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| 1 | The therapeutic potential of targeting exchange protein directly activated by cyclic adenosine 3',5'-monophosphate(Epac)for central nervous system trauma显示文摘Millions of people worldwide are affected by traumatic spinal cord injury,which usually results in permanent sensorimotor disability.Damage to the spinal cord leads to a series of detrimental events including ischaemia,haemorrhage and neuroinflammation,which over time result in further neural tissue loss.Eventually,at chronic stages of traumatic spinal cord injury,the formation of a glial scar,cystic cavitation and the presence of numerous inhibitory molecules act as physical and chemical barriers to axonal regrowth.This is further hindered by a lack of intrinsic regrowth ability of adult neurons in the central nervous system.The intracellular signalling molecule,cyclic adenosine 3′,5′-monophosphate(cAMP),is known to play many important roles in the central nervous system,and elevating its levels as shown to improve axonal regeneration outcomes following traumatic spinal cord injury in animal models.However,therapies directly targeting cAMP have not found their way into the clinic,as cAMP is ubiquitously present in all cell types and its manipulation may have additional deleterious effects.A downstream effector of cAMP,exchange protein directly activated by cAMP 2(Epac2),is mainly expressed in the adult central nervous system,and its activation has been shown to mediate the positive effects of cAMP on axonal guidance and regeneration.Recently,using ex vivo modelling of traumatic spinal cord injury,Epac2 activation was found to profoundly modulate the post-lesion environment,such as decreasing the activation of astrocytes and microglia.Pilot data with Epac2 activation also suggested functional improvement assessed by in vivo models of traumatic spinal cord injury.Therefore,targeting Epac2 in traumatic spinal cord injury could represent a novel strategy in traumatic spinal cord injury repair,and future work is needed to fully establish its therapeutic potential. | Alba Guijarro-Belmar Dominik Mateusz Domanski Xuenong Bo Derryck Shewan Wenlong Huang | 2021 | Neural Regeneration Research2021，16，3： | 3 |
| 2 | Isolated systolis hypertension prognostic information provided by pulse pressure显示文摘 | Domanski MJ Davis BR Pfeffer MA | 1999 | Hypertension1999，34，4： | 1 |
| 3 | Isolated diastolic hypertension prognostic information provided by pulse pressure显示文摘 | Domanski MJ Davis BR Pfeffer MA | 1999 | Hyoertension1999，34，： | 1 |
| 4 | Isolated systolic hypertension prognostic information provided by pulse pressure显示文摘 | Domanski MJ Davis BR Pfeffer MA | 1999 | Hypertension1999，34，： | 1 |
| 5 | Polypetides of hepatitis B surface antigen produced in transgenic potato显示文摘 | Ehsani P Khabiri A Domansky NN | 1997 | Gene1997，190，： | 1 |
| 6 | The prognostic implications of renal insufficiency in asymptomatic and symptomatic patients with left ventricular systolic dysfunction显示文摘 | Dries DL Exner DV Domanski MJ | 2000 | J Am Coll Cardiol2000，35，3： | 1 |
| 7 | DNA microsatellite analysis in families with autosomal dominant polycystic kidney disease (ADPKD): the first Polish study显示文摘 | Binczak-Kuleta A Rozanski J Domanski L | 2006 | J Appl Genet2006，47，4： | 1 |
| 8 | Pretransplant Nephrectomy in Patients With Autosomal Dominant Polycystic Kidney Disease显示文摘 | J. Rozanski I. Kozlowska M. Myslak L. Domanski J. Sienko K. Ciechanowski M. Ostrowski | 2005 | Transplantation Proceedings2005，，2： | 1 |
| 9 | Light-to-moderate alcohol consumption and prognosis in patients with left ventricular systolic disfunction 显示文摘 | COOPER H A EXNER D V DOMANSKI M J | 2000 | J Am Coil Cardiol2000，35，7： | 1 |
| 10 | Isolated systolic hypertonsion: prognostic information provided by pulse pressure显示文摘 | Domanski MJ Davis BR Pfeffer MA | 1999 | Hypertension1999，34，： | 1 |
| 11 | An improved corre- lation for two-phase pressure drop of R-22 and R-410A in 180° return bends 显示文摘 | DOMANSKI P A HERMES C J L | 2008 | Applied Thermal Engineering2008，28，7： | 1 |
| 12 | Pulse pressure and cardiovascular disease-related mortality:follow-up study of the multiple risk factor intervention trial显示文摘 | Domanski M Mitchell G Pfeffer M | | 0，，20： | 1 |
| 13 | Pressure-relief continuous positive airway pressure vs constant continuous positive airway pressure:a comparison of efficacy and compliance显示文摘 | Georg Nilius Andreas Happel Ulrike Domanski | 2006 | Chest2006，130，： | 1 |
| 14 | Cardiovascular risk assessment using pulse pressure in the first national health and nutrition examination survey显示文摘 | Domanski D Normal J Wolz M | 2001 | Hypertension2001，38，： | 1 |
| 15 | Identification and functional characterization of eight CYP3A4 protein variants显示文摘 | Eiselt R Domanski TL Zibat A | 2001 | Pharmacogenetics2001，11，5： | 1 |
| 16 | Independent prognostic information provided by sphygmomanometrically determined pulse pressure and mean arterial pressure in patients with left ventricular dysfunction 显示文摘 | Domanski MJ Mitchell GF Norman JE | 1999 | J Am Coll Cardiol1999，33，4： | 1 |
| 17 | Effects of nasal insufflation on arterial gas exchange and breathing pattern in patients with chronic obstructive pulmonary disease and hypercapnic respiratory failure 显示文摘 | Nilius G Franke K J Domanski U | 2013 | Adv Exp Med Biol2013，755，： | 1 |
| 18 | Cytology of pilomatrixoma(calcifying epithelioma of Malherbe)in fine needle aspirates显示文摘 | DOMANSKI HA DOMANSKI AM | 1997 | Acta Cytol1997，41，3： | 1 |
| 19 | Effect of preservation solu- tions UW and EC on the expression of matrix metalloproteinase Ⅱ and tissue inhibitor of metalloproteinase II genes in rat kidney 显示文摘 | Sulikowski T Domanski L Zietek Z | 2012 | Postepy Hig Med Dosw (Online)2012，66，： | 1 |
| 20 | Thermodynamic evaluation of R22 alternative refrigerants and refrigerant mixtures显示文摘 | Domanski P A Didion D A | 1993 | ASHRAE Transactions1993，99，2： | 1 |
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