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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | GRIMSEL现场的气体渗透试验(英文)显示文摘自 1976 年以来,日本核废料管理基金会与研究中心(RWMC)一直在进行核废料处置的研究。最近,RWMC非常关注核废料处置库的监测、遥控以及现场勘查技术等重要的社会公众与技术问题。其中,处置库溢出气体是一项重要的安全可靠性评估项目。这项名为“工程屏障的气体渗透试验”(GMT)的研究是在瑞士 Nagra 的 Grimsel现场实验室进行的。GMT 集中研究在粮仓形的处置库中由核废料产生的气体在工程屏障中的渗透问题。在 Grimsel现场,一个按比例缩小的工程屏障库由一个具有透气孔的混凝土仓和砂–膨润土缓冲材料组成,缓冲材料被放置在一个专门建造的洞室中。混凝土仓直径为 2.5 m,高为 2.5 m,放置在直径为 4 m 的从上到下开挖而成的竖井中。在工程屏障饱和及水渗透试验之后,气体分两个阶段被注入地窖中。气体第一次被注入之后,重复进行水渗透试验,以便观察工程屏障库的变化。第二次气体注入的时候,在工程屏障及岩石圈中采用一种可以多点取样的鸡尾酒气体跟踪器。在气体注入之后,小心挖掘出工程屏障库,然后用各种方法来进行鉴定,并采用实验室以及建模程序来进行现场的模拟研究。 | Fujiwara A Okamoto S Tsuboya T Vomvoris S Marschall P Ando K Shimura T | 2006 | 岩石力学与工程学报2006，25，4： | 2 |
| 3 | Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts显示文摘 | T Komori H Yagi S Nomura A Yamaguchi K Sasaki K Deguchi Y Shimizu R.T Bronson Y.-H Gao M Inada M Sato R Okamoto Y Kitamura S Yoshiki T Kishimoto | 1997 | Cell1997，，5： | 2 |
| 4 | Indoleamine 2, 3-dioxygenase serves as a marker of poor prognosis in gene expression profiles of serous ovarian cancer cells显示文摘 | Okamoto A Nikaido T Ochiai K | 2005 | Clin Cancer Res2005，11，： | 1 |
| 5 | Effect of sulfidation temperature on the intrinsic activity of Co-MoS2 and Co-WS2 hydrodesulfurization catalysts显示文摘 | Okamoto Y Kato A Usman | 2009 | Journal of Catalysis2009，265，： | 1 |
| 6 | Chemical approach toward efficient DNA methylation analysis显示文摘 | Okamoto A | 2009 | Organic & Biomolecular Chemistry2009，7，1： | 1 |
| 7 | Trichostatin A, an inhibitor of histone deacetylase,inhibits smooth muscle cell proliferation via induction of p21 (WAF1) 显示文摘 | Okamoto H Fujioka Y Takahashi A Takahashi T Taniguchi T Ishikawa Y | 2006 | J Atheroscler Thromb2006，13，： | 1 |
| 8 | Heat shock pro- tein 27 was up- regulated in Cisplatin resistant human ovarian tumor cell line and associated with the Cisplatin resistance 显示文摘 | Yamamoto K Okamoto A Isonishi S | 2001 | Cancer Lett2001，168，2： | 1 |
| 9 | Induction of actinorhodin by rpaL(Eneoding ribosomal protein S12)mutations that confer streptomyein resistance in Streptomyces lividans and streptomyces coelicolor A3(2) 显示文摘 | Shima J Hesketh A Okamoto S | 1996 | J Bacteriol1996，178，： | 1 |
| 10 | Bondinteraction between concrete pavement and lean concrete base显示文摘 | SCOTT M TARR PAUL A OKAMOTO MATTHEW J SHEEHAN ROBERT G PACKARD | 1999 | Transportation Research Record 16681999，，： | 1 |
| 11 | Plasmid-encoded metallo-beta-lactamase(IMP-6) conferring resistance to carbapenems, especially meropenem显示文摘 | Yano H Kuga A Okamoto R | 2001 | Antimicrob Agents Chemother2001，45，： | 1 |
| 12 | Non-recurrent inferior laryngeal nerve with multiple arterial abnormalities 显示文摘 | Kobayashi M Yuta A Okamoto K | 2007 | Acta Otolaryngol2007，127，3： | 1 |
| 13 | Etodolac, a selective cyclooxygenase-2 inhibitor, induces upregulation of E- cadherin and has antitumor effect on human bladder cancer cell- sin vitroandin vivo 显示文摘 | OKAMOTO A SHIRAKAWA T BITO T | 2008 | Urology2008，71，： | 1 |
| 14 | Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction显示文摘 | Sato K Suematsu A Okamoto K | 2006 | J Exp Med2006，203，： | 1 |
| 15 | Phase I and pharmaco- kinetic study of ammbiein, a synthetic 9 - aminoanthraeyeline, in patients with refractory or relapsed lung cancer显示文摘 | Okamoto I Hamada A Matsunaga Y | 2006 | Cancer Chemoth- er Pharmacol2006，57，： | 1 |
| 16 | Combination Therapy with Infliximab and Thiopurine Compared to Infliximab Monotherapy in Maintaining Remission of Postoperative Crohn's Disease显示文摘 | Sakuraba A Okamoto S Matsuoka K | 2015 | Digestion2015，91，3： | 1 |
| 17 | Olfactometric characterization of aroma active compounds in fermented fish paste in co MParison with fish sauce, fermented soy paste and sauce products显示文摘 | Giri A Osako K Okamoto A | 2010 | Food Research International2010，43，4： | 1 |
| 18 | Ongoing subclinical infection of hepatitis E virus a- mong blood donors with an elevated alanine amin- otransferase level in Japan显示文摘 | Gotanda Y Iwata A Ohnuma H Yoshikawa A Mizoguchi H Endo K Takahashi M Okamoto H | 2007 | Journal of Medical Vi- rology2007，79，6： | 1 |
| 19 | Reducing Elliptic Curve Logarithms to Logarithms in a Finite Field显示文摘 | Menezes A Okamoto T Vanstone S | 1993 | IEEE Trans on Information Theory1993，39，5： | 1 |
| 20 | A novel peculiar mutation in the sodium/iodide symporter gene in Spanish siblings with iodide transport defect显示文摘 | Koangi S Okamoto H Tamada A | 2002 | J Clin Endocrinol Metab2002，87，8： | 1 |
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