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| 1 | Caloric test and video - head -impulse: a study of vertigo/dizziness patients in a communityhospital显示文摘 | Mahringer A Rambold HA | 2013 | Eur Arch Otorhinolaryngol2013，271，： | 1 |
| 2 | Glutaric aciduria type Ⅰ and methylmalonic aciduria:simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in in vitro models of the blood-brain barrier and the choroid plexus显示文摘 | Sauer SW Opp S Mahringer A | | 0，，06： | 1 |
| 3 | The pivotal role of astrocytes in an in vitro stroke model of the blood brain bar rier显示文摘 | Neuhaus W Gaiser F Mahringer A | 2014 | Front Cell Neurosci2014，8，： | 1 |
| 4 | Relation of video-head -impulse test and caloric irrigation: a study on the re-covery in unilateral vestibular neuritis显示文摘 | Zellhuber S Mahringer A Rambold HA | 2013 | Eur Arch Otorhi-nolaryngol2013，，： | 1 |
| 5 | The ABC of the blood-brain barrier--regulation of drug efflux pumps 显示文摘 | Mahringer A Ott M Reimold I | 2011 | Curr Pharm Des2011，17，26： | 1 |
| 6 | Relation of video-head-impulse test and caloric irri- gation: a study on the recovery in unilateral vestibular neuritis显示文摘 | ZELLHUBER S MAHRINGER A RAMBOLD H A | 2014 | Eur Arch Otorhinolaryngol2014，271，： | 1 |
| 7 | Cytotoxicity and P-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa 显示文摘 | Adams M Mahringer A Kunert O | 2007 | Planta Med2007，73，15： | 1 |
| 8 | Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa显示文摘 | ADAMS M MAHRINGER A KUNERT O | 2007 | Planta M ed2007，73，15： | 1 |
| 9 | BCRP at the blood-brain barrier: genomic regulation by 17beta-estradiol 显示文摘 | Mahringer A Fricker G | 2010 | Mol Pharm2010，7，： | 1 |
| 10 | Cytotoxicity and P-glycoprotein modulating effects of quinolones and indoloquinazolines fi'om the Chinese herb Evodia rutaecarpa 显示文摘 | Adams M Mahringer A Ktmert O | 2007 | PlantaMed2007，73，15： | 1 |
| 11 | Glutaric aciduria type I and methylmalonic aciduria:simulation of cerebral import and export of accumulating neurotoxic dicarboxylic acids in vitro models of the blood-brain barrier and the choroid plexus显示文摘 | Sauer SW Opp S Mahringer A | 2010 | Biochim Biophys Acta2010，1802，6： | 1 |
| 12 | A fluorescence-based in vitro assay for drug interactions with breast cancer resistance protein (BCRP, ABCG2)显示文摘 | Mahringer A Belzer J Fricker G | 2009 | Eur J Pharm Biopharm2009，72，3： | 1 |
| 13 | Cytotoxicity and p-glycoprotein modulating effects of quinolones and indoloquinazolines from the Chinese herb Evodia rutaecarpa显示文摘 | Adams M Mahringer A Kunert O | | 0，，15： | 1 |
| 14 | 17-beta-Estradiol: a powerful modulator of blood-brain barrier BCRP activity显示文摘 | Hartz AM Mahringer A Miller DS etal | 2010 | J Cereb Blood Flow Metab2010，30，10： | 1 |
| 15 | Inhibition of P-glycoprotein by two artemisinin derivatives显示文摘P-Glycoprotein/MDR1 represents an important component of the blood brain barrier and contributes to multidrug resistance.We investigated two derivatives of the anti-malarial artemisinin,SM616 and GHP-AJM-3/23,concerning their ability to interact with P-glycoprotein.The ability of the two compounds to inhibit P-glycoprotein(P-gp)activity was examined in sensitive CCRF-CEM and P-gp over-expressing and multidrug-resistant CEM/ADR5000 cells as well as in porcine brain capillary endothelial cells(PBCEC)by means of calcein-AM assays.Verapamil as well-known P-gp inhibitor was used as control drug.CEM/ADR5000 cells exhibited cross-resistance to GHP-AJM-3/23,but slight collateral sensitivity to SM616.Furthermore,SM616 inhibited calcein efflux both in CEM/ADR5000 and PBCEC,whereas GHP-AJM-3/23 did only increase calcein fluorescence in PBCEC,but not CEM/ADR5000.This may be explained by the fact that CEM/ADR5000 only express P-gp but not other ATP-binding cassette transporters,whereas PBCEC are known to express several ABC transporters and calcein is transported by more than one ABC transporter.Hence,SM616 may be the more specific P-gp inhibitor.In conclusion,the collateral sensitivity of SM616 as well as the inhibition of calcein efflux in both CEM/ADR5000 cells and PBCEC indicate that this compound may be a promising P-gp inhibitor to treat cancer therapy and to overcome the blood brain barrier. | Babette STEGLICH Anne MAHRINGER Ying LI Gary H.POSNER Gert FRICKER Thomas EFFERTH | 2012 | Natural Products and Bioprospecting2012，2，2： | 0 |
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