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| 1 | mTOR inhibitors counteract tamoxifen-induced activation of breast cancer stem cells显示文摘 | Govindasamy-Muralidharan Karthik Ran Ma John L?vrot Lorand Levente Kis Claes Lindh Lennart Blomquist Irma Fredriksson Jonas Bergh Johan Hartman | 2015 | Cancer Letters2015，，1： | 1 |
| 2 | Method of DNA extraction and application of multiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and O139 from aquatic ecosystems显示文摘 | Irma N Rivera L Erin K | 2003 | Environ Microbiol2003，5，7： | 1 |
| 3 | Molecular cloning and functional expression of the gene for a cotton Delta-12 fatty acid desaturase(FAD2)显示文摘 | Pirtle Irma L Kongcharoensuntorn Wisatre Nampaisansuk Mongkol | 2001 | Biochim Biophys Acta2001，1522，2： | 1 |
| 4 | Genetic testing for reti- nal dystrophies and dysfunctions:benefits, dilemmas and solu- tions显示文摘 | Robert K K Irma L den Anneke I H et aI | 2007 | Clinical and Experimental Ophthalmology2007，35，5： | 1 |
| 5 | Egetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables显示文摘 | Ociel M Oscar P D Irma L | | 0，，： | 1 |
| 6 | Cloud point extraction for ultra-trace Cd determination in microwave-digested biological samples by ETAAS显示文摘 | Pedro R. Aranda Raúl A. Gil Susana Moyano Irma De Vito Luis D. Martinez | 2008 | Talanta2008，，2： | 1 |
| 7 | An integrated approach to fast and informative morphological vouchering of nematodes for applications in molecular barcoding显示文摘 | PAUL D L IRMA T D KRYSTALYNNE M | 2005 | Phil Trans R Soc B2005，360，： | 1 |
| 8 | Method of DNA extraction and application of muhiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and 0139 from aquatic ecosystems 显示文摘 | Irma N G R Erin K L Ana G | 2003 | Environ Microbiol2003，5，7： | 1 |
| 9 | The effect of nutri-tion on the neural mechanisms potentially involved inmelatonin-stimulated LH secretion in female Mediter-ranean goats显示文摘 | Luis A Z Irma C Jose L G | 2011 | Journal of Endocrinology2011，211，： | 1 |
| 10 | Vegetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables 显示文摘 | Ociel M Oscar P D Irma L el al | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 11 | Contribution of water, bread, and vegetables ( raw and cooked )to dietary intake of inorganic arsenic in a rural village of northern Chile显示文摘 | Oscar P D Irma L Ociel M el al | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 12 | TNFα和IL-6体外对颗粒物的反应:随颗粒物大小、季节、多环芳烃和土壤含量的变化显示文摘[背景]颗粒物(PM)与人类健康之间的关联随着季节变化而不同,这种现象可能与颗粒物的成分以及毒性相关的季节性交互作用有关。[目的]检测PM成分的季节性变化,并使用多个PM样本评估PM的体外促炎症可能性。[方法]以5个污染源不同的城市地区为采集地点,每周采集样本,在多雨温暖季节和干燥寒冷季节累积采集90份PM_(10)和PM_(2.5)样本。对其中检测到的元素、多环芳烃(PAHs)和内毒素进行主成分分析(PCA)。在人单核细胞(THP-1)中检测PM诱导肿瘤坏死因子α(TNFα)和白介素6(IL-6)分泌的可能性,并用组分评分建立促炎症反应的模型。[结果]PM的成分随其大小和季节而变化。PCA确定了PM中两种随季节变化的主要组分。燃烧相关的成分(如钒、苯并(a)芘、苯并(a)蒽)组成组分1(C_1),土壤相关的成分(如内毒素、硅、铝)组成组分2(C_2)。多雨温暖季节采集的PM中C_2含量较高,而干燥寒冷季节采集的PM(尤其是PM_(2.5))中C_1含量较高。细胞因子生成水平与PM_(10)和C_2(多雨温暖季节)正相关,但与PM_(2.5)和C_1(干燥寒冷季节)负相关。C_2含量较高的PM暴露水平越高,TNFα分泌越多;样本含有≥0.1%的C_1相关PAHs时,无论样本中C_2含量高低,暴露于该样本后TNFα对PM的反应性分泌都会降低。IL-6检测结果提示PM成分和颗粒大小之间存在复杂的交互作用。[结论]TNFα分泌具有季节性并与PM大小相关,PM中的土壤含量及PAH含量的变化是其根本原因。这些结果提示,流行病学研究中一些健康结局与PM之间关联的季节性差异能用PM组分的混合物来解释。 | Natalia Manzano-León Jesús Serrano-Lomelin Brisa N.Sánchez Raúl Quintana-Belmares Elizabeth Vega Inés Vázquez-López Leonora Rojas-Bracho Maria Tania López-Villegas Felipe Vadillo-Ortega Andrea De Vizcaya-Ruiz Irma Rosas Perez Marie S.O’Neill Alvaro R.Osornio-Vargas 季麟(翻译) 金泰廙(审校) | 2016 | 环境与职业医学2016，33，12： | 1 |
| 13 | 15 Laccase 显示文摘 | Octavio L C Cristina Irma P P Ma Rieardo B R J | 2006 | Advances in Agricultural and Food Biotechnology2006，，： | 1 |
| 14 | Synthesis,characterization and bioactivity of polyoxometalates on osteoblasts in culture显示文摘 | Botto Irma L Barrio Daniel A Eguzquiza Maria G | 2004 | Metal Ions in Biology and Medicine2004，7，： | 1 |
| 15 | Vegetables collected in the cultivated Andean area of northern Chile:total and inorganic arsenic contents in raw vegetables显示文摘 | Ociel M Oscar P D Irma L | 2002 | Journal of Agricultural and Food Chemistry2002，50，： | 1 |
| 16 | Contribution of water, bread and vegetables (raw and cooked) to dietary intake of inorganic arsenic in a rural village of northern Chile 显示文摘 | Oscar P D Irma L Ociel M | 2004 | Journal of Agricultural and Food Chemistry2004，52，： | 1 |
| 17 | The inhibitory effects on sexual behavior and ambulatory activity of the mixed GABAA/GABAB agonist progabide are differentially blocked by GABA receptor antagonists显示文摘 | A. ?gmo Raúl G. Paredes Laura Sierra Irma Garcés | 1997 | Psychopharmacology1997，，1： | 1 |
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