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| 1 | Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the "master clock"显示文摘 | Wu YH Fischer DF Kalsbcck A Garidou-Boof ML van der Vliet J van Heijningen C Liu RY Zhou JN Swaab DE | 2006 | 中国生物学文摘2006，20，9： | 7 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Factors associated with long-term survival after liver transplantation:A retrospective cohort study显示文摘AIM To identify predictive factors associated with long-term patient and graft survival(> 15 years) in liver transplant recipients.METHODS Medical charts of all de novo adult liver transplant recipients(n = 140) who were transplanted in Hamburg between 1997 and 1999 were retrospectively reviewed.In total,155 transplantations were identified in this time period(15 re-transplantations).Twenty-six orthotopic liver transplant(OLT) recipients were early lost to followup due to moving to other places within 1 year after transplantation.All remaining 114 patients were included in the analysis.The following recipient factors were analysed:Age,sex,underlying liver disease,pre-OLT body mass index(BMI),and levels of alanine aminotransferase(ALT),bilirubin,creatinine and gammaglutamyltransferase(gamma-GT),as well as warm and cold ischemia times.Furthermore,the following donor factors were assessed:Age,BMI,cold ischemia time and warm ischemia time.All surviving patients were followed until December 2014.We divided patients into groups according to their underlying diagnosis:(1) hepatocellularcarcinoma(n = 5,4%);(2) alcohol toxic liver disease(n = 25,22.0%);(3) primary sclerosing cholangitis(n = 6,5%);(4) autoimmune liver diseases(n = 7,6%);(5) hepatitis C virus cirrhosis(n = 15,13%);(6) hepatitis B virus cirrhosis(n = 21,19%);and(7) other(n = 35,31%).The group 'other' included rare diagnoses,such as acute liver failure,unknown liver failure,stenosis and thrombosis of the arteria hepatica,polycystic liver disease,Morbus Osler and Caroli disease.RESULTS The majority of patients were male(n = 70,61%).Age and BMI at the time point of transplantation ranged from 16 years to 69 years(median:53 years) and from 15 kg/m^2 to 33 kg/m^2(median:24),respectively.Sixty-six OLT recipients(58%) experienced a follow-up of 15 years after transplantation.Recipient's age(P = 0.009) and BMI(P = 0.029) were identified as risk factors for death by χ~2-test.Kaplan-Meier analysis confirmed BMI or age above the median as predictors of decreased long-term survival(P = 0.008 and P = 0.020).Hepatitis B as underlying disease showed a trend for improved long-term survival(P = 0.049,χ~2-test,P = 0.055;Kaplan-Meier analysis,Log rank).Pre-transplant bilirubin,creatinine,ALT and gamma-GT levels were not associated with survival in these patients of the pre-era of the model of end stage liver disease.CONCLUSION The recipients' age and BMI were predictors of longterm survival after OLT,as well as hepatitis B as underlying disease.In contrast,donors' age and BMI were not associated with decreased survival.These findings indicate that recipient factors especially have a high impact on long-term outcome after liver transplantation. | Sven Pischke Marie C Lege Moritz von Wulffen Antonio Galante Benjamin Otto Malte H Wehmeyer Uta Herden Lutz Fischer Bjorn Nashan Ansgar W Lohse Martina Sterneck | 2017 | World Journal of Hepatology2017，9，8： | 5 |
| 4 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 5 | Plant Productivity in the Arid and Semiarid Zones显示文摘 | R A Fischer N C Turner | 1978 | Annual Review of Plant Physiology1978，，： | 3 |
| 6 | The sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors显示文摘 | Hobler S C Tiao G Fischer J E | 1998 | Am J Physiol1998，274，： | 2 |
| 7 | Nanotoxicity: the growing need for in vivo study显示文摘 | Hans C Fischer Warren CW Chan | 2007 | Current Opinion in Biotechnology2007，，6： | 2 |
| 8 | High expression of MAGE-3 protein in spuamous-cell lung carcinoma显示文摘 | Fischer C Gudat F Stulz P | 1997 | Int J Cancer1997，71，： | 2 |
| 9 | Environmental and technology policies for climate mitigation 显示文摘 | Fischer C Newell R G | 2008 | Journal of Environmental Economics and Management2008，55，： | 1 |
| 10 | Development of high performance multifilamentary Nb-Ti-Ta superconductor for LHC insertion quadrupoles 显示文摘 | Lee P J Fischer C M Larbalestier D C | 1999 | IEEE Trans Applied Superconductivity1999，9，2： | 1 |
| 11 | Biodegradable magnesium-hydroxyapatite metal matrix composites显示文摘 | WITTE F FEYERABEND F MAIER P FISCHER J STORMER M BLAWERT C DIETZEL W HORT N | 2007 | Biomaterials2007，28，： | 1 |
| 12 | RF MEMS for ubiquitous wireless connectivity:Part 1-Fabrication显示文摘 | De Los Santos H J Fischer G Tilmans H A C | 2004 | IEEE Microwave Mag2004，5，4： | 1 |
| 13 | CD44s,E-cadherin and PCNA as markers for progression in renal cell carcinoma显示文摘 | Fischer C Georg C Kraus S | 1999 | Anticancer Res1999，19，2： | 1 |
| 14 | Parturition at term:parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment显示文摘 | Winkler M Fischer D C Ruck P | 1999 | Hum Reprod1999，14，： | 1 |
| 15 | Plant productivity in the arid and semiarid zones显示文摘 | Fischer R A Turner N C | 1978 | Annual Review of Plant Physiology1978，29，： | 1 |
| 16 | Ubiquitin-conjugating enzyme E2-25K increases aggregate formation and cell death inpolyglutamine diseases显示文摘 | de Pril R Fischer D F Roos R A C | 2007 | Mol Cell Neurosci2007，34，： | 1 |
| 17 | Shading and the growth and photosynthetic responses of Ammann/a coccinnea 显示文摘 | Gibson K D Fischer A J Foin T C | 2001 | Weed Re- seareh2001，41，： | 1 |
| 18 | The actue deafness of definite multiple scleresis: BAEP pasterns显示文摘 | Fischer C Mauguitere F Ibanez V | 1985 | Electroenceph alography1985，61，3： | 1 |
| 19 | Policy, plan and pro- gramme environmental assessment in England, the Netherlands and Germany: practice and prospects显示文摘 | Fischer T B Wood C Jones C | 2002 | Environment and Planning B: Planning and Design2002，29，2： | 1 |
| 20 | Arsenic trioxide plus cisplatin/interferon a -2b/doxorubicin/capecitabine combination chemotherapy for unresectable hepatocellular carcinoma 显示文摘 | Tomuleasa C Soritau O Fischer - Fodor E | 2011 | He- matol Oncol Stem Cell Ther2011，2，4： | 1 |
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