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| 1 | Complementary and alternative medicines in irritable bowel syndrome: An integrative view显示文摘Irritable bowel syndrome(IBS)is a common gastrointestinal disorder with a high incidence in the general population.The diagnosis of IBS is mainly based on exclusion of other intestinal conditions through the absence of inflammatory markers and specific antigens.The current pharmacological treatment approaches available focus on reducing symptom severity while often limiting quality of life because of significant side effects.This has led to an effectiveness gap for IBS patients that seek further relief to increase their quality of life.Complementary and alternative medicines(CAM)have been associated with a higher degree of symptom management and quality of life in IBS patients.Over the past decade,a number of important clinical trials have shown that specific herbal therapies(peppermint oil and Iberogast?),hypnotherapy,cognitive behavior therapy,acupuncture,and yoga present with improved treatment outcomes in IBS patients.We propose an integrative approach to treating the diverse symptoms of IBS by combining the benefits of and need for pharmacotherapy with known CAM therapies to provide IBS patients with the best treatment outcome achievable.Initial steps in this direction are already being considered with an increasing number of practitioners recommending CAM therapies to their patients if pharmacotherapy alone does not alleviate symptoms sufficiently. | Oliver Grundmann Saunjoo L Yoon | 2014 | World Journal of Gastroenterology2014，20，2： | 13 |
| 2 | Chronic intestinal failure and short bowel syndrome in Crohn’s disease显示文摘Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s disease.Depending on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal failure.Management of CIF has improved significantly in recent years.Advances in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of life.Nevertheless,60%of patients are permanently reliant on parenteral nutrition.Encouraging results with new drugs such as teduglutide have added a new dimension to CIF therapy.The outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and treatment.In complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of life.Here,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease. | Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein | 2021 | World Journal of Gastroenterology2021，27，24： | 4 |
| 3 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 4 | Population Incidence of Guillain-Barre Syndrome: A Systematic Review and Meta-Analysis显示文摘 | Sejvar James J Baughman Andrew L Wise Matthew Morgan Oliver W | 2011 | EN2011，，2： | 2 |
| 5 | Infrared spectroscopic study of potassium and cesium acetate-intercalated kaolinites显示文摘 | Ray L Frost Oliver B Locos Janos Kristof J.Theo Kloprogge | 2001 | Vibrational Spectroscopy2001，，1： | 2 |
| 6 | Intraperitoneal chemotherapy in the first-line treatment of women with stage Ⅲ epithelial ovarian cancer: a systematic review with metaanalyses显示文摘 | Elit L Oliver TK Covens A | 2007 | Cancer2007，109，4： | 1 |
| 7 | Whence Consumer Loyalty? 显示文摘 | Oliver Richard L | 1999 | Journal of Marketing1999，，63： | 1 |
| 8 | A cognitive model of the antecedents and consequences of satisfaction decisions显示文摘 | Olive R L | 1980 | Journal of Marketing Research1980，17，4： | 1 |
| 9 | A Cognitive Model of the Antecedents and Consequences of Satisfaction Decisions显示文摘 | Oliver Richard L | 1980 | Journal of Marketing Re- search1980，17，4： | 1 |
| 10 | Conceptual issues in the structural analysis of Consumption emotion, satisfaction, and quality: Evidence in a service setting显示文摘 | Oliver R L | 1994 | Advances in Consumer Research1994，21，1： | 1 |
| 11 | On the Measurement of Stress-strain Curves by Spherical Indentation显示文摘 | E G Herbert G M Pharr W C Oliver B N Lucas J L Hay | 2001 | Thin Solid Films2001，，： | 1 |
| 12 | Upregulation of alveolar epithelial fluid transport after subacute lung injury in rats from bleomycin 显示文摘 | FOLKESSON H G NITENBERG G OLIVER B L | 1998 | Am J Physiol1998，275，31： | 1 |
| 13 | Montelukast improves pulmonary function measured by impulse oscillometry in children with asthma ( Mio study) 显示文摘 | Nieto A Pamies R Oliver F Medina A Caballero L Mazon A | 2006 | Respir Med2006，100，7： | 1 |
| 14 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 15 | Whence consumer loyalty? 显示文摘 | OLIVER R L | 1999 | Journal of Marketing1999，63，： | 1 |
| 16 | Crystallographic and NMR evidence for the enol tautomer of 3-methoxy-4-hydroxy-5-chloro-phenylpyruvic acid显示文摘 | D. W. Oliver P. P. Haasbroek J. M. Léger A. J. M. Carpy | 1994 | Journal of Chemical Crystallography1994，，10： | 1 |
| 17 | A cognitive model of the antecedents and consequences of satisfaction decisions显示文摘 | Oliver R L | 1980 | Journal of marketingresearch1980，17，4： | 1 |
| 18 | A cognitive model for the antecedents and consequences of satisfaction显示文摘 | OLIVER R L | 1980 | Journal of Marketing research1980，17，： | 1 |
| 19 | Cytotoxicity, mutagenicity and DNA damage by hoechst 33342显示文摘 | DURAND R E OLIVE P L | 1982 | J Histochem Cytochem1982，30，2： | 1 |
| 20 | Response Determi-nants in Satisfaction Judgments显示文摘 | DESARBO W S | 1998 | Journal of Con-sumer Research1998，14，3： | 1 |
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