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| 1 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 2 | 《日本慢性耳鸣诊治临床实践指南》摘译显示文摘人群中耳鸣的患病率为10%~15%,其中存在临床问题的占20%。在日本,出现耳鸣并深感痛苦的患者大约有300万,一些难治性耳鸣的治疗效果不尽如人意。本指南适用于慢性耳鸣患者,旨在规范耳鸣的循证诊断和治疗,提高耳鸣患者的生活质量。近年来发现,认知行为疗法和声治疗是减少耳鸣患者痛苦的有效方法。在日本医疗机构的医生都有权决定是否进行不同的治疗,并且还确定了治疗耳鸣的设施区域之间的差异。做到耳鸣评价标准化,以及为慢性耳鸣制定循证治疗指南。耳鸣临床实践指南的循证标准化是提高日本耳鸣医学检查水平的重要课题,该指南由小组委员会成员制定,由日本听力学会编辑,并由日本耳鼻喉科学会授权。 | 夏红艳(摘译) 赵立东(摘译) 王秋菊(审校) Ogawa K Sato H Takahashi M | 2021 | 听力学及言语疾病杂志2021，29，1： | 8 |
| 3 | Microwave dielectric properties of low temperature sintering Ca O3-δ 显示文摘 | Liu Peng Ogawa H Kim E S | 2004 | Journal of European Ceramic Society2004，24，： | 2 |
| 4 | Pre-treatment role of inosine triphosphate pyrophosphatase polymorphism for predicting anemia in Egyptian hepatitis C virus patients显示文摘AIM: To investigate and clarify, for the first time, the role of inosine triphosphate pyrophosphatase (ITPA ) polymorphism in Egyptian chronic hepatitis C virus (HCV) patients.METHODS:The human genomic DNA of all patients was extracted from peripheral blood cells in order to determine the single nucleotide polymorphism (SNP) of ITPA (rs1127354). SNP genotyping was performed by real time polymerase chain reaction (PCR, ABI TaqMan allelic discrimination kit) for 102 treatment-naive Egyptian patients with chronic HCV. All patients had no evidence of cardiovascular or renal diseases. They received a combination treatment of pegylated interferon α (PEG-IFNα) as a weekly subcutaneous dose plus an oral weight-adjusted dose of ribavirin (RBV). The majority received PEG-IFNα2a (70.6%) while 29.4% received PEG-IFNα2b. The planned duration of treatment was 24-48 wk according to the viral kinetics throughout the course of treatment. Pre-treatment liver biopsy was done for each patient for evaluation of fibrosis stage and liver disease activity. The basal viral load level was detected quantitatively by real time PCR while viral load throughout the treatment course was performed qualitatively by COBAS TaqMan assay. RESULTS: Ninety-three patients (91.2%) had ITPA SNP CC genotype and 9 (8.8%) had non-CC genotype (CA and AA). The percentage of hemoglobin (Hb) decline was higher for CC patients than for non-CC patients, particularly at weeks 4 and 8 (P=0.047 and 0.034, respectively). During the first 12 wk of treatment, CC patients had significantly more Hb decline > 3 g/dL than non-CC patients: 64.5% vs 22.2% at weeks 8 and 12, respectively, (P=0.024 and 0.038). Reduction of the amount of the planned RBV dose was significantly higher for CC patients than non-CC patients during the first 12 wk (18% ± 12.1% vs 8.5% ± 10.2%, P=0.021). The percentage of CC patients with RBV dose reduction was significantly greater than that of non-CC patients (77.4% vs 44.4%, P=0.044). Multivariate analysis identified only the percentage of RBV dose as a predictor for Hb decline. Platelet decline was significantly higher in non-CC patients than CC patients at weeks 12, 24 and 48 (P=0.018, 0.009 and 0.026, respectively). CONCLUSION: Rs1127354 ITPA polymorphism plays a decisive role in protecting against treatment-induced anemia and the need for RBV dose reduction in Egyptian HCV patients. | Walaa H Ahmed Norihiro Furusyo Saad Zaky Abeer Sharaf Eldin Hany Aboalam Eiichi Ogawa Masayuki Murata Jun Hayashi | 2013 | World Journal of Gastroenterology2013，19，9： | 2 |
| 5 | α-subunit of β- conglycinin,an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic dermatitis显示文摘 | OGAWA T BANDO N TSUJI H | 1995 | Biosceni Biotech Biochem1995，59，5： | 1 |
| 6 | Low-temperature sintering and microstructure of Mg4(Nb(2-x)Vx)O9 microwave dielectric ceramic by V substitution for Nb显示文摘 | KAN A OGAWA H | 2003 | Jpn J Appl Phys2003，42，9： | 1 |
| 7 | BetaKlotho is required for metabolic activity of fibroblast growth factor 21显示文摘 | Ogawa Y Kurosu H Yamamoto M | 2007 | Proc Natl Acad Sci USA2007，104，18： | 1 |
| 8 | Rapid transcriptional activation and early mRNA turnover of brain natriuretie peptide in cardiocyte hypertrophy: evidence for brain natriuretie peptide as an 'emergeney'eardieae hormone against ventrieular overload显示文摘 | Nakagawa O Ogawa Y Itoh H | 1995 | J Clin Invest1995，96，： | 1 |
| 9 | Cerebral atrophy in pa- tients with lacunar infaltion and extensive leukoaraiosis 显示文摘 | Yamacuchi H Fukuyama H Ogawa M | 1994 | Stroke1994，25，9： | 1 |
| 10 | Effects of imidapril therapy on endogenous fibrinolysis in patients with recent myocardial infarction显示文摘 | Soejima H Ogawa H Yasue H | 1997 | Clin Cardiol1997，20，： | 1 |
| 11 | Ferroelectric properties of lead-zirconate-titanate films prepared by laser ablation显示文摘 | KIDOH H OGAWA T MARIMOTO A | 1991 | Appl Phys Lett1991，58，： | 1 |
| 12 | Identification of CYP2C23 expressed in rat kidney as an arachidonic acid epoxygenase显示文摘 | Imaoka S Wedlund PJ Ogawa H | 1993 | J Pharmacol Exp Ther1993，267，2： | 1 |
| 13 | Cardiac fibrosis in mice lacking brain natriuretic peptide 显示文摘 | TAMURA N OGAWA Y CHUSHO H | 2000 | PNAS2000，97，8： | 1 |
| 14 | Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences显示文摘 | Ogawa R Mizuno H Watanabe A | 2004 | Biochem Biophys Res Commun2004，319，： | 1 |
| 15 | Microwave dielectric properties of low-temperature sintered ceramics显示文摘 | LIU P OGAWA H KIM E S | 2004 | J Eur Ceram Soc2004，24，6： | 1 |
| 16 | Soluble P-selectin is released into thecoronary circulation after coronary spasm显示文摘 | Kaikita K Ogawa H Yasue H | 1995 | Circulation1995，92，7： | 1 |
| 17 | Secretion of flavins by Shewanella species and their role in extracellular electron transfer显示文摘 | Von Canstein H Ogawa J Shimizu S | 2008 | Applied and Environmental Microbiology2008，74，3： | 1 |
| 18 | Theoretical study on fabrication of functionally graded material with density gradient by a centrifugal solid-particle method显示文摘 | OGAWA T WATANABE Y SATO H KIM I S FUKUI Y | 2006 | Composites Part A2006，37，12： | 1 |
| 19 | SIRT1/eNOS axis as a poten- tial target against vascular senescence, dysfunction and ath- eroselemsis显示文摘 | Ota H Eto M Ogawa S | 2010 | J Atheroscler Thmmb2010，17，5： | 1 |
| 20 | A bacterial effector targets Mad2L2, an APC inhibitor, to modulate host cell cycling显示文摘 | Iwai H Kim M Yoshikawa Y Ashida H Ogawa M Fujita Y Muller D Kirikae T Jackson PK Kotani S | 2007 | Cell2007，130，4： | 1 |
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