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| 1 | Ecohydrological advances and applications in plant–water relations research:a review显示文摘Aims The field of ecohydrology is providing new theoretical frameworks and methodological approaches for understanding the complex interactions and feedbacks between vegetation and hydrologic flows at multiple scales.Here we review some of the major scientific and technological advances in ecohydrology as related to understanding the mechanisms by which plant–water relations influence water fluxes at ecosystem,watershed and landscape scales.Important Findings We identify several cross-cutting themes related to the role of plant–water relations in the ecohydrological literature,including the contrasting dynamics of water-limited and water-abundant ecosystems,transferring information about water fluxes across scales,understanding spatiotemporal heterogeneity and complexity,ecohydrological triggers associated with threshold behavior and shifts between alternative stable states and the need for long-term data sets at multiple scales.We then show how these themes are embedded within three key research areas where improved understanding of the linkages between plant–water relations and the hydrologic cycle have led to important advances in the field of ecohydrology:upscaling water fluxes from the leaf to the watershed and landscape,effects of plant–soil interactions on soil moisture dynamics and controls exerted by plant water use patterns and mechanisms on streamflow regime.In particular,we highlight several pressing environmental challenges facing society today where ecohydrology can contribute to the scientific knowledge for developing sound management and policy solutions.We conclude by identifying key challenges and opportunities for advancing contributions of plant–water relations research to ecohydrology in the future. | Heidi Asbjornsen Gregory R.Goldsmith Maria S.Alvarado-Barrientos Karin Rebel Floortje P.Van Osch Max Rietkerk Jiquan Chen Sybil Gotsch Conrado Tobon Daniel R.Geissert Alberto Gomez-Tagle Kellie Vache Todd E.Dawson | 2011 | Journal of Plant Ecology2011，4，1： | 15 |
| 2 | Cerebral magnetic resonance imaging in quiescent Crohn's disease patients with fatigue显示文摘AIM To evaluate brain involvement in quiescent Crohn's disease (CD) patients with fatigue using quantitative magnetic resonance imaging(MRI).METHODS Multiple MRI techniques were used to assess cerebral changes in 20 quiescent CD patients with fatigue(defined with at least 6 points out of an 11-point numeric rating scale compared with 17 healthy age and gender matched controls without fatigue. Furthermore, mental status was assessed by cognitive functioning, based on the neuropsychological inventory including the different domains global cognitive functioning, memory and executive functioning and in addition mood and quality of life scores. Cognitive functioning and mood status were correlated with MRI findings in the both study groups.RESULTS Reduced glutamate + glutamine (Glx = Glu + Gln) concentrations (P = 0.02) and ratios to total creatine(P = 0.02) were found in CD patients compared with controls. Significant increased Cerebral Blood Flow(P = 0.05) was found in CD patients (53.08 ± 6.14 mL/100 g/min) compared with controls (47.60 ± 8.62 mL/100 g/min). CD patients encountered significantly more depressive symptoms (P < 0.001). Cognitive functioning scores related to memory (P = 0.007) and executive functioning (P = 0.02) were lower in CD patients and both scores showed correlation with depression and anxiety. No correlation was found subcortical volumes between CD patients and controls in the T1-weighted analysis. In addition, no correlation was found between mental status and MRI findings.CONCLUSION This work shows evidence for perfusion, neurochemical and mental differences in the brain of CD patients with fatigue compared with healthy controls. | Sanne van Erp Ece Ercan Perla Breedveld Lianne Brakenhoff Eidrees Ghariq Sophie Schmid Matthias van Osch Mark van Buchem Bart Emmer Jeroen van der Grond Ron Wolterbeek Daniel Hommes Herma Fidder Nic van der Wee Tom Huizinga Désirée van der Heijde Huub Middelkoop Itamar Ronen Andrea van der Meulen-de Jong | 2017 | World Journal of Gastroenterology2017，23，6： | 2 |
| 3 | Ecohydrological advances and applications in plant–water relations research:a review显示文摘 | H.Asbjornsen G.R.Goldsmith M.S.Alvarado-Barrientos K.Rebel F.P.Van Osch M.Rietkerk J.Chen S.Gotsch C.Tobon D.R.Geissert A.Gomez-Tagle K.Vache T.E.Dawson | 2011 | Journal of Plant Ecology2011，4，3： | 1 |
| 4 | Effect of glucosaminesulfate on hip osteo arthritis a randomized trial显示文摘 | Rozendaal RM Koes BW Van Osch GJ | 2008 | Ann Inter Med2008，148，： | 1 |
| 5 | The role of hypoxia in bone marrow- derived mesenchymal stem cells : considerations for regenerative medicine approaches显示文摘 | Das R Jahr H van Osch GJ | 2010 | Tissue Eng Part B Rev2010，16，2： | 1 |
| 6 | MRI of blood flow of the human retina 显示文摘 | Peng Q Zhang Y Nateras as van Osch MJ Duong TQ | | Magn Reson Med0，65，6： | 1 |
| 7 | Development of os- teoarthritic features in estrogen receptor knockout mice 显示文摘 | Snickers YH van Osch G J Ederveen AG | 2009 | Osteoar- thritis Cartilage2009，17，10： | 1 |
| 8 | Simultaneous quantitative cerebral perfusion and Gd-DTPA extravasation measurement with dual-echo dynamic susceptibility contrast MRI 显示文摘 | Vonken EP van Osch MJ Bakker CJ | 2000 | Magn Reson Med2000，43，： | 1 |
| 9 | Statin use is associated with reduced incidence and progression of knee osteoarthrifis in the Rotterdam study显示文摘 | CAockaerts S van Osch GJ INstiaansen-Jenniskens YM | 2012 | Ann Rheum Dis2012，71，5： | 1 |
| 10 | Synovial inflammation, immune cells and their cy- tokines in osteoarthritis: a review 显示文摘 | de Lange-Brokaar BJ Ioan-Facsinay A van Osch GJ | 2012 | Osteoarthritis Cartilage2012，20，12： | 1 |
| 11 | Effect of glucosamine sulfate on hip osteoarthritis: a randomized trial显示文摘 | Rozendaal RM Koes BW van Osch GJ | 2008 | Ann Intern Med2008，148，4： | 1 |
| 12 | Identification of acidsensing ion channels in bone显示文摘 | Jahr H van Driel M van Osch G J | 2005 | Biochem Biophys Res Commun2005，337，1： | 1 |
| 13 | Effect of glucosamine sulphate on joint space narrowing, pain and function in patients with hip osteoarthritis; subgroup analyses of a randomized controlled trial显示文摘 | Rozendaal RM Uitterlinden EJ van Osch GJ | 2009 | Osteoarthritis Cartilage2009，17，4： | 1 |
| 14 | Functionalized Hydrogels for Articular Cartilage Tissue Engineering显示文摘Articular cartilage(AC)is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints.AC defects are common in the knees of young and physically active individuals.Because of the lack of suitable tissue-engineered artificial matrices,current therapies for AC defects,espe-cially full-thickness AC defects and osteochondral interfaces,fail to replace or regenerate damaged carti-lage adequately.With rapid research and development advancements in AC tissue engineering(ACTE),functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favor-able biomechanical properties,water content,swelling ability,cytocompatibility,biodegradability,and lubricating behaviors.They can be rationally designed and conveniently tuned to simulate the extracel-lular matrix of cartilage.This article briefly introduces the composition,structure,and function of AC and its defects,followed by a comprehensive review of the exquisite(bio)design and(bio)fabrication of func-tionalized hydrogels for AC repair.Finally,we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation. | Liangbin Zhou Peng Guo Matteo D’Este Wenxue Tong Jiankun Xu Hao Yao Martin J.Stoddart Gerjo J.V.M.van Osch Kevin Ki-Wai Ho Zhen Li Ling Qin | 2022 | Engineering2022，8，6： | 1 |
| 15 | Alginate as a chondrocyte-delivery substance in combination with a non-woven scaffold for cartilage tissue engineering显示文摘 | Marijinissen WJCM Van Osch GJVM Aigner J | 2002 | Biomaterials2002，23，： | 1 |
| 16 | Oestrogen is impor- tant for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis显示文摘 | Sniekers YH Weinans H van Osch GJ | 2010 | Arthritis Res Ther2010，12，： | 1 |
| 17 | Cerebrovascular reactivity within peffusion territories in patients with an internal carotid artery occlusion 显示文摘 | Bokkers RP van Osch MJ Klijn CJ | 2011 | Neurol Neurosurg Psychiatry(0022 - 3050)2011，82，9： | 1 |
| 18 | Differential effects of IGF-1 and TGFβ-2 on the assembly of proteoglycans in pericellular and territorial matrix by cultured bovine articular chondrocytes显示文摘 | van den berg WB Hunziker EB | 1998 | Osteoarthritis Cartilage1998，6，3： | 1 |
| 19 | The role of hypoxiain bone marrow-derived mesenchymal stem cells:considerations for regenerative medicine approaches显示文摘 | Das R Jahr H van Osch GJ | 2010 | Tissue Eng Part B Rev2010，16，2： | 1 |
| 20 | Cerebrovascular reactivity within perfusion territories in patients with an internal carotid artery occlusion显示文摘 | Bokkers RP van Osch MJ Klijn CJ | | 0，，： | 1 |
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