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| 1 | Management of recurrent rectal cancer:A population based study in greater Amsterdam显示文摘AIM: To analyze,retrospectively in a population-based study,the management and survival of patients with recurrent rectal cancer initially treated with a macroscopically radical resection obtained with total mesorectal excision (TME). METHODS: All rectal carcinomas diagnosed during 1998 to 2000 and initially treated with a macroscopically radical resection (632 patients) were selected from the Amsterdam Cancer Registry. For patients with recurrent disease,information on treatment of the recurrence was collected from the medical records. RESULTS: Local recurrence with or without clinically apparent distant dissemination occurred in 62 patients (10%). Thirty-two patients had an isolated local recurrence. Ten of these 32 patients (31%) underwent radical re-resection and experienced the highest survival (three quarters survived for at least 3 years). Eight patients (25%) underwent non-radical surgery (median survival 24 mo),seven patients (22%) were treated with radio-and/or chemotherapy without surgery (median survival 15 mo) and seven patients (22%) only received best supportive care (median survival 5 mo). Distant dissemination occurred in 124 patients (20%) of whom 30 patients also had a local recurrence. The majority (54%) of these patients were treated with radio-and/or chemotherapy without surgery (median survival 15 mo). Twenty-seven percent of these patients only received best supportive care (median survival 6 mo),while 16% underwent surgery for their recurrence. Survival was best in the latter group (median survival 32 mo). CONCLUSION: Although treatment options and survival are limited in case of recurrent rectal cancer after radical local resection obtained with TME,patients can benefit from additional treatment,especially if a radical resection is feasible. | Roel Bakx Otto Visser Judith Josso Sybren Meijer J Frederik M Slors J Jan B van Lanschot | 2008 | World Journal of Gastroenterology2008，14，39： | 17 |
| 2 | Liver transplantation and BCLC classification:Limitations impede optimum treatment显示文摘Background:The Barcelona Clinic Liver Cancer(BCLC)system has been endorsed by international guidelines as a staging algorithm of hepatocellular carcinoma.This analysis was performed to assess the outcome of liver transplantation in patients treated against the BCLC recommendations.Methods:The data of 198 patients who underwent liver transplantation for hepatocellular carcinoma were extracted from a prospectively maintained database to classify the patients according to the BCLC system.Results:BCLC staging was as follows:0,n=5;A,n=77;B,n=41;C,n=53;and D,n=22.Accordingly,liver transplantation was performed in the majority of patients against BCLC recommendations.Surgery(n=16),radiofrequency ablation(n=15)and transarterial chemoembolization(n=151)preceded liver transplantation in 182 patients.Sixteen patients were transplanted without pretreatment.The 1-,5-and 10-year survival rates were 83.8%,62.4%and 45.9%,and 1-,5-,and 10-year recurrence rates were 7.7%,22.7%and 26.7%.The BCLC classification did neither impact survival(P=0.796)nor recurrence(P=0.693).In the Cox analysis,RECIST tumor progression and initial alpha fetoprotein were independent predictors of outcome.Conclusions:Neither the oncological nor the functional stratification imposed by the BCLC system was of importance for outcome.Lack of flexibility and disregard of biological parameters hamper its clinical applicability in liver transplantation. | Gerd Otto Michael B Pitton Maria Hoppe-Lotichius Arndt Weinmann | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，1： | 4 |
| 3 | Hepatocellular carcinoma: Surgeon's view on latest findings and future perspectives显示文摘Hepatocellular carcinoma(HCC) is the most common liver-derived malignancy with a high fatality rate. Risk factors for the development of HCC have been identified and are clearly described. However, due to the lack of tumor-specific symptoms, HCC are diagnosed at progressed tumor stages in most patients, and thus curative therapeutic options are limited. The focus of this review is on surgical therapeutic options which can be offered to patients with HCC with special regard to recent findings, not exclusively focused on surgical therapy, but also to other treatment modalities. Further, potential promising future perspectives for the treatment of HCC are discussed. | Jan Erik Slotta Otto Kollmar Volker Ellenrieder B Michael Ghadimi Kia Homayounfar | 2015 | World Journal of Hepatology2015，7，9： | 2 |
| 4 | Persistent immune activation in HIV-1 infection is associated with progression to AIDS显示文摘 | Hazenberg M D Otto S A van Benthem B H | 2003 | AIDS2003，17，： | 1 |
| 5 | Persistent immune activation in HIV-1 infection is associated with progression to AIDS显示文摘 | Hazenberg M D Otto S A van Benthem B H | 2003 | AIDS2003，17，： | 1 |
| 6 | Seasonal effects of 19 plant species on COD removal in subsurface treat- ment wetland microcosms 显示文摘 | Carrie R T Paul B H Otto R S | 2011 | Ecological Engineering2011，37，5： | 1 |
| 7 | Diels-Alder reactions in water显示文摘 | SIJBREN OTTO JAN B F N ENGBERTS | 2000 | Pure Appl Chem2000，72，7： | 1 |
| 8 | Synthesis of Graphene on Silicon Dioxide by a Solid Carbon Source显示文摘 | Hofrichter J Szafranek B N Otto M | 2010 | Nano Letters2010，10，1： | 1 |
| 9 | Depression and influence on reproductive endocrine and menstrual cycle markers associated with perimenopause:the Harvard Study of Moods and Cycles显示文摘 | HARLOW B L WISE L A OTTO M W | 2003 | Arch Gen Psychiatry2003，60，1： | 1 |
| 10 | Modutar product architecture显示文摘 | DAHMUS J B GONZALEZ-ZUGASTI J P OTTO K N | 2001 | Design Studies2001，22，5： | 1 |
| 11 | Cellular origin and diag- nostic significance of high-fluorescent cells in cerebrospinal fluid detected by the XE-5000 hematology analyzer显示文摘 | Zimmermann M Otto C Gonzalez J B et 01 | 2013 | Int J Lab Hematol2013，35，6： | 1 |
| 12 | Minimised gear lubrica-tion by a minimum oil/air flow rate显示文摘 | Hohn B R Michaelis K Otto H P | 2009 | Wear2009，266，34： | 1 |
| 13 | Agitation of non-Newtonian fluids显示文摘 | Metzner A B Otto R E | 1957 | AIChE J1957，3，1： | 1 |
| 14 | Cell specific expression of the mercury insensitive plasma-membra ne aquaporin NtAQP1 from Nicotiana tabacum显示文摘 | OTTO B KALDENHOFF R | 2000 | Planta2000，211，： | 1 |
| 15 | Endogenous and exogenous glucocorticoids decrease plasma Ghrelin in humans 显示文摘 | Otto B Tsctop M H eldwein W | 2004 | Eur J Endocrinol2004，151，1： | 1 |
| 16 | Effects of the hydrophobicity of the reactions on Diels-Alder reactions in water显示文摘 | Otto S Engberts J B | 1998 | J Org Chem1998，63，24： | 1 |
| 17 | Association of aortic valve sclerosis with cardiovascular mortality and morbidity in the elderly 显示文摘 | OTtO C M LIND B K KITZMAN D W | 1999 | N Engl J Med1999，341，1： | 1 |
| 18 | Persistence ectopic pregnancy after liner salpingotomy:a non-predictable complication to conservative surgery for tubal gestation显示文摘 | Otto LC Lisbeth N Nannie B | 2002 | Acta Obstet Gynecol Scand2002，81，11： | 1 |
| 19 | Resveratrol in metabolic health: an overview of the current evidence and perspectives显示文摘 | Morten M?ller Poulsen Jens Otto Lunde J?rgensen Niels Jessen Bj?rn Richelsen Steen B?nl?kke Pedersen | 2013 | Ann. N.Y. Acad. Sci2013，，1： | 1 |
| 20 | Increase in adiponecfin levels during pioglitazone therapy in relation to glucose control, insulin resistanee as well as ghrelin and resist in levels 显示文摘 | Otto C Otto B Coke B | 2006 | J Endocrinal Invest2006，29，3： | 1 |
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