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| 1 | Residual renal function in peritoneal dialysis with failed allograft and minimum immunosuppression显示文摘Immunosuppression(IS) is often withdrawn in patients with end stage renal disease secondary to a failed renal allograft, and this can lead to an accelerated loss of residual renal function(RRF). As maintenance of RRF appears to provide a survival benefit to peritoneal dialysis(PD) patients, it is not clear whether this benefit of maintaining RRF in failed allograft patients returning to PD outweigh the risks of maintaining IS. A 49 year-old Caucasian male developed progressive allograft failure nine years after living-donor renal transplantation. Hemodialysis was initiated via tunneled dialysis catheter(TDC) and IS was gradually withdrawn. Two weeksafter IS withdrawal he developed a febrile illness, which necessitate removal of the TDC and conversion to PD. He was maintained on small dose of tacrolimus(1 mg/d) and prednisone(5 mg/d). Currently(1 year later) he is doing exceedingly well on cycler-assisted PD. Residual urine output ranges between 600-1200 m L/d. Total weekly Kt/V achieved 1.82. RRF remained well preserved in this patient with failed renal allograft with minimal immunosuppressive therapy. This strategy will need further study in well-defined cohorts of PD patients with failed allografts and residual RRF to determine efficacy and safety. | Nadear Elmahi éva Csongrádi Kenneth Kokko Jack R Lewin Jamie Davison Tibor Fülp | 2013 | World Journal of Transplantation2013，3，2： | 5 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Human Immunodeficiency Virus Infection-Associated Mortality during Pulmonary Tuberculosis Treatment in Six Provinces of China显示文摘Objective To investigate the risk factors attributable to tuberculosis-related deaths in areas with human immunodeficiency virus(HIV) infection epidemics. Methods A prospective cohort study of newly registered patients in tuberculosis(TB) dispensaries in six representative Chinese provinces was conducted from September 1, 2009 to August 31, 2011. Risk factors for TB-associated death were identified through logistic regression analysis. Results Of 19,103 newly registered pulmonary TB patients, 925(4.8%) were found to be HIV-positive. Miliary TB and acid-fast bacillus smear-negative TB were more common among these patients. Out of a total of 322(1.7%) deaths that occurred during TB treatment, 85(26%) of the patients were co-infected with HIV. Multivariate analysis revealed that HIV infection was the strongest predictor of death [adjusted odds ratio(aO R) 7.86]. Other significant mortality risk factors included presentation with miliary TB(aO R 4.10; 95% confidence interval: 2.14-7.88), ≥35 years of age(aO R 3.04), non-Han ethnicity(aO R 1.67), and farming as an occupation(aO R 1.59). For patients with TB/HIV co-infection, miliary TB was the strongest risk factor for death(aO R 5.48). A low CD4 count(≤ 200 cells/μL)(aO R 3.27) at the time of TB treatment initiation and a lack of antiretroviral therapy(ART) administration(aO R 3.78) were also correlated with an increased risk of death. Conclusion Infection with HIV was independently associated with increased mortality during TB treatment. Offering HIV testing at the time of diagnosis with TB, early TB diagnosis among HIV/acquired immunodeficiency syndrome patients, and the timely provision of ART were identified as the key approaches that could reduce the number of HIV-associated TB deaths. | LAI Yu Ji LIU Er Yong WANG Li Ming Jamie P MORANO WANG Ning Kaveh KHOSHNOOD ZHOU Lin CHENG Shi Ming | 2015 | Biomedical and Environmental Sciences2015，28，6： | 4 |
| 4 | Diarrhea as a risk factor for acute lower respiratory tract infections among young children in low income settings 显示文摘 | Christa L Fischer W Jamie P | 2013 | J Glob Health2013，3，01： | 1 |
| 5 | Craniometric and Velopharyngeal Assessment of Infants With and Without Cleft Palate显示文摘 | Jamie L Perry David P Kuehn T Bradley P Sutton | | 0，，： | 1 |
| 6 | The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model 显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabetologia1994，37，12： | 1 |
| 7 | Evaluation of the fundamental properties of quantum dot infrared detectors显示文摘 | JAMIE P | 2002 | J of Appl Phys2002，91，： | 1 |
| 8 | Postharvest changes in broccoli and lettuce during storage in mgon,helium,and nitrogen atmospheres containing 2% oxygen显示文摘 | JAMIE P SALTVEIT M E | 2002 | Postharvest Biology and Technology2002，26，1： | 1 |
| 9 | Increased frequency and noc-turia in a middle aged male may not always be due to benignprostatic hypertrophy: a case report显示文摘 | Kumar G Jamie F Mukta P | 2009 | Cases J2009，2，1： | 1 |
| 10 | The potential immunogenicity of human insulin and insulin analogues evaluated in a transgenic mouse model显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabetologia1994，37，： | 1 |
| 11 | The potential immunogenieity of human insulin and insulin analogues evaluated in a transgenic mouse mede显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabetologia1994，37，12： | 1 |
| 12 | Review of image fusion technology in 2005显示文摘 | MOIRA I S JAMIE P H | 2005 | SPIE2005，5782，： | 1 |
| 13 | The moral challkenge of green technology 显示文摘 | Aarne Vesilind P Lauren Heine Jamie Hendry | 2006 | Trames2006，10，6055： | 1 |
| 14 | Struggling with the creative class显示文摘 | JAMIE P | 2005 | International Journal of Urban and Regional Research2005，29，4： | 1 |
| 15 | Postharvest changes in broccoli and lettuce during storage in argon, helium, and nitrogen atmospheres containing 2% oxygen显示文摘 | Jamie P Saltveit ME | 2002 | Postharvest Biol Techno12002，26，： | 1 |
| 16 | Strategic Sustainable Development Using the ISO14001 Standard显示文摘 | | 2005 | Journal of Cleaner Production2005，13，6： | 1 |
| 17 | The potential immu- nogenicity of human insulin and insulin analogus evaluated in a transgenic mouse model显示文摘 | Ottesen JL Nilsson P Jami J | 1994 | Diabete Ologia1994，37，： | 1 |
| 18 | Targeted disruption of the α1,3-galactosytransferase gene in cloned pigs显示文摘 | Todd D V Jeremy B Shu-Hung Chen Carol J P Suyapa B Jeff A M Peter M J Kenneth J M Ashley E Lamborn Jamie L Cowell-Lucero Kevin D W Alan C Irina A P David L A | 2002 | Nat Biotechnology2002，20，3： | 1 |
| 19 | Integrated methanol fuel processors for portable fuel cell systems显示文摘 | DANIEL R P JAMIE D H ROBERT A D | 2005 | Microreactor Technology and Process Intensification2005，，13： | 1 |
| 20 | A general optimization method using adjoint equation for solving multidimensional inverse heat conduction显示文摘 | Y · Jamy M · N · OZISIK J · P · Bardon | | 0，，11： | 1 |
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