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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | Dual-action penems and carbapenems显示文摘 | Alfred J C Scott L D Norma K D | 1992 | J Med Chem1992，35，10： | 1 |
| 3 | The effect of early age feed restriction on subsequent response to high environmental temperatures in female broiler chickens显示文摘 | ZULKIFLI I CHE NORMA M T ISRAF D A | 2000 | Poultry Science2000，79，10： | 1 |
| 4 | An examination of the organizational and cross -cultural challenges facing international hotel managers in Russia 显示文摘 | Norma D'Annunzio - Green | 2002 | International Journal of Contemporary Hospitality Management2002，，14： | 1 |
| 5 | Frequeneyand determinants for hemorrhagic transformation of cerebral infarction显示文摘 | VALERIA TERRUSO MARCO D'AMELIO NORMA | 2009 | Neuroepidemiology2009，33，3： | 1 |
| 6 | Time course of hexachlorobenzene - induced alterations of lipid metabolima and their relation to Forphyria显示文摘 | SILVIA B D C NORMA S S MARIA C F | 1997 | Int J Biochern Cell Biol1997，，29： | 1 |
| 7 | Nematicidal activity of the essential oils of several argentina plants against the root-knot nematode显示文摘 | Claudia B D Angelica N M Norma V A | 2004 | Journal of Essential Oil Research2004，16，6： | 1 |
| 8 | Nematicidal Activity of the 'Essential Oils of Several Argentina Plants Against the Root-Knot Nematode显示文摘 | Claudia B D Angelica N M Norma V A | 2004 | Journal of Essential Oil Research2004，16，6： | 1 |
| 9 | Nematicidal activity of the essential oils of several argentina plants against the root - knot nematode 显示文摘 | Claudia B D Angelica N M Norma V A | 2004 | Journal of Essential Oil Research2004，16，6： | 1 |
| 10 | Nematicidal Activity of the Essential Oils of Several Argentina Plants Against the Root-Knot Nematode显示文摘 | Claudia B D Angelica N M Norma V A | 2004 | Journal of Essential Oil Research2004，16，6： | 1 |
| 11 | Survivin: A new target for anti-cancer therapy显示文摘 | Bríd M. Ryan Norma O’Donovan Michael J. Duffy | 2009 | Cancer Treatment Reviews2009，，7： | 1 |
| 12 | Spect roelectrochemist ry of palladium hexaeyanoferrate films on platinum substrates 显示文摘 | REYNALDO O L ROBERTO R NORMA R D T | 2003 | Journal of Electroanalytical Chemistry2003，544，： | 1 |
| 13 | Nematicidal activity of the essential oils of several argentina plants against the root-knot nematode显示文摘 | Claudia B D Angelica N M Norma V A | 2004 | Journal of Essential Oil Research2004，16，6： | 1 |
| 14 | RAPD and ISSR markers indicate diminished gene flow due to recent fragmentation of Polylepis australis woodlands in central Argendna显示文摘 | NORMA J ANA S JUAN R D JULIO D R DANIEL R ISABELL H | 2008 | Biockemical Systematics and Ecology2008，36，： | 1 |
| 15 | Endothelial NO Synthase Genotype and Risk of Preeclampsia: A Multicenter Case - Control Study显示文摘 | Norma C Serrano Juan P Casas Luis A Díaz | 2004 | Hypertension2004，44，： | 1 |
| 16 | The effect of early age feed restriction on subsequent response to high environmental temperatures in female broiler chickens 显示文摘 | Zulkifli I Norma M T C Israf D A | 2000 | Poultry Science2000，79，： | 1 |
| 17 | The effect of early age feed restriction on subsequent response to high environmental temperatures in female broiler chickens 显示文摘 | Zulkifli I Che Norma M T Israf D A | 2000 | Poultry Science2000，79，： | 1 |
| 18 | Mercaftoacyl dipeptides as dual in hibiors of angiotensin-converting enzyme and neutral endopeptidase preliminary structure-activity studies 显示文摘 | Norma G D Joel C B Richard N | 1994 | Bioorg Med Chem Lett1994，4，15： | 1 |
| 19 | Immunomodulatory oligonucleotide IMT504:Effects on mesenchymal stem cells as a first-in-class immunoprotective/immunoregenerative therapy显示文摘The immune responses of humans and animals to insults(i.e., infections, traumas, tumoral transformation and radiation) are based on an intricate network of cells and chemical messengers. Abnormally high inflammation immediately after insult or abnormally prolonged proinflammatory stimuli bringing about chronic inflammation can lead to life-threatening or severely debilitating diseases. Mesenchymal stem cell(MSC) transplant has proved to be an effective therapy in preclinical studies which evaluated a vast diversity of inflammatory conditions. MSCs lead to resolution of inflammation, preparation for regeneration and actual regeneration, and then ultimate return to normal baseline or homeostasis. However, in clinical trials of transplanted MSCs, the expectations of great medical benefit have not yet been fulfilled. As a practical alternative to MSC transplant, a synthetic drug with the capacity to boost endogenous MSC expansion and/or activation may also be effective. Regarding this, IMT504, the prototype of a major class of immunomodulatory oligonucleotides, induces in vivo expansion of MSCs, resulting in a marked improvement in preclinical models of neuropathic pain, osteoporosis, diabetes and sepsis. IMT504 is easily manufactured and has an excellent preclinical safety record. In the small number of patients studied thus far, IMT504 has been well-tolerated, even at very high dosage. Further clinical investigation is necessary to demonstrate the utility of IMT504 for resolution of inflammation and regeneration in a broad array of human diseases that would likely benefit from an immunoprotective/immunoregenerative therapy. | Jorge Zorzopulos Steven M Opal Andrés Hernando-Insúa Juan M Rodriguez Fernanda Elías Juan Fló Ricardo A López Norma A Chasseing Victoria A Lux-Lantos Maria F Coronel Raul Franco Alejandro D Montaner David L Horn | 2017 | World Journal of Stem Cells2017，9，3： | 1 |
| 20 | Theobservability of the Fibonacci and Lucas cubes 显示文摘 | Dedo E Torri D and Norma Zagaglia Salvi | 2002 | Discrete Mathematics2002，255，： | 1 |
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