scale synthesis methods and fascinating properties,have attracted significant interest and triggered revolutions in corresponding device applications.However,facile methods to realize accurate,intelligent,and large-area characterizations of these 2D nanostructures are still highly desired.Herein,we report the successful application of machine-learning strategy in the optical identification of 2D nanostructures.The machine-leaming optical identification (MOI)method endows optical microscopy with intelligent insight into the characteristic color information of 2D nanostructures in the optical photograph.The experimental results indicate that the MOI method enables accurate,intelligent,and large-area characterizations of graphene,molybdenum disulfide,and their heterostructures, including identifications of the thickness,existence of impurities,and even stacking order.With the convergence of artificial intelligence and nanoscience,this intelligent identification method can certainly promote fundamental research and wafer-scale device applications of 2D nanostructures. | Xiaoyang Lin Zhizhong Si Wenzhi Fu Jianlei Yang Side Guo Yuan Cao Jin Zhang Xinhe Wang Peng Liu Kaili Jiang Weisheng Zhao | 2018 | Nano Research2018，11，12： | 5 |
| 5 | The protection effect of β-CD on DNA damage induced by ultrafine TiO_2显示文摘Under the photocatalysis of 365 nm ultraviolet radiation,ultrafine TiO2 caused the oxidative damage of Teasy plasmid DNA. The damage was determined by gel-electrophoresis. Then,a different dose of β-CD was added to the reaction,and the damage was restrained. The rate of damage restraining reached 97% when the mass of β-CD was 4 times as that of TiO2. Through UV scan and IR spectroscopy,it was found that the Ti-O of ultrafine TiO2 was bound with -OH of β-CD cavum and the -OH on the surface of ultrafine TiO2 disappeared,so the formation of ?OH was controlled. The ultrafine TiO2 has been widely used,but it was determined to be carcinogenic by some research. The protection effect of β-CD to DNA in the molecular level takes a new look on the surface modification of nano particles to decrease the toxic effect. | ZHU RongRong,WANG ShiLong,SUN XiaoYu,ZHANG Rui & YAO SiDe School of Life Science and Technology,Tongji University,Shanghai 200092,China | 2007 | Science China Chemistry2007，50，2： | 5 |
| 6 | In-situ synthesis of PHEMA magnetic nanogels via photochemical method显示文摘One-pot synthesis of magnetic nanogels via photochemical method is reported in this paper. Poly(2-hydroxyethyl methacrylate)(PHEMA) magnetic nanogels are synthesized by in-situ polymeriza-tion of 2-hydroxyethyl methacrylate(HEMA) and N,N'-methylene-bis-(acrylamide)(MBA) in Fe3O4 aqueous suspension under UV irradiation. The structure and compositions of magnetic nanogels are characterized by FTIR,TGA,SEM,TEM and PCS. TGA measurement indicates that magnetic nanogels contain 90% magnetite. Both naked Fe3O4 and magnetic nanogels are superparamagnatic at room temperature according to magnetization curves. The swollen capability of the hydrogel shell is proved by contrasting the particles sizes obtained by SEM,TEM and PCS. Particle diameters can be manipu-lated by changing monomer concentration and irradiation time. A mechanism of the coating process is proposed. | GONG PeiJun SUN HanWen HONG Jun XU DongMei YAO SiDe | 2007 | Science China Chemistry2007，50，2： | 4 |
| 7 | Orbital control on cyclical organic matter accumulation in Early Silurian Longmaxi Formation shales显示文摘High resolution(939 samples)total organic carbon content(TOC)analyses were conducted on the Shuanghe Section of^152.6 m in the Changning area,Sichuan Basin.The sampling section was divided into two units considering the distinct-different deposit environment and sediments accumulation rate.The lower part(Unit 1)and the peer part(Unit 2)with high resolution sample spacing(0.08–0.4 m)enables the identification of the precession cycle in two sedimentary sequences with distinct different sedimentary accumulation rate.MTM Power spectral analyses on untuned TOC series reveals significant peaks exceeding above the 95%confidence level and shows that both Unit 1 and Unit 2 have recorded Milankovitch cycles of 405 kyr long eccentricity,short eccentricity,obliquity and precession.The floating astronomical time scale(ATS)was constructed on the Shuanghe Section in the Early Silurian(~439.673–444.681 Ma),and which was calibrated by 405 kyr long eccentricity cycles.The total duration of the Wufeng and Longmaxi shales is 5.01 Myr.The floating ATS used for estimating the duration of the graptolite zones and each stage in the study interval.Finally,we postulated two models that could verify the linkage between orbital cycle and organic accumulation.To make sure whether productivity or preservation is the main factor that under long eccentricity control,the phase correlation between the obtained filtered signal and the theoretical orbital solution should be made clear in the further research. | Siding Jin Hucheng Deng Xing Zhu Yan Liu Sibing Liu Meiyan Fu | 2020 | Geoscience Frontiers2020，11，2： | 4 |
| 8 | Analysis of genetic alterations identifies the frequent mutation of GNAS in colorectal laterally spreading tumors显示文摘Dear Editor,Colorectal cancer(CRC)is among the most commonly diagnosed cancer and the leading cause of cancer-related death worldwide[1].Most CRCs develop from adenomas.Laterally spreading tumors(LSTs)are non-polypoid superficial colorectal neoplasms(CRNs)that are larger than 1 cm and typically extend laterally along the luminal wall.Based on surface morphology,it can be classified into a granular or nongranular type.The pathological morphology of LST manifests only as adenoma or with cancer.Recent studies have characterized 45-79%of LSTs as high-grade intraepithelial neoplasia(HGIN)or submucosal invasion;and the risk of submucosal invasion increases with lesion size[2].Hence,LST is considered a precancerous CRC lesion.Patients with LSTs are usually asymptomatic and diagnosis typically occurs during physical examinations or screening colonoscopy. | Lei Pan Junsheng Chen Chaojun Zhu Lu Han Aimin Li Side Liu | 2020 | Cancer Communications2020，40，11： | 3 |
| 9 | SDS-PAGE study on photooxidation damage of lysozyme induced by riboflavin显示文摘The photooxidation damage of lysozyme under 315-375 nm irradiation in the presence of riboflavin was studied by using sodium dodecyl sulfate-polyacrylamide gel electrophoresis(SDS-PAGE).Indica- tions showed that the mechanisms and products of oxidative damage were relative to the concentra- tion of riboflavin,the time of irradiation and the ambience.The type I process was examined in a nitrogen saturated solution,whereas both type I and type II were observed in an aerobic atmosphere and type II was the dominant process.The study also suggested that antioxidants,such as melatonin, can reduce the damage of lysozyme effectively. | ZHANG ZhaoXia ZHAO HongWei ZHU HongPing GE Min WANG WenFeng YAO SiDe LI WenXin | 2007 | Science China Chemistry2007，50，1： | 3 |
| 10 | Pulse radiolysis study on gatifloxacin——A fluoroquinolone antibiotic显示文摘The reactions between gatifloxacin(GFX) and various one-electron oxidants,such as ˙OH,N3˙,Br2˙ˉ,and SO4˙ˉ,have been studied by pulse radiolysis techniques.The GFX radical anion formed in the reaction of GFX with eaqˉ could either be protonated or deprotonated,and the absorption of GFX radical anion was located at 390 nm.The transient species produced by the reaction of GFX with ˙OH radical shows a broad band in the 380?600 nm region with a shoulder,while the oxidation by N3˙,SO4˙ˉ,and Br2˙ˉ results in an absorption band with λmax = 370 nm.At neutral condition(pH 7),the rate constants of GFX reacting with ˙OH,N3˙,Br2˙ˉ,SO4˙ˉ and eaqˉ are estimated to be 1.0 × 1010,3.1 × 109,2.8 × 109,3.0 × 109,and 1.8 × 1010 dm3 mol?1 s?1,respectively.From the pH dependence on the formation of electron adducts and on the rate constant of GFX with eaqˉ,the pKa of GFX radical anion is estimated to be 5.5 and 9.3. | LI HaiXia LIU YanCheng TANG RuiZhi ZHANG Peng FU HaiYing YAO SiDe WANG WenFeng | 2012 | Science China Chemistry2012，55，7： | 3 |
| 11 | Impact and mechanism of TiO_2 nanoparticles on DNA synthesis in vitro显示文摘The impact of TiO2 nanoparticles on DNA synthesis in vitro in the dark and the molecular mechanism of such impact were studied. The impact of TiO2 nanoparticles on DNA synthesis was investigated by adding TiO2 nanoparticles in different sizes and at various concentrations into the polymerase chain reaction (PCR) system. TiO2 nanoparticles were premixed with the DNA polymerase, the primer or the template, respectively and then the supernatant and the precipitation of each mixture were added into the PCR system separately to observe the impact on DNA synthesis. Sequentially the interaction be- tween TiO2 nanoparticles and the DNA polymerase, the primer or the template was further analyzed by using UV-visible spectroscopy and polyacrylamide gel electrophoresis (PAGE). The results suggest that TiO2 nanoparticles inhibit DNA synthesis in the PCR system in the dark more severely than mi- croscale TiO2 particles at the equivalent concentration and the inhibition effect of TiO2 nanoparticles is concentration dependent. The molecular mechanism of such inhibition is that in the dark, TiO2 nanoparticles interact with the DNA polymerase through physical adsorption while TiO2 nanoparticles do with the primer or the template in a chemical adsorption manner. The disfunction levels of the bio-molecules under the impact of TiO2 nanoparticles are in the following order: the primer > the tem- plate > the DNA polymerase. | LI ShiQiang, ZHU Hong, ZHU RongRong, SUN XiaoYu, YAO SiDe & WANG ShiLong School of Life Science and Technology, Tongji University, Shanghai 200092, China | 2008 | Science China Chemistry2008，51，4： | 3 |
| 12 | Development of China NdFeB industry in Recent Years显示文摘1.Production Total 82,600 tons of rare earth permanent magnetic materials(quantities)were produced in China in 2010,up 48.56%over 2009.Of the total,output of sintered NdFeB magnets was 78,000 tons,up 50% over 2009 and that of the bonded NdFeB magnets was 4,000 tons,up 33.33%.Production of SmCo magnets was 600 tons,keeping the same as 2009. Table 1 shows the production of NdFeB magnet during 2001~2010 in China. | LIU Side | 2011 | China Rare Earth Information2011，17，9： | 2 |
| 13 | Reliability evaluation on sense-switch p-channel flash显示文摘In this paper,the reliability of sense-switch p-channel flash is evaluated extensively.The endurance result indicates that the p-channel flash could be programmed and erased for more than 10000 cycles;the room temperature read stress shows negligible influence on the p-channel flash cell;high temperature data retention at 150℃ is extrapolated to be about 5 years and 53 years corresponding to 30% and 40% degradation in the drive current,respectively.Moreover,the electrical parameters of the p-channel flash at different operation temperature are found to be less affected.All the results above indicate that the sense-switch p-channel flash is suitable to be used as the configuration cell in flash-based FPGA. | Side Song Guozhu Liu Hailiang Zhang Lichao Chao Jinghe Wei Wei Zhao Genshen Hong Qi He | 2021 | Journal of Semiconductors2021，42，8： | 2 |
| 14 | Effects of pH and polarity on the excited states of norfloxacin and its 4′-N-acetyl derivative:a steady-state and time-resolved study显示文摘The properties of norfloxacin(NFX)and its 4?-N-acetyl derivative(ANFX)are investigated in different pH aqueous solutions and H2O-CH3CN mixed solutions,to determine the effects of pH and polarity on their ground and excited states.The triplet states of NFX and ANFX are affected more by pH than by polarity.The pH dependence of the NFX and ANFX triplet states is likely due to the different quantum yields of different protonated forms.Steady-state fluorescence,time-resolved fluorescence,and laser flash photolysis experiments at different pH values provide clear evidence of the involvement of different intramolecular charge-transfer pathways in the singlet states of NFX and ANFX.The different electron-donating capacities of 1-N,1?-N,and 4?-N under different conditions determine the major pathway. | ZHANG Peng LI HaiXia YAO SiDe WANG WenFeng | 2014 | Science China Chemistry2014，57，3： | 2 |
| 15 | 缩小精神病生物学模型与社会心理学模型研究间的差距(英文)显示文摘Paul Bebbington最近发表的专题文章对精神病的社会心理学研究的最新进展做了一个极好的综述。然而,我们对一个仅仅基于社会流行病学和认知理论的模型可以完全描述精神病持有疑虑,并且公平地说,Bebbington也不认为这个模型可以完全描述。一个完整的模型必须纳入我们从非社会流行病学、神经科学和遗传学中汲取的经验教训。有证据表明,Bebbington感兴趣的社会风险因素,和诸如滥用兴奋剂和大麻之类的生物危险因素都可以通过纹状体多巴胺失调而激发精神病症状。在精神分裂症样精神病的病因学中,我们也需要考虑神经发育异常。此外,我们对精神病的遗传学理解上的惊人进展为研究探讨基因-环境相关性和基因-环境相互作用打开一扇令人兴奋的大门。总之,Bebbington阐述了认知领域的学者与社会研究者互相交流的价值,但偶尔更倾向于生物学方面的角度可能发展出一个更全面的模型。 | Murray RM Sideli L La Cascia C La Barbera D | 2015 | 上海精神医学2015，27，3： | 2 |
| 16 | Construction and expression of nucleic acid vaccine pVAX1-h-alpha S_(1-140) coding human alpha-synuclein显示文摘BACKGROUND: The deposition of α-synuclein (α-syn) aggregates is a neuropathological feature of Parkinson’s disease. It remains impossible to involve α-syn aggregation in the treatment of Parkinson’s disease. A nucleic acid vaccine will provide a new pathway to immunotherapy for Parkinson’s disease. OBJECTIVE: To construct a recombinant eukaryotic expression vector pVAX1 coding human α-syn and to observe its expression level in COS-7 cells. DESIGN AND SETTING: The present bioengineering and molecular biology experiment was performed at Department of Neurology, First Affiliated Hospital of Chongqing Medical University & Chongqing Key Laboratory of Neurology. MATERIALS: The eukaryotic expression plasmid pVAX1, human embryonic brain tissue, healthy human blood cells, and COS-7 cells were purchased from Promega Company, USA. METHODS: The full-length CDS sequence of the human α-syn gene was amplified by RT-PCR, which contained restriction sites for the enzymes KpnⅠ, XbaⅠand Kozak consensus sequence. Then the PCR products and eukaryotic expression vector pVAX1 were digested with KpnⅠand XbaⅠsimultaneously, and were extracted and ligated by T4 ligase. The recombinant constructs pVAX1-hα-S1-140 were transformed into competent E. coli TOP 10 cells and the positive clones were screened and selected using PCR analysis, restriction digestion analysis, and DNA sequencing. The constructs were then tested for protein expression in COS-7 cells by RT-PCR and Western blotting. MAIN OUTCOME MEASURES: Identification of an eukaryotic expression vector containing the human α-syn gene, pVAX1-hα-S1-140, and detection of the expression in mammalian cell COS-7. RESULTS: The pVAX1 vector was successfully cloned with humanα-syn in the correct orientation and in-frame. The DNA vaccine constructs pVAX1-hα-S1-140 with the humanα-syn gene were shown to be expressed in COS-7 cells. Humanα-syn was successfully expressed in the mammalian cell line and was detected by RT-PCR and western blotting. CONCLUSION: Nucleic acid vaccine pVAX1-hα S1-140 was successfully constructed and expressed in COS-7 cells. | Jiacai Wang Yingsong Ouyang Shaojun Wang Guoguang Peng Qin Luo Side Jiang FaxiangWang | 2008 | Neural Regeneration Research2008，3，12： | 2 |
| 17 | Poly(PEGMA) magnetic nanogels:Preparation via photochemical method,characterization and application as drug carrier显示文摘One-pot synthesis of magnetic nanogels with excellent biocompatibility via the photochemical method is reported in this paper.Poly(PEGMA) modified superparamagnetic nanogels(poly(PEGMA) magnetic nanogels) were synthesized by in-situ polymerization using poly(ethylene glycol) methacrylate(PEGMA) as the monomer and N,N'-methylene-bis-(acrylamide)(MBA) as the cross-linking agent in magnetite aqueous suspension under UV irradiation.The surface functional groups and components of magnetic nanogels were analyzed by Fourier transform infrared spectroscopy(FTIR) and a thermogra-vimetric analyzer(TGA).The results indicated that the poly(PEGMA) magnetic nanogels were synthe-sized successfully by coating poly(PEGMA) on the Fe3O4 nanoparticles under UV irradiation,and the Fe3O4 nanoparticles content in this nanogels was above 50 wt%.The morphology,size,zeta-potential and magnetic property were also characterized.The magnetic nanogels had a nearly spherical shape and core-shell structure,the average size in aqueous system measured by photon correlation spec-troscopy(PCS) was 68.4 nm,which was much bigger than that in the dry state,the nanogels behaved superparamagnetically with saturated magnetization of 58.6 emu/g,and the zeta-potential was-16.3-_17.3 mV at physiological pH(6.8-7.4) which could help to maintain stability in blood.The preliminary application as drug carrier was made and the doxorubicin-loaded magnetic nanogels had an excellent property in slow-release.The experiment indicated that the magnetic nanogel was an ideal candidate carrier in target drug delivery systems and other biomedical application. | SUN HanWen ZHANG LianYing ZHU XinJun KONG ChunYan ZHANG CunLan YAO SiDe | 2009 | Science China Chemistry2009，52，1： | 2 |
| 18 | Comparison of three different method to merge multiresolution and multispectral data,Landsat TM and SPOT panchromatic 显示文摘 | Sides S C Anderson J A | 1991 | Photogrammetric Engineering & Remote Sensing1991，57，3： | 1 |
| 19 | Compari-son of three different methods to merge multiresolutionand multispectral data:TM&SPOT pan显示文摘 | CHAVEZ P S SIDES S C ANDERSON J A | 1991 | Photoga-mmetric Engineering and Remote Sensing1991，57，3： | 1 |
| 20 | Comparison of three different methods to merge multiresolution and multispeetral data显示文摘 | Chavez P R Sides S C Anderson J A | 1991 | Photogrammetric Engineering and Remote Sensing1991，57，3： | 1 |
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