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23篇 您的检索式：作者名="Novillo A"

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	题名	作者	年代	出处	被引量
1	Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports显示文摘BACKGROUND In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)alone.This benefit is not,however,observed in all patients.While increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug efficacy.This study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to treatment.CASE SUMMARY We report six cases of stage IV KRAS-mutated mCRC.Patients were given first line treatment with BVZ-containing chemotherapy in University Hospital of Fuenlabrada.The six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease course.Before treatment onset,total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR procedures.Our main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of treatment.CONCLUSION A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment.	Apolonia Novillo María Gaibar Alicia Romero-Lorca María Fuencisla Gilsanz Laura Beltrán Miguel Galán Beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander	2020	World Journal of Gastroenterology2020，26，16：	2
2	Renal histological lesions in patients with type II diabetes mellitus显示文摘	Castellano I Covarsi A Novillo R	2002	Nefrologia2002，22，2：	1
3	Mobility and availability to plants of two zinc sources applied to a calcareous soil显示文摘	Obrador A Novillo J Alvarez J M	2003	Soil Science Society of America Journal2003，67，2：	1
4	Toxicity and bioaccumulation of Cadmium in Olisthodiscus luteus显示文摘	Leborans G F Novillo A	1996	Water Resources1996，，：	1
5	War Res显示文摘	Leborans G F Novillo A	1996	30(1) :571996，30，1：	1
6	Frequency of bacterial overgrowth in patients with clinical lactose intolerance显示文摘	Novillo A Peralta D Dima G	2010	Acta Gastroenterol Latinoam2010，40，3：	1
7	Comparison of EDTA and sequential extraction tests for phytoavailability prediction of manganese and zinc in agricultural alkaline soils显示文摘	José M. Alvarez Luis M. Lopez-Valdivia Jesus Novillo Ana Obrador María I. Rico	2005	Geoderma2005，，3：	1
8	Impacts of the glucuronidase genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on tamoxifen metabolism in breast cancer patients 显示文摘	Romero-Lorca A Novillo A Gaibar M	2015	PLoS One2015，10，01：	1
9	Determination of bisphenol A and related aromatic compounds released from Bis - GMA - Based composites and sealants by high performance liquid chromatography显示文摘	Pulgar R Olea - Serrano MF Novillo - Fertrell A	2000	Environ Health Persp2000，108，：	1
10	Gliomatosis cerebri: review of 22 patients显示文摘	Novillo Lopez ME Gomez-Ibanez A Rosenfeld M	2010	Neurologia2010，25，3：	1
11	Experimental approach to cadmium effects on a marine protozoan community显示文摘	Fernández-Leborans G Novillo A	1994	Acta Hydrochem Hydrobiol1994，22，1：	1
12	Renal histological lesions in patients with type 2 diabetes mellitus显示文摘	Castellano I Covarsi A Novillo R	2002	Nefrologia2002，22，2：	1
13	Rela-tionship between genotypes Sult1a2 and CYP2D6 and tamoxifen metabolism in breast cancer patients 显示文摘	Fernandez-Santander A Gaibar M Novillo A	2013	PLoS One2013，8，70：	1
14	Determination of Bisphenol A and Related Aromatic Compounds Releasedfrom Bis -GMA -Based Composites and Sealants by High Performance LiquidChroma- tography 显示文摘	Pulgar R Olea - Serrano M F Novillo - Fertvell A	2000	Environmental Health Perspectives2000，105，1：	1
15	Gliomat- osis cerebfi : review of 22 patients 显示文摘	Novillo Lopez ME Gomez-Ibanez A Rosenfeld M	2010	Neurologia2010，25，：	1
16	Renal histological lesions in Patients with tyPe II diabetes mellitus显示文摘	Castellano I Covarsi A Novillo R	2002	Nefrologia2002，22，2：	1
17	Renal histological damage in pa- tients with type II diabetes mellitus显示文摘	Castellano I Covarsi A Novillo R	2002	Nefrologia2002，22，2：	1
18	Relationshipbetween Genotypes Sult1a2 and Cyp2d6 and TamoxifenMetabolism in Breast Cancer Patients 显示文摘	FERNA'NDEZ-SANTANDER A GAIBAR M NOVILLO A	2013	PLoS ONE2013，8，70：	1
19	Multiple struc- turally distinct ERa mRNA variants in zebrafish are dif- ferentially expressed by tissue type, stage of development and estrogen exposure显示文摘	Cotter K A Yershov A Novillo A	2013	General and comparative endo- crinology2013，194，：	1
20	Renal histological lesions in patients with type 2 diabetes mellitus显示文摘	Castellano I Covarsi A Novillo R	2002	Nefrologia2002，22，2：	1

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