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| 1 | Comprehensive review of autoantibodies in patients with hyper-IgM syndrome显示文摘Hyper-immunoglobulin M syndrome is an X-linked primary immunodeficiency disease caused by mutations in the CD40 ligand gene.The CD40 ligand has been recently highlighted as playing a key role in the pathogenesis of primary biliary cholangitis.In the present study,we assessed an extensive set of serum autoantibodies in a series of well-defined patients with hyper-immunoglobulin M syndrome.Serum,liver-related and liver-not-related autoantibodies IgG,IgM and IgA were tested by ELISA and standard indirect immunofluorescence in HEp-2 cells in 13 Tunisian patients(8 males and 5 females,aged 1–12 years)with hyper-immunoglobulin M syndrome during 1995–2012 and,as controls,21 age-and gender-matched blood donors.The level of IgM antibody against MIT3 was significantly higher in patients than in controls(35.8 vs 10.7,P=0.002).Half of the hyperimmunoglobulin M syndrome patients were found to be anti-MIT3 IgM positive vs none of the controls(Po0.0001).Twenty-three percent of patients were found to be anti-sp100 antibody positive vs only 0.05%of controls.By immunofluorescence,92.3%of patients were MIT3 IgM positive vs none of the controls.In conclusion,the IgM class of anti-MIT3 antibodies was shown to be present by both ELISA and immunofluorescence in most of the patients with hyper-immunoglobulin M syndrome.The presence of the hallmark of primary biliary cholangitis,a disease where the CD40 ligand is a key player,in an immunodeficiency disease caused by mutations in the CD40 ligand gene is very intriguing and opens new scenarios in understanding the immune pathogenesis of primary biliary cholangitis. | Mohamed-Ridha Barbouche Qubo Chen Marco Carbone Imen Ben-Mustapha Zakera Shums Mehdi Trifa Federica Malinverno Francesca Bernuzzi Haiyan Zhang Nourhen Agrebi Gary L Norman Christopher Chang M Eric Gershwin Pietro Invernizzi | 2018 | Cellular & Molecular Immunology2018，15，6： | 2 |
| 2 | Phenotypic characterization and RAPD fingerprinting of Vibrio parahaemolyticus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks显示文摘 | Sadok K Mejdi S Nourhen S | 2013 | Folia Microbiology (Praha)2013，58，1： | 1 |
| 3 | Phenotypic Characterization and RAPD Fingerprinting of Vibrio Parahae- molyticus and Vibrio Alginolyticus Isolated During Tunisian Fish Farm Outbreaks显示文摘 | NSADOK K MEJDI S NOURHEN S | 2013 | Folia Microbiologica2013，58，1： | 1 |
| 4 | Phenotypic characterization and RAPD fingerprinting of Vibrio parahaemolyticus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks显示文摘 | Sadok K Mejdi S Nourhen S | 2013 | Folia Microbiologica(Praha)2013，58，1： | 1 |
| 5 | Phenotypic characterization and RAPD fingerprinting of Vibrio parahaemolyticus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks显示文摘 | Sadok K Mejdi S Nourhen S | 2013 | Folia Microbiol(Praha)2013，58，1： | 1 |
| 6 | Phenotypic character- ization and RAPD fingerprinting of Vibrio parahaemolyti- cus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks 显示文摘 | Sadok K Mejdi S Nourhen S | 2013 | Folia Microbiol (Praha)2013，58，1： | 1 |
| 7 | Drying of sardine muscles: Experimental and mathematical investigations显示文摘 | NADIA DJENDOUBI NOURHENE BOUDHRIOUA CATHERINE BONAZZI | 2009 | Food and Bioproducts Processing2009，87，2： | 1 |
| 8 | Phenotypic characterization and RAPD fingerprinting of Vibrio parahaemolyticus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks显示文摘 | Khouadja Sadok Snoussi Mejdi Saidi Nourhen Bakhrouf Amina | 2013 | Folia Microbiologica2013，，1： | 1 |
| 9 | Phenotypic characterization and RAPD fingerprinting of Vibrio parahaemolyticus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks显示文摘 | Sadok.K Mejdi S Nourhen S | | 0，，： | 1 |
| 10 | Audit com- mittee financial expertise and misappropriation of assets 显示文摘 | Sameer T Mustafa Nourhene Ben Youssef | 2010 | Managerial Auditing Journal2010，25，3： | 1 |
| 11 | Phenotypic characterization and RAPD fingerprinting of Vibrio parahaemolyticus and Vibrio alginolyticus isolated during Tunisian fish farm outbreaks 显示文摘 | SADOK K MEJDI S NOURHEN S | 2013 | Folia microbiologica2013，58，1： | 1 |
| 12 | Phenotypic characterizationand RAPD fingerprinting of Vibrio parahaemolyticus and Vibrioalginolyticus isolated during Tunisian fish farm outbreaks 显示文摘 | Sadok K Mejdi S Nourhen S | 2013 | Folia Microbiol (Praha )2013，58，1： | 1 |
| 13 | Evidence of Mutational Heterogeneity of the ALDH7A1 Gene in Tunisian Families: Molecular and Insilico Investigations显示文摘 | Abdelaziz Tlili Marwa kharrat Emna Mkaouar-Rebai Nadia Hamida-Hentati Sawssan Ben Romdhan Nourhene Fendri-Kriaa Faiza Fakhfakh | 2016 | 材料科学与工程(中英文B版)2016，6，4： | 0 |
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