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| 1 | Helicobacter pylori,gastric microbiota and gastric cancer relationship:Unrolling the tangle显示文摘Helicobacter pylori infection(Hp-I)represents a typical microbial agent intervening in the complex mechanisms of gastric homeostasis by disturbing the balance between the host gastric microbiota and mucosa-related factors,leading to inflammatory changes,dysbiosis and eventually gastric cancer.The normal gastric microbiota shows diversity,with Proteobacteria[Helicobacter pylori(H.pylori)belongs to this family],Firmicutes,Actinobacteria,Bacteroides and Fusobacteria being the most abundant phyla.Most studies indicate that H.pylori has inhibitory effects on the colonization of other bacteria,harboring a lower diversity of them in the stomach.When comparing the healthy with the diseased stomach,there is a change in the composition of the gastric microbiome with increasing abundance of H.pylori(where present)in the gastritis stage,while as the gastric carcinogenesis cascade progresses to gastric cancer,the oral and intestinal-type pathogenic microbial strains predominate.Hp-I creates a premalignant environment of atrophy and intestinal metaplasia and the subsequent alteration in gastric microbiota seems to play a crucial role in gastric tumorigenesis itself.Successful H.pylori eradication is suggested to restore gastric microbiota,at least in primary stages.It is more than clear that Hp-I,gastric microbiota and gastric cancer constitute a challenging tangle and the strong interaction between them makes it difficult to unroll.Future studies are considered of crucial importance to test the complex interaction on the modulation of the gastric microbiota by H.pylori as well as on the relationships between the gastric microbiota and gastric carcinogenesis. | Christos Liatsos Apostolis Papaefthymiou Nikolaos Kyriakos Michail Galanopoulos Michael Doulberis Marios Giakoumis Evangelia Petridou Christos Mavrogiannis Theodore Rokkas Jannis Kountouras | 2022 | World Journal of Gastrointestinal Oncology2022，14，5： | 6 |
| 2 | Role of autophagy in gastric carcinogenesis显示文摘Gastric cancer represents a common and highly fatal malignancy,and thus a pathophysiology-based reconsideration is necessary,given the absence of efficient therapeutic regimens.In this regard,emerging data reveal a significant role of autophagy in gastric oncogenesis,progression,metastasis and chemoresistance.Although autophagy comprises a normal primordial process,ensuring cellular homeostasis under energy depletion and stress conditions,alterations at any stage of the complex regulatory system could stimulate a tumorigenic and promoting cascade.Among others,Helicobacter pylori infection induces a variety of signaling molecules modifying autophagy,during acute infection or after chronic autophagy degeneration.Subsequently,defective autophagy allows malignant transformation and upon cancer establishment,an overactive autophagy is stimulated.This overexpressed autophagy provides energy supplies and resistance mechanisms to gastric cancer cells against hosts defenses and anticancer treatment.This review interprets the implicated autophagic pathways in normal cells and in gastric cancer to illuminate the potential preventive,therapeutic and prognostic benefits of understanding and intervening autophagy. | Apostolis Papaefthymiou Gregory Christodoulidis Apostolos Koffas Michael Doulberis Stergios A Polyzos Anastasios Manolakis Spyros Potamianos Andreas Kapsoritakis Jannis Kountouras | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 2 |
| 3 | Staged radiosurgical treatment for large benign cerebral lesions显示文摘 | Pendl G Unger F Papaefthymiou G | 2009 | J Neurosurg2009，933，： | 1 |
| 4 | Incidence of radiation retinopathy af ter high-dosage single-fraction gamma knife radiosurgery for choroidal melanoma显示文摘 | Haas A Pinter O Papaefthymiou G | | 0，，： | 1 |
| 5 | Integration of stochastic generation in power systems显示文摘 | G. Papaefthymiou P.H. Schavemaker L. van der Sluis W.L. Kling D. Kurowicka R.M. Cooke | 2006 | International Journal of Electrical Power and Energy Systems2006，，9： | 1 |
| 6 | Using copulas for mo-deling stochastic dependence in power system uncertainty ana- lysis 显示文摘 | PAPAEFTHYMIOU G KUROWICKA D | 2009 | IEEE Trans on Power Systems2009，24，1： | 1 |
| 7 | Fe3O4 precipitation in magnetotactic bacteria显示文摘 | Frankel R B Papaefthymiou G C Blakemore R P | 1983 | Biphys Acta1983，763，： | 1 |
| 8 | Computing strictly-second shortest paths显示文摘 | LALGUDI K N PAPAEFTHYMIOU M C | | 0，，04： | 1 |
| 9 | Computing strictly-second shortest paths显示文摘 | Lalgudi K N Papaefthymiou M C | 1997 | Information processing letters1997，63，4： | 1 |
| 10 | Size-dependent magnetic properties of single-crystalline multiferroic BiFeO3 nanoparticles显示文摘 | Park T J Papaefthymiou G C Viescas A J | 2007 | Nano Lett2007，7，3： | 1 |
| 11 | Charge-recovery computing on silicon显示文摘 | Suhwan Kim Ziesler C H Papaefthymiou M C | 2005 | IEEE Transactions on Computers2005，54，6： | 1 |
| 12 | Sizedependent magnetic properties of single-crystalline multiferroic Bi Fe O3nanoparticles显示文摘 | Tae J Park G C Papaefthymiou A J Viescas | 2007 | Nano Lett2007，7，： | 1 |
| 13 | Naturalradionuclides and 137 Cs distributions and their relationship withsedimentological processes in Patras Harbour, Greece 显示文摘 | Papaefthymiou H Papatheodorou G Moustakli A | 2007 | Journal of Environmental Radioactivity2007，94，2： | 1 |
| 14 | Magnetic,electronic,and structural characterization of onstoichiometric iron oxides at the nanoscale显示文摘 | REDL F X BLACK C T PAPAEFTHYMIOU G C | 2004 | Journal of American Chemical Society2004，126，14： | 1 |
| 15 | A wind-hydro-pumped storage station leading to high RES penetration in the autonomous island system of ikaria显示文摘 | Papaefthymiou S V Karamanou E G Papathanassiou S A | 2010 | IEEE Transactions on Sustainable Energy2010，1，3： | 1 |
| 16 | Using Copulas for modeling stochastic dependence in power system uncertainty analysis 显示文摘 | Papaefthymiou G Kurowicka D | 2009 | IEEE Transactions on Power Systems2009，24，： | 1 |
| 17 | Microstructure and tensile properties in dual phase and TRIP steels显示文摘 | Bleck W Papaefthymiou S Frehn A | | 0，，10： | 1 |
| 18 | MCMC for wind power simulation显示文摘 | Papaefthymiou G Kl(o)ckl B | 2008 | IEEE Transactions Energy Conversion2008，23，1： | 1 |
| 19 | X-ray Mossbauer studies of Sm-Fe-Nb(Zr) (2: 17: 2)alloys and their nitrides显示文摘 | Moukarika A Papaefthymiou V Bakas T | 1996 | J Magn Magn Mater1996，163，： | 1 |
| 20 | MCMC for wind power simulation显示文摘 | George Papaefthymiou Bernd Klockl | 2008 | IEEE Trans on Energy Conversion2008，23，1： | 1 |
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