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| 1 | Decreased levels of plasma adiponectin associated with increased risk of colorectal cancer显示文摘AIM:To investigate the association between adiponectin levels and risk of colorectal adenoma and cancer (early and advanced).METHODS: A cross-sectional study in a cohort of hospital-based patients was conducted between January 2004 and March 2006 at Yamagata University Hospital. Male subjects, who had colorectal tumors detected by endoscopic examination, were enrolled according to inclusion and exclusion criteria. Based on the T factor of the TNM system, intraepithelial carcinoma and submucosally invasive carcinoma were def ined as early cancer, and invasion into the muscularis propria or deeper was defined as advanced cancer. The plasma levels of glucose, insulin, total cholesterol, triglyceride, high sensitivity C-reactive protein, insulin like growth factor (IGF)-1, IGF binding protein-3, adiponectin, leptin, and resistin were measured. Each factor level was designated low or high, and the risk of adenoma or cancer was estimated by univariate and multivariate logistic regression analysis.RESULTS: We enrolled 124 male subjects (47 with adenoma, 34 with early cancer, 17 with advanced cancer, and 26 without tumors as controls). In patients with adenoma, high triglyceride and low adiponectin were associated with a significant increase in the odds ratio (OR) by univariate analysis. Only a low adiponectin level was related to increased adenoma risk, with an adjusted OR for low level (<11 μg/mL) to high (≥11 μg/mL) of 5.762 (95% confidence interval (CI):1.683-19.739, P=0.005). In the patients with early cancer, high body mass index, high triglyceride, and low adiponectin were associated with a significant increase in OR in univariate analysis. Imultivariate analysis, only low adiponectin was significantly associated with early cancer, with an adjusted OR of 4.495 (95% CI:1.090-18.528, P=0.038). However, in patients with advanced cancer, low adiponectin was not recognized as a significant risk factor for advanced cancer.CONCLUSION: A decreased level of adiponectin is strongly associated with an increased risk of colorectal adenoma and early cancer. These data call for further investigation, including a controlled prospective study. | Sayaka Otake Hiroaki Takeda Shoichiro Fujishima Tadahisa Fukui Tomohiko Orii Takeshi Sato Yu Sasaki Shoichi Nishise Sumio Kawata | 2010 | World Journal of Gastroenterology2010，16，10： | 14 |
| 2 | Endoscopic submucosal dissection for colorectal neoplasms:A review显示文摘The introduction of colorectal endoscopic submucosal dissection(ESD)has expanded the application of endoscopic treatment,which can be used for lesions with a low metastatic potential regardless of their size.ESD has the advantage of achieving en bloc resection with a lower local recurrence rate compared with that of piecemeal endoscopic mucosal resection.Moreover,in the past,surgery was indicated in patients with large lesions spreading to almost the entire circumference of the rectum,regardless of the depth of invasion,as endoscopic resection of these lesions was technically difficult.Therefore,a prime benefit of ESD is significant improvement in the quality of life for patients who have large rectal lesions.On the other hand,ESD is not as widely applied in the treatment of colorectal neoplasms as it is in gastric cancers owing to the associated technical difficulty,longer procedural duration,and increased risk of perforation.To diversify the available endoscopic treatment strategies for superficial colorectal neoplasms,endoscopists performing ESD need torecognize its indications,the technical issues involved in its application,and the associated complications.This review outlines the methods and type of devices used for colorectal ESD,and the training required by endoscopists to perform this procedure. | Taku Sakamoto Genki Mori Masayoshi Yamada Yuzuru Kinjo Eriko So Seiichiro Abe Yosuke Otake Takeshi Nakajima Takahisa Matsuda Yutaka Saito | 2014 | World Journal of Gastroenterology2014，20，43： | 13 |
| 3 | A prospective, multicenter study of 1111 colorectal endoscopic submucosal dissections (with video)显示文摘 | Yutaka Saito Toshio Uraoka Yuichiro Yamaguchi Kinichi Hotta Naoto Sakamoto Hiroaki Ikematsu Masakatsu Fukuzawa Nozomu Kobayashi Junichirou Nasu Tomoki Michida Shigeaki Yoshida Hisatomo Ikehara Yosuke Otake Takeshi Nakajima Takahisa Matsuda Daizo Saito | 2010 | Gastrointestinal Endoscopy2010，，6： | 6 |
| 4 | 制定科学合理的生物安全措施显示文摘在当今的生猪产业,生物安全措施是保护和维持猪群健康和有效利用率的重要科学基础程序。 | Scott Dee Andrea Pitkin Satoshi Otake 贾海燕(翻译) | 2009 | 猪业科学2009，26，12： | 3 |
| 5 | Down-regulation of p73 correlates with high histological grade in Japanese with breast carcinomas显示文摘 | DU Cai-wen Izo Kimijima Tom Otake Rikiya Abe Seiichi Takenoshita ZHANG Guo-jun | 2011 | Chinese Medical Journal2011，，15： | 2 |
| 6 | Colorectal endoscopic submucosal dissection: T echnical advantages compared to endoscopic mucosal resection and minimally invasive surgery显示文摘 | Yutaka Saito Masayoshi Yamada Eriko So Seiichiro Abe Taku Sakamoto Takeshi Nakajima Yosuke Otake Akiko Ono Takahisa Matsuda | 2014 | Digestive Endoscopy2014，，： | 2 |
| 7 | Association of gastric cancer risk factors with DNA methylation levels in gastric mucosa of healthy Japanese: a cross-sectional study显示文摘 | Shimazu Taichi Asada Kiyoshi Charvat Hadrien Kusano Chika Otake Yosuke Kakugawa Yasuo Watanabe Hidenobu Gotoda Takuji Ushijima Toshikazu Tsugane Shoichiro | 2015 | Carcinogenesis2015，，： | 2 |
| 8 | Usefulness of a novel electrosurgical knife, the insulation-tipped diathermic knife-2, for endoscopic submucosal dissection of early gastric cancer显示文摘 | Hiroyuki Ono Noriaki Hasuike Tetsuya Inui Kohei Takizawa Hisatomo Ikehara Yuichiro Yamaguchi Yosuke Otake Hiroyuki Matsubayashi | 2008 | Gastric Cancer2008，，1： | 2 |
| 9 | 数字高清等离子电视图像质量技术的发展显示文摘随着数字广播服务的展开及数字通用光盘(DVD)普及,对具有高画质的平面、薄型电视的需求正在增长。我们已经开发了一种新的数字高清等离子电视来满足这种需求。这一新产品具有一个改善图像质量的系统,可以显示36.2亿种彩色以及最大2048级灰度的图像。该新系统与创新的彩色生成技术结合可以创造出生动的图像,其独有的运动图案降噪技术可以消除大部分持续困扰等离子屏(PDP)电视的运动图像畸形和赝像。这一技术使得在降低10%功耗的同时增加10%的亮度成为可能。 | Susumu Tsujihara Keiich Otake 陈小平 | 2006 | 现代显示2006，，3： | 2 |
| 10 | An inferior mesenteric-caval shunt via the internal iliac vein with portosystemic encephalopathy显示文摘 | Otake M Kobayashi Y Hashimoto D | 2001 | Intern Med2001，40，： | 1 |
| 11 | Relation between plasma adiponectin, high-sensitivity C-reactive protein, and coronary plaque components in patients with acute coronary syndrome显示文摘 | Otake H Shite J Shinke T | 2008 | Am J Cardiol2008，101，1： | 1 |
| 12 | Oceanic spawning e- cology of freshwater eels in the western north Pacific 显示文摘 | Tsukamoto K Chow S Otake T | 2011 | Nature Communications2011，2，179： | 1 |
| 13 | Evalutation of angiogenesis in non - small cell lung cancer: comparsion bettween anti - CD34 antibody and anti- CD105 antibody 显示文摘 | Tanaka F Otake Y Yanagihara K | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 14 | Anti-HIV-1activities of crude drug,shikon (Lithospermi radix),in vitro显示文摘 | Ueba N Otake T Yamazaki K | 1993 | Nippon Rinsho1993，51，： | 1 |
| 15 | Analysis of organic esters of plasticizer in indoor air by GC-MS and GC-FPD 显示文摘 | Otake T Yoshinaga J Yanagisawa Y | 2001 | Environ Sci Technol2001，35，： | 1 |
| 16 | Catheter-based transcoronary myocardial hypothermia attenuates arrhythmia and myocardial necrosis in pigs with acute myocardial infarction显示文摘 | Otake H Shite J Paredes OL | 2007 | J Am Coll Cardiol2007，49，2： | 1 |
| 17 | Radiation-induced chan- ges in MR signal intensity and contrast enhancement of lum- bosacral vertebrae: do changes occur only inside the radiation theraoy field? 显示文摘 | Otake S Mayr NA Ueda T et ai | 2002 | Radiology2002，222，1： | 1 |
| 18 | A pilot study of sensory feedback bytranscutaneous electrical nerve stimulation to improve manipulation deficit caused by severe sensory loss after stroke显示文摘 | Kahori Kita Yohei Otakal Kotaro Takeda | 2013 | Journal of Neuro- Engineering and Rehabilitation2013，，10： | 1 |
| 19 | Anticaries effect of polyphenolic compounds from Japanese green tea显示文摘 | OTAKE S MAKIMURA M KUROKI T | | 0，，06： | 1 |
| 20 | Effect of corticosteroids or diuretics in low-tone sensorineural hearing loss显示文摘 | Suzuki M Otake R Kashio A | 2006 | ORL J Otorhinolaryngol Relat Spec2006，68，3： | 1 |
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