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| 1 | 高比转速轴流泵正交优化设计研究显示文摘为了研究叶轮与导叶匹配对高比转速轴流泵水力性能的影响,以一台比转速为1 500 r/min的轴流泵为研究对象,选取了叶轮与导叶的7个几何参数进行正交试验优化设计。为拓宽其高效运行范围,本次优化以三个工况点(0. 8Qd、1. 0Qd、1. 2Qd)的加权平均效率为优化目标,采用L_(18)(3~7)正交表设计了18组方案。在ANSYS CFX 14. 5中采用SST k-ω湍流模型对各方案进行定常计算。通过极差分析得到了各参数对目标影响的主次顺序并获得了最优参数组合。结果表明:优化后轴流泵加权平均效率提高了4. 68%,大流量下效率提高十分明显,而设计扬程基本不变;叶轮与导叶的动静匹配对轴流泵水力性能有重要影响。 | 袁建平 范猛 Giovanni Pace 陆荣 李彦军 付燕霞 | 2018 | 振动与冲击2018，37，22： | 6 |
| 2 | Colorectal cancer and 18FDG-PET/CT:What about adding the T to the N parameter in loco-regional staging?显示文摘AIM:To evaluate whether FDG-positron emission tomography(PET)/computed tomography(CT)may be an accurate technique in the assessment of the T stage in patients with colorectal cancer.METHODS:Thirty four consecutive patients(20 men and 14 women;mean age:63 years)with a histologically proven diagnosis of colorectal adenocarcinoma and scheduled for surgery in our hospital were enrolled in this study.All patients underwent FDG-PET/CT preoperatively.The primary tumor site and extent were evaluated on PET/CT images.Colorectal wall invasion was analysed according to a modified T classification that considers only three stages(≤T2,T3,T4).Assessment of accuracy was carried out using 95%confidence intervals for T.RESULTS:Thirty five/37(94.6%)adenocarcinomas were identified and correctly located on PET/CT images.PET/CT correctly staged the T of 33/35 lesions identified showing an accuracy of 94.3%(95%CI:87%-100%).All T1,T3 and T4 lesions were correctly staged,while two T2 neoplasms were overstated as T3.CONCLUSION:Our data suggest that FDG-PET/CT may be an accurate modality for identifying primary tumor and defining its local extent in patients with colorectal cancer. | Pier Paolo Mainenti Delfina Iodice Sabrina Segreto Giovanni Storto Mario Magliulo Giovanni Domenico De Palma Marco Salvatore Leonardo Pace | 2011 | World Journal of Gastroenterology2011，17，11： | 5 |
| 3 | Is flexible bronchoscopy necessary to confirm the position of double-lumen tubes before thoracic surgery? ☆显示文摘 | Mario de Bellis Rosanna Accardo Massimo Di Maio Carmine Lamanna Giovanni Battista Rossi Maria Caterina Pace Vincenzo Romano Gaetano Rocco | 2011 | European Journal of Cardio-Thoracic Surgery2011，，4： | 1 |
| 4 | Outcomes assessment of hepatitis C virus-positive psoriatic patients treated using pegylated interferon in combination with ribavirin compared to new Direct-Acting Antiviral agents显示文摘AIM To evaluate the outcomes in biological treatment and quality of life of psoriatic patients with chronic hepatitis C(CHC) treated with new Direct-Acting Antiviral agents(DAAs) compared to pegylated interferon-2α plus ribavirin(P/R) therapy.METHODS This is a retrospective study involving psoriatic patients in biological therapy who underwent anti-hepatitis C virus(HCV) treatment at the Department of Dermatology Galeazzi Orthopaedic Institute Milan, Italy from January 2010 to November 2017. The patients were divided into two groups: patients that underwent therapy with DAAs and patients that underwent HCV treatment with P/R. Patients were assessed by a dermatologist for psoriasis symptoms, collecting Psoriasis Area Severity Index(PASI) scores and the Dermatology Quality of Life Index(DLQI). PASI and DLQI scores were evaluated 24 wk after the end of HCV treatment and were assumed as an outcome of the progression of psoriasis. Switching to a different b DMARD was considered as an inadequate response to biological therapy. The dropout of HCV therapy and sustained virological response(SVR) were considered as outcomes of HCV therapy.RESULTS Fifty-nine psoriatic patients in biological therapy underwent antiviral therapy for CHC. Of this, 27 patients were treated with DAAs and 32 with P/R. After 24 wk post treatment, the DLQI and the PASI scores were significantly lower(P < 0.001 and P < 0.005, respectively) in the DAAs group compared with P/R group. None of the patients in the DAAs group(0/27) compared to 8 patients of the P/R group(8/32) needed a shift in biological treatment.CONCLUSION DAAs seem to be more effective and safe than P/R in HCV-positive psoriatic patients on biological treatment. Fewer dermatological adverse events may be due to interferon-free therapy. | Giovanni Damiani Chiara Franchi Paolo Pigatto Andrea Altomare Alessia Pacifico Stephen Petrou Sebastiano Leone Maria Caterina Pace Marco Fiore | 2018 | World Journal of Hepatology2018，10，2： | 1 |
| 5 | Accuracy of single phase contrast enhanced multidetector CT colonography in the preoperative staging of colo-rectal cancer显示文摘 | Pier Paolo Mainenti Luigi Carlo Cirillo Luigi Camera Francesco Persico Teresa Cantalupo Leonardo Pace Giovanni Domenico De Palma Giovanni Persico Marco Salvatore | 2006 | European Journal of Radiology2006，，3： | 1 |
| 6 | Medicinal cannabis products for the treatment of acute pain显示文摘For thousands of years,medicinal cannabis has been used for pain treatment,but its use for pain management is still controversial.Meta-analysis of the literature has shown contrasting results on the addition of cannabinoids to opioids compared with placebo/other active agents to reduce pain.Clinical studies are mainly focused on medicinal cannabis use in chronic pain management,for which the analgesic effect has been proven in many studies.This review focuses on the potential use of medical cannabis for acute pain management in preclinical studies,studies on healthy subjects and the few pioneering studies in the clinical setting. | Marco Fiore Aniello Alfieri Sveva Di Franco Stephen Petrou Giovanni Damiani Maria Caterina Pace | 2023 | World Journal of Clinical Cases2023，11，12： | 0 |
| 7 | Early post-operative MRI: correlation with progression-free survival and overall survival time in malignant gliomas显示文摘 | Vidiri A Carapella CM Pace A Mirri A Fabis A Carosi M Giannarelli D Pompili A Jandolo B Occhipinti E Di Giovanni S Crecco M | 2006 | 中国神经肿瘤杂志2006，4，3： | 0 |
| 8 | Current status of COVID-19 treatment:An opinion review显示文摘The pandemic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection has garnered the attention of scientists worldwide in the search for an effective treatment while also focusing on vaccine development.Several drugs have been used for the management of coronavirus disease 2019(COVID-19),which has affected many hospitals and health centers worldwide.Statistically significant results are lacking on the effectiveness of the experimented drugs in reducing COVID-19 morbidity or mortality,as there are very few published randomized clinical trials.Despite this,the literature offers some material for study and reflection.This opinion review attempts to address three burning questions on COVID-19 treatment options.(1)What kind of studies are currently published or ongoing in the treatment of patients with COVID-19?(2)What drugs are currently described in the literature as options of treatment for patients affected by the infection?And(3)Are there specific clinical manifestations related to COVID-19 that can be treated with a customized and targeted therapy?By answering these questions,we wish to create a summary of current COVID-19 treatments and the anti-COVID-19 treatments proposed in the recent clinical trials developed in the last 3 mo,and to describe examples of clinical manifestations of the SARS-CoV-2 infection with a cause-related treatment. | Sveva Di Franco Aniello Alfieri Stephen Petrou Giovanni Damiani Maria Beatrice Passavanti Maria Caterina Pace Sebastiano Leone Marco Fiore | 2020 | World Journal of Virology2020，9，3： | 0 |
| 9 | Review and update on the management of triangular fibrocartilage complex injuries in professional athletes显示文摘Triangular fibrocartilage complex injuries are common in amateur and professional sports.These injuries are mainly caused by acute or chronic repetitive axial loads on the wrist,particularly on the ulnar side and in association with rotations or radial/ulnar deviations.In order to treat professional athletes,a detailed specific knowledge of the pathology is needed.Moreover,the clinician should fully understand the specific and unique environment and needs of the athletes,their priorities and goals,the type of sport,the time of the season,and the position played.An early diagnosis and appropriate management with the quickest possible recovery time are the uppermost goals for both the athlete and the surgeon.A compromise between conservative vs surgical indications,athletes’needs and expectations,and financial implications should be achieved.Arthroscopic procedures should be timely planned when indicated as they could allow early diagnosis and treatment at the same time.Conservative measures are often used as first line treatment when possible.Peripheral lesions are treated by arthroscopic repair,whilst central lesions are treated by arthroscopic debridement.Further procedures(such as the Wafer procedure,ulnar osteotomies,etc.)have specific indications and great implications with regard to rehabilitation. | Valerio Pace Francesco Bronzini Giovanni Novello Giuseppe Mosillo Luca Braghiroli | 2024 | World Journal of Orthopedics2024，15，2： | 0 |
| 10 | Influence of specific speed on hydraulic performances and pressure fluctuations in mixed-flow pumps显示文摘A series of steady and unsteady numerical calculations of the internal flow in mixed-flow pumps with three different specific speeds were carried out based on the N-S equation coupled with the standard k-εturbulence model under different operating conditions to investigate the relationship between the impeller specific speed and the pump performance as well as pressure pulsations.Meanwhile,the pump performance and pressure pulsations inside the mixed-flow pump with three different specific speeds were also analyzed and compared with the corresponding test data.From the results,the averaged deviations between the predicted and tested head among different impellers are below 5%,and with respect to the equivalent impeller specific speeds of 280 and 260,the values are 4.30%and 3.69%,respectively.For all the impeller schemes,the best efficiency point of the mixed-flow pump is found at the flow rate of 1.2 Q_(d) and the higher head deviation occurs at lower flow rates.Especially,it can be found that the specific speed has a slight effect on the pressure fluctuation in the impellers.Eventually,it is determined that the pump performance curves calculated by numerical simu-lations have good agreement with the relevant experimental results,which verifies that the numerical methods used in the present study are accurate to a certain extent.Furthermore,the results also provide some references to the pressure pulsation analysis and the performance improvement of the mixed-flow pump design. | FU Yanxia JIA Qi SHEN Yang PACE Giovanni | 2023 | 排灌机械工程学报2023，41，10： | 0 |
| 11 | Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver(NAFL) and non-alcoholic steatohepatitis(NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease(ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern.Hidradenitis suppurativa(HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed.AIM To evaluate the prevalence and characteristics of NASH/NAFL in HS patients.METHODS This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH.RESULTS Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients(P < 0.001). Similarly, mean Autoinflammatory Disease Damage Index(ADDI) was significantly higher among patients with HS/NASH(5.3 ± 2.2, P < 0.001) compared to patients with HS/NAFL or HS only(2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups.CONCLUSION HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores. | Giovanni Damiani Sebastiano Leone Kristen Fajgenbaum Nicola L Bragazzi Alessia Pacifico Rosalynn RZ Conic Paolo DM Pigatto Carlo Maiorana Pierpaolo Poli Emilio Berti Maria C Pace Piergiorgio Malagoli Vincenzo Bettoli Marco Fiore | 2019 | World Journal of Hepatology2019，11，4： | 0 |
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