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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | 星形胶质细胞和嗅鞘细胞之间的Panglial缝隙连接介导Ca^(2+)瞬变的传递和神经血管耦合显示文摘星形胶质细胞排列在有高度组织性的缝隙连接耦合网络中,通过Ca^(2+)波的传播进行通信。星形胶质细胞不仅与邻近的星形胶质细胞结合,而且还与少突胶质细胞偶联,形成panglial合胞体。但panglial合胞体中的神经胶质细胞是否通过Ca^(2+)信号传递信息尚不清楚。我们使用共聚焦Ca^(2+)成像来研究小鼠嗅球中星形胶质细胞和嗅鞘神经胶质细胞(OECs)之间的细胞间通讯。研究结果表明,通过'笼状' ATP和'笼状' tACPD的局部光解可引起的肾小球旁星形胶质细胞中的Ca^(2+)瞬变,导致OEC中随之而来的Ca^(2+)反应。这种从星形胶质细胞到OEC的Ca^(2+)反应的传递在神经元抑制的情况下持续存在,但是当用甘珀酸抑制缝隙连接偶联时消失。当通过DHPG的抽吸在OEC中直接诱发Ca^(2+)瞬变时,它们导致肾小球星形胶质细胞中的Ca^(2+)反应延迟,表明Ca^(2+)信号的panglial传递以双向方式发生。此外,从星形胶质细胞到OEC的Ca^(2+)信号的panglial传递导致嗅觉神经层中OEC相关血管的收缩。本研究结果证明了在缝隙连接耦合的panglial网络中,不同类别的神经胶质细胞之间通过Ca^(2+)进行信号传递,并借此调节嗅球中血管的直径。 | Beiersdorfer A Scheller A Kirchhoff F Lohr C 聂昊 | 2019 | 神经损伤与功能重建2019，14，3： | 2 |
| 3 | Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion 显示文摘 | Kirchhoff K Machicao F Haupt A | 2008 | Diabetologia2008，51，4： | 1 |
| 4 | Calcium microdomaius in regulated exocytosis显示文摘 | Oheim M Kirchhoff F Stuhmer W | 2006 | Cell Calcium2006，40，56： | 1 |
| 5 | AN2/NG2 protein-expressing glial progenitor cells in the murine CNS:isolation,differentiation,and association with radial glia显示文摘 | Diers-Fenger M Kirchhoff F Kettenmann H | 2001 | Glia2001，34，3： | 1 |
| 6 | Resting mieroglial cells are highly dynamic surveillants of brain parenchyma in vivo 显示文摘 | Nimmerjahn A Kirchhoff F Helmchen F | 2005 | Science2005，308，： | 1 |
| 7 | NMDA receptors mediate neuron-to-glia signaling in mouse cortical astrocytes显示文摘 | Lalo U Pankratov Y Kirchhoff F North RA Verkhratsky A | 2006 | J Neurosci2006，26，10： | 1 |
| 8 | Pathways of neuronastrocyte interactions and their possible role in neuroprotection 显示文摘 | Kirchhoff F Dringen R Giaume C | 2001 | Eur Arch Psychiatry Clin Neurosei2001，251，： | 1 |
| 9 | AN2/NG2 protein-expressing glial progenitor cells in the murine CNS:isolation,differentiation,and association with radial glia显示文摘 | Diers-Fenger M Kirchhoff F Kettenmann H | 2001 | Glia2001，34，3： | 1 |
| 10 | Pathways of neuron-astrocyte interactions and their possible role in neuroprotection显示文摘 | Kirchhoff F Dringen R Giaume C | 2001 | Eur Arch Psychiatry Clin Neurosci2001，251，4： | 1 |
| 11 | Energetics and Electronic Structure of Silver Chloride显示文摘 | Kirchhoff F Holender J M Gillan M J | 1994 | Phys Rev B1994，49，17： | 1 |
| 12 | Mannitol-sucrose mixtures: versatile formulations for protein lyophilization显示文摘 | JOHNSON R E KIRCHHOFF C F GAUD H T | 2002 | Journal of Pharmaceutical Sciences2002，91，4： | 1 |
| 13 | Percutaneous core needle biopsy versus open biopsy in diagnostics of bone and soft tissue sarcoma: a retrospective study显示文摘 | Pohlig F Kirchhoff C Lenze U | 2012 | Eur J Med Res2012，17，： | 1 |
| 14 | Glutamat-triggered calcium signaling in mouse bergann glial cells in situ:role of inositol-1,4,5-trisphosphate-mediated intracellular calcium release显示文摘 | Kirschuk S Kirchhoff F Matyash V | 1999 | Neurosci1999，92，3： | 1 |
| 15 | Brief report : absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection 显示文摘 | KIRCHHOFF F GREENOUGH T C BRETTLER D B | 1995 | N Engl J Med1995，332，4： | 1 |
| 16 | Polymorphisms in the TCF7L2,CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion显示文摘 | Kirchhoff K Machicao F Haupt A | | 0，，： | 1 |
| 17 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo显示文摘 | NIMMERJAHN A KIRCHHOFF F HELMCHEN F | 2005 | Science2005，308，5726： | 1 |
| 18 | Resting mi-croglial cells are highly dynamic surveillants of brain pa-renchyma in vivo显示文摘 | Nimmerjahn A Kirchhoff F Helmchen F | 2005 | Science2005，308，5726： | 1 |
| 19 | Immunohistological localization of the adhesion molecules L1, N-CAM, and MAG in the developing and adult optic nerve of mice 显示文摘 | Bartsch U Kirchhoff F Schachner M | 1989 | J Comp Neural1989，284，3： | 1 |
| 20 | Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo显示文摘 | Nimmerjahn A Kirchhoff F Helmchen F | 2005 | Science2005，308，： | 1 |
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