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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae-independent endocytic pathway显示文摘当严重急性呼吸症候群日冕病毒(SARS-CoV ) 开始被认为与质膜通过直接熔化进入房间时,更最近的证据建议那个病毒条目可以也包含 endocytosis。我们发现了那 SARS-CoV 进入房间经由 pH 依赖并且受体依赖者 endocytosis。有任何一个 SARS-CoV 尖铁蛋白质或忍受尖铁的假病毒的房间的治疗导致了变换血管收缩素的酶的 translocation 2 (ACE2 ) , SARS-CoV 的功能的受体,从房间表面到内涵体。另外,忍受尖铁的假病毒和 1 在内涵体被发现到 colocalize 的早内涵体抗原。用象 caveolin-1 colocalization 学习一样的特定的 endocytic 小径禁止者和主导否定的 Eps15 的进一步的分析建议那个病毒条目被 clathrin 独立、 caveolae 独立的机制调停。而且,在质膜的微域,它被显示出到为许多生理的发信号小径作为平台扮演的充满胆固醇、 sphingolipid 富有的类脂化合物木排,被显示涉及病毒入口。SARS-CoV 的 Endocytic 入口可以扩展这里的 SARS-CoV 感染,和我们的调查结果的细胞的范围贡献 SARS-CoV 致病的理解,为抗病毒的药研究提供新信息。 | Wang,H Yang,P Liu,K Guo,F Zhang,Y Zhang,G Jiang,C | 2008 | Cell Research2008，18，2： | 50 |
| 3 | Fluorescence enhancement effect and the interaction between donor and acceptor显示文摘A new theoretical equation for fluorescence enhancement effect between donor and acceptor has been introduced.By using it we determined the binding constants and numbers of binding sites of five medicines,including chlorogenic acid,forsythiaside norfloxacin,Ciprofloxacin and fluorenone,to γ-globulin. | Yang, P Yang, MM Yang, BS | 1996 | Chinese Journal of Chemistry1996，14，2： | 23 |
| 4 | Upper-gastrointestinal bleeding secondary to peptic ulcer disease:Incidence and outcomes显示文摘AIM:To evaluate the incidence,surgery,mortality,and readmission of upper gastrointestinal bleeding(UGIB)secondary to peptic ulcer disease(PUD).METHODS:Administrative databases identified all hospitalizations for UGIB secondary to PUD in Alberta,Canada from 2004 to 2010(n=7079)using the International Classification of Diseases Codes(ICD-10).A subset of the data was validated using endoscopy reports.Positive predictive value and sensitivity with 95%confidence intervals(CI)were calculated.Incidence of UGIB secondary to PUD was calculated.Logistic regression was used to evaluate surgery,in-hospital mortality,and 30-d readmission to hospital with recurrent UGIB secondary to PUD.Co-variants accounted for in our logistic regression model included:age,sex,area of residence(i.e.,urban vs rural),number of Charlson comorbidities,presence of perforated PUD,undergoing upper endoscopy,year of admission,and interventional radiological attempt at controlling bleeding.A subgroup analysis(n=6356)compared outcomes of patients with gastric ulcers to those with duodenal ulcers.Adjusted estimates are presented as odds ratios(OR)with95%CI.RESULTS:The positive predictive value and sensitivity of ICD-10 coding for UGIB secondary to PUD were85.2%(95%CI:80.2%-90.2%)and 77.1%(95%CI:69.1%-85.2%),respectively.The annual incidence between 2004 and 2010 ranged from 35.4 to 41.2 per100000.Overall risk of surgery,in-hospital mortality,and 30-d readmission to hospital for UGIB secondary to PUD were 4.3%,8.5%,and 4.7%,respectively.Interventional radiology to control bleeding was performed in 0.6%of patients and 76%of these patients avoided surgical intervention.Thirty-day readmission significantly increased from 3.1%in 2004 to 5.2%in 2010(OR=1.07;95%CI:1.01-1.14).Rural residents(OR rural vs urban:2.35;95%CI:1.83-3.01)and older individuals(OR≥65 vs<65:1.57;95%CI:1.21-2.04)were at higher odds of being readmitted to hospital.Patients with duodenal ulcers had higher odds of dying(OR=1.27;95%CI:1.05-1.53),requiring surgery(OR=1.73;95%CI:1.34-2.23),and being readmitted to hospital(OR=1.54;95%CI:1.19-1.99)when compared to gastric ulcers.CONCLUSION:UGIB secondary to PUD,particularly duodenal ulcers,was associated with significant morbidity and mortality.Early readmissions increased over time and occurred more commonly in rural areas. | Samuel Quan Alexandra Frolkis Kaylee Milne Natalie Molodecky Hong Yang Elijah Dixon Chad G Ball Robert P Myers Subrata Ghosh Robert Hilsden Sander Veldhuyzen van Zanten Gilaad G Kaplan | 2014 | World Journal of Gastroenterology2014，20，46： | 21 |
| 5 | Proton accumulation accelerated by heavy chemical nitrogen fertilization and its long-term impact on acidifying rate in a typical arable soil in the Huang-Huai-Hai Plain显示文摘Cropland productivity has been significantly impacted by soil acidification resulted from nitrogen(N) fertilization, especially as a result of excess ammoniacal N input. With decades' intensive agricultural cultivation and heavy chemical N input in the Huang-Huai-Hai Plain, the impact extent of induced proton input on soil p H in the long term was not yet clear. In this study, acidification rates of different soil layers in the soil profile(0–120 cm) were calculated by p H buffer capacity(p HBC) and net input of protons due to chemical N incorporation. Topsoil(0–20 cm) p H changes of a long-term fertilization field(from 1989) were determined to validate the predicted values. The results showed that the acid and alkali buffer capacities varied significantly in the soil profile, averaged 692 and 39.8 mmolc kg–1 p H–1, respectively. A significant(P<0.05) correlation was found between p HBC and the content of calcium carbonate. Based on the commonly used application rate of urea(500 kg N ha–1 yr–1), the induced proton input in this region was predicted to be 16.1 kmol ha–1 yr–1, and nitrification and plant uptake of nitrate were the most important mechanisms for proton producing and consuming, respectively. The acidification rate of topsoil(0–20 cm) was estimated to be 0.01 unit p H yr–1 at the assumed N fertilization level. From 1989 to 2009, topsoil p H(0–20 cm) of the long-term fertilization field decreased from 8.65 to 8.50 for the PK(phosphorus, 150 kg P2O5 ha–1 yr–1; potassium, 300 kg K2 O ha–1 yr–1; without N fertilization), and 8.30 for NPK(nitrogen, 300 kg N ha–1 yr–1; phosphorus, 150 kg P2O5 ha–1 yr–1; potassium, 300 kg K2 O ha–1 yr–1), respectively. Therefore, the apparent soil acidification rate induced by N fertilization equaled to 0.01 unit p H yr–1, which can be a reference to the estimated result, considering the effect of atmospheric N deposition, crop biomass, field management and plant uptake of other nutrients and cations. As protons could be consumed by some field practices, such as stubble return and coupled water and nutrient management, soil p H would maintain relatively stable if proper management practices can be adopted in this region. | HUANG P ing ZHANG Jia-bao XIN Xiu-li ZHU An-ning ZHANG Cong-zhi MA Dong-hao ZHU Qiang-gen YANG Shan WU Sheng-jun | 2015 | Journal of Integrative Agriculture2015，14，1： | 18 |
| 6 | Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes显示文摘 | Yang, JA Luan, XF Gui, HY Yan, P Yang, DF Song, XL Liu, W Hu, G Yah, BF | 2011 | 南京医科大学学报(自然科学版)2011，31，4： | 8 |
| 7 | Zinc-induced aggregation of Abeta (10-21) potentiates its action on voltage-gated potassium channel.显示文摘 | Zhang CF Yang P | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 8 | Effects of radical cholecystectomy on nutritional and immune status in patients with gallbladder carcinoma显示文摘INTRODUCTION Carcinoma of the gallbladder is the most commonneoplasm in biliary tract,and its incidence has beenrising in recent years.The rate of correct diagnosisin early gallbladder carcinoma has been raised afterthe wide use of CT,ultrasound scans and frozensection examination.Now radical cholecystectomyis advocated as the best management for patientswith early gallbladder carcinoma.In the | Jiao XY Shi JS Wang JS Yang YJ He P | 2000 | World Journal of Gastroenterology2000，6，3： | 6 |
| 9 | Expression and release of IL-29 by mast cells and modulation of mast cell behavior by IL-29显示文摘 | He, S Zhang, H Chen, H Yang, H Huang, T Chen, Y Lin, J Wang, F Chen, X Li, TL Yang, P | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 6 |
| 10 | Competition between collective oblate rotation and non-collective prolate K isomerism in neutron-rich tungsten isotopes显示文摘Recent experiments open up the possibility to investigate oblate rotation-aligned states and prolate high-K isomers in neutron-rich tungsten isotopes.In the present work,we perform the projected-shell-model calculations for A ~ 190 tungsten nuclei.The 190 W results are compared with experimental data.The observed 8 + isomer is assigned as a two-quasiproton K π = 8 + configuration.Low-lying high-K four-quasiparticle states are predicted.Of particular interest is the prediction of the K π = 20 + state in 190,192 W,which may form a long-lived spin trap.In competition with the prolate high-K states,rotational alignment leads to near-yrast collective oblate rotation. | JIAO ChangFeng SHI Yue XU FuRong SUN Yang WALKER P M | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，9： | 5 |
| 11 | Responses of Plant Community and Soil Properties to Inter-Annual Precipitation Variability and Grazing Durations in a Desert Steppe in Inner Mongolia显示文摘Grazing can dramatically affect arid grassland communities that are very vulnerable to environmental changes due to its relatively short and sparse ground coverage, low biomass, sandy soil and inter-annual precipitation found in the desert steppe. The study investigates the effects of different grazing durations on vegetation and soil properties of a desert steppe community. The experiment was conducted in Xisu Banner in Inner Mongolia with five treatments: CG(continuous grazing), 40UG(40 d ungrazed), 50UG(50 d ungrazed), 60UG(60 d ungrazed) and UG(ungrazed). The biomass of both shrub and annual-biennial plant communities were significantly decreased by CG. Continuous grazing and 40UG significantly reduced the ANPP(aboveground net primary productivity) by the end of the three year study. 60UG treatment increased soil organic carbon(OC), total nitrogen concentration(TN) and total phosphorus concentration(TP) concentrations and 50UG increased the TN and total phosphorus concentration(TK) concentrations, whereas CG, 40UG and 50UG decreased soil OC, TP and available phosphorus concentration(AP) concentrations. The perennial plant species of the desert steppe were generally tolerant for grazing. The annual-biennial plant species had large variability in ANPP because of the inter-annual precipitation. Our results highlight that inter-annual precipitation variations could strongly modify the community responses to grazing in arid ecosystems. | WANG Zhen YUN Xiang-jun WEI Zhi-jun Michael P Schellenberg WANG Yun-feng YANG Xia HOU Xiang-yang | 2014 | Journal of Integrative Agriculture2014，13，6： | 5 |
| 12 | 中国慢性病的挑战与应对显示文摘中国在短短几十年内,完成了从传染病向慢性病的流行病学模式转变,转变速度远远高于其他许多国家。而行为模式的转变,包括膳食习惯变化、体力活动减少、高水平的男性吸烟率等危险因素是中国疾病模式快速转变的重要原因。其结果是,这些本可避免的慢性病的发病率和死亡率快速上升。引发了医疗卫生服务费用显著上升。目前,中国有1.77亿高血压患者,有3.03亿烟民(占世界烟民的1/3),并有5.3亿人遭受被动吸烟危害。 | Gonghuan Yang Lingzhi Kong Wenhua Zhao Xia Wan Yi Zhai Lincoln C Chen Jeffrey P Koplan | 2008 | 世界临床医学2008，2，6： | 5 |
| 13 | URBAN COMPETITIVE PATTERN AND ITS CHANGES IN CHINA显示文摘With the national economy’s transition from a planning one to a market one, the factors affecting regional economic pattern has changed greatly. In this paper we first construct an index system for evaluating competitiveness of Chinese cities based on modern competitive advantage theory. With principal component analysis and cluster analysis methods, we compare the factors affecling cities’ integrated competitiveness in 1990 and 1997. We find that four major factors are capital (including investment, FDI and urban financial revenue ), urban ithestructure (transporiation and communication, urbanization level, education etc. ), industrial performance and structure, degree of market openness and that these factors have become more advanced and complicated since 1990. Most Chinese cities are transforming from productive factors-oriented type to investment-oriented type and a few are becoming innovation oriented. The integrated competitiveness is closely related to cities’ scale, urban function, regional policy and degree of market openness and displays an uneven spatial pattern. The difference between the south and the north and the difference between the west and the east co-exist bul the former has been more larger. Finally, we discuss the mechanism behind the pattern and attribute the unevenness to change of factors dominating the cities’ compehtiveness regional innovation capacity and geographical differenceof traditional culture. | DOU Wen-zhang LI Guo-ping GAN Ying-jin WANG Li-ming YANG Kai-zhong(Department of Urban and Environmental Sciences, Peking University, Beijing 100871, P R. China) | 2000 | Chinese Geographical Science2000，10，2： | 5 |
| 14 | 连柱框架结构基于性能的塑性设计与评估(英文)显示文摘抗弯钢框架结构(MRF)是目前研究最广泛、最流行的抗震系统,具有建筑灵活度高和施工效率高等优点。然而,这种结构常常缺乏足够的侧向刚度来限制结构的位移角,会导致在强震下结构和非结构构件产生严重的破坏。相反,偏心支撑钢框架结构(EBF)却有很大的侧向刚度来限制结构的位移角和有专属的抗震耗能构件。但是,支撑结构并不为建筑师所广泛接纳。为了结合抗弯钢框架结构和偏心支撑钢框架结构的优点,于2007年首次提出一种新型的抗震系统——连柱框架结构(LCF)。这种双抗震系统有相似于偏心支撑钢框架结构的窄连梁框架作为主要的抗震系统,而抗弯钢框架结构则作为次要的抗震系统。连梁作为结构保险丝可以在中震到大震中消耗地震能量,而且在震后很容易就可以被替代和修复。另一方面,抗弯钢框架结构可以提供附加的侧向抵抗力来防止结构在大震下倒塌。采用2008年提出的基于性能的塑性设计方法(PBPD)对建筑原型位于美国强震地区——加州洛杉矶的连柱框架结构进行设计。最后,使用先进的基于性能的评估步骤对原型结构的抗震性能进行了研究。研究结果表明,连柱框架结构(LCF)是一种具有良好抗震性能的结构。 | YANG T Y TUNG D P 李元杰 | 2015 | 建筑钢结构进展2015，17，1： | 5 |
| 15 | Power management unit chip design for automobile active-matrix organic light-emitting diode display module显示文摘A power management unit (PMU) chip supplying dual panel supply voltage, which has a low electro-magnetic interference (EMI) characteristic and is favorable for miniaturization, is designed. A two-phase charge pump circuit using external pumping capacitor increases its pumping current and works out the charge-loss problem by using bulk-potential biasing circuit. A low-power start-up circuit is also proposed to reduce the power consumption of the band-gap reference voltage generator. And the ring oscillator used in the ELVSS power circuit is designed with logic devices by supplying the logic power supply to reduce the layout area. The PMU chip is designed with MagnaChip’s 0.25 μm high-voltage process. The driving currents of ELVDD and ELVSS are more than 50 mA when a SPICE simulation is done. | KIM J H PARK J H KIM J H CAO T V LEE T Y BAN H J YANG K KIM H G HA P B KIM Y H | 2009 | Journal of Central South University2009，16，4： | 4 |
| 16 | Bonding between fluorescence dyes and proteins显示文摘SOME small dye molecules can bond with proteins, the spectrum of which has a characteristic of energy transferring, i.e. enhancement or quenching of fluorescence. Much information can be obtained from this phenomenon, and can be used to determine the distance between the macrobiomolecules and some groups, such as the distance between aromatic amino acid of proteins and ligands. So they are often called 'a spectroscopic ruler'. We deduced the theoreti- | Yang, MM Yang, P Xi, XL | 1997 | Chinese Science Bulletin1997，42，17： | 4 |
| 17 | p53 isoform △113p53/△133p53 promotes DNA double-strand break repair to protect cell from death and senescence in response to DNA damage显示文摘在 DNA 双海滨的 p53 的禁止的角色裂缝(DSB ) 修理对它的压制肿瘤的性质似乎矛盾。p53 isoform Δ 113p53/Δ 133p53 是反对 p53 apoptotic 的 p53 目标基因活动。然而,它在 DNA 损坏修理的功能的信息正在缺乏。这里,我们报导那 Δ 113p53 表示被 γ 强烈导致; -irradiation, 然而并非由紫外照耀或热电震疗法。惊人地, Δ 113p53 支持 DNA DSB 修理小径包括相应再结合,非相应的结束加入并且单个海滨的退火。学习 Δ 的生物意义;在支持 DNA DSB 修理的 113p53,我们产生了 zebrafish Δ 113p53 经由抄写的 M/M 异种像使活跃之物的受动器核酸酶技术并且发现异种对 γ 更敏感;照耀。人的 ortholog, Δ 133p53,被 γ 仅仅也导致;照耀和功能修理支持 DNA DSB。Δ 133p53-knockdown 房间响应 γ 在以后的阶段在 G2 阶段被逮捕;照耀由于 unrepaired DNA DSB 的高水平,它最后导致了房间老朽。而且, Δ 113p53/Δ 133p53 经由 upregulating 支持 DNA DSB 修理由到在他们的倡导者的 p53 应答的元素的一种新奇类型的绑定的修理基因 rad51, lig4 和 rad52 的抄写。我们的结果表明那 Δ 113p53/Δ 133p53 是为由阻止 apoptosis 并且支持 DNA DSB 修理禁止房间老朽的 DNA 损坏应力的一个进化地保存的支持幸存的因素。我们的数据也建议 Δ 的正式就职;在正常房间或纸巾的 133p53 表示为癌症病人提供一个重要忍耐标记给放射疗法。 | Lu Gong Hongjian Gong Xiao Pan Changqing Chang Zhao Ou Shengfan Ye Le Yin Lina Yang Ting Tao Zhenhai Zhang Cong Liu David P Lane Jinrong Peng Jun Chen | 2015 | Cell Research2015，25，3： | 4 |
| 18 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 19 | Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans显示文摘 | Omenetti Alessia Porrello Alessandro Jung Youngmi Yang Liu Popov Yury Choi Steve S Witek Rafal P Alpini Gianfranco Venter Juliet Vandongen Hendrika M Syn Wing-Kin Baroni Gianluca Svegliati Benedetti Antonio Schuppan Detlef Diehl Anna Mae | 2008 | Journal of Clinical Investigation2008，，10： | 3 |
| 20 | Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries显示文摘冠的动脉把血流动带到心肌肉。理解冠的动脉的发展程序提供卓见进冠的动脉疾病的治疗。多重来源被描述了为包括 proepicardium,湾穴 venosus (SV ) ,和心内膜贡献冠的动脉。然而,冠的容器的发展起源仍然在强烈学习下面。我们为学习冠的开发生产了一个新基因工具,一只 AplnCreER 老鼠在开发冠的容器明确地衬里 recombinase,它表示可诱导的 Cre。冠的开发和 AplnCreER 命运跟踪的预定正式就职的定量分析证明 subepicardial endothelial 房间(EC ) 的子孙两个都入侵紧缩的心肌层形成冠的动脉并且在表面上留下生产静脉。我们发现这些 subepicardial EC 是 intramyocardial 的主要来源在发展中的心的冠的容器。在 vitro 将生物的活组织移植于培养基中培养,试金显示这些 subepicardial EC 的多数从 SV 和中庭的心内膜,然而并非从室的心内膜产生。Apln 积极的房间的同种细胞的分析显示单个 subepicardial EC 同等地作出贡献到冠的动脉和静脉。一起,这些数据建议 subepicardial EC 是 intramyocardial 的主要来源在室的冠的动脉墙,和那冠的动脉和静脉在发展中的心有普通起源。 | Xueying Tian Tianyuan Hu Hui Zhang Lingjuan He Xiuzhen Huang Qiaozhen Liu Wei Yu Liang He Zhongzhou Yang Zhen Zhang Tao P Zhong Xiao Yang Zhen Yang Yan Yan Antonio Baldini Yunfu Sun Jie Lu Robert J Schwartz Sylvia M Evans Adriana C Gittenberger-de Groot Kristy Red-Horse Bin Zhou | 2013 | Cell Research2013，23，9： | 3 |
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