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| 1 | Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review显示文摘Type 2 diabetes is a complicated metabolic disorder with both short- and long-term undesirable complications. In recent years, there has been growing evidence that functional foods and their bioactive compounds, due to their biological properties, may be used as complementary treatment for type 2 diabetes mellitus. In this review, we have highlighted various functional foods as missing part of medical nutrition therapy in diabetic patients. Several in vitro, animal models and some human studies, have demonstrated that functional foods and nutraceuticals may improve postprandial hyperglycemia and adipose tissue metabolism modulatecarbohydrate and lipid metabolism. Functional foods may also improve dyslipidemia and insulin resistance, and attenuate oxidative stress and inflammatory processes and subsequently could prevent the development of long-term diabetes complications including cardiovascular disease, neuropathy, nephropathy and retinopathy. In conclusion available data indicate that a functional foods-based diet may be a novel and comprehensive dietary approach for management of type 2 diabetes. | Parvin Mirmiran Zahra Bahadoran Fereidoun Azizi | 2014 | World Journal of Diabetes2014，5，3： | 18 |
| 2 | Kaempferol attenuates cognitive deficit via regulating oxidative stress and neuroinflammation in an ovariectomized rat model of sporadic dementia显示文摘Alzheimer's disease(AD) is associated with oxidative stress, and ultimately results in cognitive deficit. Despite existing literature on the pathophysiology of AD, there is currently no cure for AD. The present study investigated the effects of kaempferol(Kmp) isolated from the extract of Mespilus germanica L.(medlar) leaves on cognitive impairment, hippocampal antioxidants, apoptosis, lipid peroxidation and neuro-inflammation markers in ovariectomized(OVX) rat models of sporadic AD. Kaempferol, as the main flavonoid of medlar extract has been previously known for anti-oxidative, anti-inflammatory and anti-neurotoxic effects. Thirty-two female Wistar rats were ovariectomized, and randomly divided into four groups: sham, OVX + saline, OVX + streptozotocin(STZ) + saline, OVX + STZ + Kmp. Animals received intracerebroventricular injection of STZ(3 mg/kg, twice with one day interval) to establish models of sporadic AD. Intraperitoneal injection of Kmp(10 mg/kg) for 21 days was performed in the OVX + STZ + Kmp group. Spatial learning and memory of rats were evaluated using a Morris water maze. Finally, brain homogenates were used for biochemical analysis by enzyme-linked immunosorbent assay. The results showed a significant improvement in spatial learning and memory as evidenced by shortened escape latency and searching distance in Morris water maze in the OVX + STZ + Kmp group compared with the OVX + STZ group. Kmp also exhibited significant elevations in brain levels of antioxidant enzymes of superoxide dismutase and glutathione, while reduction in tumor necrosis factor-α and malondialdehyde. Our results demonstrate that Kmp is capable of alleviating STZ-induced memory impairment in OVX rats, probably by elevating endogenous hippocampal antioxidants of superoxide dismutase and glutathione, and reducing neuroinflammation. This study suggests that Kmp may be a potential neuroprotective agent against cognitive deficit in AD. | Somayeh Kouhestani Adele Jafari Parvin Babaei | 2018 | Neural Regeneration Research2018，13，10： | 11 |
| 3 | 轴向和循环荷载组合下夹角对纤维复合材料包裹钢筋混凝土梁柱节点性能的影响显示文摘通过数字分析,研究轴向和循环荷载作用下夹角对采用碳纤维复合包裹的钢筋混凝土梁柱节点的剪力和延性的影响。对于梁柱节点,建立了三维非线性有限元模型并采用Marc.MentatTM2001有限元分析软件进行模拟。采用已有文献中纤维增强复合材料包裹梁柱节点试验研究所提供的资料,对有限元模型的精度进行评估。用有限元方法分析不同夹角配置的碳纤维增强复合聚合物包裹加固的3个梁-柱节点的性能。分析结果显示:与水平轴成±45°,连续4层包裹纤维增强复合聚合物,对于提高轴向和循环荷载组合下梁-柱节点的剪力和延性,是最好的设计方案。 | Azadeh Parvin | 2008 | 钢结构2008，23，7： | 9 |
| 4 | 5-羟色胺2c受体拮抗剂减弱高血压大鼠血压及主动脉的收缩性显示文摘目的观察慢性颅室内给予选择性5-HT2C受体拮抗剂RS102221是否能阻止醋酸脱氧肾上腺皮质激素-盐(DOCA)高血压大鼠血压的发展,以证实中枢神经系统5-HT2C受体参与了血压的调节和高血压的病理。方法通过导管,用微型渗透泵以恒定速率脑室输注选择性5-HT2C受体拮抗剂RS102221,观察拮抗中枢神经5-HT2C受体后对醋DOCA高血压大鼠(n=6)血压的影响。此外检测了5-HT2C受体拮抗剂对DOCA大鼠主动脉等张收缩力的影响。结果脑室输注RS102221减低DOCA大鼠血压的发展。5-HT2c受体拮抗剂的治疗消除了DOCA大鼠和对照组大鼠主动脉环对5-HT的反应差异。结论中枢神经系统5-HT2C受体参与了DOCA大鼠血压的调节和高血压的病理,其主动脉5-HT受体亚型的改变可能是高血压病理之一。 | 司晓晨 Parvine Shakui Richrd F.Keep | 2003 | 中国临床康复2003，7，15： | 7 |
| 5 | Protective effect of ginger volatile oil against acetic acid-induced colitis in rats: a light microscopic evaluation显示文摘OBJECTIVE: Ulcerative colitis is a chronically recurrent infl ammatory bowel disease of unknown origin. In the present study, the effect of ginger(rhizome of Zing iber officinale Roscoe) volatile oil on a rat model of colitis was evaluated. METHODS: Volatile oil of ginger with doses of 100, 200, and 400 mg/kg, prednisolone(4 mg/kg), or vehicle were administered orally to groups of male Wistar rats(n = 6) for 5 d. Animals were randomly divided into 6 groups, each group consisting of 6 rats. Colitis was induced by intracolonic instillation of 2 mL of 4%(v/v) acetic acid solution. All rats were sacrificed 24 h later and the tissue injuries were assessed macroscopically and histopathologically. RESULTS: Ginger volatile oil with all doses reduced colon weight/length ratio(P < 0.01) and the effects were similar to the reference drugs. Higher oral doses of volatile oil(200 and 400 mg/kg) reduced ulcer severity(P < 0.05 and P < 0.01), ulcer area(P < 0.01) and ulcer index(P < 0.01). On the other hand, evaluation of microscopic scores showed that the dose of 400 mg/kg of volatile oil was effective to reduce infl ammation severity(P < 0.01) and infl ammation extent(P < 0.05) compared to the control group.CONCLUSION: It is concluded that ginger volatile oil could effectively reduce symptoms of experimental colitis in a dose-dependent manner. | Amir Rashidian Saeed Mehrzadi Ali Reza Ghannadi Parvin Mahzooni Samira Sadr Mohsen Minaiyan | 2014 | Journal of Integrative Medicine2014，12，2： | 7 |
| 6 | Antioxidant therapy in acute,chronic and post-endoscopic retrograde cholangiopancreatography pancreatitis:An updated systematic review and meta-analysis显示文摘AIM:To investigate the efficacy and adverse effects of antioxidant therapy in acute pancreatitis(AP),chronic pancreatitis(CP) and post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP).METHODS:Pub Med,Scopus,Google Scholar,Cochrane library database,and Evidence-based medicine/clinical trials published before August 2014 were searched. Clinical and laboratory outcomes of randomized trials of antioxidant therapy in patients with AP,CP and PEP were included. The methodological quality of the trials was assessed by the Jadad score based on the description of randomization,blinding,and dropouts(withdrawals). The results of the studies were pooled and meta-analyzed to provide estimates of the efficacy of antioxidant therapy.RESULTS:Thirty four trials out of 1069 potentially relevant studies with data for 4898 patients wereeligible for inclusion. Antioxidant therapy significantly reduced the length of hospital stay in AP patients {mean difference-2.59 d(95%CI:-4.25-(-0.93)],P = 0.002}. Although,antioxidant therapy had no significant effect on serum C reactive protein(CRP) after 5-7 d in AP patients [mean difference-9.57(95%CI:-40.61-21.48,P = 0.55],it significantly reduced serum CRP after 10 d {mean difference-45.16 [95%CI:-89.99-(-0.33)],P = 0.048}. In addition,antioxidant therapy had no significant effect on CP-induced pain [mean difference-2.13(95%CI:-5.87-1.6),P = 0.26]. Antioxidant therapy had no significant effects on the incidence of all types of PEP [mean difference 1.05(95%CI:0.74-1.5),P = 0.78],severe PEP [mean difference 0.92(95%CI:0.43-1.97),P = 0.83],moderate PEP [mean difference 0.82(95%CI:0.54-1.23),P = 0.33],and mild PEP [mean difference 1.33(95%CI:0.99-1.78),P = 0.06]. Furthermore,while antioxidant therapy had no significant effect on serum amylase after less than 8 h sampling [mean difference-20.61(95%CI:-143.61-102.39),P = 0.74],it significantly reduced serum amylase close to 24-h sampling {mean difference-16.13 [95%CI:-22.98-(-9.28)],P < 0.0001}.CONCLUSION:While there is some evidence to support antioxidant therapy in AP,its effect on CP and PEP is still controversial. | Maziar Gooshe Amir Hossein Abdolghaffari Shekoufeh Nikfar Parvin Mahdaviani Mohammad Abdollahi | 2015 | World Journal of Gastroenterology2015，21，30： | 6 |
| 7 | GIS-based landslide susceptibility modeling:A comparison between fuzzy multi-criteria and machine learning algorithms显示文摘Hazards and disasters have always negative impacts on the way of life.Landslide is an overwhelming natural as well as man-made disaster that causes loss of natural resources and human properties throughout theworld.The present study aimed to assess and compare the prediction efficiency of different models in landslide susceptibility in the Kysuca river basin,Slovakia.In this regard,the fuzzy decision-making trial and evaluation laboratory combining with the analytic network process(FDEMATEL-ANP),Naïve Bayes(NB)classifier,and random forest(RF)classifier were considered.Initially,a landslide inventory map was produced with 2000 landslide and nonlandslide points by randomly dividedwith a ratio of 70%:30%for training and testing,respectively.The geospatial database for assessing the landslide susceptibility was generated with the help of 16 landslide conditioning factors by allowing for topographical,hydrological,lithological,and land cover factors.The ReliefF methodwas considered for determining the significance of selected conditioning factors and inclusion in the model building.Consequently,the landslide susceptibility maps(LSMs)were generated using the FDEMATEL-ANP,Naïve Bayes(NB)classifier,and random forest(RF)classifier models.Finally,the area under curve(AUC)and different arithmetic evaluation were used for validating and comparing the results and models.The results revealed that random forest(RF)classifier is a promising and optimum model for landslide susceptibility in the study area with a very high value of area under curve(AUC=0.954),lower value of mean absolute error(MAE=0.1238)and root mean square error(RMSE=0.2555),and higher value of Kappa index(K=0.8435)and overall accuracy(OAC=92.2%). | Sk Ajim Ali Farhana Parvin Jana Vojteková Romulus Costache Nguyen Thi Thuy Linh Quoc Bao Pham Matej Vojtek Ljubomir Gigović Ateeque Ahmad Mohammad Ali Ghorbani | 2021 | Geoscience Frontiers2021，12，2： | 3 |
| 8 | Synthesis of a PEG-PNIPAm Thermosensitive Dendritic Copolymer and Investigation of Its Self-association显示文摘A Novel thermosensitive dendritic copolymer based on polyethylene glycol(PEG) and poly(Nisopropylacrylamide)(PNIPAm) with a cloud point(CP) around 36 ?C was successfully synthesized by preparation of a dendritic polyol and followed by atom transfer radical polymerization(ATRP) of N-isopropylacrylamide. The dendritic copolymer was characterized using gel-permeation chromatography(GPC), FTIR and 1H-NMR spectroscopy. The selfassociation behavior of the copolymer in aqueous medium was investigated by dynamic light scattering(DLS) and transmission electron microscopy(TEM). These investigations confirmed that the dendritic copolymer showed different association behaviors at various temperatures. | Farzad Seidi Parvin Heshmati | 2015 | Chinese Journal of Polymer Science2015，33，1： | 3 |
| 9 | 使用OculusKeratograph 5M测量圆锥角膜患者NITBUT和TMH(英文)显示文摘目的:比较圆锥角膜患者和正常人使用Oculus Keratograph 5M(K5M)测得的非侵入性泪膜破裂时间(NITBUT)和泪河高度(TMH),以确定这两项指标和圆锥角膜的关系。方法:50例100眼圆锥角膜患者和50例100眼正常人参加了这项研究。圆锥角膜组患者的年龄为15~60(平均28.33±8.60)y。对照组为18~60(平均26.25±1.11)岁。使用K5M测量所有受试者的NITBUT和TMH。结果:两组之间的NITBUT和TMH平均值差异无统计学意义(P=0.58,0.69)。两参数的相关性研究显示,两组中NITBUT和TMH之间均无相关性(圆锥角膜组:r=0.053,P=0.721;对照组:r=-0.0501,P=0.7098)。 | Masoud Safarzadeh Parvin Azizzadeh Pedram Akbarshahi Laleh Heidari | 2017 | 国际眼科杂志2017，17，9： | 3 |
| 10 | Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer显示文摘Through advances in technology,the genetic basis of cancer has been investigated at the genomic level,and many fundamental questions have begun to be addressed.Among several key unresolved questions in cancer biology,the molecular basis for the link between nuclear deformation and malignancy has not been determined.Another hallmark of human cancer is aneuploidy;however,the causes and consequences of aneuploidy are unanswered and are hotly contested topics.We found that nuclear lamina proteins lamin A/C are absent in a significant fraction(38%) of human breast cancer tissues.Even in lamin A/C-positive breast cancer,lamin A/C expression is heterogeneous or aberrant(such as non-nuclear distribution) in the population of tumor cells,as determined by immunohistology and immunofluorescence microscopy.In most breast cancer cell lines,a significant fraction of the lamin A/C-negative population was observed.To determine the consequences of the loss of lamin A/C,we suppressed their expression by shRNA in noncancerous primary breast epithelial cells.Down-regulation of lamin A/C in breast epithelial cells led to morphological deformation,resembling that of cancer cells,as observed by immunofluorescence microscopy.The lamin A/C-suppressed breast epithelial cells developed aneuploidy as determined by both flow cytometry and fluorescence in situ hybridization.We conclude that the loss of nuclear envelope structural proteins lamin A/C in breast cancer underlies the two hallmarks of cancer aberrations in nuclear morphology and aneuploidy. | Callinice D. Capo-chichi Kathy Q. Cai Jennifer Smedberg Parvin Ganjei-Azar Andrew K. Godwin Xiang-Xi Xu | 2011 | Chinese Journal of Cancer2011，30，6： | 2 |
| 11 | 中枢给予5-羟色胺2C受体拮抗剂对DOCA高血压大鼠血压的作用显示文摘目的 :本实验是为了证实中枢神经系统的 5 -HT2C受体是否参与了血压的调节和高血压的发病。方法 :使用SD造模DOCA高血压大鼠 ,通过植入右侧脑室的不锈钢导管 ,用微型渗透泵以恒定速率慢性脑室输注选择性 5 -HT2C受体拮抗剂RS1 0 2 2 2 1 ,观察拮抗中枢神经 5 -HT2C受体后对DOCA高血压大鼠血压的影响。另一个实验使用SD大鼠 ,慢性脑室输注选择性 5 -HT2C受体促进剂MK2 1 2 ,以及MK2 1 2和RS1 0 2 2 2 1同时输注 ,以进一步证实 5 -HT2C受体对大鼠血压的作用。结果 :脑室输注RS1 0 2 2 2 1能减低DOCA大鼠血压的发展 ,MK2 1 2能使SD大鼠发展为高血压 ,而同时使用RS1 0 2 2 2 1的SD大鼠血压则保持正常。结论 :中枢神经系统 5 | 司晓晨 Parvine Shakui Richrd F Keep | 2003 | 中国病理生理杂志2003，19，1： | 2 |
| 12 | Methanolic extract of African mistletoe(Viscum album) improves carbohydrate metabolism and hyperlipidemia in streptozotocin-induced diabetic rats显示文摘Objective:To justify the use of African mistletoe(AM) Viscum album {V.album) in folkoric medicine to treat diabetes.Methods:In one experiment,the fasting blood glucose(FBG) leveb of diabetic rats were monitored for 4 h.Diabetic rats were treated with AM at doses of 50 mg/kg(AM1) and 100 mg/kg(AM2),glibenclamide(GB)(positive control) and saline solution(SS).In another experiment,diabetic rats were treated with AM2,GB and SS daily for 3 weeks.Results:AM1 and AM2 elicited significant(P<0.05) hypoglycaemic effects within 4 h of extract administration. AM1 and AM2 decreased the FBG by 41%and 49%,respectively,at 2 h.AM2 was found to lower FBC by 51%,relative to baseline,which was comparable to GB at 3 h.In the second experiment, AM2 and GB significantly(P<0.05) decreased the FBG by 34%and 51%,respectively.This was followed by marked decrease in levels of HbAlC in AM2- and GB- treated diabetic rats.AM2 significantly(P<0.05) decreased the STZ-induced increase in levels of serum triglyceride,urea, lactate dehydrogenase,α-amylase and low-density lipoprotein-cholesterol.Furthermore, diabetic rats treated with AM2 had significanlly(P<0.05) elevated high-density lipoprotein-cholesterol. In contrast,STZ administration produced insignificant(P<0.05) effect on the levels of serum creatinine and total bilirubin.Conclusions:Extract of African mistletoe has anti-diabetic and anti-hyperlipidemic effects in STZ-diabetic rats.AM may find clinical application in the amelioration of diabetes-induced lipid disorders. | Oluwatosin Adaramoye Massoud Amanlou Mehran Habibi-Rezaei Parvin Pasalar Ali Moosavi-Movahedi | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，6： | 2 |
| 13 | Floor tile glass-ceramic glaze for improvement of glaze surface properties显示文摘 | Bijan Eftekhari Yekta Parvin Alizadeh Leila Rezazadeh | 2006 | Journal of the European Ceramic Society2006，，16： | 2 |
| 14 | Nitrate-nitrite-nitrosamines exposure and the risk of type 1 diabetes: A review of current data显示文摘The potential toxic effects of nitrate-nitrite-nitrosamine on pancreatic β cell have remained a controversial issue over the past two decades. In this study, we reviewed epidemiological studies investigated the associations between nitrate-nitrite-nitrosamines exposure, from both diet and drinking water to ascertain whether these compounds may contribute to development of type 1 diabetes. To identify relevant studies, a systematic search strategy of Pub Med, Scopus, and Science Direct was conducted using queries including the key words 'nitrate', 'nitrite', 'nitrosamine' with 'type 1 diabetes' or 'insulin dependent diabetes mellitus'. All searches were limited to studies published in English. Ecologic surveys, case-control and cohort studies have indicated conflicting results in relation to nitrate-nitrite exposure from drinking water and the risk of type 1 diabetes. A null, sometimes even negative association has been mainly reported in regions with a mean nitrate levels < 25 mg/L in drinking water, while increased risk of type 1 diabetes was observed in those with a maximum nitrate levels > 40-80 mg/L. Limited data are available regarding the potential diabetogenic effect of nitrite from drinking water, although there is evidence indicating dietary nitrite could be a risk factor for development of type 1 diabetes, an effect however that seems to be significant in a higher range of acceptable limit for nitrate/nitrite. Current data regarding dietary exposure of nitrosamine and development of type 1 diabetes is also inconsistent. Considering to an increasing trend of type 1 diabetes mellitus(T1DM) along with an elevated nitrate-nitrite exposure, additional research is critical to clarify potential harmful effects of nitrate-nitritenitrosamine exposure on β-cell autoimmunity and the risk of T1DM. | Zahra Bahadoran Asghar Ghasemi Parvin Mirmiran Fereidoun Azizi Farzad Hadaegh | 2016 | World Journal of Diabetes2016，7，18： | 2 |
| 15 | DNA-binding studies of valrubicin as a chemotherapy drug using spectroscopy and electrochemical techniques显示文摘In this study, the molecular interactions between valrubicin, an anticancer drug, and fish sperm DNA have been studied in phosphate buffer solution(pH 7.4) using UV–Vis spectrophotometry and cyclic voltammetry techniques. Valrubicin intercalated into double stranded DNA under a weak displacement reaction with methylene blue(MB) molecule in a competitive reaction. The binding constant(kb) of valrubicin-DNA was determined as 1.75×10~3L/mol by spectrophotometric titration. The value of non-electrostatic binding constant(k_t^0) was almost constant at different ionic strengths while the ratio of k_t^0/k_b increased from 4.51% to 23.77%.These results indicate that valrubicin binds to ds-DNA via electrostatic and intercalation modes.Thermodynamic parameters including ΔH^0, ΔS^0and ΔG^0for valrubicin-DNA interaction were determined as-25.21×10~3k J/mol, 1.55×10~2k J/mol K and-22.03 k J/mol, respectively. Cyclic voltammetry study shows a pair of redox peaks for valrubicin at 0.45 V and 0.36 V(vs. Ag/Ag Cl). The peak currents decreased and peak positions shifted to positive direction in the presence of DNA, showing intercalation mechanism due to the variation in formal potential. | Reza Hajian Parvin Hossaini Zahra Mehrayin Pei Meng Woi Nafiseh Shams | 2017 | Journal of Pharmaceutical Analysis2017，7，3： | 2 |
| 16 | Prognostic Value of Promoter Hypermethylation of Retinoic Acid Receptor Beta (RARB) and CDKN2 (p16/MTS1) in Prostate Cancer显示文摘Objective: The molecular mechanism of prostate cancer is poorly understood. The aim of the study was to investigate the prevalence and prognostic value of promoter hypermethylation of retinoic acid receptor beta (RARB) and p16 among benign prostatic hyperplasia (BPH) and prostate cancer patients. Methods: In this case-control study, 63 patients were included in three groups; 21 with BPH as the control group, 21 with prostate cancer and good prognostic factors (based on prostate-specific antigen, Gleason score and stage) as good prognosis group, and 21 with prostate cancer and poor prognostic features as poor prognosis group. The prostate biopsy specimen of each individual was examined for hypermethylation of RARB and p16 promoters by methylation specific PCR (MSPCR). Results: Seven (33.3%) patients with good prognosis and 15 (71.4%) patients with poor prognosis were positive for RARB methylation, which were significantly higher than controls (P <0.0001). p16 promoter methylation was shown in 19.0% and 47.6% patients with good and poor prognosis, respectively. The RARB and p16 promoter methylation in the poor prognosis group was significantly higher than that in the good prognosis group (P =0.02 for RARB and P<0.0001 for p16). Conclusion: Hypermethylation of RARB and p16 promoters may predict prognosis in prostate cancer. | Ameri A Alidoosti A Hosseini Y Parvin M Emranpour MH Taslimi F Salehi E Fadavi P | 2011 | Chinese Journal of Cancer Research2011，23，4： | 2 |
| 17 | 显示文摘 | Host J J Block J A Parvin K | 1998 | J Appl Phys1998，83，2： | 1 |
| 18 | Dual-laser-beam-induced breakdown spectroscopy of copper using simultaneous continuous wave CO2 and Q-switched Nd:YAG lasers 显示文摘 | Shoursheini SZ Parvin P Sajad B | 2009 | Appl Spectrosc2009，63，4： | 1 |
| 19 | Use of serum FSH to identify perimenopausal women with pituitary HCG显示文摘 | Gronowski AM Fantz CR Parvin CA | 2008 | Clin Chem2008，54，： | 1 |
| 20 | Performance of Externally FRP Reinforced Columns for Changes in Angle and Thickness of the Wrap and Concrete Strength显示文摘 | PARVIN A JAMWAL A S | 2006 | Composite Struetures2006，73，4： | 1 |
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