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| 1 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 2 | Exosomes-the enigmatic regulators of bone homeostasis显示文摘Exosomes are a heterogeneous group of cell-derived membranous structures, which mediate crosstalk interaction between cells.Recent studies have revealed a close relationship between exosomes and bone homeostasis. It is suggested that bone cells can spontaneously secret exosomes containing proteins, lipids and nucleic acids, which then to regulate osteoclastogenesis and osteogenesis. However, the network of regulatory activities of exosomes in bone homeostasis as well as their therapeutic potential in bone injury remain largely unknown. This review will detail and discuss the characteristics of exosomes, the regulatory activities of exosomes in bone homeostasis as well as the clinical potential of exosomes in bone injury. | Minhao Gao Weiyang Gao J. M. Papadimitriou Changqing Zhang Junjie Gao Minghao Zheng | 2018 | Bone Research2018，6，4： | 13 |
| 3 | 断层相互作用对中国川滇地区地震危险评估的意义显示文摘研究了1904年以来发生在中国四川、云南地区的强烈地震所伴生的库仑应力变化.研究区涉及了中国大陆最活动的地震带.由于欧亚板块与印度板块沿喜马拉雅会聚带的碰撞,菱形区域的构造运动受到西藏高原向东扩展的影响,在东—西方向上受到主要板内走滑断裂运动的调节.在研究区,断层顺时针逐步旋转,转动角达90°,造成了应力场的复杂性.计算了由强地震(MS≥6.5)的同震滑动和连续构造加载在主要断裂上产生的库仑破裂函数变化(ΔCFF).在应力评估模型的每一步,对是否能触发下一次地震的可能性都进行了判断.最后,模型给出了下一次地震中断层易于破裂的证据,对未来危险性进行了评估. | Ch. Gkarlaouni E. E. Papadimitriou V. G. Karakostas 闻学泽 金学申 A.Kilias 潘华 | 2008 | 地震学报2008，30，2： | 9 |
| 4 | Utilization of steel slag for Portland cement clinker production显示文摘 | P.E. Tsakiridis G.D. Papadimitriou S. Tsivilis C. Koroneos | 2007 | Journal of Hazardous Materials2007，，2： | 4 |
| 5 | Utilization of steel slag for Portland cement clinker production显示文摘 | P.E. Tsakiridis G.D. Papadimitriou S. Tsivilis C. Koroneos | 2007 | Journal of Hazardous Materials2007，，2： | 4 |
| 6 | Berth allocation in a container port: using a continuous location space approach显示文摘 | Akio Imai Xin Sun Etsuko Nishimura Stratos Papadimitriou | 2004 | Transportation Research Part B2004，，3： | 3 |
| 7 | The new global map of human brucellosis显示文摘 | Georgios Pappas Photini Papadimitriou Nikolaos Akritidis Leonidas Christou Epameinondas V Tsianos | 2006 | The Lancet Infectious Diseases2006，，2： | 3 |
| 8 | Review and assessment of different perspectives of vehicle-pedestrian conflicts and crashes:Passive and active analysis approaches显示文摘The importance of investigating pedestrian safety has been evaluated repeatedly in safety studies.The present study attempts to evaluate the various methods used by previous researchers in a hierarchical process,to determine the characteristics,advantages,and limitations of each method.Two general analysis approaches(passive and active) were taken into account to categorize 169 previous types of research.In the passive approach,the studied methods were those based on crash databases,questionnaires,and post-crash field observation data;while,in the active approach,the studied methods were those based on driving simulations and videography.The result of the passive approach reveals that road users’ features and road characteristics(crash database studies),and error,lapses,intentional and unintentional violations(questionnaire studies) by them were among the most important causes of crashes and conflicts.Furthermore,road users’ distractions also reported a set of factors affecting the possibility of conflicts and crashes based on postcrash field observation studies.Also,results of the active approach showed that risky behaviors are the most important factor in threatening pedestrian safety such as unauthorized speeding,non-compliance with traffic law,unauthorized overtaking by drivers,and illegal crossing.Furthermore,risk perception and decision-making processes are the mostimportant bond between the attitude and behavior of road users in dangerous driving situations.Examining studies through passive approach would lead to identifying the causes of crashes,recognizing the attitude of road users towards safety,and determining road users’ behavioral patterns in certain situations,while the active approach has led to a more detailed understanding of behaviors and attitudes of road users.The inference of the findings obtained in this study will lead to a better understanding of the behavior of road users for studies on advanced driving assistance systems(ADAS). | Abbas Sheykhfard Farshidreza Haghighi Eleonora Papadimitriou Pieter Van Gelder | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，5： | 2 |
| 9 | Association between population vitamin D status and SARS-CoV-2 related serious-critical illness and deaths:An ecological integrative approach显示文摘BACKGROUND Vitamin D population status may have possible unappreciated consequences to the coronavirus disease 2019(COVID-19)pandemic.Αsignificant association between vitamin D sufficiency and reduction in clinical severity and inpatient mortality from COVID-19 disease has recently been shown,while a recent study has claimed lower COVID-19 cases in European countries with a better vitamin D status.Low serum 25-hydroxyvitamin-D[25(OH)D]was identified as an independent risk factor for COVID-19 infection and hospitalization,and administration of 0.532 mg(21280 IU)of calcifediol or 25(OH)D,followed by 0.266 mg on days 3 and 7 and then weekly until discharge or intensive care unit admission significantly reduced the need for intensive care unit treatment.AIM To elucidate the role of vitamin D European population status in the COVID-19 pandemic,data from the Worldometer were analyzed.METHODS Linear regression explored the correlation between published representativestandardized population vitamin D concentrations and the number of total cases/million(M),recovered/M,deaths/M and serious-critically ill/M from COVID-19 for 26 European countries populated>4 M(Worldometer).Life expectancy was analyzed with semi-parametric regression.Weighted analysis of variance/analysis of covariance evaluated serious-critical/M and deaths/M by the vitamin D population status:Deficient<50,insufficient:50-62.5,mildly insufficient>62.5-75 and sufficient>75 nmol/L,while controlling for life expectancy for deaths/M.Statistical analyses were performed in XLSTAT LIFE SCIENCE and R(SemiPar Library).RESULTS Linear regression found no correlation between population vitamin D concentrations and the total cases-recovered/M,but negative correlations predicting a reduction of 47%-64%-80%in serious-critical illnesses/M and of 61%-82%-102.4%in deaths/M further enhanced when adapting for life expectancy by 133-177-221%if 25(OH)D concentrations reach 100-125-150 nmol/L,sustained on August 15,2020,indicating a truthful association.Weighted analysis of variance was performed to evaluate serious-critical/M(r2=0.22)by the vitamin D population status and analysis of covariance the deaths/M(r2=0.629)controlling for life expectancy(r2=0.47).Serious-critical showed a decreasing trend(P<0.001)from population status deficient(P<0.001)to insufficient by 9.2%(P<0.001),to mildly insufficient by 47.6%(P<0.044)and to sufficient by 100%(reference,P<0.001).For deaths/M the respective decreasing trend(P<0.001)was 62.9%from deficient(P<0.001)to insufficient(P<0.001),65.15%to mildly insufficient(P<0.001)and 78.8%to sufficient(P=0.041).CONCLUSION Achieving serum 25(OH)D 100-150 nmol/L(40-60 ng/mL)(upper tolerable daily doses followed by maintenance proposed doses not requiring medical supervision,Endocrine Society)may protect from serious-critical illness/death from COVID-19 disease. | Dimitrios T Papadimitriou Alexandros K Vassaras Michael F Holick | 2021 | World Journal of Virology2021，10，3： | 2 |
| 10 | Negativation of type 1 diabetes‐associated autoantibodies to glutamic acid decarboxylase and insulin in children treated with oral calcitriol (口服骨化三醇治疗维持儿童1型糖尿病相关的谷氨酸脱羧酶与胰岛素自身抗体阴性)显示文摘 | Dimitrios T. Papadimitriou Chrisanthi Marakaki Andreas Fretzayas Polyxeni Nicolaidou Anastasios Papadimitriou | 2013 | Journal of Diabetes2013，，3： | 2 |
| 11 | Correlation of proliferation indices, apoptosis, and related oncogene expression (bcl 2 and c erbB 2) and p53 in proliferative, hyperplastic, and malignant endometrium 显示文摘 | Ioffe OB Papadimitriou JC Drachenberg CB | 1998 | Hum Pathol1998，29，10： | 1 |
| 12 | New approximations for reliability integrals显示文摘 | Polidori D C Beck J L Papadimitriou C | 1999 | Internat J Engng Mech ASCE1999，125，4： | 1 |
| 13 | Somatic stem cell research for neural repair:Current evidence and emerging perspectives显示文摘 | Corti S Locatelli F Papadimitriou D | 2004 | J Cell Mol Med2004，8，3： | 1 |
| 14 | Inhibition of intracerebral glioblastoma growth by local treatment with the scatter factor / hepatocyte growth factorantagonist NK4 显示文摘 | Brockmann MA Papadimitriou A Brandt M | 2003 | Clin Cancer Res2003，9，12： | 1 |
| 15 | Berth allocationwith service priority显示文摘 | Imai A Nishirnura E Papadimitriou S | 2003 | Transportation Research Part B2003，37，： | 1 |
| 16 | Exposure of the Frog Rana ridibunda to Copper: Impact on Two Biomarkers, Lipid Peroxidation, and Glutathione显示文摘 | E. Papadimitriou N. S. Loumbourdis | 2002 | Bulletin of Environmental Contamination and Toxicology2002，，6： | 1 |
| 17 | Platelet- rich plasma versus autologous whole blood for the treatment of ehroniclateral elbow epieondylitis: a randomized controlled clinical trial显示文摘 | Thanasas C Papadimitriou G Charalambidis C | 2011 | Am J Sports Med2011，39，10： | 1 |
| 18 | On the complexity of edge traversing 显示文摘 | Papadimitriou H | 1976 | Journal of the Association for Computing Machinery1976，23，： | 1 |
| 19 | Component mode synthesis techniques for finite element model updating显示文摘 | PAPADIMITRIOU C PAPADIOTI D C | 2013 | Computers & Structures2013，126，1： | 1 |
| 20 | Phase Ⅱ trial of paclitaxel and cisplatin in metastatic and recurrent carcinoma of the uterine cervix显示文摘 | Christos A Papadimitriou Kyrillos S | 1999 | J Clin Oncol1999，17，3： | 1 |
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