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| 1 | 博斯腾湖流域山区地表径流对近期气候变化的响应显示文摘近年来,在全球和区域气候变化影响下,新疆博斯腾湖主要产流区开都河出山径流呈现异常波动,引起气候变化研究的关注。鉴于产流区复杂地形和径流补给特征以及传统观测资料的不足,借助雷达、微波及可见光等多源遥感数据从山区降水、积雪和冰川等方面与出山径流变化关系进行比较来揭示径流突变原因。结果表明,产流区平均径流深与降水量关系的转变是引起出山径流异常波动直接原因;进一步的冰川变化分析显示,径流深的波动主要由冰川融水径流变化引起:20世纪80年代中期后的温度上升加速了山顶冰川消融,导致1987~2002年的径流增加和湖泊水位升高;1984~2000年间,流域山顶冰川面积消退近40%,随着分布在较低海拔,对温度升高最敏感的中小冰川的消失,冰雪消融带来的径流增加效应开始减弱;2002年后,在流域气温、降水等变化并不显著的情况下,出山径流量却急剧降低,反映了特定冰川分布条件地区在气候变暖中融水径流先升后降的现象。 | 孙占东 Christian Opp 王润 高前兆 | 2010 | 山地学报2010，28，2： | 16 |
| 2 | 胡杨冠幅对塔里木河下游应急生态输水的响应显示文摘以塔里木河下游10次生态输水的效果为背景,根据近5 a在塔里木河下游阿拉干断面的大量野外调查数据,分析了胡杨冠幅对应急生态输水的响应。结果显示:随着输水次数的增加,胡杨冠幅呈梯度变化的趋势,输水对增加胡杨叶量和活枝有一定的促进作用,不同冠幅级的胡杨主要分布在距河道200 m的范围,且其分布都与离河道距离呈显著负相关关系,由于离河道距离的不同,胡杨冠幅对输水响应也不一样;总体趋势为,随着离河道距离(地下水埋深)的增加,胡杨冠幅变化幅度不明显。 | 玉米提.哈力克 塔依尔江.艾山 艾里西尔.库尔班 Bernd Cyffka Christian Opp | 2011 | 东北林业大学学报2011，39，9： | 16 |
| 3 | 塔里木河下游阿拉干断面胡杨林空间分布特征及其影响因素显示文摘通过小尺度生态监测与遥感数据分析获取塔里木河下游荒漠河岸林现状信息,集中对阿拉干断面设立的100hm2长期监测样方内的胡杨树进行了详细的调查,对该断面胡杨林空间分布特征及其影响因素进行了分析。研究结果表明:塔里木河下游的胡杨具有伴河生长的特性;随着离河距离的增加,胡杨株数呈递减趋势;大部分胡杨主要分布在离河道200m范围内,且其分布都与离河道距离呈显著负相关关系;与此同时随着离河岸距离增加,胡杨的密度也同样呈现降低规律。不同地下水埋深条件下生长的胡杨总体状况显示,地下水埋深,即与河道距离的近远是影响胡杨分布最重要的因素之一。 | 塔依尔江·艾山 玉米提·哈力克 艾尔肯·艾白不拉 Bernd Cvffka Christian Opp | 2011 | 干旱区资源与环境2011，25，12： | 10 |
| 4 | 塔里木河下游输水恢复过程中胡杨生长对地下水位的响应显示文摘通过近几年对塔里木河下游3个典型断面的胡杨各项生态指标的实地监测,分析了输水恢复过程中胡杨生长对地下水位的响应程度。研究表明:(1)河岸胡杨林生长与地下水埋深有密切的关系,通过10次生态输水,下游河道沿岸的地下水得到补充,水位明显抬升,胡杨长势也随着地下水位的抬升有不同程度的好转。(2)地下水位愈深,胡杨的干旱胁迫程度愈强。横向上,胡杨对生态输水的响应随着河道距离的增加逐渐减弱;纵向上,从上段至下段胡杨生长对输水的响应范围逐渐减小。(3)在输水河道两侧过水湿润岸滩,虽有胡杨实生苗零星出现,但就目前输水方式,还无法实现胡杨大面积繁殖更新。 | 玉米提.哈力克 柴政 艾尔肯.艾白不拉 塔依尔江.艾山 Bernd Cyffka Christian Opp | 2011 | 水土保持通报2011，31，5： | 6 |
| 5 | 经验正交函数方法和TRMM数据对长江流域降水模式与极端水文过程的研究显示文摘气候变化加剧了极端天气和水文事件的发生,降水是区域干旱与洪水事件最直接驱动因素。以TRMM/PR月累积降水反演遥感数据为基础,利用经验正交函数EOF(Empirical Orthogonal Function)方法对长江流域降水时空变化模式进行提取,并对比分析了主要模式振幅强弱与极端水文事件的对应关系。结果表明在流域尺度上EOF方法及TRMM/PR数据可以较好地识别降水主要模式,通过时空尺度变换成功揭示主要降水模式强弱与流域极端水文事件的对应关系。鉴于日益丰富的巨量水文气象时空数据,EOF方法在模式提取、水文模拟、极端事件预估及灾害适应性研究等方面具有应用潜力。 | 孙占东 黄群 姜加虎 OPP Christian | 2012 | 长江流域资源与环境2012，21，3： | 5 |
| 6 | Cytokines and sleep显示文摘 | Mark R. Opp | 2005 | Sleep Medicine Reviews2005，，5： | 2 |
| 7 | Cytokine involvement in the regulation of sleep显示文摘 | Opp MR Kapas L Toth LA | 1992 | Proc Soc Exp Biol Med1992，201，1： | 1 |
| 8 | Cytokines and sleep显示文摘 | Opp MR | 2005 | Sleep Med Rev2005，9，： | 1 |
| 9 | An overview of NSPCG:A nonsymmetric preconditioned conjugate gradient package显示文摘 | THOMAS C OPPE WAYNE D | | 0，，53： | 1 |
| 10 | Multiple Mating and Reproductive Success of Male and Female Apple Maggot Flies, Rhagoletis pomonella ( Diptera : Tephritidae) 显示文摘 | Opp S B Prokopy R J | 2000 | Journal of Insect Behavior2000，13，6： | 1 |
| 11 | Corticotropin-releasing factor at tenuates interleukinl induced sleep and fever in rabbits显示文摘 | Opp M Obal F Jr Krueger JM | 1989 | Am J Physiol1989，257，32： | 1 |
| 12 | Dentification and characterization of a pseudomonas strain capable of metabolizing phenoxybenzoates显示文摘 | Opp E Akhtar M H I | 1991 | Applicated and Environmental Microbiology1991，57，5： | 1 |
| 13 | Glutaric aciduria type Ⅰ and methylmalonic aciduria:simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus显示文摘 | Sauer SW Opp S Mahringer A | | 0，，06： | 1 |
| 14 | Benehmarking road safety performances of countries 显示文摘 | Fred Wegman Siem Oppe | 2010 | Safety Seienee2010，48，9： | 1 |
| 15 | Comparing the immunogenicity of glycosidase-directed resiquimod prodrugs mediated by cancer cell metabolism显示文摘We have recently developed an enzyme-directed immunostimulant(EDI)prodrug motif,which is metabolized to active immunostimulant by cancer cells and,following drug efflux,activates nearby immune cells,resulting in immunogenicity.In this study,we synthesized several EDI prodrugs featuring an imidazoquinoline immunostimulant resiquimod(a Toll-like receptor 7/8 agonist)covalently modified with glycosidase enzyme-directing groups selected from substrates of β-glucuronidase,α-mannosidase,or β-galactosidase.We compared the glycosidase-dependent immunogenicity elicited by each EDI in RAW-Blue macrophages following conversion to active immunostimulant by complementary glycosidase.At a cellular level,we examined EDI metabolism across three cancer cell lines(B16 melanoma,TC2 prostate,and 4T1 breast cancer).Comparing the relative immunogenicity elicited by each EDI/cancer cell combination,we found that B16 cells produced the highest EDI prodrug immunogenicity,achieving>95% of that elicited by unmodified resiquimod,followed by TC2 and 4T1 cells(40% and 30%,respectively).Immunogenicity elicited was comparable for a given cell type and independent of the glycosidase substrate in the EDIs or differences in functional glycosidase activity between cell lines.Measuring drug efflux of the immunostimulant payload and efflux protein expression revealed that EDI/cancer cell-mediated immunogenicity was governed by efflux potential of the cancer cells.We determined that,following EDI conversion,immunostimulant efflux occurred through both P-glycoprotein-dependent and P-glycoprotein-independent transport mechanisms.Overall,this study highlights the broad ability of EDIs to couple immunogenicity to the metabolism of many cancers that exhibit drug efflux and suggests that designing future generations of EDIs with immunostimulant payloads that are optimized for drug efflux could be particularly beneficial. | Austin T Ryan Anunay J Pulukuri Maryam Davaritouchaee Armina Abbasi Aaron T Hendricksen Larissa K Opp Anthony J Burt Amy E Nielsen Rock J Mancini | 2020 | Acta Pharmacologica Sinica2020，41，7： | 1 |
| 16 | Levetiracetam in children with refractory epilepsy: a multicenter open label study in Germany 显示文摘 | Opp J Tuxhorn I May T Kluger G Wiemer-Kruel A Kurlemann G | 2005 | Seizure2005，14，7： | 1 |
| 17 | Rating Agencies in the Face of Regulation显示文摘 | Opp Christian C Opp Marcus M Harris Milton | 2013 | Journal of Financial Economies2013，108，1： | 1 |
| 18 | Intercellular adhesion molecule-1expression induced by interleukin (IL)-1 β or IL-1β fragment is blocked by an IL-1 receptor antagonist and a soluble IL-1 receptor显示文摘 | Hong L Imeri L Opp MR | 1993 | J Neuroimmunol1993，44，： | 1 |
| 19 | Evaluation of the utility of computed tomo- graphy in the initial assess ment of the critical care pa- tient with chest trauma显示文摘 | Guerrero-Lopez F Vazguez-Mata G A Leazar-Romer- opp | 2000 | Crit Care Med2000，28，5： | 1 |
| 20 | Variation in laboratory oviposition by Rhagoletis pomonella (Diptera: Tephritidae) in relation to mating status显示文摘 | Opp S B Prokopy R J | 1986 | Annals of the Entomological Society of America1986，79，4： | 1 |
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