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| 1 | 日本东北9.0级地震的同震与震后滑动显示文摘大部分强震都发生在海沟,那里是海洋板块向大陆板块俯冲的地方。大量矩震级MW9.0以上的地震发生在若干区域,包括智利,阿拉斯加,堪察加半岛和苏门答腊岛等。位于太平洋板块俯冲鄂霍茨克板块的日本海沟,历史记载上没有发生过MW9.0地震,除了至今震级还有争议的公元869年Jogan大地震[1](可能超过MW9.0)。然而,根据最新的大地测量资料估算的应变积累速率比已发生的板块间地震的平均释放速率要高[2~6]。这一发现又引发了这样的疑问:这些区域如何释放积累的应变。2011年3月11日发生的逆冲型MW9.0强震(下文中均称为日本东北大地震),撕裂了日本东北部的太平洋海岸板块边界。我们报道根据GPS网络监测到的地表位移确定的同震与震后滑动特征。同震滑移区域沿日本海沟方向长约400 km,与震前闭锁区域基本吻合[4]。震后滑动不仅覆盖了同震滑移区域,而且扩展到了其邻区,甚至其影响已经达到100 km深度区域,引起2011年3月25日的MW8.3地震。由于东北地震释放了积累数百年的应变,之前提到的应变积累与释放不平衡的问题可能得到部分解释。这次东北地震同时也提醒我们,即使在过去没有发生过强震的其它海沟地区,也有发生MW9.0强震的潜在危险。因此,利用空间对地形变观测技术监测应变积累,以确定强震潜在危险区是非常重要的。 | Shinzaburo Ozawa Takuya Nishimura Hisashi Suito Tomokazu Kobayashi Mikio Tobita Tetsuro Imakiire 张慧(译) 焦明若(校) | 2011 | 华南地震2011，31，3： | 30 |
| 2 | Perivascular nitric oxide activates notch signaling and promotes stem-like character in PDGF-induced glioma cells显示文摘 | Charles N Ozawa T Squatrito M Bleau AM Brennan CW Hambardzumyan D Holland EC. | 2010 | 中国神经肿瘤杂志2010，8，1： | 24 |
| 3 | Imaging of community-acquired pneumonia: Roles of imaging examinations, imaging diagnosis of specific pathogens and discrimination from noninfectious diseases显示文摘This article reviews roles of imaging examinations in the management of community-acquired pneumonia(CAP), imaging diagnosis of specific CAP and discrimination between CAP and noninfectious diseases. Chest radiography is usually enough to confirm the diagnosis of CAP, whereas computed tomography is required to suggest specific pathogens and to discriminate from noninfectious diseases. Mycoplasma pneumoniae pneumonia, tuberculosis, Pneumocystis jirovecii pneumonia and some cases of viral pneumonia sometimes show specific imaging findings. Peribronchial nodules, especially tree-in-bud appearance, are fairly specific for infection. Evidences of organization, such as concavity of the opacities, traction bronchiectasis, visualization of air bronchograms over the entire length of the bronchi, or mild parenchymal distortion are suggestive of organizing pneumonia. We will introduce tips to effectively make use of imaging examinations in the management of CAP. | Atsushi Nambu Katsura Ozawa Noriko Kobayashi Masao Tago | 2014 | World Journal of Radiology2014，6，10： | 15 |
| 4 | 鼠Ⅱ型糖尿病减弱种植体骨整合能力的实验研究显示文摘目的:Ⅱ型糖尿病(成人非胰岛素依赖性糖尿病)是临床上的常见病,但有关此类病变对种植体骨整合能力影响的相关动物模型研究仍少见报道。为此本实验在Ⅱ型糖尿病鼠模型上,从组织学和组织形态测量学的角度检测钛种植体周围骨愈合的情况。方法:特制的中空钛种植体被植入普通雄鼠和经基因修饰的Ⅱ型糖尿病雄鼠的股骨。 | Hasegawa H Ozawa S Hashimoto K 王鹏 | 2008 | 口腔颌面外科杂志2008，18，5： | 13 |
| 5 | Treatment and prevention of gastrointestinal bleeding in patients receiving antiplatelet therapy显示文摘Antiplatelet therapy is the standard of care for the secondary prevention of acute coronary syndrome and ischemic stroke, especially after coronary intervention. However, this therapy is associated with bleeding complications such as gastrointestinal bleeding, which is one of the most common life-threatening complications. Early endoscopy is recommended for most patients with acute upper gastrointestinal bleeding. After successful endoscopic hemostasis, immediate resumption of antiplatelet therapy with proton-pump inhibitors(PPIs) is recommended to prevent further ischemic events. PPI prophylaxis during antiplatelet therapy reduces the risk of upper gastrointestinal bleeding. The potential negative metabolic interaction between PPIs and clopidogrel is still unclear. | Hiroshi Yasuda Yasumasa Matsuo Yoshinori Sato Sun-ichiro Ozawa Shinya Ishigooka Masaki Yamashita Hiroyuki Yamamoto Fumio Itoh | 2015 | World Journal of Critical Care Medicine2015，4，1： | 13 |
| 6 | An updated review of gastric cancer in the next-generation sequencing era:Insights from bench to bedside and vice versa显示文摘Gastric cancer(GC)is one of the most common malignancies and remains the second leading cause of cancer-related death worldwide.There is an increasing understanding of the roles that genetic and epigenetic alterations play in GCs.Recent studies using nextgeneration sequencing(NGS)have revealed a number of potential cancer-driving genes in GC.Whole-exome sequencing of GC has identified recurrent somatic mutations in the chromatin remodeling gene ARID1A and alterations in the cell adhesion gene FAT4,a member of the cadherin gene family.Mutations in chromatin remodeling genes(ARID1A,MLL3 and MLL)have been found in 47%of GCs.Whole-genome sequencing and whole-transcriptome sequencing analyses have also discovered novel alterations in GC.Recent studies of cancer epigenetics have revealed widespread alterations in genes involved in the epigenetic machinery,such as DNA methylation,histone modifications,nucleosome positioning,noncoding RNAs and microRNAs.Recent advances in molecular research on GC have resulted in the introduction of new diagnostic and therapeutic strategies into clinical settings.The antihuman epidermal growth receptor 2(HER2)antibody trastuzumab has led to an era of personalized therapy in GC.In addition,ramucirumab,a monoclonal antibody targeting vascular endothelial growth factor receptor(VEGFR)-2,is the first biological treatment that showed survival benefits as a single-agent therapy in patients with advanced GC who progressed after firstline chemotherapy.Using NGS to systematically identify gene alterations in GC is a promising approach with remarkable potential for investigating the pathogenesis of GC and identifying novel therapeutic targets,as well as useful biomarkers.In this review,we will summarize the recent advances in the understanding of the molecular pathogenesis of GC,focusing on the potential use of these genetic and epigenetic alterations as diagnostic biomarkers and novel therapeutic targets. | Hiroyuki Yamamoto Yoshiyuki Watanabe Tadateru Maehata Ryo Morita Yoshihito Yoshida Ritsuko Oikawa Shinya Ishigooka Shun-ichiro Ozawa Yasumasa Matsuo Kosuke Hosoya Masaki Yamashita Hiroaki Taniguchi Katsuhiko Nosho Hiromu Suzuki Hiroshi Yasuda Yasuhisa Shinomura Fumio Itoh | 2014 | World Journal of Gastroenterology2014，20，14： | 12 |
| 7 | Eubacterium limosum ameliorates experimental colitis and metabolite of microbe attenuates colonic inflammatory action with increase of mucosal integrity显示文摘瞄准:为了检验真细菌类高级轿车的效果,加(E。高级轿车和) 在结肠的上皮的房间线在试管内上,并且到评估 E 的效果。试验性的大肠炎上的高级轿车和。方法:E。高级轿车和被接种厌氧的联盟者和它的代谢物被获得。E 的生长 stimulatory 效果。T84 房间上的高级轿车和代谢物被 IL-6 生产被 SUDH 活动,和反煽动性的效果评估。在象受体 4 一样的使用费(TLR4 ) 的 mRNA 的变化被实时 PCR 评估。大肠炎被用 2.0% 葡聚糖硫酸钠喂 BALB/C 老鼠导致。这些老鼠收到了任何一个 5% lyophilized E。高级轿车和(n = 7 ) 或控制节食(n = 7 ) 。在大肠炎正式就职,临床、组织学的分数,冒号长度,和盲肠的有机酸层次以后的七天是坚定的。结果:E。高级轿车和在 0.25, 1.0, 0.025 和 0.07 mmol/L 生产了丁酸盐,醋酸盐,丙酸盐,和 lactate,分别地在里面中等。在这集中,每酸没有生长在 T84 细胞上刺激活动;然而,当这些酸在上述层次一起被混合时,它比控制显示出显著地高的活动。除了 lactate,这些酸显著地在就 0.1 mmol/L 稀释了 IL-6 生产。在 TNF-alpha 刺激下面,另外,丁酸盐稀释了 TLR4 mRNA 的生产。有 E 的处理。高级轿车和显著地随盲肠的丁酸盐层次的增加稀释了大肠炎的临床、组织学的分数,与控制组相比。结论:E。高级轿车和能改善试验性的结肠的发炎。部分地, E 的代谢物。高级轿车和,丁酸盐,增加粘膜正直和表演经由 TLR4 的粘膜防卫系统的反煽动性的行动调整。 | Osamu Kanauchi Masanobu Fukuda Yoshiaki Matsumoto Shino Ishii Toyokazu Ozawa Makiko Shimizu Keiichi Mitsuyama Akira Andoh | 2006 | World Journal of Gastroenterology2006，12，7： | 6 |
| 8 | 碳化镍钼催化剂的制备及其甲烷干气重整活性(英文)显示文摘Nickel molybdenum carbide catalysts were prepared and their activities in the CO2 reforming of methane at a low CO2/CH4 reactant ratio were investigated using a microreactor at atmospheric pressure and at 973 K.The effect of the catalyst preparation method and the Ni/Mo ratio on the increase in catalyst life and the promotion of catalytic activity were investigated using N2 adsorption,X-ray diffraction, temperature-programmed carburization,temperature-programmed reaction,and a reforming reaction.The 25Ni75Mo catalyst that was carburized at 813 K exhibited the highest hydrogen formation ability and gave the least carbon deposition.The incomplete carburization of the Mo oxide species in the catalyst that was carburized at a lower temperature gradually gave a more active carburized species.The NiMoOxCy in the catalyst was more active in hydrogen formation during the dry reforming of methane whileβ-Mo2C andη-Mo3C2 were less active. | Taro HIROSE Yasushi OZAWA Masatoshi NAGAI | 2011 | 催化学报2011，32，5： | 4 |
| 9 | Ni-induced stepwise capacity increase in Ni-poor Li-rich cathode materials for high performance lithium ion batteries显示文摘Li 富有的阴极材料为高精力的锂离子电池(解放) 被认为候选人同样有希望。在这研究,我们报导Li富有的材料的一个新系列(李[李<潜水艇class=“ a-plus-plus ”> 1/32x/3 Mn <潜水艇class=“ a-plus-plus ”> 2/3x/3 Ni <潜水艇class=“ a-plus-plus ”> x ]O 2 ( 0.09 x 0.2 ))在解放作为阴极材料与 Ni 的小数量做了,它由于李的连续激活展出了能力增加的不平常的现象直到十个周期<潜水艇class=“ a-plus-plus ”> 2 MnO <潜水艇class= a-plus-plus > 3 阶段。试验性、计算的结果显示不同于通常学习的做 Ni 的 Li 富有的阴极材料,做的 Ni 的更小的数量能提拔逐步的李 < 潜水艇 class= “ a-plus-plus ” > 2 MnO < 潜水艇 class= “ a-plus-plus ” > 获得的 3 激活增加了特定的能力和更好骑车的能力。相反,过多的 Ni 愿望在激活上李 < 潜水艇 class= “ a-plus-plus ” > 2 MnO < 潜水艇 class= “ a-plus-plus ” > 在在第一的大能力损失的 3 和结果骑车。李<潜水艇class=“ a-plus-plus ”> 1.25 Mn <潜水艇class=“ a-plus-plus ”> 0.625 Ni <潜水艇class=“ a-plus-plus ”> 0.125 O <潜水艇class=“ a-plus-plus ”>有 Ni 的一个优化内容的 2 材料高交付了上级能力 280 mAh ?瀠汯??瑳特湥?潣洭污楥??€ ????????????????????楢慬敹?????搠獩潣摩污?慮潮慰瑲捩敬?? | Delai Ye Chenghua Sun Yu Chen Kiyoshi Ozawa Denisa Hulicova-JurcakovaI Jin Zou Lianzhou Wang | 2015 | Nano Research2015，8，3： | 4 |
| 10 | Indocyanine green fluorescence and three-dimensional imaging of right gastroepiploic artery in gastric tube cancer显示文摘A 79-year-old male was admitted to our hospital for the treatment of cancer of the gastric tube.Gastrointestinal examination revealed a T1 b Union for International Cancer Control(UICC) tumor at the pyloric region of the gastric tube.Laparotomy did not reveal infiltration intothe serosa,peritoneal dissemination,regional lymph node swelling,or distant metastasis.We performed a distal gastrectomy preserving the right gastroepiploic artery by referencing the preoperative three-dimensional computed tomoangiography.We also evaluated the blood flow of the right gastroepiploic artery and in the proximal gastric tube by using indocyanine green fluorescence imaging intra-operatively and then followed with a gastrojejunal anastomosis with Roux-en-Y reconstruction.The definitive diagnosis was moderately differentiated adenocarcinoma of the gastric tube,pT 1bN 0M0,pS tage IA(UICC).His postoperative course was uneventful.Three-dimensional computed tomographic imaging is effective for assessing the course of blood vessels and the relationship with the surrounding structures.Intraoperative evaluation of blood flow of the right gastroepiploic artery and of the gastric tube in the anastomotic portion is very valuable information and could contribute to a safe gastrointestinal reconstruction. | Toru Nakano Tadashi Sakurai Shota Maruyama Yohei Ozawa Takashi Kamei Go Miyata Noriaki Ohuchi | 2015 | World Journal of Gastroenterology2015，21，1： | 3 |
| 11 | A new sodium iron phosphate as a stable high-rate cathode material for sodium ion batteries显示文摘Low-cost room-temperature sodium-ion batteries (SIBs) are expected to promote the development of stationary energy storage applications.However,due to the large size of Na+,most Na+ host structures resembling their Li+ counterparts show sluggish ion mobility and destructive volume changes during Na ion (de)intercalation,resulting in unsatisfactory rate and cycling performances.Herein,we report a new type of sodium iron phosphate (Na0.71Fe1.07PO4),which exhibits an extremely small volume change (~ 1%) during desodiation.When applied as a cathode material for SIBs,this new phosphate delivers a capacity of 78 mA·h·g-1 even at a high rate of 50 C and maintains its capacity over 5,000 cycles at 20 C.In situ synchrotron characterization disclosed a highly reversible solid-solution mechanism during charging/discharging.The findings are believed to contribute to the development of high-performance batteries based on Earth-abundant elements. | Xiaobo Zhu Takashi Mochiku Hiroki Fujii Kaibin Tang Yuxiang Hu Zhenguo Huang Bin Luo Kiyoshi Ozawa Lianzhou Wang | 2018 | Nano Research2018，11，12： | 3 |
| 12 | Spatiotemporal changes of coxsackievirus and adenovirus receptor in rat hearts during postnatal development and in cultured cardiomyocytes of neonatal rat显示文摘 | Takeshi Kashimura Makoto Kodama Yuko Hotta Junichi Hosoya Kaori Yoshida Takuya Ozawa Ritsuo Watanabe Yuji Okura Kiminori Kato Haruo Hanawa Ryozo Kuwano Yoshifusa Aizawa | 2004 | Virchows Archiv2004，，3： | 2 |
| 13 | Combination gene therapy of HGF and truncated type II TGF-β receptor for rat liver cirrhosis after partial hepatectomy显示文摘 | Satoru Ozawa Kazuhisa Uchiyama Mikihito Nakamori Kentaro Ueda Makoto Iwahashi Hikaru Ueno Yasuteru Muragaki Akira Ooshima Hiroki Yamaue | 2006 | Surgery2006，，4： | 2 |
| 14 | Evaluation of safety for hepatectomy in a novel mouse model with nonalcoholic-steatohepatitis显示文摘AIM To investigate whether the liver resection volume in a newly developed nonalcoholic steatohepatitis(NASH) model influences surgical outcome.METHODS For establishment of a NASH model, mice were fed a high-fat diet for 4 wk, administered CCl_4 for the last 2 wk, and administered T0901317 for the last 5 d. We divided these mice into two groups: A 30% partial hepatectomy(PH) of NASH liver group and a 70% PH of NASH liver group. In addition, a 70% PH of normal liver group served as the control. Each group was evaluated for survival rate, regeneration, apoptosis, necrosis and DNA expression after PH.RESULTS In the 70% PH of NASH group, the survival rate was significantly decreased compared with that in the control and 30% PH of NASH groups(P < 0.01). 10 of 32 mice in the NASH 70% PH group died within 48 h after PH. Serum aspartate aminotransferase(AST) levels and total bilirubin(T-Bil) in the NASH 70% PH group were significantly higher than the levels in the other two groups(AST: P < 0.05, T-Bil: P < 0.01). In both PH of NASH groups, signaling proteins involved in regeneration were expressed at lower levels than those in the control group(P < 0.01). The 70% PH of NASH group also exhibited a lower number of Ki-67-positive cells and higher rates of apoptosis and necrosis than the NASH 30% PH group(P < 0.01). In addition, DNA microarray assays showed differences in gene expression associated with cell cycle arrest and apoptosis.CONCLUSION The function of the residual liver is impaired in fatty liver compared to normal liver. A larger residual volume is required to maintain liver functions in mice with NASH. | Yusuke Ozawa Takafumi Tamura Yohei Owada Yoshio Shimizu Akira Kemmochi Katsuji Hisakura Takashi Matsuzaka Hitoshi Shimano Hiroko Isoda Nobuhiro Ohkohchi | 2018 | World Journal of Gastroenterology2018，24，15： | 2 |
| 15 | Evaluation of Pesticide Residues in Mango by a Multi-residue Analysis and GC/MS Triple Quadrupole显示文摘 | Claudia Helena Pastor Ciscato Kumi Shiota Ozawa Claudia Maria Barbosa Amir Bertoni Gebara | 2015 | Journal of Agricultural Science and Technology(B)2015，5，8： | 2 |
| 16 | Contrast-enhanced sonography of pancreatic carcinoma: correlations with pathological findings显示文摘 | Kazushi Numata Yutaka Ozawa Noritoshi Kobayashi Toru Kubota Hiroshi Shimada Akinori Nozawa Yukio Nakatani Kazuya Sugimori Kenichi Matsuo Toshio Imada Katsuaki Tanaka | 2005 | Journal of Gastroenterology2005，，6： | 2 |
| 17 | Cellular irinotecan resistance in colorectal cancer and overcoming irinotecan refractoriness through various combination trials including DNA methyltransferase inhibitors: a review显示文摘Treatment with pharmacological drugs for colorectal cancer(CRC)remains unsatisfactory.A major cause of failure in pharmacotherapy is the resistance of colon cancer cells to the drugs,creating an urgent issue.In this review,we summarize previous studies on the resistance of CRC cells to irinotecan and discuss possible reasons for refractoriness.Our review presents the following five major causes of irinotecan resistance in human CRC:(1)cellular irinotecan resistance is induced mainly through the increased expression of the drug efflux transporter,ABCG2;(2)cellular irinotecan resistance is also induced in association with a nuclear receptor,pregnane/steroid X receptor(PXR/SXR),which is enriched in the CYP3A4 gene enhancer region in CRC cells by exposing the cells to SN-38;(3)irinotecan-resistant cells possess either reduced DNA topoisomerase I(Top1)expression at both the mRNA and protein levels or Top1 missense mutations;(4)alterations in the tumor microenvironment lead to drug resistance through intercellular vesicle-mediated transmission of miRNAs;and(5)CRC stem cells are the most difficult targets to successfully treat CRC.In the clinical setting,CRC gradually develops resistance to initially effective irinotecan-based therapy.To solve this problem,several clinical trials,such as irinotecan plus cetuximab vs.cetuximab monotherapy,have been conducted.Another clinical trial on irinotecan plus guadecitabine,a DNA-methyltransferase inhibitor,has also been conducted. | Shogo Ozawa Toshitaka Miura Jun Terashima Wataru Habano | 2021 | Cancer Drug Resistance2021，4，4： | 2 |
| 18 | ^(17)C反应截面和去中子截面显示文摘利用日本理化学研究所的放射性束流线RIPS,测量了能量为79A MeV的^(17)C在^(12)C反应靶上的反应截面,并同时得到了^(17)C的移去1个、2个及3个中子的截面;分别利用有限力程Glauber模型和少体Glauber模型结合壳模型的谱因子分析了反应截面和移去1个中子截面,研究了^(17)C的密度分布、结构和价中子布居。反应截面和中子移去截面是两个相互独立的量,通过对两者的分析,都可以得出^(17)C由芯核^(16)C和价中子组成,并且价中子主要处于d_(5/2)轨道的结论。总结了现有的碳同位素的反应截面和相互作用截面的工作。 | 吴翠娥 叶沿林 江栋兴 郑涛 华辉 李智焕 李湘庆 陈志强 胡青元 张高龙 庞丹阳 王佳 Yamaguchi Y Ozawa A Tanihata I | 2005 | 高能物理与核物理2005，29，11： | 2 |
| 19 | Kinetic of non-isothermal crystallization显示文摘 | OZAWA T | 1971 | Polymer1971，12，： | 2 |
| 20 | Thermal shock resistance of β - prime-Sialon - BN composites prepared by pressureless sintering and reaction bonding显示文摘 | HAYAMA S OZAWA M SUZUKI S etal | 1996 | J Soc Mater Sci Jpn1996，45，6： | 2 |
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