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118篇 您的检索式：作者名="Oertle"

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	题名	作者	年代	出处	被引量
1	Endothelial adhesion of synchronized gastric tumor cells changes during cell cycle transit and correlates with the expression level of CD44 splice variants显示文摘AIM: To study adhesion capacity and CD44 expression of human gastric adenocarcinoma MKN45 cells at different stages of a first cell cycle.METHODS: MKN45 cells were synchronized by aphidicolin and assayed for adhesion to an endothelial cell (HUVEC)monolayer. Surface expression of CD44 and CD44 splice variants on MKN45 cells was evaluated by flow cytometry.Functional relevance of CD44 adhesion receptors was investigated by blocking studies using anti CD44 monoclonal antibodies or by hyaluronan digestion.RESULTS: Adhesion of MKN45 to HUVEC was increased during G2/M transit, after which adhesion returned to baseline levels with cell cycle completion. In parallel, CD44splice variants CD44v4, CD44v5, and CD44v7 were all upregulated on MKN45 during cell cycle progression with a maximum effect in G2/M. The function of CD44 surface receptors was assessed with specific receptor blocking monodonal antibodies or removal of hyaluronan by digestion with hyaluronidase. Both strategies inhibited tumor cell adhesion to HUVEC by nearly 50%, which indicates that MKN45-HUVEC-interaction is CD44 dependent.CONCLUSION: CD44 expression level is linked to the cell cycle in gastrointestinal tumor cells, which in turn leads to cell cyde dependent alterations of their adhesion behaviour to endothelium.	Anton Oertl Jens Castein Tobias Engl Wolf-Dietrich Beecken Dietger Jonas Richard Melamed Roman A. Blaheta	2005	World Journal of Gastroenterology2005，11，40：	3
2	Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4显示文摘	Oertle T Huber C van der Putten H	2003	J Mol Biol2003，325，2：	1
3	Analysis of the reticulon gene family demonstrates the absence of the neurite growth inhibitor Nogo A in fish显示文摘	Diekmann H Klinger M Oertle T	2005	Mol Biol Evol2005，，：	1
4	Percutaneous transluminal angioplasty of crural arteries显示文摘	Horvath W Oertl M Haidinger D	1990	Radiology1990，177，2：	1
5	Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions显示文摘	Oertle T van der Haar ME Bandtlow CE	2003	J Neurosci2003，23，13：	1
6	Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Rac1显示文摘	Niederost B Oertle T Fritsche J McKinney RA Bandtlow CE	2002	J Neurosci2002，22，10：	1
7	Nogo-A and Myelin-associated Glycoprotein Mediate Nenrite Growth Inhibition by Antagonistic Regulation of RhoA and Racl 显示文摘	Niederost B Oertle T Fritsehe J	2002	Neurosci (S0270-6474)2002，22，10：	1
8	Value of repeated fine needle aspirations of the thyroid:an analysis of over ten thou-sand FNAs显示文摘	Oertl YC Miyahara-Felipe L Mendoza MG	2007	Thyroid2007，17，20：	1
9	Nogo and its paRTNers 显示文摘	OERTLE T SCHWAB M E	2003	Trends Cell Biol2003，13，4：	1
10	Nogo-A and myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Racl 显示文摘	Niederost B Oertle T Ffitsche J McKinney RA Bandtlow CE	2002	J Neurosci2002，22，10：	1
11	Nogo-A and Myelin-associated glycoprotein mediate neurite growth inhibition by antagonistic regulation of RhoA and Racl显示文摘	Niederost B Oertle T Fritsche J		0，，：	1
12	Versican V2 and the central inhibitory domain of Nogo-A inhibit neurite growth via p75NTR/ NgR-independent pathways that converge at RhoA 显示文摘	Schweigreiter R Walmsley AR Niederost B Zimmermann DR Oertle T Casademunt E	2004	Mol Cell Neurosci2004，27，2：	1
13	Genomic structure and functional characterization of the promoters of human and mouse nogo/rtn4 显示文摘	Oertle T Huber C Vanderputten H	2003	J MolBiol2003，325，2：	1
14	Nogo and its partners显示文摘	Oertle T Schwab ME	2003	Trends Cell Biol2003，13，：	1
15	Genomic structure and functional characterisation of the promoters of human and mouse Nogo/rtn4 显示文摘	Huber C van der Putten H	2003	J Mol Biol2003，325，2：	1
16	Genomic structure and functional charaeterisation of the promoters of human and mouse nogo/rtn4显示文摘	Oertle T Huber C Vanderputten H	2003	J Mol Biol2003，325，2：	1
17	A reticular rhapsody : phylogenic evolution and nomenclature of the RTN/Nogo gene family 显示文摘	Oertle T Klinger M Stuermer CA	2003	FASEB J2003，17，10：	1
18	Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions显示文摘	Oertle T van der Haar ME Bandtlow CE	2003	J Neurosci2003，23，13：	1
19	Genornic struc- ture and functional characterisation of the promoters of human and mouse Nogo/RTN4显示文摘	OERTLE T HUBER C VAN DER P H	2003	Journal of molecular biology2003，325，2：	1
20	Genomic structure and funtional characterisation of the promoters of human and mouse nogo/rtn 4显示文摘	Oertle T Huber C van der Putten H	2003	J Mol Biol2003，325，2：	1

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