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317篇 您的检索式：作者名="OTTO E"

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	题名	作者	年代	出处	被引量
1	EGFR and HER2 expression in advanced biliary tract cancer显示文摘AIM:To analyze the pathogenetic role and potential clinical usefulness of the epidermal growth factor receptor(EGFR)and the human epidermal growth factor receptor 2(HER2)in patients with advanced biliary tract cancer(BTC). METHODS:EGFR and HER2 expression was studied in biopsy samples from 124 patients(51%women; median age 64.8 years),with advanced BTC diagnosed between 1997 and 2004.Five micrometers sections of paraffin embedded tissue were examined by standard, FDA approved immunohistochemistry.Tumors with scores of 2+or 3+for HER2 expression on immunochemistry were additionally tested for HER2 gene amplification by fluorescence in situ hybridisation(FISH).RESULTS:34/124 patients(27.4%)had gallbladder cancer,47(37.9%)had intrahepatic BTC and 43(34.7%)had extrahepatic or perihilar BTC.EGFR expression was examined in a subset of 56 samples. EGFR expression was absent in 22/56 tumors(39.3%). Of the remaining samples expression was scored as 1+in 12(21.5%),2+in 13(23.2%)and 3+in 9(16%), respectively.HER2 expression was as follows:score 0 73/124(58.8%),score 1+27/124(21.8%),score 2+ 21/124(17%)and score 3+4/124(3.2%).HER2 gene amplification was present in 6/124,resulting in an overall amplification rate of 5%. CONCLUSION:Our data suggest that routine testing and therapeutic targeting of HER2 does not seem to be useful in patients with BTC,while targeting EGFR may be promising.	Jan Harder Oliver Waiz Florian Otto Michael Geissler Manfred Olschewski Brigitte Weinhold Hubert E Blum Annette Schmitt-Graeff Oliver G Opitz	2009	World Journal of Gastroenterology2009，15，36：	18
2	显示文摘	Otto E M	1968	J Electrochem Soc1968，115，：	2
3	hMLHI and hMSH2 somatic inactivation mechanisms in sporadic colorectal cancer patients显示文摘	Kamory E Kolaesck O Otto S	2003	Pathol Oncol Rcs2003，9，4：	1
4	Incidence of pressure ulcers in a neurologic intensive care unit显示文摘	Fife C Otto G Capsuto E G	2001	Crit Care Med2001，29，2：	1
5	Analysis of orbital T cells in thyroid-asssociated ophthalmopathy显示文摘	Forster G Otto E Hansen C	1998	Clin Exp Imunol1998，11，2：	1
6	Decrease of S100 beta protein in serum of patients with amyotrophic lateral sclerosis显示文摘	Otto M Bahn E Wiltfang J	1998	Neurosci Lett1998，240，3：	1
7	Multiple facets of altruism and their influence on blood donation 显示文摘	Otto P E Bolle F	2011	The Journal of Socio-Eco- nomics2011，40，5：	1
8	Release characteristics of cardic biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a marathon race显示文摘	APPLE F S QUIST H E OTTO A P	2002	Clin Chem2002，48，7：	1
9	Induction of mucosal antibodies by live attenuated and inactivated influenza virus vaccines in the chronically ill elderly显示文摘	Otto E E Powers D C	1996	J Infect Dis1996，173，2：	1
10	Molecular genetics of nephronophthisis and medullary cystic kidney disease显示文摘	Hildebrandt F Otto E	2000	J Am Soc Nephrol2000，11，：	1
11	Evaluation of a new measure of blood glucose variability in diabetes显示文摘	Kovatchev BP Otto E Cox D	2006	Diabetes Care2006，29，1：	1
12	Evaluation of a new measure of blood glucose variability in diabetes显示文摘	Kovatchev BP Otto E Cox D	2006	Diabetes Care2006，29，11：	1
13	Agitation of non-Newtonian fluids显示文摘	Metzner A B Otto R E	1957	AIChE J1957，3，1：	1
14	Release characteristics of cardiac biomarkers and ischemia-modified albumin as measured by the albumin cobalt-binding test after a Marathon race显示文摘	Apple F S Quist H E Otto A P	2002	Clin Chem2002，48，7：	1
15	Incidence of pressure ulcers in a neurological intensive care unit显示文摘	FIFE C OTTO G CAPSUTO E G	2001	Crit Care Med2001，29，2：	1
16	Evolution of neuroendoerine peptide systems: Gonadotropin--releasing hormone and somatostatin显示文摘	Lin X W Otto Carla J Peter R E	1998	Comparative Biochemistry and Physiology C1998，119，：	1
17	A wireless body area network of intelligent motion sensors for computer assisted physical rehabilitation显示文摘	JOVANOV E MILENKOVIC A OTTO C	2005	J Neuroeng Rehabil2005，2，1：	1
18	Real- time fluorescence detection of a single DNA molecule显示文摘	Lockey C Otto E Long Z	1998	Bio Techniques1998，24，5：	1
19	Nephronophthi- sis : disease mechanisms of a ciliopathy 显示文摘	HILDEBRANDT F ATTANASIO M OTTO E	2009	J Am Soc Nephrol2009，20，1：	1
20	Efficacy and safety of great sa- phenous vein sclerotherapy using standardized polidocanol foam (ES- AF) :a randomised controlled muhicentre clinical trial显示文摘	Rabe E Otto J Schliephake D	2008	Eur J Vasc Endovasc Surg2008，35，2：	1

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