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| 1 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 2 | Immunogenicity of a monovalent 2009 influenza A(H1N1) vaecine in infants and children :a randomized trial 显示文摘 | Nolan T McVernon J Skeljo M | 2010 | JAMA2010，303，1： | 1 |
| 3 | The Constructive, Destructive, and Reconstructive Power of Social Norms 显示文摘 | Schuhz P W Nolan J M Cialdini R B | 2007 | Psychological Science2007，18，5： | 1 |
| 4 | Survival after pulmonary edema due to enterovirus 71 encephalitis显示文摘 | NOLAN N A CRAIG M E LAHRA M M | 2003 | Neurology2003，60，10： | 1 |
| 5 | Tools and tactics for the optical detection of mercuric ion显示文摘 | Nolan E M Lippard S J | 2008 | Chemistry Review2008，108，34： | 1 |
| 6 | The role of nitrogen doping on the development of visible light induced photocatalytic activi ty in thin TiO2 films grown on glass by chemical vapour deposition显示文摘 | Yates H M Nolan | 2006 | J Photochem Photobiolo A Chem2006，179，12： | 1 |
| 7 | The ProSeal laryngeal mask airway: a review of the literature显示文摘 | COOK T M LEE G NOLAN J P | 2005 | Can J Anaesth2005，52，7： | 1 |
| 8 | Near-surface moisture gradients and in situ permeation tests显示文摘 | Basheer P A M Nolan 1 | 2001 | Construction and Building Materials2001，15，23： | 1 |
| 9 | Midrange affinity fluorescent Zn( Ⅱ ) sensors of the zinpyr family: Syntheses, characterization, and biological imaging applications显示文摘 | Nolan E M Jaworski J Racine M E | 2006 | Inorg Chem2006，45，： | 1 |
| 10 | Transforming students' views of gerontological nursing:Realising the potential of ' enriched' environments of learning and care: A multi-method longitudinal study显示文摘 | Brown J Nolan M Davies S | 2008 | Int J Nurs Stud2008，45，8： | 1 |
| 11 | Matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in the human lens:implications for cortical cataract formation显示文摘 | Sachdev N H Girolamo N D Nolan T M | 2004 | Invest Ophthalmol Vis Sci2004，45，11： | 1 |
| 12 | Widespread sexual disruption in wild fish 显示文摘 | Jobling S Nolan M Tyler C R | 1998 | Environmental Science and Technology1998，32，17： | 1 |
| 13 | Transformingviews of gerontological nursing: realising thepotential of ” enriched' environments of learning andcare: a multi-method longitudinal study 显示文摘 | Brown J Nolan M Davies S | 2008 | Int J NursStud2008，45，8： | 1 |
| 14 | Epigenetics and gene expression 显示文摘 | Gibney E R Nolan C M | 2010 | Heredity2010，105，： | 1 |
| 15 | LASIK surgery in children显示文摘 | Keefe M Nolan L | 2004 | Br J Ophthalmol2004，88，1： | 1 |
| 16 | Widespread sexual disruption in wild fish显示文摘 | Jobling S Nolan M Tyler C R | 1998 | Environmental Science & Technology1998，32，17： | 1 |
| 17 | Quantitative real-time RT-PCR a perspective显示文摘 | Bustin S A Benes V Nolan T Pfaffl M W | 2005 | Journal of Molecular Endocrinology2005，34，： | 1 |
| 18 | Production of high titer helper-free retroviruses by transient transfection 显示文摘 | Pear W Nolan GP Scott M | 1993 | Proc Natl Acad Sci USA1993，90，18： | 1 |
| 19 | Electromyogram Median Frequency, Spectral Compression and Muscle Fiber Conduction Velocity during Sustained submaximal Contraction of the Brachioradialis Muscle显示文摘 | M LOWERY P NOLAN M O'Malley | 2002 | J Electromyography Kinesiol2002，12，： | 1 |
| 20 | Detection and verification of quantitative trait loci for resistance to Dothistroma needle blight in Pinus radiate显示文摘 | Devey M E Groom K A Nolan M F | 2004 | Theor Appl Genet2004，108，： | 1 |
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