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| 1 | Moving forward in the treatment of cholangiocarcinoma显示文摘Despite being the second most frequent primary liver tumor in humans,early diagnosis and treatment of cholangiocarcinoma(CCA)are still unsatisfactory.In fact,survival after 5 years is expected in less than one fourth of patients diagnosed with this disease.Rare incidence,late appearance of symptoms and heterogeneous biology are all factors contributing to our limited knowledge of this cancer and determining its poor prognosis in the clinical setting.Several efforts have been made in the last decades in order to achieve an improved classification/understanding with regard to the diverse CCA forms.Location within the biliary tree has helped to distinguish between intrahepatic,perihilar and distal CCA types.Sequence analysis contributed to identifying several characteristic genetic aberrations in CCA that may also serve as possible targets for therapy.Novel findings are expected to significantly improve the management of this malignancy in the near future.In this changing scenario our review focuses on the current and future strategies for CCA treatment.Both systemic and surgical treatments are discussed in detail.The results of the main studies in this field are reported,together with the ongoing trials.The current findings suggest that an integrated multidisciplinary approach to this malignancy would be helpful to improve its outcome. | Tommaso M Manzia Alessandro Parente Ilaria Lenci Bruno Sensi Martina Milana Carlo Gazia Alessandro Signorello Roberta Angelico Giuseppe Grassi Giuseppe Tisone Leonardo Baiocchi | 2021 | World Journal of Gastrointestinal Oncology2021，13，12： | 6 |
| 2 | Inflammatory bowel disease in an underdeveloped region of Northeastern Brazil显示文摘AIM: To evaluate the demographic characteristics and clinical phenotypes of inflammatory bowel disease(IBD) in a geographic area in Northeastern Brazil.METHODS: This retrospective study was conducted at the Hospital of the Federal University of Piauí in Northeastern Brazil. Demographic characteristics and clinical phenotypes of IBD were analyzed in relation to the time of diagnostic confirmation, which was defined as the date of disease onset. Data were collected between January 2011 and December 2012 and included all census patients 18 years of age or older during that period for whom there was diagnostic confirmation of Crohn's disease(CD), ulcerative colitis(UC), or unclassified colitis according to the Montreal criteria. We also analyzed the period of time between the onset of clinical manifestations and the diagnosis of IBD(delay in the diagnosis). Statistical analyses included means and standard deviations for numeric variables and the Pearson χ2 adherence test for nominal variables. The annual index occurrence and overall prevalence of IBD at our institution were also calculated, with P values < 0.05 indicating statistical significance. This study was approved by the Institutional Ethics and Research Committee.RESULTS: A total of 252 patients with IBD were included, including 152(60.3%) UC patients and 100(39.7%) CD patients. The clinical and demographic characteristics of all patients with IBD showed a female to male ratio of 1.3:1.0 and a mean age of35.2(SD = 14.5) years. In addition, the majority of patients were miscegenated(171, 67.9%), had received higher education(157, 62.4%), lived in urban areas(217, 86.1%), and were under the age of 40 years(97, 62.5%). For patients with CD, according to the Montreal classification, the predominant features present from the onset of disease were an age between 17 and 40 years(A2); colonic disease location(L2); and nonstricturing, nonfistulizing disease behavior(B1). However, approximately one-quarter of all CD patients demonstrated perineal involvement. We also observed considerable delay in the diagnosis of IBD throughout the entire study period(mean = 35.5 mo). In addition, the annual index occurrence rose from 0.08 to 1.53 cases/105 inhabitants/year during the study period, and the prevalence rate was 12.8 cases/105 inhabitants in 2012. Over the last two decades, there was a noted increase in the frequency of IBD in the study area.CONCLUSION: In this study, there was a predominance of patients with UC, young people under 40 years of age, individuals with racial miscegenation, and low annual incomes. | José Miguel Luz Parente Claudio Saddy Rodrigues Coy Viriato Campelo Mírian Perpétua Palha Dias Parente Leonardo Araújo Costa Renata Mendes da Silva Celso Stephan José Murilo Robilotta Zeitune | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Interverte-bral disk disease in dogs with signs of back pain alone:25cases(1986-1993)显示文摘 | Sukhiani H R Parent J M Atilola M A O | 1996 | Journal of the American Veterinary Medi-cal Association1996，209，： | 1 |
| 5 | Knowledge creation in focus groups:can group technologies help显示文摘 | PARENT M GALLUPE R B SALISBURY W D | 2000 | Information & Management2000，38，1： | 1 |
| 6 | Germination responses of 64 wetland species in relation to seed size,minimum time to reproduetion and seedling relative growth rate显示文摘 | Shipley B Parent M | 1991 | Functional Ecology1991，，5： | 1 |
| 7 | Score distribution of the scoliosis quality of life index questionnaire in differ- ent subgroups of patients with adolescent idiopathic scoliosis 显示文摘 | Parent EC Doug HPE Moreau M | 2007 | Spine2007，32，16： | 1 |
| 8 | Expression of the β-glucosidase gene Pgβglu-1 underpins natural resistance of white spruce against spruce budworm 显示文摘 | Mageroy M H Parent G Germanos G | 2015 | Plant Journal for Cell & Molecular Biology2015，81，1： | 1 |
| 9 | Advanced urban transport: automation is on the way显示文摘 | Parent M | 2007 | IEEE Intelligent Systems2007，22，2： | 1 |
| 10 | Human type Ⅶ collagen: genetic linkage of the gene ( COL7A1 ) on chromosome 3 to dominant dystrophic epidermolysis bullosa 显示文摘 | Ryynanen M Knowlton RG Parente MG | 1991 | Am J Hum Genet1991，49，4： | 1 |
| 11 | Knowledge creation in focus groups: can group technologies help?显示文摘 | Parent M Gallupe R B | 2000 | Information & Management2000，38，： | 1 |
| 12 | 肺动脉高压启动治疗后血流动力学指标的预后价值显示文摘血流动力学指标,如心脏指数和右心房压力(right atrial pressure,RAP)与患者确诊肺动脉高压时的生存率持续相关。近期研究表明,肺动脉顺应性(pulmon aryarterial compliance,Pea)也可能预测肺动脉高压的预后。而在治疗开始之后测定的血流动力学指标对预后的价值还未确定。 | 黄洁 叶鹏 Weatherald J Boucly A Chemla D Savale L Peng M Jevnikar M Ja?s X Taniguchi Y O'Connell C Parent F Sattler C Hervé P Simonneau G Montani D Humbert M Adir Y Sitbon O | 2017 | 中华高血压杂志2017，25，11： | 1 |
| 13 | Propagation of super-Gaussian field distribution显示文摘 | Parent A Marin M Lavigne P | 1992 | Opt and Quant Electron1992，24，9： | 1 |
| 14 | Management of uret eropelvic junction obstruction with high pressure balloon dilatation long-term outcome in 50 children under 18 months of age显示文摘 | Parente A Angulo J M Romero R M | 2013 | Urol ogy2013，82，5： | 1 |
| 15 | Mono(:hromatie aberrations as a function of age, from childhood to advanced age 显示文摘 | Brunette I Bueno JM Parent M | 2003 | Invest Ophthahnol Vis Sci2003，44，12： | 1 |
| 16 | Regulation of COX-2 protein expression by Akt in endometrial cancer cells is mediated through NF?kappaB/lkappaB pathway显示文摘 | ST-GERMAIN M E GAGNON V PARENT S | 2004 | Mol Cancer2004，3，： | 1 |
| 17 | Relationships between Job Skills and Performance: A Study of Webmasters 显示文摘 | Wade M Parent M | 2001 | Journal of Management Information Systems2001，18，3： | 1 |
| 18 | Aberrant seizure-induced neurogenesis in experimental temporal lobe epilepsy显示文摘 | PARENT J M ELLIOTT R C PLEASURE S J | 2006 | Ann Neurol2006，59，1： | 1 |
| 19 | Task-dependent effects of the antidepressant/antipanic drug phenelzine on memory 显示文摘 | Parent M B Habib M K Baker G B | 1999 | Psychopharmacology1999，142，3： | 1 |
| 20 | Determinants of cross-national knowledge transfer and its effect on firm innovation显示文摘 | Kotabe M Dunlap-Hinkler D Parente R | 2007 | Journal of International Business Studies2007，38，： | 1 |
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