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| 1 | The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming显示文摘新陈代谢对房间功能的每个方面重要,然而,导致的 pluripotent 干细胞(iPSCs ) 的 metabolome 仍然保持大部分未经勘探。这里,我们报导,用一条 untargeted metabolomics 途径,那人的 iPSCs 份额有从他们的父母房间是不同的胚胎的干细胞(转换字符) 的 pluripotent metabolomic 签名,并且那被变化在涉及细胞的呼吸的代谢物描绘。细胞的 bioenergetics 的检查与我们的 metabolomic 分析支持了,并且证明体的房间在 pluripotency 从一个氧化状态变换成一个 glycolytic 状态。有趣地,各种各样的体的房间的 bioenergetics 与他们的 reprogramming 效率相关。我们进一步识别了在 iPSCs 和转换字符之间不同的代谢物,它揭示了在调整体的房间 reprogramming 起一个关键作用的新奇新陈代谢的小径。我们的调查结果是第一全球性分析 iPSCs 的 metabolome,并且提供机械学的卓见进涉及导致 pluripotency,并且在评估 iPSC 和转换字符等价的规定的新层。 | Athanasia D Panopoulos Oscar Yanes Sergio Ruiz Yasuyuki S Kida Dinh Diep Ralf Tautenhahn Aida Herrerias Erika M Batchelder Nongluk Plongthongkum Margaret Lutz W Travis Berggren Kun Zhang Ronald M Evans Gary Siuzdak Juan Carlos Izpisua Belmonte] | 2012 | Cell Research2012，22，1： | 12 |
| 2 | A light-weight authentica- tion scheme for wireless sensor networks 显示文摘 | OSCAR D M AMPARO F S JOSE M S | 2011 | Ad Hoc Networks2011，9，5： | 1 |
| 3 | Native Point Defects in Binary InP Semiconductors 显示文摘 | Roha M Oscar D R Ashutosh K | 2012 | Journal of Materials Science2012，47，21： | 1 |
| 4 | Controls andpredictability of carbonate facies architecture in a Lower Jurassicthreedimensionalbarriershoalcomplex (Djebel Bou Dahar,High Atlas,Morocco)显示文摘 | Verwer K Porta G D Oscar M T | 2009 | Sedimentology2009，56，6： | 1 |
| 5 | A Light-weight Authentication Scheme for Wireless Sensor Networks显示文摘 | Oscar D M Amparo F S Jose M S | 2011 | Ad Hoc Networks2011，，9： | 1 |
| 6 | Trehalose Metabolism in Plants显示文摘 | Oscar J M Goddijn K D | 1999 | Trends in Plant Science1999，4，8： | 1 |
| 7 | Controlled atmosphereas coadjuvant to chilled storage for prevention of melanosis inshrimps (Parapenaeus longirostris) 显示文摘 | OSCAR M A PILAR M MARIA D C G | 2005 | European Food Researchand Technology2005，220，2： | 1 |
| 8 | The financial and operating performance of China's newly privatized firms显示文摘 | Zuobao Wei Oscar Varela M Kabir Hassan Juliet D'Souza | 2003 | Financial Management2003，32，2： | 1 |
| 9 | Immiscible CO2 flooding for increased oil recovery and reduced emissions显示文摘 | Randal M B James D H Oscar B A | 2000 | SPE593282000，，： | 1 |
| 10 | Trehalose metabolism in plants显示文摘 | Oscar J M Goddijn Kees V D | 1999 | Trends in Plant Science1999，4，8： | 1 |
| 11 | Egetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables显示文摘 | Ociel M Oscar P D Irma L | | 0，，： | 1 |
| 12 | A filtration-based real-time PCR method for the quantitative detection of viable Salmonellaenterica and Listeria monocytogenes in food samples显示文摘 | OSCAR F D PALMIRO P SANTO M | 2009 | FoodMicrobiology2009，26，： | 1 |
| 13 | Vegetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables 显示文摘 | Ociel M Oscar P D Irma L el al | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 14 | Contribution of water, bread, and vegetables ( raw and cooked )to dietary intake of inorganic arsenic in a rural village of northern Chile显示文摘 | Oscar P D Irma L Ociel M el al | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 15 | Controls and Predictability of Carbonate Facies Architecture in a Lower Jurassic Three-Dimensional Barrier-Shoal Complex (Djebel Bou Dahar,High Atlas,Morocco)显示文摘 | VERWER K PORTA G D OSCAR M T | | 0，，6： | 1 |
| 16 | A light-weight authentication scheme for wireless sensor networks 显示文摘 | Oscar D M Amparo F S Jos6 M S | 2011 | Ad Hoc Networks2011，9，5： | 1 |
| 17 | Vegetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables显示文摘 | Ociel M Oscar P D Irma L | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 18 | Contribution of water, bread and vegetables (raw and cooked) to dietary intake of inorganic arsenic in a rural village of northern Chile 显示文摘 | Oscar P D Irma L Ociel M | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 19 | Root proliferation in native perennial grasses of arid Patagonia,Argentina显示文摘Pappophorum vaginatum is the most abundant C4perennial grass desirable to livestock in rangelands of northeastern Patagonia,Argentina.We hypothesized that(1)defoliation reduce net primary productivity,and root length density and weight in the native species,and(2)root net primary productivity,and root length density and weight,are greater in P.vaginatum than in the other,less desirable,native species(i.e.,Aristida spegazzinii,A.subulata and Sporobolus cryptandrus).Plants of all species were either exposed or not to a severe defoliation twice a year during two growing seasons.Root proliferation was measured using the cylinder method.Cylindrical,iron structures,wrapped up using nylon mesh,were buried diagonally from the periphery to the center on individual plants.These structures,initially filled with soil without any organic residue,were dug up from the soil on 25April 2008,after two successive defoliations in mid-spring 2007.During the second growing season(2008–2009),cylinders were destructively harvested on 4 April 2009,after one or two defoliations in midand/or late-spring,respectively.Roots grown into the cylinders were obtained after washing the soil manually.Defoliation during two successive years did reduce the study variables only after plants of all species were defoliated twice,which supported the first hypothesis.The greater root net primary productivity,root length density and weight in P.vaginatum than in the other native species,in support of the second hypothesis,could help to explain its greater abundance in rangelands of Argentina. | Yanina A TORRES Carlos A BUSSO Oscar A MONTENEGRO Leticia ITHURRART Hugo D GIORGETT Gustavo RODRíGUEZ Diego BENTIVEGNA Roberto E BREVEDAN Osvaldo A FERNáNDEZ María M MUJICA Sandra S BAIONI José ENTíO María N FIORETTI Guillermo TUCAT | 2014 | Journal of Arid Land2014，6，2： | 0 |
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