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| 1 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 2 | CIOMS and ICH Initiatives in Pharmacovigilance and Risk Management显示文摘 | Tsintis P La Mache E | 2004 | Drug Safety2004，27，8： | 1 |
| 3 | T lymphocytes induce endothelial cell matrix metalloproteinase expression by a CD40L-dependent mechanism:implications for tubule formation显示文摘 | Mach F Schonbeck U Fabunmi R P | 1999 | Am J Pathol1999，154，1： | 1 |
| 4 | An ELISA using recombinant proteins for the detection of neutralizing antibodies against human cytomegalovirus显示文摘 | KROPFF B LANDINI M P MACH M | 1993 | Journal of Medical Virology1993，39，3： | 1 |
| 5 | Autonomic nervous system activity in constipation-predominant irritable bowel syndrome patients显示文摘 | Mazur M Mach T Thor P | | 0，，08： | 1 |
| 6 | Generation of biologically active IL-1 beta by matrix metalloproteinases:a novel caspase-1-independent pathway of IL-1 beta processing显示文摘 | Schonbech U Mach F Libby P | 1998 | Immuno11998，161，7： | 1 |
| 7 | DEAP-HUS:Deficiency of CFHR plasma proteins and autoantibody-positive form of hemolytic uremic syndrome 显示文摘 | ZIPFEL P F MACHE C | 2010 | Pediatric Nephrol2010，25，： | 1 |
| 8 | Monolithically integrated,flexible display of polymer-dispersed liquid crystal driven by rubber-stamped organic thin-film transistors显示文摘 | MACH P RODRIGUEZ S J NORTRUP R | | 0，，23： | 1 |
| 9 | Inhibition of CD40 signaling limits evolution established atherosclerosis in mice显示文摘 | Schonbeck U Sukhova GK Shimizu K Mach F Libby P | 2000 | Proc Natl Acad Sci USA2000，97，： | 1 |
| 10 | Biological effect of increased maintenance dose of Clopidogret in cardiovascular outpatients and influence of the cytoehrome P450 2C19 2 allele on Clopidogrel responsiveness 显示文摘 | Fontana P Senouf D Mach F | 2008 | Thromb Res2008，121，4： | 1 |
| 11 | Trichoderma:from genes to biocontrol显示文摘 | KUBICEK C P MACH R L PETERBAUER C K | 2001 | Journal of plant pathology2001，83，2： | 1 |
| 12 | CD154(CD40 ligand)显示文摘 | Schonbeck U Mach F Libby P | 2000 | Int J Biochem Cell Biol2000，32，7： | 1 |
| 13 | Not all statins interfere with clopidogrel during antiplatelet therapy显示文摘 | Mach FF Senouf D Fontana P | 2005 | Eur J Clin Invest2005，35，8： | 1 |
| 14 | Generation of biologically active IL-1 beta by Matrix Metalloprotinases:a novel caspase-1-independent pathway of IL-1 beta processing 显示文摘 | SCHONBECK U MACH F LIBBY P | 1998 | J IMMunol1998，161，7： | 1 |
| 15 | The analysis of RCAS1, HLA-G, and B7H4-positive macrophages in partial and complete hydatidiform mole in both applied therapeutic surgery and surgery followed by chemotherapy 显示文摘 | Basta P Galazka K Mach P | 2011 | Am J Reprod Immunol2011，65，2： | 1 |
| 16 | The immunohistochemical a-nalysis of RCAS1, HLA-G, and B7H4-positive macrophages in partial and complete hydatidiform mole in both applied thera peutic surgery and surgery followed by chemotherapy 显示文摘 | Basta P Galazka K Mach P | 2011 | Am J Reprod Immunol2011，65，2： | 1 |
| 17 | Tunable liquid microlens 显示文摘 | T Krupenkin S Yang P Mach | 2003 | Appl Phys Lett2003，82，3： | 1 |
| 18 | Not all statins interfere with clopidogrel during antiplatelet therapy显示文摘 | Mach F Senouf D Fontana P | 2005 | Eur J Clin Invest2005，35，8： | 1 |
| 19 | Transformation of Trichoderma reesei based on hygromycin B resistance using homologous expression signals显示文摘 | MACH R L SCHINDLER M KUBICEK C P | 1994 | Curr Genet1994，25，6： | 1 |
| 20 | Generation of biologically active IL-1β by matrix metalloproteinases:A novel caspase-1independent pathway of IL-1 β processing显示文摘 | MACH F LIBBY P | 1998 | J Immunol1998，161，7： | 1 |
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