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| 1 | 肝细胞特异性NRF2激活可改善脂肪性肝炎的纤维化和癌变显示文摘慢性肝病中的炎症诱导氧化应激,因此可能导致肝损伤、纤维化和癌变的进展。KEAP1/NRF2轴是细胞氧化还原平衡的主要调节器。该研究探讨了KEAP1/NRF2系统是否参与了人类和小鼠肝病的进展。 | MOHS A OTTO T SCHNEIDER KM 李丽 华瑞 | 2021 | 临床肝胆病杂志2021，37，3： | 19 |
| 2 | Effect of hepatic artery embolization on liver hypertrophy response in a rabbit liver VX2tumor model显示文摘BACKGROUND:Portal vein embolization not only induces hypertrophy of the non-embolized liver,but also enhances tumor growth.The latter could be prevented by embolizing the hepatic arteries supplying the tumor-bearing liver segments.This study aimed to determine the effects of transcatheter arterial embolization(TAE)on tumor volume and liver regeneration in a rabbit VX2 tumor model.METHODS:Twenty-three rabbits underwent subcapsular tumor implantation with a VX2 tumor.Two weeks after implantation,18 rabbits were used for TAE experiments,5were for sham controls.Tumor response and liver regeneration response of the embolized cranial and non-embolized caudal liver lobes were assessed by CT volumetry,liver to body weight index,and the amount of proliferating hepatocytes.RESULTS:All super-selective arterial tumor embolization procedures were performed successfully.Despite embolization,the tumor volume increased after an initial steady state.The tumor volume after embolization was smaller than that of the sham group,but this difference was not significant.Massive necrosis of the tumor,however,was seen after embolization,without damage of the surrounding liver parenchyma.There was a significant atrophy response of the tumor bearing cranial lobe after super-selective arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized,caudal lobe.This regeneration response was confirmed histologically by a significantly higher number of proliferating hepatocytes on the Ki-67 stained slides.CONCLUSIONS:Super-selective,bland arterial coil embolization causes massive necrosis of the tumor,despite increase of volume on CT scan.Atrophy of the tumor bearing liver lobe is seen after arterial embolization of the tumor with a concomitant hypertrophy response of the non-embolized lobe,despite absence of histological damage of the tumor-surrounding liver parenchyma. | Krijn P van Lienden Lisette T Hoekstra Jessica D van Trigt Joris J Roelofs Otto M van Delden Thomas M van Gulik | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，6： | 2 |
| 3 | Pulsatile drug-deliverysystems 显示文摘 | Bussemer T Otto I Bodmeier R | 2001 | Crit Rev Ther Drug Carrier Syst2001，18，5： | 2 |
| 4 | 多晶铜和铝单轴棘轮行为的循环晶体塑性本构模拟显示文摘针对实验揭示的面心立方金属多晶紫铜和多晶纯铝的单轴棘轮行为演化特征,采用一种基于晶体塑性理论的循环多晶塑性本构模型,对这两种多晶金属材料的单轴棘轮行为进行了本构描述。采用的循环多晶塑性本构模型中使用了一种简单的显式尺度过渡法则。结果表明:该本构模型对两种材料的单轴棘轮行为及其应力幅值和平均应力依赖性给出了很好地理论描述;同时,还揭示了面心立方单晶棘轮行为对单晶晶向的强烈依赖性。 | 罗娟 康国政 董亚伟 Otto T Bruhns | 2012 | 四川大学学报(工程科学版)2012，44，S2： | 2 |
| 5 | A 'region-growing' algorithm for matching of terrain images显示文摘 | OTTO G P CHAU T K W | 1989 | Image and Vision Computing1989，7，2： | 1 |
| 6 | Pulsatile drug-delivery systems 显示文摘 | BUSSEMER T OTTO I BODMEIER R | 2001 | Crit Rev Ther Drug Cartier Syst2001，18，5： | 1 |
| 7 | Deletion analysis at the DEL- 27, APC and MTS1 loci in bladder cancer: LOH at the DEL-27locus on 5p13-12 is a prognostic marker of tumor progression 显示文摘 | Bohm M Kirch H Otto T | 1997 | Int J Cancer1997，74，3： | 1 |
| 8 | Portable light-addressable potentiometric sensor(LAPS) for mul- tisensor applications显示文摘 | Yoshinobu T Schoning M J Otto R | 2003 | Sensors and Actuators B2003，95，： | 1 |
| 9 | Seasonal effects of 19 plant species on COD removal in subsurface treat- ment wetland microcosms 显示文摘 | Carrie R T Paul B H Otto R S | 2011 | Ecological Engineering2011，37，5： | 1 |
| 10 | 'Region-growing” algorithm for matching of terrain images显示文摘 | Otto G P Chau T K W | | 0，，02： | 1 |
| 11 | Cbfal, a candi- date gene for eleidoeranial dysplasia syndrome, is essential for osteoblast differentiation and bone development 显示文摘 | Otto F Thornell AP Crompton T | 1997 | Cell1997，89，： | 1 |
| 12 | Computer-aided direct all-ceramic crowns: pre- liminary 1-year results of a prospective clinical study 显示文摘 | Otto T | 2004 | Int J Periodontics Restorative Dent2004，24，5： | 1 |
| 13 | Evidence of interspeciestransmission and reassortment among avian group A rotaviruses 显示文摘 | Schumann T Hotzel H Otto P | 2009 | Virology2009，386，2： | 1 |
| 14 | Occurrence of phthalates and bisphenol A and F in the environment显示文摘 | Fromme H Kuchler T Otto T | | 0，，06： | 1 |
| 15 | A comparison of Kneipp hydrotherapy with conventional physiotherapy in the treatment of osteoarthritis of the hip or knee:protocol of a prospective randomised controlled clinical trial显示文摘 | Schencking M Otto A Deutsch T | | 0，，： | 1 |
| 16 | β-Thymosins, small acidic peptides with multiple func tions 显示文摘 | Huff T Muller C S Otto A M | 2001 | The International Journal of Biochemistry & Cell Biology2001，33，： | 1 |
| 17 | Inverse relation of Ecadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas显示文摘 | Otto T Birchmeier W Schmidt U | 1994 | Cancer Res1994，54，12： | 1 |
| 18 | beta-thymosins, small acidic pep- tides with multiple functions 显示文摘 | Huff T Muller C S Otto A M | 2001 | Int J Biochem Cell Biol2001，33，3： | 1 |
| 19 | GDP dissociation inhibitor D4-GDI(Rho-GDI2), but not the homologous Rho-GDII, is cleaved by caspase-3 during drug-induced apoptosis显示文摘 | Essmann F Wieder T Otto A | 2000 | Biochem J2000，346，3： | 1 |
| 20 | Occurrence of phthalates and bisphenol A and F in the environment 显示文摘 | Fromme H Kuchler T Otto T Pilz K Miiller J Wenzel A | 2002 | Water Research2002，36，： | 1 |
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