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| 1 | Prognostic value of site-specific metastases in pancreatic adenocarcinoma: A Surveillance Epidemiology and End Results database analysis显示文摘AIM To evaluate the prognostic value of site-specific metastases among patients with metastatic pancreaticc arcinoma registered within the Surveillance, Epidemiology and End Results(SEER) database.METHODS SEER database(2010-2013) has been queried through SEER*Stat program to determine the presentation, treatment outcomes and prognostic outcomes of metastatic pancreatic adenocarcinoma according to the site of metastasis. In this study, metastatic pancreatic adenocarcinoma patients were classified according to the site of metastases(liver, lung, bone, brain and distant lymph nodes). We utilized chi-square test to compare the clinicopathological characteristics among different sites of metastases. We used Kaplan-Meier analysis and log-rank testing for survival comparisons. We employed Cox proportional model to perform multivariate analyses of the patient population; and accordingly hazard ratios with corresponding 95%CI were generated. Statistical significance was considered if a two-tailed P value < 0.05 was achieved. RESULTS A total of 13233 patients with stage Ⅳ pancreatic cancer and known sites of distant metastases were identified in the period from 2010-2013 and they were included into the current analysis. Patients with isolated distant nodal involvement or lung metastases have better overall and pancreatic cancer-specific survival compared to patients with isolated liver metastases(for overall survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001)(for pancreatic cancer-specific survival: lung vs liver metastases: P < 0.0001; distant nodal vs liver metastases: P < 0.0001). Multivariate analysis revealed that age < 65 years, white race, being married, female gender; surgery to the primary tumor and surgery to the metastatic disease were associated with better overall survival and pancreatic cancer-specific survival.CONCLUSION Pancreatic adenocarcinoma patients with isolated liver metastases have worse outcomes compared to patients with isolated lung or distant nodal metastases. Further research is needed to identify the highly selected subset of patients who may benefit from local treatment of the primary tumor and/or metastatic disease. | Hani Oweira Ulf Petrausch Daniel Helbling Jan Schmidt Meinrad Mannhart Arianeb Mehrabi Othmar Schob Anwar Giryes Michael Decker Omar Abdel-Rahman | 2017 | World Journal of Gastroenterology2017，23，10： | 13 |
| 2 | 一座传授木材技术的木建筑显示文摘在瑞士的汝拉山脚下,有一座人口约5万的小城市——比尔(Biel/Bienne),自19世纪起就一直拥有繁荣的工业和手表制造业。与这座城市的工业氛围相得益彰的,是充满实用精神的应用科学教育。所属于伯尔尼应用科学大学(Bern University of Applied Sciences)的比尔高等木材技术学校(Higher Technical School of Wood Biel,HTS)即坐落于这里。 | Marcel Meili Markus Peter Zeno Vogel Thomas Kühne Marc Loeliger Andreas Schmidt Thomas Schnabel Urs Schnenberger Othmar Villiger | 2018 | 世界建筑2018，，7： | 2 |
| 3 | The dynamic neutralization system for the spine: a multi-center study of a novel non-fusion system显示文摘 | Thomas M. Stoll Gilles Dubois Othmar Schwarzenbach | 2002 | European Spine Journal2002，，2： | 2 |
| 4 | Selection and application of soft-ware testing techniques to specific conditions of softwareprojects 显示文摘 | Othmar M Oleksandr L | 2013 | International Journal of Computer Applica-tions2013，70，18： | 1 |
| 5 | Mycotoxin de- toxication of animal feed by different adsorbents 显示文摘 | Alexander H Stefan F Othmar K | 2001 | Toxicology Letters2001，122，2： | 1 |
| 6 | A Microarray-based Detection System for Genetically Modified (GM) Food Ingredients显示文摘 | Serge Leimanis Marta Hernández Sophie Fernández Francine Boyer Malcolm Burns Shirin Bruderer Thomas Glouden Neil Harris Othmar Kaeppeli Patrick Philipp Maria Pla Pere Puigdomènech Marc Vaitilingom Yves Bertheau José Remacle | 2006 | Plant Molecular Biology (-)2006，，1： | 1 |
| 7 | LTE and beyond - the long way to 4G mobile communication显示文摘 | Othmar Kyas | 2009 | Microwave Engineering Europe2009，，： | 1 |
| 8 | Skin tuberculosis with atypical mycobacteria 8 years after combined pancreas-kidney transplantation显示文摘 | Bernhard Schmekal Othmar Janko Jan Zazgornik | 2002 | American Journal of Nephrology2002，22，5： | 1 |
| 9 | Spaining for enzymatic activity after gel electrophoresis显示文摘 | Othmar Gabriel Douglas M | 1992 | Gersten Anal Biochem1992，，203： | 1 |
| 10 | A new non-degrading isolation process for 1,3-β-D-glucan of high purity from baker' s yeast Saccharomyces cerevisiae 显示文摘 | Stefan Freimunda Martin Sautera Othmar Kappeli | 2003 | Carbohydrate Polymers2003，，54： | 1 |
| 11 | Association of glaucoma with neurodegenerative diseases with apoptotic cell death:Alzheimer's disease and Parkinson' s disease显示文摘 | Andreas U Othmar N Francis F | 2002 | Am J Ophthalmol2002，133，： | 1 |
| 12 | Mycotoxin detoxication of animal feed by different adsorbents 显示文摘 | ALEXANDER H STEFAN F OTHMAR K | 2001 | Toxicol Lett2001，122，： | 1 |
| 13 | Plasma Levels of Interleukin-18 and Interleukin-18 Binding Protein Are Elevated in Patients with Chronic Liver Disease显示文摘 | Othmar Ludwiczek Arthur Kaser Daniela Novick Charles A. Dinarello Menachem Rubinstein Wolfgang Vogel Herbert Tilg | 2002 | Journal of Clinical Immunology2002，，6： | 1 |
| 14 | Mycotoxin detoxication of animal feed by different adsorbents显示文摘 | Alexander Huwig Stefan Freimund Othmar Kappeli | 2001 | Toxicology Letters2001，122，2： | 1 |
| 15 | Spaining for enzymatic activity after gel electrophoresis 显示文摘 | Othmar Gabriel Douglas M | 1992 | Gersten Anal Biochem1992，，203： | 1 |
| 16 | Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer’s disease and Parkinson’s disease显示文摘 | Andreas U Bayer Othmar N Keller Francis Ferrari Klaus-Peter Maag | 2002 | American Journal of Ophthalmology2002，，1： | 1 |
| 17 | Posterior dynamic Stabilizationsystem:DYNES YS显示文摘 | Othmar S Ulrich B Thomas M | 2005 | O~lhop Clin NAm2005，36，3： | 1 |
| 18 | Products of linear recurring sequences with maximum complexity显示文摘 | RAINER A R OTHMAR J S | 1987 | IEEE Transactions on Information Theory1987，33，1： | 1 |
| 19 | Effects of WBV in patients with multiple sclerosis: a pilot study显示文摘 | Othmar Schuhfried | 2005 | Clinical Rehabilitation2005，19，： | 1 |
| 20 | A new non-degrading isolation process for1,3-β-D-glucan of high purity from baker's yeast Saccharomyces cerevisiae显示文摘 | Stefan Freimund Martin Sauter Othmar Kappeli | 2003 | Carbohydrate Polymers2003，54，： | 1 |
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