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| 1 | Efficacy of bevacizumab-containing chemotherapy in metastatic colorectal cancer and CXCL5 expression: Six case reports显示文摘BACKGROUND In metastatic colorectal cancer(mCRC),the anti-vascular endothelial growth factor drug bevacizumab(BVZ)plus chemotherapy significantly improves progression-free survival compared to chemotherapy(CT)alone.This benefit is not,however,observed in all patients.While increased chemokine CXCL5 gene expression promoting angiogenesis has been proposed as a prognostic mCRC biomarker,few studies have examined its relationship with drug efficacy.This study sought to analyze tumor CXCL5 gene expression in six patients with different efficacy of BVZ-containing CT in terms of the tumor response to treatment.CASE SUMMARY We report six cases of stage IV KRAS-mutated mCRC.Patients were given first line treatment with BVZ-containing chemotherapy in University Hospital of Fuenlabrada.The six patients differed in terms of primary tumor location(right/left side),tumor burden(mostly hepatic and peritoneal disease)and clinical disease course.Before treatment onset,total RNA was isolated from paraffinated tumor biopsy specimens and CXCL5 gene expression quantified through conventional RT-qPCR procedures.Our main finding was that CXCL5 expression levels were several times higher in three patients with lower progression free survival(under 6 mo)from the start of treatment.CONCLUSION A higher expression of CXCL5 was observed in the three patients showing worse tumor response to treatment. | Apolonia Novillo María Gaibar Alicia Romero-Lorca María Fuencisla Gilsanz Laura Beltrán Miguel Galán Beatriz Antón Diego Malón Amalia Moreno Ana Fernández-Santander | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 2 | Arabidopsis CBF1 and CBF3 have a different function than CBF2 in cold acclimation and define different gene clas- ses in the CBF regulon显示文摘 | Novillo F Medina J Salinas J | 2001 | Proc Natl Acad Sci USA2001，104，21： | 1 |
| 3 | CBF2/DREBIC is a negative regula tor of CBF1/DREB1B and CBF3/DREB1A expression and plays a central rol in stress tolerance in Arabidopsis显示文摘 | Novillo F Alonso J M Ecker J R | 2004 | Proc Natl Acad Sci USA2004，101，： | 1 |
| 4 | Renal histological lesions in patients with type II diabetes mellitus显示文摘 | Castellano I Covarsi A Novillo R | 2002 | Nefrologia2002，22，2： | 1 |
| 5 | Genetic analysis reveals a complex regulatory network modulating CBF gene expression and Arabidopsis response to abiotic stress显示文摘 | NOVILLO F MEDINA J RODRIGUEZ-FRANCO M | 2012 | J Exp Bot2012，63，1： | 1 |
| 6 | 2006, Comparison of EDTA and sequential extraction tests for phytoavailability prediction of manganese and zinc in agricultural alkaline soils显示文摘 | ALVAREZ J M LOPEZ-VALDIVIA L M NOVILLO J | 2006 | Geoderma2006，132，： | 1 |
| 7 | Mobility and availability to plants of two zinc sources applied to a calcareous soil显示文摘 | Obrador A Novillo J Alvarez J M | 2003 | Soil Science Society of America Journal2003，67，2： | 1 |
| 8 | CBF2 /DREB1C is a negative regulator of CBF1 /DREB1B and CBF3 /DREB1A expression and p lays a central role in stress tolerance in A rabidopsis显示文摘 | Novillo F Alonso J M Ecker J R S | 2004 | Proceedings of the National Academy of Sciences2004，101，11： | 1 |
| 9 | CBF2/DREB1C is a negative regulator of CBF1/I)REB1B and CBF3/DREB1A expression and plays a central role in stress tolerance in Arabidopsis显示文摘 | Fernmado Novillo | 2004 | PNAS2004，101，11： | 1 |
| 10 | Genetic analysis reveals a complex regula- tory network modulating CBF gene expression and Arabidopsis re- spouse to abiotic stress显示文摘 | NOVILLO F MEDINA J RODR1GUEZ-FRANCO M NEU- HAUS G SALINAS J | 2012 | Journal of Experimental Botany2012，63，： | 1 |
| 11 | Toxicity and bioaccumulation of Cadmium in Olisthodiscus luteus显示文摘 | Leborans G F Novillo A | 1996 | Water Resources1996，，： | 1 |
| 12 | War Res显示文摘 | Leborans G F Novillo A | 1996 | 30(1) :571996，30，1： | 1 |
| 13 | Inhibition of digestive trypsin like proteases from larvae of several lepidopteran species by the diagnostic cysteine protease inhibitor E64 显示文摘 | Novillo C Castanear P Ortego F | 1997 | Insect Biochemistry and MolecularBiology1997，27，： | 1 |
| 14 | Frequency of bacterial overgrowth in patients with clinical lactose intolerance显示文摘 | Novillo A Peralta D Dima G | 2010 | Acta Gastroenterol Latinoam2010，40，3： | 1 |
| 15 | Comparison of EDTA and sequential extraction tests for phytoavailability prediction of manganese and zinc in agricultural alkaline soils显示文摘 | José M. Alvarez Luis M. Lopez-Valdivia Jesus Novillo Ana Obrador María I. Rico | 2005 | Geoderma2005，，3： | 1 |
| 16 | Orientation related microstructure evolution during continuous annealing of a cold-rolled low carbon steel显示文摘 | Bocos J L Novillo E Petite M M | 2003 | Mater Sci Forun2003，，426432： | 1 |
| 17 | Comparison of EDTA and sequential extraction tests for phytoavailability prediction of manganese and zinc in agricultural alkaline soils显示文摘 | Alvarez J M Lopez-Valdivia L M Novillo J | 2006 | Geoderma2006，132，： | 1 |
| 18 | Impacts of the glucuronidase genotypes UGT1A4, UGT2B7, UGT2B15 and UGT2B17 on tamoxifen metabolism in breast cancer patients 显示文摘 | Romero-Lorca A Novillo A Gaibar M | 2015 | PLoS One2015，10，01： | 1 |
| 19 | Characterization and distribution of digestive proteases of the stalk corn borer,Sesamia nonagrioides Lef Arc显示文摘 | Ortego F Novillo P | 1996 | Insect Biochem Physiol1996，33，： | 1 |
| 20 | Determination of bisphenol A and related aromatic compounds released from Bis - GMA - Based composites and sealants by high performance liquid chromatography显示文摘 | Pulgar R Olea - Serrano MF Novillo - Fertrell A | 2000 | Environ Health Persp2000，108，： | 1 |
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