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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Rendering and animation of gaseous phenomena by combining fast volume and seanline a-buffer techniques 显示文摘 | EBERT D S PARENT R E | 1990 | Computer Graphics1990，94，4： | 1 |
| 3 | Interverte-bral disk disease in dogs with signs of back pain alone:25cases(1986-1993)显示文摘 | Sukhiani H R Parent J M Atilola M A O | 1996 | Journal of the American Veterinary Medi-cal Association1996，209，： | 1 |
| 4 | Conditional geneexpression and lineage tracing of tubal a expressing cells duringzebrafish development and retina regeneration显示文摘 | Ramachandran R Reifler A Parent JM | 2010 | J Comp Neurol2010，518，41： | 1 |
| 5 | Influence of specific energy on the properties of hydroentangled nonwoven pabrics 显示文摘 | Connolly T J Parent L R | 1993 | Nonwovens Conference1993，，1： | 1 |
| 6 | Knowledge creation in focus groups:can group technologies help显示文摘 | PARENT M GALLUPE R B SALISBURY W D | 2000 | Information & Management2000，38，1： | 1 |
| 7 | Layered construction for deformable animated characters 显示文摘 | Chadwick J E Haumann D R Parent R E | 1989 | ACM Siggraph Com- puter Gra-phics1989，23，3： | 1 |
| 8 | Derivation of DRIS norms from a high-density apple orchard established in the Quebec Appalachian Mountains显示文摘 | Parent L E Granger R L | 1989 | J Amer Soc Hort Sci1989，114，： | 1 |
| 9 | Shape transformation for polyhedral objects 显示文摘 | Kent J 1L Carlson W E Parent R E | 1992 | Computer Graphics (ACM)1992，26，2： | 1 |
| 10 | Motion control: computing the arc length of parametric curves显示文摘 | Guenter B Parent R | 1990 | IEEE Computer Graphics & Applications1990，10，3： | 1 |
| 11 | Knowledge creation in focus groups: can group technologies help?显示文摘 | Parent M Gallupe R B | 2000 | Information & Management2000，38，： | 1 |
| 12 | Proteomics in the study of liver pathology 显示文摘 | PARENT R BERETTA L | 2005 | Journal of Herpetology2005，43，1： | 1 |
| 13 | Canine demodectic mange: Clinical observation in a treatment trial with ivernectin显示文摘 | Belt J Parent R | 1984 | Point Vdg Vet1984，16，： | 1 |
| 14 | Management of uret eropelvic junction obstruction with high pressure balloon dilatation long-term outcome in 50 children under 18 months of age显示文摘 | Parente A Angulo J M Romero R M | 2013 | Urol ogy2013，82，5： | 1 |
| 15 | Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy显示文摘 | PARENT J M ELLIOTT R C PLEASURE S J | 2006 | Ann Neurol2006，59，1： | 1 |
| 16 | Induction of somostatin immunoreactivity in cultured ciliary ganglion neurons by activin in choroids cell-conditioned medium显示文摘 | Coulombe JN Schwall R Parent AS | 1993 | Neuron1993，10，： | 1 |
| 17 | Determinants of cross-national knowledge transfer and its effect on firm innovation显示文摘 | Kotabe M Dunlap-Hinkler D Parente R | 2007 | Journal of International Business Studies2007，38，： | 1 |
| 18 | Shape transformation for polyhedral objects 显示文摘 | Kent J R Carlson W E Parent R E | 1992 | Computer graphics1992，29，3： | 1 |
| 19 | Computing the arc length of parametric curves显示文摘 | GUENTER B PARENT R | 1990 | IEEE Computer Graphics & Applications1990，10，3： | 1 |
| 20 | Sheet metal forming simulation using EAS solid shell finite elements显示文摘 | Parente M P L Fontes-Valente R A Natal-Jorge R M | 2006 | Finite Elements in Analysis and Design2006，42，13： | 1 |
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