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| 1 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 2 | IL23R single nucleotide polymorphisms could be either beneficial or harmful in ulcerative colitis显示文摘AIM To investigate the association of seven single nucleotide polymorphisms(SNPs) of the IL23 R gene with the clinical picture of ulcerative colitis(UC). METHODS Genomic DNA samples of 131 patients (66 males, 65 females, mean age 55.4 ± 15.8 years) with Caucasian origin, diagnosed with UC were investigated. The diagnosis of UC was based on the established clinical, endoscopic, radiological, and histopathological guidelines. DNA was extracted from peripheral blood leukocytes by routine salting out method. Polymerase chain reaction and restriction fragment length polymorphism were used to identify the alleles of seven SNPs of IL23 R gene(rs11209026, rs10889677, rs1004819, rs2201841, rs7517847, rs10489629, rs7530511).RESULTS Four out of seven analyzed SNPs had statistically significant influence on the clinical picture of UC. Two SNPs were associated with greater colonic extension(rs2201841 P = 0.0084; rs10489629 P = 0.0405). For two of the SNPs, there was more frequently need for operations (rs2201841 P = 0.0348, OR = 8.0; rs10889677 P = 0.0347, OR = 8.0). The rs2201841 showed to be a risk factor for the development of iron deficiency (P = 0.0388, OR = 6.1837). For patients with the rs10889677, a therapy with azathioprine was more frequently necessary(P = 0.0116, OR = 6.1707). Patients with rs10489629 SNP had a lower risk for weight loss(P = 0.0169, OR = 0.3394). Carriers of the heterozygous variant had a higher risk for an extended disease (P = 0.0284). The rs7517847 showed a protective character leading to mild bowel movements. Three SNPs demonstrated no statistically significant influence on any examined clinical features of UC.CONCLUSION We demonstrated susceptible or protective character of the investigated IL23 R SNPs on the phenotype of UC, confirming the genetic association. | Sarah Fischer Erzsébet Kovesdi Lili Magyari Veronika Csongei Kinga Hadzsiev Béla Melegh Péter Hegyi Patrícia Sarlós | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 3 | The effects of Spirulina on anemia and immune function in senior citizens显示文摘Anemia and immunological dysfunction(i.e.immunosenescence)are commonly found in older subjects and nutritional approaches are sought to counteract these phenomena.Spirulina is a filamentous and multicellular bule-green alga capable of reducing inflammation and also manifesting antioxidant effects.We hypothesized that Spirulina may ameliorate anemia and immunosenescence in senior citizens with a history of anemia.We enrolled 40 volunteers of both sexes with an age of 50 years or older who had no history of major chronic diseases.Participants took a Spirulina supplementation for 12 weeks and were administered comprehensive dietary questionnaires to determine their nutritional regimen during the study.Complete cell count(CCC)and indoleamine 2,3-dioxygenase(IDO)enzyme activity,as a sign of immune function,were determined at baseline and weeks 6 and 12 of supplementation.Thirty study participants completed the entire study and the data obtained were analyzed.Over the 12-week study period,there was a steady increase in average values of mean corpuscular hemoglobin in subjects of both sexes.In addition,mean corpuscular volume and mean corpuscular hemoglobin concentration also increased in male participants.Older women appeared to benefit more rapidly from Spirulina supplements.Similarly,the majority of subjects manifested increased IDO activity and white blood cell count at 6 and 12 weeks of Spirulina supplementation.Spirulina may ameliorate anemia and immunosenescence in older subjects.We encourage large human studies to determine whether this safe supplement could prove beneficial in randomized clinical trials. | Carlo Selmi Patrick SC Leung Laura Fischer Bruce German Chen-Yen Yang Thomas P Kenny Gerry R Cysewski M Eric Gershwin | 2011 | Cellular & Molecular Immunology2011，8，3： | 2 |
| 4 | High expression of MAGE-3 protein in spuamous-cell lung carcinoma显示文摘 | Fischer C Gudat F Stulz P | 1997 | Int J Cancer1997，71，： | 2 |
| 5 | MODIFIED MELT TEXTURING PROCESS FOR YBCO BASED ON THE POLYTHERMIC SECTION YO1.5-BA0.4CU0.6O IN THE Y-BA-CU-O PHASE DIAGRAM AT 0.21 BAR OXYGEN PRESSURE显示文摘 | Krabbes G Schatzle P Bieger W Wiesner U Stover G Wu M Strasser T Litzkendorf D Fischer K Gornert P | | 0，，： | 2 |
| 6 | Two independent triggers for the Indian Ocean dipole/zonal mode in a coupled GCM显示文摘 | FISCHER A S TERRAY P GUILYARDI E | 2005 | J Climate2005，18，17： | 1 |
| 7 | Development of high performance multifilamentary Nb-Ti-Ta superconductor for LHC insertion quadrupoles 显示文摘 | Lee P J Fischer C M Larbalestier D C | 1999 | IEEE Trans Applied Superconductivity1999，9，2： | 1 |
| 8 | Information, contracting and quality costs 显示文摘 | Baiman S Fischer P E Rajah M V | 2000 | Management Science2000，46，6： | 1 |
| 9 | Project-modelling inAEC to integrate design and construction显示文摘 | Luiten G T Tolman F P Fischer M A | 1998 | Computers inIndustry1998，，35： | 1 |
| 10 | Biodegradable magnesium-hydroxyapatite metal matrix composites显示文摘 | WITTE F FEYERABEND F MAIER P FISCHER J STORMER M BLAWERT C DIETZEL W HORT N | 2007 | Biomaterials2007，28，： | 1 |
| 11 | Parturition at term:parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment显示文摘 | Winkler M Fischer D C Ruck P | 1999 | Hum Reprod1999，14，： | 1 |
| 12 | Absorptive capacity and new product development显示文摘 | Stock G N Greis N P Fischer W A | 2001 | Journal of High Technology Management Research2001，12，1： | 1 |
| 13 | Biodegradable starch/day nanocomposite films for food packaging applications显示文摘 | Avella M De Vlieger J J Erfico M E Fischer S Vacca P & Volpe M G | 2005 | Food Chemistry2005，93，： | 1 |
| 14 | Analysis and application of a parallel spectral element method for the solution of the Navier-Stokes equations显示文摘 | Fischer P F | 1990 | Computer Methods in Applied Mechanics and Engineering1990，80，13： | 1 |
| 15 | Acupuncture for idiopathic headaehe显示文摘 | Melchart D Linde K Fischer P | 2001 | Cochrane Database Syst Rev2001，，00： | 1 |
| 16 | Diarrhea as a risk factor for acute lower respiratory tract infections among young children in low income settings 显示文摘 | Christa L Fischer W Jamie P | 2013 | J Glob Health2013，3，01： | 1 |
| 17 | Spatial growthregressions: Model specification, estimation andinterpretation显示文摘 | LESAGE J P FISCHER M M | 2007 | Spatial Economic Analysis2007，3，3： | 1 |
| 18 | Galanthamine hydrobromide is a long-term treatment of Alzheimer’s disease:selectivity toward human brain acetylcholinesterase compared with butyrylcholinesterase显示文摘 | BICKEL U FISCHER J P | 1995 | J Pharmacol Exp Ther1995，274，2： | 1 |
| 19 | Identification of novel proteins associated with the development of chemoresistance in malignant melanoma using two-dimensional electrophoresis显示文摘 | Sinha P Kohl S Fischer J | 2000 | Electrophoresis2000，21，： | 1 |
| 20 | Gas analysis by infra- red spectroscopy as a tool for electrical fault diagnostics in SF~ insulated equipment显示文摘 | Heise H M Kurte R Fischer P | 1997 | Fresenius Journal of Analytical Chem istry1997，358，5： | 1 |
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