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| 1 | Two strategies for prevention of cytomegalovirus infections after liver transplantation显示文摘AIM: To analyze differences in patients' clinical course, we compared two regimes of either preemptive therapy or prophylaxis after liver transplantation.METHODS: This retrospective study was reviewed and approved by the institutional review board of the University of Leipzig. Cytomegalovirus(CMV) prophylaxis with valganciclovir hydrochloride for liver transplant recipients was replaced by a preemptive strategy in October 2009. We retrospectively compared liver transplant recipients 2 years before and after October 2009. During the first period, all patients received valganciclovir daily. During the second period all patients included in the analysis were treated following a preemptive strategy. Outcomes included one year survival and therapeutic intervention due to CMV viremia or infection.RESULTS: Between 2007 and 2010 n = 226 patients underwent liver transplantation in our center. n = 55 patients were D^+/R^- high risk recipients and were excluded from further analysis. A further 43 patients had to be excluded since CMV prophylaxis/preemptive strategy was not followed although there was no clinical reason for the deviation. Of the remaining 128 patients whose data were analyzed, 60 receivedprophylaxis and 68 were treated following a preemptive strategy. The difference in overall mortality was not significant, nor was it significant for one-year mortality where it was 10%(95%CI: 8%-28%, P = 0.31) higher for the preemptive group. No significant differences in blood count abnormalities or the incidence of sepsis and infections were observed other than CMV. In total, 19 patients(14.7%) received ganciclovir due to CMV viremia and/or infections. Patients who were treated according to the preemptive algorithm had a significantly higher rate risk of therapeutic intervention with ganciclovir [n = 16(23.5%) vs n = 3(4.9%), P = 0.003)].CONCLUSION: These data suggest that CMV prophylaxis is superior to a preemptive strategy in patients undergoing liver transplantation. | Philipp Simon Max Sasse Sven Laudi David Petroff Michael Bartels Udo X Kaisers Sven Bercker | 2016 | World Journal of Gastroenterology2016，22，12： | 5 |
| 2 | Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension显示文摘AIM: To study the mechanism involved in the potentially beneficial effect of ultra low dose aspirin (ULDA) in prehepatic portal hypertension, rats were pretreated with selective COX 1 or 2 inhibitors (SC-560 or NS-398 respectively), and subsequently injected with ULDA or placebo. METHODS: Portal hypertension was induced by portal vein ligation. Platelet activity was investigated with an in-vivo model of laser induced thrombus production in mesenteric circulation and induced hemorrhagic time (IHT). Platelet aggregation induced by ADP and dosing of prostanoid products 6-keto-PGF1α, TXB2, PGE2 and LTB4 were also performed. RESULTS: The portal hypertensive group receiving a placebo showed a decreased in vivo platelet activity with prolonged IHT, an effect that was normalized by ULDA. SC-560 induced a mild antithrombotic effect in the normal rats, and an unmodified effect of ULDA. NS-398 had a mild prothrombotic action in portal hypertensive rats, similar to ULDA, but inhibited a further effect when ULDA was added. An increased 6-keto-PGF1α was observed in portal hypertensive group that was normalised after ULDA administration. TXA2 level after ULDA, remained unchanged. CONCLUSION: These results suggest that the effect of ULDA on platelet activity in portal hypertensive rats, could act through a COX 2 pathway more than the COX 1, predominant for aspirin at higher doses. | Francisco X Eizayaga Omar Aguejouf Vanessa Desplat Philippe Belon Christian Doutremepuich | 2007 | World Journal of Gastroenterology2007，13，38： | 4 |
| 3 | Gaseous emis sions from weaned pigs raised on different floor systems显示文摘 | Cabaraux J F Philippe F X Laitat M | 2009 | Agriculture Ecosystems & Environment2009，130，34： | 1 |
| 4 | Compliance with and effective- ness of adaptive servoventilation versus continuous positive airway pressure in the treatment of Cheyne-Stokes respiration in heart failure over a six month pe- riod显示文摘 | Philippe C Stoica-Herman M Drouot X | 2006 | Heart2006，92，： | 1 |
| 5 | Application of a hybrid finite difference/finite volume method to solve an automotive EMC problem显示文摘 | Ferrieres X Philippe Parmantier J Solange Bertuol | 2004 | IEEE Transactions on Electromagnetic Compatibility2004，40，4： | 1 |
| 6 | Comparison ofammonia and greenhouse gas emission during the fatt-ening of pigs,kept either on ful y slat-ted floor or on deep litter显示文摘 | Philippe F X Laitat M Canart B | | 0，，1： | 1 |
| 7 | SVET, AFM and AES study of pitting corrosion initiated on MnS inclusions by microinjection显示文摘 | Vuillemin B Philippe X Okra R | 2003 | Corrosion Science2003，45，： | 1 |
| 8 | Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation显示文摘 | Yang X M Philipp S Downey J M | 2005 | Basic Res Cardiol2005，100，： | 1 |
| 9 | Postconditioning's protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires PI3-kinaseand guanylyl cyclase activation显示文摘 | YANG X M PHILIPP S DOWNEY J M | 2005 | Basic Res Cardiol2005，100，： | 1 |
| 10 | Postconditioning protects rabbit hearts through a protein kinase C-adenosine A2b receptor cascade显示文摘 | Philipp S Yang X M Cui L | 2006 | Cardiovasc Res2006，70，： | 1 |
| 11 | Ammonia emissions from pig houses: Influencing factors and mitigation techniques显示文摘 | Philippe F X Cabaraux J F Nicks B | 2011 | Agriculture Ecosystems & Environment2011，141，3： | 1 |
| 12 | Compliance with and effectiveness of adaptive servoventilation versus continuous posi- tive airway pressure in the treatment of Cheyne-Stokes respiration in heart failure over a six month period显示文摘 | Philippe C Stoica-Herman M Drouot X | 2006 | Heart2006，92，3： | 1 |
| 13 | Postconditioning's protection is not dependent on circulatin blood factors or cells but involves adenosine receptors and requires PI3-kinase and guanylyl cyclase activation显示文摘 | YANG X M PHILIPP S DOWNEY J M | 2005 | Basic Res Cardiol2005，100，1： | 1 |
| 14 | Ammonia and greenhouse gas emissions during the fattening of pigs kept on two types of straw floor 显示文摘 | Philippe F X Laitat M Nicks B | 2012 | Agr Ecosyst Environ2012，150，： | 1 |
| 15 | Ammonia and greenhouse gas emissions during the fattening of pigs kept on two types of straw floor显示文摘 | Philippe F X Laitat M Nicks B | 2012 | Agriculture Ecosystems and Environment2012，150，： | 1 |
| 16 | Mu opioid recep- tor expression is increased in inflammatory bowel dis- eases:implications for homeostatic intestinal inflamma- tion显示文摘 | Philippe D Chakass D Thuru X | 2006 | Gut2006，55，： | 1 |
| 17 | Isoflurane may not influence postoperative cardiac troponin I release and clinical outcome in adult cardiac surgery 显示文摘 | Fellahi JL Gue X Philippe E | 2004 | Eur Anaesthesiology2004，21，9： | 1 |
| 18 | Postconditioning'S protection is not dependent on circulating blood factors or cells but involves adenosine receptors and requires Pl3-kinase and guanylyl cyclase activation显示文摘 | YANG X M PHILIPP S DOWNEY J M | 2005 | Basic Res Cardiol2005，100，： | 1 |
| 19 | SVET, AFM and AES study of pitting corrosion initi- ated on MnS inclusions by microinjection显示文摘 | VUILLEMIN B PHILIPPE X OLTRA R | 2002 | Corro- sion Science2002，45，6： | 1 |
| 20 | TRPM3 is a nociceptor channel involved in the detection of noxious heat显示文摘 | Vriens J Owsianik G Hofmann T Philipp SE Stab J Chen X | 2011 | Neuron2011，70，3： | 1 |
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