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| 1 | Dedifferentiated fat cells: an alternative source of adult multipotent cells from the adipose tissues显示文摘When adipose-derived stem cells (ASCs) are retrieved from the stromal vascular portion of adipose tissue, a large amount of mature adipocytes are often discarded. However, by modified ceiling culture technique based on their buoyancy, mature adipocytes can be easily isolated from the adipose cell suspension and dedifferen- tiated into lipid-free fibroblast-like cells, named dedifferentiated fat (DFAT) cells. DFAT cells re-establish active proliferation ability and undertake multipotent capacities. Compared with ASCs and other adult stem cells, DFAT cells showed unique advantages in their abundance, isolation and homogeneity. In this concise review, the establishment and culture methods of DFAT cells are introduced and the current profiles of their cellular nature are summarized. Under proper induction culture in vitro or environment in vivo, DFAT cells could demonstrate adipogenic, osteogenic, chondrogenic and myogenic potentials. In angiogenic conditions, DFAT cells could exhibit perivascular characteristics and elicit neovascularization. Our preliminary findings also suggested the pericyte phenotype underlying such cell lineage, which supported a novel interpretation about the common origin of mesenchymal stem cells and tissue-specific stem cells within blood vessel walls. Current research on DFAT cells indicated that this alternative source of adult multipotent cells has great potential in tissue engineering and regenerative medicine. | Jie-fei Shen Atsunori Sugawara Joe Yamashita Hideo Ogura Soh Sato | 2011 | International Journal of Oral Science2011，3，3： | 16 |
| 2 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 3 | Macrophage migration inhibitory factor stimulated by He/icobacter py/oriincreases proliferation of gastric epithelial cells显示文摘AIM: Helicobacter pylori (H pylori) is associated with increased gastric inflammatory and epithelial expression of macrophage migration inhibitory factor (MIF) and gastric epithelial cell proliferation. This study aimed at determining whether H pylori directly stimulates release of MIF in monocytes, whether the cay pathogenicity island (PAI) is involved for this function, and whether MIF stimulated by H pylori increases gastric epithelial cell proliferation in vitro.METHODS: A cytotoxic wild-type H pylori strain (TN2),its three isogenic mutants (TN2△cag, TN2△cagA and TN2△cagE) were co-cultured with cells of a human monocyte cell line, THP-1, for 24 h at different organism/cell ratios. MIF in the supernatants was measured by an ELISA. Cells of a human gastric cancer cell line, MKN45,were then co-cultured with the supernatants, with and without monoclonal anti-MIF antibody for 24 h. The cells were further incubated for 12 h after addition of 3H-thymidine, and the levels of incorporation of 3H-thymidine were measured with a liquid scintillation counter.RESULTS: The wild-type strain and the isogenic mutants,TN2△cagA and TN2△cagE, increased MIF release at organism/cell ratios of 200/1 and 400/1, but not at the ratios of 50/1 and 100/1. However, the mutant TN2△cag did not increase the release of MIF at any of the four ratios.3H-thymidine readings for MKN-45 cells were significantly increased with supernatants derived from the wild-type strain and the mutants TN2△cagA and TN2△cagE, but not from the mutant TN2△cag. Moreover, in the presence of monoclonal anti-MIF antibody, the stimulatory effects of the wild-type strain on cell proliferation disappeared.CONCLUSION: H pylori stimulates MIF release in monocytes, likely through its cag PAI, but not related to cagA or cagE. H pylori-stimulated monocyte culture supernatant increases gastric cell proliferation, which is blocked by anti-MIF antibody, suggesting that MIF plays an important role in H pylori-induced gastric epithelial cell proliferation. | Harry Hua-Xiang Xia Shiu Kum Lam Annie O.O.Chan Marie Chia Mi Lin Hsiang Fu Kung Keiji Ogura Douglas E.Berg Benjamin Chun-Yu Wong | 2005 | World Journal of Gastroenterology2005，11，13： | 12 |
| 4 | NF-κB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection显示文摘AIM: To elucidate the sequential gene expression profile in AGS cells co-cultured with wild-type Hellcobacter pylori (Hpylon) as a model of H pylori-infected gastric epithelium, and to further examine the contribution of cag-pathogenicity islands (cagPAI)-coding type Ⅳ secretion system and the two pathways, nuclear factor kappa B (NF-κB) and extracellular signal-regulated kinases (ERK) on wild-type H pylori-induced gene expression. METHODS: Gene expression profiles induced by H pylori were evaluated in AGS gastric epithelial cells using cDNA microarray, which were present in the 4 600 independent clones picked up from the human gastric tissue. We also analyzed the contribution of NF-κB and ERK signaling on H pylori-induced gene expression by using inhibitors of specific signal pathways. The isogenic mutant with disrupted capE (△cagE) was used to elucidate the role of capPAI-encoding type Ⅳ secretion system in the gene expression profile. RESULTS: According to the expression profile, the genes were classified into four clusters. Among them, the clusters characterized by continuous upregulation were most conspicuous, and it contained many signal transducer activity-associated genes. The role of cagPAI on cultured cells was also investigated using isogenic mutant cagE, which carries non-functional cagPAI. Then the upregulation of more than 80% of the induced genes (476/566) was found to depend on cagPAI. Signal transducer pathway through NF-κB or ERK are the major pathways which are known to be activated by cagPAI-positive H pylori. The role of these pathways in the whole signal activation by cagPAI- positive H pylori was analyzed. The specific inhibitors against NF-κB or ERK pathway blocked the activation of gene expression in 65% (367/566) or 76% (429/566) of the genes whose activation appealed to depend on cagPAI. CONCLUSION: These results suggest that more than half of the genes induced by cagPAI-positive H pylori depend on NF-κB and ERK signaling activation, and these pathways may play a role in the gene expression induced by host-bacterial interaction which may associate with H pylori-related gastro-duodenal diseases. | Wataru Shibata Yoshihiro Hirata Haruhiko Yoshida Motoyuki Otsuka Yujin Hoshida Keiji Ogura Shin Maeda Tomoya Ohmae Ayako Yanai Yuzo Mitsuno Naohiko Seki Takao Kawabe Masao Omata | 2005 | World Journal of Gastroenterology2005，11，39： | 12 |
| 5 | Dispersoid Formation and Recrystallization Behavior in an Al-Mg-Si-Mn Alloy显示文摘The nucleation and precipitation of Mn-containing dispersoids in an Al-Mg-Si-Mn alloy (6082) have been studied by optical microscopy,EPMA (electron probe microanalysis) and TEM (transmission electron microscopy).The influence of Mn-containing dispersoids on the recrystallization behavior was also investigated.The size and distribution of dispersoids were strongly affected by both the homogenization process and the alloying element distribution formed in the direct chill cast procedure.The Mn-containing dispersoids were observed to nucleate preferentially on the β-Mg 2 Si phase and to be aligned along the <100> direction of the matrix.After cold deformation,the morphology of dispersoids greatly influences the recrystallization and grain growth behavior in the annealing process. | Rong Hu Tomo Ogura Hiroyasu Tezuka Tatsuo Sato Qing Liu | 2010 | Journal of Materials Science & Technology2010，26，3： | 10 |
| 6 | Lymphoepithelioma-like esophageal carcinoma with macroscopic reduction显示文摘Esophageal lymphoepithelioma-like carcinoma(LELC) is extremely rare. We report the first case of esopha-geal LELC showing macroscopic reduction. A 67-year-old male presented with dysphagia and, by endoscopic examination, was found to have a significantly raised tumor of 10 mm in diameter in the thoracic esophagus. The biopsied material showed esophageal cancer. We performed endoscopic submucosal dissection. However, the tumor became flattened, similar to a scar, in only 2 mo. Histologically, the carcinoma cells had infiltrated the submucosal layer. Prominent infiltration of T lymphoid cells that stained positive for CD8 was observed aroundthe carcinoma cells. Therefore, this lesion was consid-ered to be an LELC with poorly differentiated squamous cells. Because the margin was positive, an esophagec-tomy was performed. Carcinoma cells were detected in the neck in one lymph node. The staging was T1N0M1 b. However, the patient has been well, without adjuvant therapy or recurrence, for more than 5 years. | Masaya Uesato Tuguaki Kono Tooru Shiratori Yasunori Akutsu Isamu Hoshino Kentarou Murakami Daisuke Horibe Tetsurou Maruyama Yoshihide Semba Ryuma Urahama Yukiko Ogura Takashi Oide Toru Tanizawa Hisahiro Matsubara | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，8： | 6 |
| 7 | Electrochemical behavior of [UO_2Cl_4]^(2-) in 1-ethyl-3-methylimidazolium based ionic liquids显示文摘In order to examine the chemical form of uranyl species in 1-ethyl-3-methylimidazolium(EMI) based ionic liquids,UV-visible absorption spectra of solutions prepared by dissolving [EMI] 2 [UO2Cl4] into a mixture of EMICl and EMIBF 4(50:50 mol%) were measured.As a result,it was confirmed that uranyl species in the mixture of EMICl and EMIBF 4 existed as [UO2Cl4]2-.Cyclic voltammograms(CVs) of [UO2Cl4]2-in the mixture were measured at 25 ℃ using a Pt working electrode,a Pt wire counter electrode,and an Ag/Ag + reference electrode(0.01 M AgNO 3,0.1 M tetrabutylammonium perchlorate in acetonitrile) in a glove box under an Ar atmosphere.Peaks corresponding to one redox couple were observed around-1.05 V(Epc) and-0.92 V(Epa) vs.ferrocene/ferrocenium ion(Fc/Fc +).The potential differences between two peaks(Ep) increased from 101 to 152 mV with an increase in the scan rate from 50 to 300 mV s-1,while the(Epc+Epa)/2 value was constant,-0.989 V vs.Fc/Fc + regardless of the scan rate.Furthermore,the diffusion coefficient of [UO2Cl4]2-and the standard rate constant were estimated to be 3.7 × 10-8 cm 2 s-1 and(2.7-2.8) × 10-4 cm s-1 at 25 oC.By using the diffusion coefficient and the standard rate constant,the simulation of CVs was performed based on the reaction,[UO2Cl4]2-+ e = [UO2Cl4]3-.The simulated CVs were found to be consistent with the experimental ones.From these results,it is concluded that [UO2Cl4]2-in the mixture of EMICl and EMIBF 4 is reduced to [UO2Cl4]3-quasi-reversibly at-0.989 V vs.Fc/Fc +. | OGURA Toshinari SASAKI Kotoe TAKAO Koichiro ARAI Tsuyoshi IKEDA Yasuhisa | 2012 | Science China Chemistry2012，55，9： | 6 |
| 8 | Non-bismuth quadruple therapy for first-line Helicobacter pylori eradication:A randomized study in Japan显示文摘AIM:To find the way to improve the eradication rate of first-line therapy in Japanese patients.METHODS:We prospectively compared the effectiveness of 7-d quadruple therapy to standard 7 d triple therapy in Japanese patients infected with Helicobacter pylori(H.pylori).One hundred and nineteen patients were randomly assigned to receive 7-d non-bismuth quadruple therapy with lansoprazole,amoxicillin,clarithromycin and metronidazole(LACM7) or 7-d triple therapy with lansoprazole,amoxicillin and clarithromycin(LAC7).After three months,H.pylori status was analyzed by 13C-urea breath test.Incidence rates of adverse events were evaluated by use of questionnaires.RESULTS:By intention-to-treat(ITT) analysis,the eradication rate in the LACM7 group was 94.9%,which was significantly higher than the LAC7 group(68.3%,P < 0.001).Per protocol analysis also showed a significantly higher eradication rate in the LACM7 group(98.3%) than the LAC7 group(73.2%,P < 0.001).Nevertheless,the incidence of serious adverse events did not differ between the two groups(RR:1.10,95% CI:0.70-1.73,P = 0.67).CONCLUSION:Seven day non-bismuth quadruple therapy(LACM7) was superior to standard 7-d triple therapy(LAC7) for first-line eradication. | Ayako Yanai Kei Sakamoto Masao Akanuma Keiji Ogura Shin Maeda | 2012 | World Journal of Gastrointestinal Pharmacology and Therapeutics2012，3，1： | 5 |
| 9 | Peeling a giant ileal lipoma with endoscopic unroofing and submucosal dissection显示文摘Lipoma is relatively common in the colon but is less often in the small intestine. Most lipomas are incidentally detected at endoscopy and are usually small and asymptomatic. However, some of them can present with obstruction and/or intussusceptions. Surgical resection is commonly recommended to remove such significant lipomas with a limited pedicle and larger than 2 cm in size, as endoscopic resection may result in unfavorable complications such as intestinal perforations. We report a case of 62-year-old man presenting with hematochezia. Colonoscopy showed a submucosal tumor, about 50 mm in size, in the terminal ileum. A clinical diagnosis of lipoma was established based on the findings of colonoscopy and abdominal computed tomography (CT). As the patient complained of hematochezia and mild iron deficiency anemia associated with repeated tumor prolapse, we decided to remove his lipoma. Consequently, the lesion was completely removed en bloc . Although abdominal CT immediately after removal of the lesion showed a small amount of free air, conservative treatment was successfully carried out for the perforation. Histologically, the removed lesion was a lipoma. | Takashi Morimoto Kuang-I Fu Hironori Konuma Yuko Izumi Syujirou Matsuyama Kanako Ogura Akihisa Miyazaki Sumio Watanabe | 2010 | World Journal of Gastroenterology2010，16，13： | 4 |
| 10 | A Modified DRASTIC Approach to Shallow Groundwater Vulnerability in the West Lake Watershed in Hangzhou, China显示文摘The quality of shallow groundwater in the West Lake watershed was investigated from March to July 2000. Integrating with Blackland GRASS GIS system, the DRASTIC model was used to compile the groud-water vulnerability map. A land use factor was added to the DRASTIC model and the modified model (LDRASTIC) increased the accuracy of prediction from 26.9% to 51.3%. The vulnerability map showed that the lowly, moderately and highly susceptible area predicted occupied about 11.6%, 70.9% and 17.5% of the whole watershed, respectively. Compared with the observed values of nitrate and electric conductivity, the LDRASTIC index improved the Pearson correlation coefficients from -0.010 to 0.237 and 0.380 to 0.503 both the improved coefficients were significant at the 0.01 level. The modified DRASTIC analysis showed a great potential as a screening tool for policy decision-making in groundwater management. | DONG LIANG, ZHU YINMEI and N. OGURA Department of Environmental Science, Zhejiang University, Hangzhou 310029 (China) The United Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183-8509 (Japan) | 2002 | Pedosphere2002，12，1： | 4 |
| 11 | Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer显示文摘瞄准:在早胰腺的致癌作用期间调查遇见 c 的表示。方法:我们使用了 46 体积纸巾和 36 件微把样品,包括正常的胰,慢性胰炎,和胰腺的癌症,为量的即时反向的抄写聚合酶链反应。结果:大批,组织分析,胰腺的癌症纸巾显著地表示了高水平比遇见 c 做了慢性胰炎和正常的胰纸巾。遇见 c 的层次没在慢性胰炎和正常的胰纸巾之间不同。在基于 microdissection 的分析,遇见 c 比在正常管的上皮细胞在微把的胰腺的癌症房间和影响胰腺炎的上皮细胞在高水平被表示(两, P <
0.01 ) 。有趣地,影响胰腺炎的上皮细胞表示了层次遇见 c 类似于那些胰腺的癌症房间。结论:Overexpression 遇见 c 在胰腺的致癌作用的早阶段期间发生,并且遇见 c 的表示的单个改变不为到胰腺的癌症房间的长期的影响胰腺炎的上皮细胞的前进是足够的。 | Kenoki Ohuchida Kazuhiro Mizumoto Nami Ishikawa Yasuhiro Ogura Daisuke Yamada Takuya Egami Hayato Fujita Seiji Ohashi Eishi Nagai Masao Tanaka | 2006 | World Journal of Gastroenterology2006，12，24： | 4 |
| 12 | Prognostic value of K - ras mutation status and subtypes in endoscopic ultrasound-guided fine-needle aspiration specimens from patients with unresectable pancreatic cancer显示文摘 | Takeshi Ogura Kenji Yamao Kazuo Hara Nobumasa Mizuno Susumu Hijioka Hiroshi Imaoka Akira Sawaki Yasumasa Niwa Masahiro Tajika Shinya Kondo Tsutomu Tanaka Yasuhiro Shimizu Vikram Bhatia Kazuhide Higuchi Waki Hosoda Yasushi Yatabe | 2013 | Journal of Gastroenterology2013，，5： | 4 |
| 13 | Does endoscopic ultrasound-guided biliary drainage really have clinical impact?显示文摘The well established, gold standard method for treatment of obstructive jaundice involves biliary drainage under endoscopic retrograde cholangiopancreatography(ERCP) performed by pancreatobiliary endoscopists. Recently, interventions using endoscopic ultrasound(EUS) have been developed not only for obtaining cytological and histological diagnosis, but also for biliary drainage as alternative method. EUS-guided biliary drainage(EUSBD) was first reported by Giovannini et al. EUS-BD broadly includes EUS-guided rendezvous technique, EUS-guided choledochoduodenostomy, and EUS-guided hepaticogastrostomy. More recently, EUS-guided antegrade stenting and EUS-guided gallbladder drainage have also been reported. many case reports, series, and retrospective studies on EUS-BD have been reported. However, because prospective studies and comparisons between the different biliary drainage methods have not been reported, the technical success, functional success, adverse events, and stent patency with long-term follow up of EUS-BD are still unclear. Therefore, prospective, randomized controlled studies addressing these issues are needed. Despite this, EUSBD undoubtedly is clinically useful as an alternative biliary drainage method. EUS-BD has the potential to be a first-line biliary drainage method instead of ERCP if results of clinical trials are favorable and the technique is simplified. | Takeshi Ogura Kazuhide Higuchi | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 14 | Hemobilia due to hepatocellular carcinoma: cholangioscopicfindings and novel endoscopic hemostasis显示文摘To the Editor:Trauma,inflammation,iatrogenic procedures such as liver biopsy and percutaneous transhepatic biliary drainage(PTBD),vascular anomalies,coagulopathy status,and malignancy can cause hemobilia[1].Malignant causes of hemobilia include cholangiocarcinoma,pancreatic cancer,gallbladder tumor,and liver metastasis,but rarely hepatocellular carcinoma(HCC).Here,we describe achieving endoscopic hemostasis for hemobilia caused by HCC,which was visualized using the single-operator,SPY-DS cholangioscope(Boston Scientific,Tokyo,Japan)under endoscopic | takeshi ogura atsushi okuda kazuhide higuchi | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，3： | 3 |
| 15 | EUS-guided hepaticogastrostomy combined with fine-gauge antegrade stenting: a pilot study显示文摘 | Takeshi Ogura Daisuke Masuda Akira Imoto Toshihisa Takeushi Rieko Kamiyama Malak Mohamed Eiji Umegaki Kazuhide Higuchi | 2014 | Endoscopy2014，，： | 3 |
| 16 | Endoscopic ultrasound-guided biliary drainage for right hepatic bile duct obstruction: novel technical tips显示文摘 | Takeshi Ogura Tatsushi Sano Saori Onda Akira Imoto Daisuke Masuda Kazuhiro Yamamoto Masayuki Kitano Toshihisa Takeuchi Takuya Inoue Kazuhide Higuchi | 2014 | Endoscopy2014，，： | 3 |
| 17 | Lower Limit of the Graft-to-Recipient Weight Ratio Can Be Safely Reduced to 0.6% in Adult-to-Adult Living Donor Liver Transplantation in Combination with Portal Pressure Control显示文摘 | T. Kaido A. Mori Y. Ogura K. Hata A. Yoshizawa T. Iida S. Yagi S. Uemoto | 2011 | Transplantation Proceedings2011，，6： | 3 |
| 18 | Changes in portal venous pressure in the early phase after living donor liver transplantation: pathogenesis and clinical implications1,2显示文摘 | Takashi Ito Tetsuya Kiuchi Hidekazu Yamamoto Fumitaka Oike Yasuhiro Ogura Yasuhiro Fujimoto Kazuhiro Hirohashi and Koichi Tanaka | 2003 | Transplantation2003，，8： | 3 |
| 19 | Systemic hemodynamics in advanced cirrhosis: Concerns during perioperative period of liver transplantation显示文摘Advanced liver cirrhosis is usually accompanied by portal hypertension. Long-term portal hypertension results in various vascular alterations. The systemic hemodynamic state in patients with cirrhosis is termed a hyperdynamic state. This peculiar hemodynamic state is characterized by an expanded blood volume, high cardiac output, and low total peripheral resistance. Vascular alterations do not disappear even long after liver transplantation(LT), and recipients with cirrhosis exhibit a persistent systemic hyperdynamic state even after LT. Stability of optimal systemic hemodynamics is indispensable for adequate portal venous flow(PVF) and successful LT, and reliable parameters for optimal systemic hemodynamics and adequate PVF are required. Even a subtle disorder in systemic hemodynamics is precisely indicated by the balance between cardiac output and blood volume. The indocyanine green(ICG) kinetics reflect the patient's functional hepatocytes and effective PVF, and PVF is a major determinant of the ICG elimination constant(kICG) in the well-preserved allograft. The kICG value is useful to set the optimal PVF during living-donor LT and to evaluate adequate PVF after LT. Perioperative management has a large influence on the postoperative course and outcome; therefore, key points and unexpected pitfalls for intensive management are herein summarized. Transplant physicians should fully understand the peculiar systemic hemodynamic behavior in LT recipients with cirrhosis and recognize the critical importance of PVF after LT. | Tomohide Hori Yasuhiro Ogura Yasuharu Onishi Hideya Kamei Nobuhiko Kurata Motoshi Kainuma Hideo Takahashi Shogo Suzuki Takashi Ichikawa Shoko Mizuno Tadashi Aoyama Yuki Ishida Takahiro Hirai Tomoko Hayashi Kazuko Hasegawa Hiromu Takeichi Atsunobu Ota Yasuhiro Kodera Hiroyuki Sugimoto Taku Iida Shintaro Yagi Kentaro Taniguchi Shinji Uemoto | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 20 | Fulminant phlegmonitis of the esophagus, stomach,and duodenum due to Bacillus thuringiensis显示文摘We report a case of phlegmonitis of the esophagus, stomach, and duodenum in patient in an immunocompromised state. Culture of gastric juice and blood yielded Bacillus thuringiensis. This case showed that even low-virulence bacilli can cause lethal gastrointestinalphlegmonous gastritis in conditions of immunodeficiency. | Hisatake Matsumoto Hiroshi Ogura Masafumi Seki Mitsuo Ohnishi Takeshi Shimazu | 2015 | World Journal of Gastroenterology2015，21，12： | 3 |
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