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22篇 您的检索式：作者名="Oheim"

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	题名	作者	年代	出处	被引量
1	Metaphyseal fracture healing in a sheep model of low turnover osteoporosis induced by hypotha- lamic - pituitary disconnection ( HPD ) 显示文摘	Bindl R Oheim R Pogoda P	2013	Journal Orthopaedic Research2013，31，11：	1
2	Calcium microdomaius in regulated exocytosis显示文摘	Oheim M Kirchhoff F Stuhmer W	2006	Cell Calcium2006，40，56：	1
3	Fluorescence imaging with two-photon evanescent wave excitation显示文摘	Schapper F Goncalves J T Oheim M	2003	Eur Biophys J2003，32，7：	1
4	Arthroscopic-assisted hook plate fixation for acromioclavicular joint dislocation显示文摘	Justus Gille Gerhard Heinrichs Andreas Unger Helge Riepenhof Jan Herzog Benjamin Kienast Ralf Oheim	2013	International Orthopaedics2013，，1：	1
5	The WNT1^(G177C) mutation specifically affects skeletal integrity in a mouse model of osteogenesis imperfecta type XV显示文摘The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV(OI-XV)has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts.Although such aninfluence was supported by subsequent studies,a mouse model of OI-XV remained to be established.Therefore,we introduced a previously identified disease-causing mutation(G177C)into the murine Wnt1 gene.Homozygous Wnt1^(G177C/G177C)mice were viable and did not display defects in brain development,but the majority of 24-week-old Wnt1^(G177C/G177C)mice had skeletal fractures.This increased bone fragility was not fully explained by reduced bone mass but also by impaired bone matrix quality.Importantly,the homozygous presence of the G177C mutation did not interfere with the osteoanabolic influence of either parathyroid hormone injection or activating mutation of LRP5,the latter mimicking the effect of sclerostin neutralization.Finally,transcriptomic analyses revealed that short-term administration of WNT1 to osteogenic cells induced not only the expression of canonical WNT signaling targets but also the expression of genes encoding extracellular matrix modifiers.Taken together,our data demonstrate that regulating bone matrix quality is a primary function of WNT1.They further suggest that individuals with WNT1 mutations should profit from existing osteoanabolic therapies.	Nele Vollersen Wenbo Zhao Tim Rolvien Fabiola Lange Felix Nikolai Schmidt Stephan Sonntag Doron Shmerling Simon von Kroge Kilian Elia Stockhausen Ahmed Sharaf Michaela Schweizer Meliha Karsak Bjorn Busse Ernesto Bockamp Oliver Semler Michael Amling Ralf Oheim Thorsten Schinke Timur Alexander Yorgan	2021	Bone Research2021，9，4：	1
6	Optimum solutions for cold - storage flooring and central frost -heave protective heating systems 显示文摘	Oheim H	1992	International Journal of Refrigeration1992，15，3：	1
7	Fluorescence imaging with two-photo evanescent wave excitation显示文摘	Schapper F Gonslves J T Oheim M	2003	European Biophysics Journal2003，32，：	1
8	Sheep model for osteoporosis: sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic -pituitary disconnection显示文摘	Oheim R Beil FT K?hne T	2013	J Orthop Res2013，31，7：	1
9	Tracking chromaffin granules on their way through the actin cortex显示文摘	Martin Oheim Walter Stühmer	2000	European Biophysics Journal2000，，2：	1
10	显示文摘	SCHAPPER F GONCALVES J T OHEIM M	2003	Eur J Biophys2003，32，：	1
11	Sheep model for osteoporosis:sustainability and biomechanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection显示文摘	OHEIM R BEIL F T KOHNE T	2013	J Orthop Res2013，31，7：	1
12	Large animal model for osteoporosis in humans: the ewe显示文摘	Oheim R Amling M Ignatius A	2012	Eur Cell Mater2012，，24：	1
13	Sbeep model for osteoporosis: sustainability and biomecbanical relevance of low turnover osteoporosis induced by hypothalamic-pituitary disconnection 显示文摘	Oheim R Bei! FT Kohne T	2013	J Orthop Res2013，31，7：	1
14	Tracking chromaffin granules on their way through the actin cortex显示文摘	Martin Oheim Walter Stühmer	2000	European Biophysics Journal2000，，2：	1
15	Spontaneous os- teonecrosis of the knee(SONK)显示文摘	Breer S Oheim R Krause M	2012	Knee Serg Sport Trau- matol Arthrosc2012，，8：	1
16	Teasing apart the effects of taphonomic and sampling bias on species diversity estimates using GIS显示文摘	CHEW A OHEIM K	2007	Journal of Vertebrate Paleontology2007，27，3：	1
17	Imaging transmitter release Ⅱ: a practical guide to evanescentwave imaging显示文摘	Oheim M	2001	Asers Med Sci2001，16，3：	1
18	Two-photon micrscopy in brain tissue:parameters influencing the imaging depth显示文摘	OHEIM M BEAUREPAIRE E CHAIGNEAU E	2001	J Neurosci Methods2001，111，1：	1
19	Two-photon microscopy in brain tissue: parameters influencing the imaging depth显示文摘	Oheim M B Chaigneau E Mertz J	2001	Neurosci Methods2001，111，9：	1
20	Large animal models of osteoporosis显示文摘	Oheim R Beil FT Barvencik F	2011	Osteologie2011，20，：	1

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