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| 1 | Convergence of neuro-endocrine-immune pathways in the pathophysiology of irritable bowel syndrome显示文摘Disordered signalling between the brain and the gut are generally accepted to underlie the functional bowel disorder, irritable bowel syndrome(IBS). However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. This common gastrointestinal disorder is characterised by alterations in bowel habit such as diarrhoea and/or constipation, bloating and abdominal pain, and symptom exacerbation has been linked with periods of stress, both psychosocial and infection-related. Indeed, a high level of comorbidity exists between IBS and stress-related mood disorders such as anxiety and depression. Moreover, studies have observed alterations in autonomic output and neuro-endocrine signalling in IBS patients. Accumulating evidence indicates that a maladaptive stress response, probably mediated by the stress hormone, corticotropin-releasing factor contributes to the initiation, persistence and severity of symptom flares.Other risk factors for developing IBS include a positive family history, childhood trauma, dietary factors and prior gastrointestinal infection. An emerging role has been attributed to the importance of immune factors in the pathophysiology of IBS with evidence of altered cytokine profiles and increased levels of mucosal immune cells. These factors have also been shown to have direct effects on neural signalling. This review discusses how pathological changes in neural, immune and endocrine pathways, and communication between these systems, contribute to symptom flares in IBS. | Maria M Buckley Siobhain M O'Mahony Dervla O'Malley | 2014 | World Journal of Gastroenterology2014，20，27： | 24 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Immunomodulation of enteric neural function in irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS) is a common functional gastrointestinal disorder which is characterised by symptoms such as bloating, altered bowel habit and visceral pain. It's generally accepted that miscommunication between the brain and gut underlies the changes in motility, absorpto-secretory functionand pain sensitivity associated with IBS. However, partly due to the lack of disease-defining biomarkers, understanding the aetiology of this complex and multifactorial disease remains elusive. Anecdotally, IBS patients have noted that periods of stress can result in symptom flares and many patients exhibit comorbid stress-related mood disorders such as anxiety and depression. However, in addition to psychosocial stressors, infection-related stress has also been linked with the initiation, persistence and severity of symptom flares. Indeed, prior gastrointestinal infection is one of the strongest predictors of developing IBS. Despite a lack of overt morphological inflammation, the importance of immune factors in the pathophysiology of IBS is gaining acceptance. Subtle changes in the numbers of mucosal immune cell infiltrates and elevated levels of circulating pro-inflammatory cytokines have been reproducibly demonstrated in IBS populations. Moreover, these immune mediators directly affect neural signalling. An exciting new area of research is the role of luminal microbiota in the modulation of neuro-immune signalling, resulting in local changes in gastrointestinal function and alterations in central neural functioning. Progress in this area has begun to unravel some of the complexities of neuroimmune and neuroendocrine interactions and how these molecular exchanges contribute to GI | Dervla O'Malley | 2015 | World Journal of Gastroenterology2015，21，24： | 5 |
| 4 | Anterior ankle arthrodesis显示文摘Ankle arthrodesis is a common procedure that resolves many conditions of the foot and ankle; however, complications following this procedure are often reported and vary depending on the fixation technique. Various techniques have been described in the attempt to achieve ankle arthrodesis and there is much debate as to the efficiency of each one. This study aims to evaluate the efficiency of anterior plating in ankle arthrodesis using customised and Synthes Tomo Fix plates. We present the outcomes of 28 ankle arthrodeses between 2005 and 2012, specifically examining rate of union, patient-reported outcomes scores, and complications. All 28 patients achieved radiographic union at an average of 36 wk; the majority of patients(92.86%) at or before 16 wk, the exceptions being two patients with Charcot joints who were noted to have bony union at a three year review. Patient-reported outcomes scores significantly increased(P < 0.05). Complications included two delayed unions as previously mentioned, infection, and extended postoperative pain. With multiple points for fixation and coaxial screw entry points, the contoured customised plate offers added compression and provides a rigid fixation for arthrodesis stabilization. | Gordon L Slater Stephanie C Sayres Martin J O'Malley | 2014 | World Journal of Orthopedics2014，5，1： | 5 |
| 5 | High gain GaAs potoconductive semiconductor switches for impulse sources显示文摘 | LOUBREIL G M ZUTAVERN F J O'MALLEY M W | 1994 | SPIE1994，2343，： | 2 |
| 6 | Delayed reconstruction of lateral complex structures of the ankle显示文摘Lateral ankle instability is one of the most common and well-recognized conditions presenting to foot and ankle surgeons.It may exist as an isolated entity or in conjunction with other concomitant pathology,making it important to appropriately diagnose and identify other conditions that may need to be addressed as part of treatment.These associated conditions may be a source of chronic pain,even when the instability has been appropriately treated,or may lead to failure of treatment by predisposing the patient to ankle inversion injuries.The primary goal of this editorial is to provide a brief summary of the common techniques used in the delayed reconstruction of lateral ankle ligamentous injuries and present a method we have successfully employed for over 15 years.We will also briefly discuss the diagnosis and treatment of the more common associated conditions,which are important to identify to achieve satisfactory results for the patient.We present the outcomes of 250 consecutive reconstructions performed over the last 10 years and describe our operative technique for addressing lateral ankle ligamentous injuries. | Gordon L Slater Alejandro E Pino Martin O’Malley | 2011 | World Journal of Orthopedics2011，2，4： | 2 |
| 7 | Advances on the Masquelet technique using a cage and nail construct显示文摘 | Natasha T. O’Malley Stephen L. Kates | 2012 | Archives of Orthopaedic and Trauma Surgery2012，，2： | 2 |
| 8 | Perioperative Use of Dexmedetomidine Is Associated With Decreased Incidence of Ventricular and Supraventricular Tachyarrhythmias After Congenital Cardiac Operations显示文摘 | Constantinos Chrysostomou Joan Sanchez-de-Toledo Peter Wearden Edmund H. Jooste Steven E. Lichtenstein Patrick M. Callahan Tunga Suresh Elizabeth O’Malley Dana Shiderly Jamie Haney Masahiro Yoshida Richard Orr Ricardo Munoz Victor O. Morell | 2011 | The Annals of Thoracic Surgery2011，，3： | 2 |
| 9 | Platelet Size in Stroke Patients显示文摘 | T. MRCP(UK) O’Malley P. Langhorne R.A. Elton C. Stewart | 1995 | Stroke A Journal of Cerebral Circulation1995，，6： | 2 |
| 10 | Patients'priorities for medical care显示文摘 | Fletcher R H O'Malley M S Earp J A | 1983 | Medical Care1983，21，2： | 1 |
| 11 | TCP Vegas: New techniques for congestion detection and avoidance显示文摘 | O'MALLEY S PETERSON L L | 1994 | Computer Communication Review1994，24，4： | 1 |
| 12 | Image-based gating of intravascular ultrasound pullback sequences显示文摘 | O'Malley SM Granada JF Carlier S | 2008 | IEEE Transactions on Information Technology in Biomedicine2008，12，3： | 1 |
| 13 | ASHP national survey of ambulatory care responsibilities of pharmacists in integrated health system显示文摘 | Reeder CE Kozma CM O'Malley C | 1998 | Am J Health Syst Pharm1998，55，： | 1 |
| 14 | Inheritance, gene ex- pression, and lignin characterization in a mutant Pine deficient in cinnamyl alcohol dehydrogenase显示文摘 | John M David M Malley O | 1997 | Plant Biology1997，94，： | 1 |
| 15 | Advances in pulsed power-driven radiography systems显示文摘 | Maenchen J Cooperstein G O'Malley J | 2004 | Proc of the IEEE2004，92，7： | 1 |
| 16 | Optimal allocation of embedded generation on distribution networks显示文摘 | Keane A O'Malley M | 2005 | IEEE Trans on Power Systems2005，20，3： | 1 |
| 17 | Using GC-MS/ Combustion/IRMS to determine the^13 C/^12 C ratios of individual hydrocarbons produced from the combustion of biomass materials--application to biomass burning 显示文摘 | O'Malley V P Burke R A Schlotzhauer W S | 1997 | Organic Geochemistry1997，27，78： | 1 |
| 18 | Risk factors for stroke due to cerebral infarction in young adults显示文摘 | You RX Mcneil LL O' Malley HM | 1997 | Stroke1997，28，10： | 1 |
| 19 | Metastatic potential of encapsulated (intracystic) papillary carcinoma of the breast: a report of 2 cases with axillary lymph node micrometastases 显示文摘 | Mulligan AM O' Malley FP | 2007 | Int J Surg Pathol2007，15，2： | 1 |
| 20 | Transoral robotic surgery: supraglottic laryngectomy in a canine model 显示文摘 | Weinstein GS O' Malley B J Hockstein NG | 2005 | Laryngoscope2005，115，7： | 1 |
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