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| 1 | Methods to produce induced pluripotent stem cell-derived mesenchymal stem cells: Mesenchymal stem cells from induced pluripotent stem cells显示文摘Mesenchymal stem cells(MSCs)have received significant attention in recent years due to their large potential for cell therapy.Indeed,they secrete a wide variety of immunomodulatory factors of interest for the treatment of immune-related disorders and inflammatory diseases.MSCs can be extracted from multiple tissues of the human body.However,several factors may restrict their use for clinical applications:the requirement of invasive procedures for their isolation,their limited numbers,and their heterogeneity according to the tissue of origin or donor.In addition,MSCs often present early signs of replicative senescence limiting their expansion in vitro,and their therapeutic capacity in vivo.Due to the clinical potential of MSCs,a considerable number of methods to differentiate induced pluripotent stem cells(iPSCs)into MSCs have emerged.iPSCs represent a new reliable,unlimited source to generate MSCs(MSCs derived from iPSC,iMSCs)from homogeneous and well-characterized cell lines,which would relieve many of the above mentioned technical and biological limitations.Additionally,the use of iPSCs prevents some of the ethical concerns surrounding the use of human embryonic stem cells.In this review,we analyze the main current protocols used to differentiate human iPSCs into MSCs,which we classify into five different categories:MSC Switch,Embryoid Body Formation,Specific Differentiation,Pathway Inhibitor,and Platelet Lysate.We also evaluate common and method-specific culture components and provide a list of positive and negative markers for MSC characterization.Further guidance on material requirements to produce iMSCs with these methods and on the phenotypic features of the iMSCs obtained is added.The information may help researchers identify protocol options to design and/or refine standardized procedures for large-scale production of iMSCs fitting clinical demands. | Victoria Dupuis Elisa Oltra | 2021 | World Journal of Stem Cells2021，13，8： | 2 |
| 2 | Extragonadal nongestational choriocarcinoma involving the lung: a report of three cases显示文摘 | Aparicio J Oltra A Martinez-Moragon E | 1996 | Respiration1996，63，4： | 1 |
| 3 | A review of the probabilistic aspects of localized corrosion显示文摘 | GABRIELLI C HUET F KEDDAM M KEDDAM M OLTRA R | 1990 | Corrosion1990，46，4： | 1 |
| 4 | Dissolution of chromium-enriched inclusions and pitting corrosion of resulfurized stainless steels显示文摘 | H. Krawiec V. Vignal O. Heintz R. Oltra H. Krawiec E. Chauveau | 2006 | Metallurgical and Materials Transactions A2006，，5： | 1 |
| 5 | The influence of firms technological capabilities on export performance in supplier-dominated industries显示文摘 | FLOR M OLTRA M J | 2005 | R&D management2005，25，3： | 1 |
| 6 | Ini, a small nuclear protein that enhances the response of the connexin43 gene to estrogen显示文摘 | Oltra E Pfeifer I Wemer R | 2003 | Endocrinology2003，144，： | 1 |
| 7 | Identification of innovating finns through technological innovation indicators: An application to the Spanish ceramic tile industry 显示文摘 | FLOR M L OLTRA M J | 2004 | Research Policy2004，，33： | 1 |
| 8 | Catastrophic antiphospholipid syndrome related to severe ovarian hyperstimulation显示文摘 | Giner V Oltra MR Esteban MJ | 2007 | Clinical rheumatology2007，26，6： | 1 |
| 9 | Antioxi- dant enzyme activities and the production of MDA and 8-oxo- dG in chronic lymphocytic leukemia显示文摘 | OLTRA AM CARBONELL F TORMOS C | 2001 | Free Radic Biol Med2001，30，11： | 1 |
| 10 | Positional assembly of enzymes in polymersome nanoreactors for cascade reactions显示文摘 | Vriezema D M Garcia P M L Oltra N S | 2007 | Angew Chem Int Ed2007，46，39： | 1 |
| 11 | Sectoral systems of environmental innovation: An application to the French automotive industry显示文摘 | Vanessa Oltra Ma?der Saint Jean | 2008 | Technological Forecasting & Social Change2008，，4： | 1 |
| 12 | Sectoral systems of environmental inno- vation: an application to the French automotive industry 显示文摘 | OLTRA V SAINT JEAN M | 2009 | Tech- nological Forecasting and Social Change2009，76，4： | 1 |
| 13 | Cut-edge corrosion of a Zn-55Al-coated steel: A comparison between sulphate and chloride solutions 显示文摘 | VU A Q VUILLEMIN U OLTRA R ALLELY C | 2011 | Corrosion Science2011，53，： | 1 |
| 14 | Metastatic follicular thyroid carcinoma to the kidney: a case report显示文摘 | Garcia-Sanchis L Lopez-Aznar D Oltra A | 1999 | Clin Nucl Med1999，24，1： | 1 |
| 15 | SVET, AFM and AES study of pitting corrosion initi- ated on MnS inclusions by microinjection显示文摘 | VUILLEMIN B PHILIPPE X OLTRA R | 2002 | Corro- sion Science2002，45，6： | 1 |
| 16 | Sectoral systems of environmental innovation:an application to the French automotive industry显示文摘 | OLTRA V SAINT JEAN M | | 0，，04： | 1 |
| 17 | Influence of an elastic stress on the conductivity of passive films显示文摘 | Vignal V Oltra R Verneau M | 2001 | Materials Science and Engineering A2001，303，12： | 1 |
| 18 | Influence of an elastic stress on the conductivity of passive films显示文摘 | VIGNAL V OLTRA R VERNEAU M | 2001 | Materials Science and Engineering: A2001，303，12： | 1 |
| 19 | Understanding the exceptional hydrogen-atom donor characteristics of water in Ti(III)-mediated free-radical chemistry显示文摘 | PARADAS M CAMPANA A G JIMENEZ T ROBLES R OLTRA J E BUNUEL E JUSTICIA J CARDENAS D J CUERVA J M | 2010 | Journal of the American Chemical Society2010，132，12： | 1 |
| 20 | Advances in local electrochmical techniques for detecting pitting corrosion显示文摘 | Vignal V Oltra R Mary N | 2004 | Corrosion2004，28，3： | 1 |
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