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| 1 | ACE2/Ang-(1-7) signaling and vascular remodeling显示文摘The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling. | ZHANG ZhenZhou CHEN LaiJiang ZHONG JiuChang GAO PingJin OUDIT Gavin Y. | 2014 | Science China(Life Sciences)2014，57，8： | 14 |
| 2 | 基质金属蛋白酶1的组织抑制剂通过介导CD63与整合素β_1的相互作用促进心肌纤维化显示文摘心肌纤维化指细胞外基质纤维胶原蛋白的过度积累。纤维化是各种心肌病的关键特征,会影响心脏收缩和舒张功能。金属蛋白酶1组织抑制剂(tissue inhibitor of metalloproteinase-1,TIMP1)水平在心肌纤维化过程中始终增加,被认为是纤维化的标记物。 | Takawale A Zhang P Patel VB Wang X Oudit G Kassiri Z 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，4： | 13 |
| 3 | The molecular physiology of the cardiac transient outward potassium current (Ito) in normal and diseased myocardium显示文摘 | Oudit G Y Kassiri Z Sah R | 2001 | J Mol Cell Cardiol2001，33，： | 3 |
| 4 | Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction显示文摘 | JiuChang Zhong Ratnadeep Basu Danny Guo Fung L. Chow Simon Byrns Manfred Schuster Hans Loibner Xiu-hua Wang Josef M. Penninger Zamaneh Kassiri Gavin Y. Oudit | 2010 | Circulation2010，，7： | 2 |
| 5 | Angiotens- in-converting enzyme 2 is an essential regulator of heart function 显示文摘 | CRACKOWER M A SARAO R OUDIT G Y | 2002 | Nature2002，417，6891： | 1 |
| 6 | Angiotensin-converting enzyme 2 is an essential regulator of heart function显示文摘 | Crackower MA Sarao R Oudit GY | 2002 | Nature2002，417，6891： | 1 |
| 7 | Role of L-type Ca2+ channels in iron transport and iron-overload cardiomyopathy显示文摘 | Oudit GY Trivieri MG Khaper N | | 0，，： | 1 |
| 8 | Angiotensin-converting enzyme 2 is an essential regulator of heart function 显示文摘 | Crackower MA Sarao R Oudit GY | 2002 | Nature2002，417，6891： | 1 |
| 9 | Angiotensin-converting enzyme 2 is an essential regulator of heart function显示文摘 | Crackower MA Sarao R Oudit GY | 2002 | Nature2002，417，： | 1 |
| 10 | Angiotensin-converting enzyme 2 is an essential regulator of heart function显示文摘 | Crackower M A Sarao R Oudit G Y | 2002 | Nature2002，417，6891： | 1 |
| 11 | Angiotensin-converting enzyme 2 is an essential regulator of heart function 显示文摘 | Crackower MA Sarao R Oudit GY | 2002 | Nature2002，417，6891： | 1 |
| 12 | ACE2 deficiency enhances angioten-sin Ⅱ-mediated aortic profilin-1 expression,inflammation and per-oxynitrite production显示文摘 | Jin HY Song B Oudit GY | | 0，，： | 1 |
| 13 | The Role of ACE2 in Cardiovascular physiology显示文摘 | OUDIT GY CRACKOWER MA BACKX PH | 2003 | Treads Cardiovasc Med2003，13，3： | 1 |
| 14 | Muscle-specific loss of apoptosis-inducing factor leads to mitochondrial dysfunction, skeletal muscle atrophy, and dilated cardiomyopathy 显示文摘 | Joza N Oudit GY Brown D | 2005 | Mol Cell Biol2005，25，10： | 1 |
| 15 | Angiotensin-converting enzymez is an essential negulator of heart function 显示文摘 | CRACKOWER M A SARAO R OUDIT G Y | 2002 | Nature2002，417，6891： | 1 |
| 16 | L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy显示文摘 | Oudit GY Sun H Trivieri MG | | 0，，： | 1 |
| 17 | Angiotensin-converting enzyme 2 is an e sential regulator of heart function显示文摘 | Crackower MA Sarao R Oudit GY | 2002 | Nature2002，417，6891： | 1 |
| 18 | Cardiac-specific elevations in thyroid hormone enhance contractility and prevent pressure overload-induced cardiac dysfunction 显示文摘 | Trivieri MG Oudit GY Sah R | 2006 | Proc Natl Acad Sci USA2006，103，15： | 1 |
| 19 | Angiotensin-converting enzyme 2 is an essential regulator of heart function 显示文摘 | Crackower M A Sarao R Oudit G Y | 2002 | Nature2002，417，： | 1 |
| 20 | The role of ACE2 in cardiovascu- lar physiology显示文摘 | Oudit GY Crackower MA Backx PH | 2003 | Trends Cardiovasc Med2003，13，3： | 1 |
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