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| 1 | Smoking increases the risk of extraintestinal manifestations in Crohn's disease显示文摘AIM:To demonstrate a high prevalence of extraintestinal manifestations(EIMs)in a prospective populationbased cohort of inflammatory bowel disease(IBD)patients at first diagnosis as well as during the early course of the disease.METHODS:EIMs are common in patients with IBD.Data on the frequency of EIMs have mostly been assessed in patients from tertiary centers;however,data about the prevalence of EIMs at first diagnosis as well as factors influencing their incidence during the early course of disease from prospective population-based cohorts are scarce.We present data of patients of our population-based'Oberpfalz cohort'(Bavaria,Germany)from first diagnosis(up to 3 mo after first diagnosis)as well as during the early course of the disease.Possible risk factors were assessed by calculating the relative risk(RR)as well as using logistic regression analysis.RESULTS:In total,data of 257 newly diagnosed patients with IBD were evaluated[161 Crohn’s disease(CD),96 ulcerative colitis(UC)].Median duration of follow-up was 50 mo after first diagnosis.In 63.4%of all patients(n=163),an EIM was diagnosed at any point during the observation period.At first diagnosis,patients with CD had a significantly increased risk of an EIM[n=69(42.9%)]compared with UC patients[n=21(21.9%);P<0.001;RR=1.96;95%CI:1.30-2.98].Active smoking increased the risk of CD patients developing an EIM during the early course of the disease,but notably not of UC patients(P=0.046;RR=1.96;95%CI:1.01-3.79).In addition,using logistic regression analysis,the need for IBD-related surgery and a young age at first diagnosis were identified as risk factors for the development of an EIM in CD patients.No association with EIMs was found for the factors sex,localization of the disease and positive family history of IBD.In contrast,no key factors which increased the risk of development of an EIM could be identified in UC patients.CONCLUSION:We found a high prevalence of EIM in this cohort at first diagnosis and during the early course of the disease.In patients with CD,smoking,need for surgery and younger age at first diagnosis were risk factors for the development of an EIM. | Claudia Ott Angela Takses Florian Obermeier Elisabeth Schnoy Martina Müller | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 2 | Platelet function in acute myocardial infarction treated with direct angioplasty 显示文摘 | Gawaz M Neumann FJ Ott I | 1996 | Circulation1996，93，2： | 1 |
| 3 | Cytokines and metabolic dysfunction after severe head injury显示文摘 | Mcllain CJ Gillespie M | 1994 | J Neurotrauma1994，11，： | 1 |
| 4 | Regulation of monocyte procoagulant activity in acute myocardial infaction:role of tissue factor and tissue factor pathway inhibitor-1显示文摘 | ANDRASSY M ZIEGLGANSBERGER D | 2001 | Blood2001，97，12： | 1 |
| 5 | A versatile rhodium catalyst for acetalization reactions under mild conditions显示文摘 | Ott G M Ramos T Grand D | 1989 | Tetrahedron Letters1989，30，45： | 1 |
| 6 | Renal retransplantation:a retrospective monocentric study显示文摘 | Ott U Busch M Steiner T | 2008 | Transplant Proc2008，40，5： | 1 |
| 7 | Pancreaticobiliary and duode- nal perforations after periampullary endoscopic proce- dures : diagnosis and management显示文摘 | Fatima J Baron T H Topazian M D Houghton S G Iqbal C W Ott B J | 2007 | Arch Surg2007，142，： | 1 |
| 8 | An increase in intracellular Ca2+ is required for the activation of mitochondrial calpain to release AIF during cell death显示文摘 | Norberg E Gogvadze V Ott M | 2008 | Cell Death Differ2008，15，12： | 1 |
| 9 | A functional phylogenomic view of the seed plants显示文摘 | Lee EK Cibrian-Jaramillo A Kolokotronis SO Katari MS Stamatakis A Ott M Chiu JC Little DP Stevenson DW McCombie WR | | 0，，： | 1 |
| 10 | Microbial responses to microgravity and other low--shear environments显示文摘 | Nickerson C A Ott C M Wilson J W | 2004 | Microbi- ology and Molecular Biology Reviews2004，68，2： | 1 |
| 11 | Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals显示文摘 | Scheid J F Mouquet H Feldhahn N Seaman M S Velinzon K Pietzsch J Ott R G Anthony R M Zebroski H Hurley A Phogat A Chakrabarti B Li Y Connors M Pereyra F Walker B D Wardemann H Ho D Wyatt R T Mascola J R Ravetch J V Nussenzweig M C | 2009 | Nature2009，458，7238： | 1 |
| 12 | Purification of Murine IgG3 and IgM Monoelonal Antibodies by Euglobulin Precipitation 显示文摘 | GARCIA-GONZALEZ M BETTINGER S OTT S | 1988 | J Immunol Methods1988，111，1： | 1 |
| 13 | Program Slices As an Abstraction for Cohesion Measurement显示文摘 | L M Ott J M Bieman | 1998 | Information and Software Technology1998，40，1112： | 1 |
| 14 | PET scanning with F-18-1a- belled fluorodeoxyglucose in 28 SLE patients 显示文摘 | Weiner SM Otte A Schumacher M | 2002 | Ann Rheumatol2002，16，： | 1 |
| 15 | Entry-level competencies of new student affairs professionals: a delphi study显示文摘 | BURKARD A COLE D C OTT M | 2005 | NASPA Journal2005，42，3： | 1 |
| 16 | Tuning RED for web traffic 显示文摘 | Christiansen M Jeffay K Ott D | 2000 | IEEE/ACM Transactions on Networking2000，9，3： | 1 |
| 17 | Organism induced accumulation of iron,zinc and arsenic in wet lands soil显示文摘 | Otte M L | 1997 | Environmental Pollution1997，96，： | 1 |
| 18 | Contribution of raloxifene and calcium and vitamin D3 supplementation to the increase of the degree of mineralization of bone in postmenopausal women 显示文摘 | BOIVIN G LIPS P OTT S M | 2003 | J Clin Endocrinol Metab2003，88，9： | 1 |
| 19 | The Release of Alginate Lyase from Growing Pseudomonas syringae pathovar phaseolicola显示文摘 | OTT C M DAY D F KOENIG D W | 2001 | Current Microbiology2001，42，2： | 1 |
| 20 | Cytokines and metabolic dysfunction after severe head injury显示文摘 | Ott L McClain CJ Sillespie M | 1994 | J Neurotrauma1994，11，5： | 1 |
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