|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising. | Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz | 2009 | World Journal of Gastroenterology2009，15，36： | 18 |
| 2 | A 'region-growing' algorithm for matching of terrain images显示文摘 | OTTO G P CHAU T K W | 1989 | Image and Vision Computing1989，7，2： | 1 |
| 3 | Incidence of pressure ulcers in a neurologic intensive care unit显示文摘 | Fife C Otto G Capsuto E G | 2001 | Crit Care Med2001，29，2： | 1 |
| 4 | Analysis of orbital T cells in thyroid-asssociated ophthalmopathy显示文摘 | Forster G Otto E Hansen C | 1998 | Clin Exp Imunol1998，11，2： | 1 |
| 5 | Discovery of recurrent KIF5B-RET fusions and other targetable alterations from clinical NSCLC specimens 显示文摘 | Capelletti M Lipson D Otto G | 2012 | J Clin Oncol2012，30，15： | 1 |
| 6 | pH-regulated gene ex- pression of the gastric pathogen Helicobacter pylori 显示文摘 | Merrell DS Goodrich ML Otto G | 2003 | Infe-ct Immun2003，71，6： | 1 |
| 7 | 'Region-growing” algorithm for matching of terrain images显示文摘 | Otto G P Chau T K W | | 0，，02： | 1 |
| 8 | Variable MLH1 promoter methylation patterns in endometrial carcinomas of endometrioid subtype lacking DNA mismatch repair显示文摘 | Helmle KE Otto C J Constantinescu G | 2005 | Int J Gynecol Cancer2005，15，6： | 1 |
| 9 | GPR30 does not me- diate estrogenic responses in reproductive organs in mice显示文摘 | Otto C Fuchs I Kauselmann G | 2009 | Biol Reprod2009，80，1： | 1 |
| 10 | Drip loss of case-ready meat and of premium cuts and their associations with earlier measured sample drip loss, meat quality and carcass traits in pigs显示文摘 | Otto G Roehe R Looft H | 2006 | Meat Science2006，72，4： | 1 |
| 11 | Induction of mucosal antibodies by live attenuated and inactivated influenza virus vaccines in the chronically ill elderly显示文摘 | Otto E E Powers D C | 1996 | J Infect Dis1996，173，2： | 1 |
| 12 | Characterization and potential applications of nanostructured aqueous dispersions 显示文摘 | Anan Y Otto G | 2009 | Adv Colloid Interface Sci2009，148，： | 1 |
| 13 | Variable MLH1 promoter methylation patterns in endometrial carcinomas of endometrioid subtype lacking DNA mismatch repair显示文摘 | Helmle KE Otto CJ Constantinescu G | 2005 | Gynecol Cancer2005，15，6： | 1 |
| 14 | Growth stimulation of human osteoblast-like cells by thromboeyte concentrates in vitro 显示文摘 | Weibrieh G Gnoth S H Otto M | 2002 | Mund- Kiefer-und Gesichtschirurgie: MKG2002，6，3： | 1 |
| 15 | Incidence of pressure ulcers in a neurological intensive care unit显示文摘 | FIFE C OTTO G CAPSUTO E G | 2001 | Crit Care Med2001，29，2： | 1 |
| 16 | Inhahsstoffe Von Daphne tangutica显示文摘 | Zhuang L G Otto S Hildebert W | 1982 | Planta Med1982，45，3： | 1 |
| 17 | G protein-coupled receptor 30 localizes to the endoplasmic reticulum and is not actirated by estradiol显示文摘 | Otto C Rohde-Schulz B Schwarz G | | 0，，： | 1 |
| 18 | Increased risk of postpartum depressive symptoms is associated with slower oormalization after pregnancy of the functional docosahexaenoic acid status显示文摘 | Otto SJ de Groot RH Hornstsa G | 2003 | Prostagtandins Leukot Essent Fatty Acid2003，69，2： | 1 |
| 19 | Daphneficin, a coumarinolignoid from Daphne tangutica 显示文摘 | Zhuang L G Otto S Hildebert W | 1983 | Phytochemistry1983，22，2： | 1 |
| 20 | Exocrine pancreatic function in insulin-dependent diabetes mellitus显示文摘 | Lankisch P G Manthey G Otto J | 1982 | Digestion1982，25，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员