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| 1 | Type 2 diabetes is associated with a worse functional outcome of ischemic stroke显示文摘AIM: To assess whether ischemic stroke severity and outcome is more adverse in patients with type 2 diabetes mellitus(T2DM). METHODS: Consecutive patients hospitalized for acute ischemic stroke between September 2010 and June 2013 were studied prospectively(n = 482; 40.2% males, age 78.8 ± 6.7 years). T2 DM was defined as self-reported T2 DM or antidiabetic treatment. Stroke severity was evaluated with the National Institutes of Health Stroke Scale(NIHSS) score at admission. The outcome was assessed with the modified Rankin scale(m RS) score at discharge and with in-hospital mortality. Adverse outcome was defined as m RS score at discharge ≥ 2 or in-hospital death. The length of hospitalization was also recorded.RESULTS: T2 DM was present in 32.2% of the study population. Patients with T2 DM had a larger waist circumference, higher serum triglyceride and glucose levels and lower serum high-density lipoprotein cholesterol levels as well as higher prevalence of hypertension, coronary heart disease and congestive heart failure than patients without T2 DM. On the other hand, diabetic patients had lower low-density lipoprotein cholesterol levels and reported smaller consumption of alcohol than non-diabetic patients. At admission, the NIHSS score did not differ between patients with and without T2DM(8.7 ± 8.8 and 8.6 ± 9.2, respectively; P = NS). At discharge, the m RS score also did not differ between the two groups(2.7 ± 2.1 and 2.7 ± 2.2 in patients with and without T2 DM, respectively; P = NS). Rates of adverse outcome were also similar in patients with and without T2DM(62.3% and 58.5%, respectively; P = NS). However, when we adjusted for the differences between patients with T2 DM and those without T2 DM in cardiovascular risk factors, T2 DM was independently associated with adverse outcome [relative risk(RR) = 2.39; 95%CI: 1.21-4.72, P = 0.012]. Inhospital mortality rates did not differ between patients with T2 DM and those without T2DM(9.0% and 9.8%, respectively; P = NS). In multivariate analysis adjusting for the difference in cardiovascular risk factors between the two groups, T2 DM was again not associated with in-hospital death. CONCLUSION: T2 DM does not appear to affect ischemic stroke severity but is independently associated with a worse functional outcome at discharge. | Konstantinos Tziomalos Marianna Spanou Stella D Bouziana Maria Papadopoulou Vasilios Giampatzis Stavroula Kostaki Vasiliki Dourliou Maria Tsopozidi Christos Savopoulos Apostolos I Hatzitolios | 2014 | World Journal of Diabetes2014，5，6： | 15 |
| 2 | Common stemness regulators of embryonic and cancer stem cells显示文摘Pluripotency of embryonic stem cells(ESCs) and induced pluripotent stem cells is regulated by a well characterized gene transcription circuitry. The circuitry is assembled by ESC specific transcription factors, signal trans-ducing molecules and epigenetic regulators. Growing understanding of stem-like cells, albeit of more complex phenotypes, present in tumors(cancer stem cells), provides a common conceptual and research frame-work for basic and applied stem cell biology. In this review, we highlight current results on biomarkers, gene signatures, signaling pathways and epigenetic regulators that are common in embryonic and cancer stem cells. We discuss their role in determining the cell phenotype and finally, their potential use to design next generation biological and pharmaceutical approaches for regenerative medicine and cancer therapies. | Christiana Hadjimichael Konstantina Chanoumidou Natalia Papadopoulou Panagiota Arampatzi Joseph Papamatheakis Androniki Kretsovali | 2015 | World Journal of Stem Cells2015，7，9： | 4 |
| 3 | A prospective cross-over study using a sphincterotome and a guidewire to increase the success rate of common bile duct cannulation显示文摘AIM: During endoscopic retrograde cholangiopancreatography (ERCP), selective cannulation of the common bile duct (CBD) is required in most of the cases.METHODS: From June 2001 till December 2002, all patients referred to our unit for ERCP were considered for entry into the study. Selective CBD cannulation was first attempted with a standard catheter with or without the use of a guidewire. In cases, where CBD cannulation was considered unsuccessful, patients were crossed over to a double-lumen sphincterotome and a guidewire. All patients were hospitalized for 24 h after the procedure in order to assess the incidence of post-ERCP complications.RESULTS: The study sample consisted of 158 patients.Selective CBD cannulation using a standard ERCP catheter with or without the assistance of a guidewire, was accomplished in 129 patients (success rate: 81.65%).From the 29 patients who were crossed over to a sphincterotome and a guidewire, selective CBD cannulation was achieved in 24; the overall success rate rising to 96.8%. Meanwhile, the use of this technique did not increase the incidence of post-ERCP complications.CONCLUSION: The use of a sphincterotome and a guidewire increases the success rate of selective bile duct cannulation in cases that this has not been accomplished with a standard catheter. | Georgios Karamanolis Aikaterini Katsikani Nikos Viazis Gerasimos Stefanidis Spilios Manolakopoulos Spiros Sgouros Efthimia Papadopoulou Apostolos Mantides | 2005 | World Journal of Gastroenterology2005，11，11： | 3 |
| 4 | Erectile dysfunction in chronic kidney disease:From pathophysiology to management显示文摘Chronic kidney disease(CKD) is encountered in millions of people worldwide,with continuously rising incidence during the past decades,affecting their quality of life despite the increase of life expectancy in these patients.Disturbance of sexual function is common among men with CKD,as both conditions share common pathophysiological causes,such as vascular or hormonal abnormalities and are both affected by similar coexisting comorbid conditions such as cardiovascular disease,hypertension and diabetes mellitus.The estimated prevalence of erectile dysfunction reaches 70% in end stage renal disease patients.Nevertheless,sexual dysfunction remains under-recognized and under-treated in a high proportion of these patients,a fact which should raise awareness among clinicians.A multifactorial approach in management and treatment is undoubtedly required in order to improve patients' quality of life and cardiovascular outcomes. | Eirini Papadopoulou Anna Varouktsi Antonios Lazaridis Chrysoula Boutari Michael Doumas | 2015 | World Journal of Nephrology2015，4，3： | 2 |
| 5 | A Practical Guide for the Diagnosis of Primary Enteric Nervous System Disorders显示文摘 | M.G. Sch?ppi A. Staiano P.J. Milla V.V. Smith J.A. Dias R. Heuschkel S. Husby M.L. Mearin A. Papadopoulou F.M. Ruemmele Yvan Vandenplas S. Koletzko | 2013 | Journal of Pediatric Gastroenterology and Nutrition2013，，5： | 2 |
| 6 | 在不含酒精的脂肪肝疾病和尖锐 ischemic 击严厉和结果之间的协会显示文摘 AIM:To evaluate the association of nonalcoholic fatty liver disease(NAFLD)with acute ischemic stroke severity and in-hospital outcome.METHODS:We prospectively studied all patients who were admitted in our Department with acute ischemic stroke between September 2010 and August 2012(n=415;39.5%males,mean age 78.8±6.6 years).The severity of stroke was assessed with the National Institutes of Health Stroke Scale(NIHSS)score at admission.NALFD was defined as serum alanine aminotransferase and/or aspartate aminotransferase levels above the upper limit of normal in the absence of other causes of elevated aminotransferases levels[chronic hepatitis B or C,drug toxicity,increased alcohol consumption(>21 and>14 drinks per week in men and women,respectively),cholestatic diseases or rhabdomyolysis].The outcome was assessed with the modified Rankin scale(mRS)score at discharge and in-hospital mortality.Adverse outcome was defined as mRS score at discharge≥2.Dependency at discharge was defined as mRS score between 2 to 5.RESULTS:NAFLD was present in 7.7%of the study population.Patients with NAFLD had lower serum high-density lipoprotein cholesterol and higher triglyceride levels than patients without NAFLD(P<0.05 for both comparisons).Demographic data,the prevalence of other cardiovascular risk factors and the prevalence of established CVD did not differ between the two groups.At admission,the NIHSS score did not differ between patients with and without NAFLD(6.3±6.4and 8.8±9.6,respectively;P=NS).At discharge,the mRS score did not differ between the two groups(1.9±2.2 and 2.6±2.2 in patients with and without NAFLD,respectively;P=NS).Rates of dependency at discharge were also similar in patients with and without NAFLD(36.8%and 55.0%,respectively;P=NS)as were the rates of adverse outcome(42.9%and58.6%,respectively;P=NS).In-hospital mortality rates also did not differ between the 2 groups(8.0%and 7.0%in patients with and without NAFLD,respectively;P=NS).CONCLUSION:The presence of NAFLD in patients admitted for acute ischemic stroke does not appear to be associated with more severe stroke or with worse in-hospital outcome. | Konstantinos Tziomalos Vasilios Giampatzis Stella D Bouziana Marianna Spanou Maria Papadopoulou Athinodoros Pavlidis Stavroula Kostaki Andreas Bozikas Christos Savopoulos Apostolos I Hatzitolios | 2013 | World Journal of Hepatology2013，5，11： | 2 |
| 7 | Is ceftriaxone-induced biliary pseudolithiasis influenced by UDP-glucuronosyltransferase1A1gene polymorphisms显示文摘 | Fretzayas A Liapi O Papadopoulou A Nicolaidou P Stamoulakatou A | 2011 | Case Report Med2011，2011，73： | 1 |
| 8 | Increased prevalence of chronic autoimmune (Hashimoto's)thyroiditis in children and adolescents with vitiligo显示文摘 | Kakourou T Kanaka-Gantenbein C Papadopoulou A | 2005 | J Am Acad Dermatol2005，53，2： | 1 |
| 9 | Emulsifying properties of high pressure treated soy protein isolate and 7S and lIS globulins显示文摘 | Molina E Papadopoulou A Ledward DA | 2001 | Food Hydrocolloids2001，，15： | 1 |
| 10 | Monomeric and oligomeric flavanols are agonists of membrane androgen receptors显示文摘 | Nifli AP Bosson-Kouamé A Papadopoulou N | | 0，，02： | 1 |
| 11 | Genetic polymor- phism and taxonomic infrastructure of the Pleurotus eryngii species-complex as determined by RAPD analysis, isozyme profiles and ecomorphological characters 显示文摘 | Zervakis G I Venturella G Papadopoulou K | 2001 | Microbiology2001，147，： | 1 |
| 12 | A 6-month follow-up of intermittent levosimendan administration effect on systolic function, specific activity questionnaire, and arrhythmia in advanced heart failure显示文摘 | Mavrogeni S Giamouzis G Papadopoulou E | 2007 | J Card Fail2007，13，7： | 1 |
| 13 | The use of dye sur- rogates to illustrate local anesthetic drug sequestration by lipid emulsion: a visual demonstration of the lipid sink effect 显示文摘 | Papadopoulou A Willers JW Samuels TL | 2012 | Reg Anesth Pain Med2012，37，2： | 1 |
| 14 | A systematic review of supportive care needs of people living with lung cancer 显示文摘 | Maguire R Papadopoulou C Kotronoulas G | 2013 | Eur J Oncol Nurs2013，17，4： | 1 |
| 15 | Application of respiration and FDA hydrolysis measurements for estimating microbial activity during composting processes显示文摘 | Ntougias S Ehaliotis C Papadopoulou K K | 2006 | Biol Fertil Soils2006，42，4： | 1 |
| 16 | Emulsifying properties of high pressure treated soy protein isolate and 7S and l1S globulins显示文摘 | Molina E Papadopoulou A Ledward D A | 2001 | Food Hydrocolloid2001，15，3： | 1 |
| 17 | Structural and functional impairment of mitochondria in adriamycin-induced cardiomyopathy in mice:suppression of cytochrome c oxidase II gene expression显示文摘 | PAPADOPOULOU L C THEOPHILIDIS G THOMOPOULOS G N | 1999 | Biochem Pharmacol1999，57，： | 1 |
| 18 | Comparative study of precipitation effects during aging in superaustenitic and superferritic stainless steels 显示文摘 | Koutsoukis T Konstantinidis K Papadopoulou E G | 2011 | Materials Science & Technology2011，27，5： | 1 |
| 19 | Persistence of encephalomyocarditis virus (EMCV) infection in piglets 显示文摘 | BILLINIS C PASCHALERI - PAPADOPOULOU E PSYCHAS V | 1999 | Vet Microbiol1999，70，： | 1 |
| 20 | Comparison of Com- patibilizer Effectiveness for PET/PP Blends: Their Me- chanical, Thermal and Morphology Characterization显示文摘 | Papadopoulou C P Kalfoglou N K | 2000 | Polymer2000，41，： | 1 |
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