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| 1 | HMGB 1 contributes to allergen-induced airway remodeling in a murine model of chronic asthma by modulating airway inflammation and activating lung fibroblasts显示文摘支持发炎的因素(HMGB1 ) 高活动性的组盒子蛋白质 1 在气喘的致病被含有。在这研究,我们使用了长期的气喘的一个鼠科的模型在航线改变上评估 HMGB1 的效果。女 BALB/c 老鼠随机被划分成四个组:控制, ovalbumin (卵) 气喘, OVA+适应于不同地区生活的动物抗体和 OVA+ anti-HMGB1 抗体。Anti-HMGB1 抗体治疗在白天 21 上被开始并且与卵在 intranasal 挑战前每星期被管理三次 6 个星期。在这个鼠标模型, HMGB1 表示显著地被提高。anti-HMGB1 抗体组展出了免疫球蛋白 E (IgE ) 和煽动性的调停人的减少的层次并且与卵组相比减少了煽动性的房间累积,航线 hyperresponsiveness (AHR ) ,粘液合成,光滑的肌肉厚度和肺骨胶原内容。有 HMGB1 的治疗增加了增长,移植,骨胶原分泌物和 α在 MRC-5 房间的光滑的肌肉肌动朊(SMA ) 表示。有 HMGB1/IL-1β 的处理;建筑群显著地增加了转变生长因素的表示和分泌物(TGF-β 1 ) ,矩阵 metalloproteinase (MMP )-9 和脉管的 endothelial 生长因素(VEGF ) 。总的来说,这些结果建议那项堵住的 HMGB1 活动可以颠倒航线由压制航线发炎和 modulating 肺成纤维细胞显型和激活改变。 | Changchun H ou Jinliang Kong Yue Liang Hong Huang Hanchun Wen Xiaowen Zheng Lihong Wu Yiqiang Chen | 2015 | Cellular & Molecular Immunology2015，12，4： | 19 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 4 | Adult metaplastic hutch diverticulum with robotic-assisted diverticulectomy and reconstruction:A case report显示文摘BACKGROUND Hutch diverticulum arises from the compromised muscular development at the ureteral orifice.It is a congenital disease and extremely rare in adult,only accounting for about 3%occurrence worldwide.It can be either symptomatic or asymptomatic,and relies on image tools for diagnosis and preoperative planning.Indications for surgery are dependent on the complications from the diverticulum.Metaplasia is about 10%among those with hutch diverticulum,and it still has chances turning into malignancy,especially urothelial cell carcinoma.CASE SUMMARY A 27-year-old man was presented with frequently recurrent urinary tract infection for one year,and had suffered from intermittent right flank pain for 3 mo.No past medical histories were recorded before.No obvious abnormalities on laboratory data and urine examination were found.Under ultrasound,right hydronephrosis was seen and an anatomical abnormality was observed on intravenous pyelography.Further computed tomography urogram showed one diverticulum seated at superolateral side of right ureteral orifice.Cystoscopy was done and biopsy results showed focal metaplasia.After discussing with him,roboticassisted diverticulectomy with reconstruction was performed.Right hydronephrosis was greatly improved after surgery.He has completed his 1.5-year follow-ups,and no malignancies were seen from urine cytology and image of intravenous pyelography.CONCLUSION Robotic-assisted diverticulectomy and reconstruction to hutch diverticulum is a safe and efficient operation,providing several advantages over open and laparoscopic ones. | Che H Yang Yi S Lin Yen C Ou Wei C Weng Li H Huang Chin H Lu Chao Y Hsu Min C Tung | 2020 | World Journal of Clinical Cases2020，8，20： | 2 |
| 5 | New and improved approaches for shared-path protection in WDM mesh networks显示文摘 | OU C ZHANG J ZANG H SHASRABUDDHE L H MUKHERJEE B | 2004 | IEEE/OSA Journal of Lightwave Technology2004，22，5： | 1 |
| 6 | A study on mechanical and pressure- sensitive properties of cement mortar with nanophase materials 显示文摘 | Li H Xiao H G Ou J P | 2004 | Cem Concr Res2004，34，： | 1 |
| 7 | The synthesis of a chiral-amino acid derivative by the Grignard reaction of an aspartic acid equivalent 显示文摘 | LIU F YU W S OU W H | 2010 | J Chem Res2010，34，9： | 1 |
| 8 | Large-scale experi- mental study of precast segmental unbonded posttensioned concrete bridge columns for seismic regions显示文摘 | OU Y C WANG P H TSAI M S | 2010 | Journal of Structural Engineering2010，136，3： | 1 |
| 9 | Crizotinib for the treatment of ALK-rearranged non-smallcell lung cancer:a success story to usher in the seconddecade of molecular targeted therapy in oncology 显示文摘 | Ou S H Bartlett C H Mino-Kenudson M | 2012 | TheOncologist2012，17，11： | 1 |
| 10 | Changes in micro-RNA profile and effects of miR-320 in insulin-resistant 3T3-L1 adipocytes显示文摘 | Ling H Y Ou H S Feng S D | | 0，，09： | 1 |
| 11 | Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding proteinlc (SREBP-lc) gene by antagonizing ligand-dependent activation of the LXR显示文摘 | Ou J Tu H Shan B Luk A DeBose-Boyd RA Bashmakov Y Goldstein JL Brown MS | | 0，，11： | 1 |
| 12 | Prevalence rate of osteoporosis inthe mid-aged and elderly in selected parts of China显示文摘 | Li N Ou P Zhu H | 2011 | Chin Med J2011，18，13： | 1 |
| 13 | Plasma interleukin-l~,-6,-8 and tumor necrosis factor-a as highly informative markers of pel- vic inflammatory disease 显示文摘 | Lee S A Tsai H T Ou H C | 2008 | Clin Chem Lab Med2008，46，7： | 1 |
| 14 | Effect of Nuclear Ae- tin on Endothelial Nitric Oxide Synthase Expression 显示文摘 | Ou H Shen YH Utama B | 2005 | Arterioscler Thromb Vasc Biol2005，25，： | 1 |
| 15 | Diagnostic accuracy of PURE - LAMPtest for pulmonary tuberculosis at the county level laboratory in China显示文摘 | Ou XC Li Q Xia H | 2014 | PLoS One2014，9，94： | 1 |
| 16 | Different syndrome types of TCM Parkinson's patients peripheral blood mononuelear cells in proteomics research显示文摘 | Ou J G Liang Q H Chen J | 2008 | Chinese Journal of Chinese Medicine Information2008，54，6： | 1 |
| 17 | Compact efficient diode-pumped N d:YVO4 Q-switched blue laser with intraeavity frequency tripling显示文摘 | CHEN Y F CHEN Y S OU T H | 2005 | Applied Physics B (S0946-2171)2005，81，4： | 1 |
| 18 | Prevalence rate og osteoporosis in the mid-aged and elderly in selected parts of China显示文摘 | Li N Ou P Zhu H | 2002 | China Med J (En- gl)2002，115，5： | 1 |
| 19 | 显示文摘 | Guan X H Dong X F Ou J P | 2007 | Proc of SPIE2007，6526，65： | 1 |
| 20 | Pathogen variability and host resistence in rice blast disease显示文摘 | OU S H | 1980 | Ann Rev Phystopathol1980，18，： | 1 |
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